INTRODUCTION

TOBRAM EYE OINTMENT contains Tobramycin which belongs to the group of medicines known as Antibiotics. It is used in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria.

Bacterial conjunctivitis is the infection of the transparent membrane (conjunctiva) that lines the eyelid and covers the white part of your eyeball. Symptoms of bacterial conjunctivitis include pain, discomfort, redness, itching, irritation and watering of the eyes.

Do not wear contact lens if you have ocular infection while using TOBRAM EYE OINTMENT. Remove the contact lenses before using TOBRAM EYE OINTMENT and can put them back after 15 minutes of use.

TOBRAM EYE OINTMENT should be used with caution in patients who have ever had neuromuscular disorders, such as myasthenia gravis or Parkinson’s disease.

TOBRAM EYE OINTMENT should be used with caution in pregnant women or if you think you may be pregnant and in breastfeeding woman. Consult your doctor before using.

The safety and effectiveness of TOBRAM EYE OINTMENT in children under the age of 2 months has not been established.

The common side effects of using this medicine are swollen, itchiness in eyelids, eye irritation, redness of eyes, watery eyes. Consult your doctor if the symptom does not improve.

USES OF TOBRAM EYE OINTMENT

• Used to treat bacterial infections of the external part of the eye, such as conjunctivitis

HOW TOBRAM EYE OINTMENT WORKS

TOBRAM EYE OINTMENT effectively works against the disease-causing bacteria by binding irreversibly to one of two amino glycoside binding sites on the 30 S ribosomal subunit of bacteria thereby terminating the bacterial growth.

DIRECTIONS FOR USE

Always use TOBRAM EYE OINTMENT exactly as directed by your physician. It is for ophthalmic use only. Apply the medicine into the affected eye 1 to 2 times a day or as directed by the physician. Your doctor will administer the right dose depends on your age, body weight and disease condition.

SIDE EFFECTS OF TOBRAM EYE OINTMENT

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

• beta lactam antibiotics like penicillin’s, cephalosporins (medicines used to treat infections of the eye, ear or the skin)
• other aminoglycoside antibiotics like gentamicin, amikacin (medicines used to treat bacterial infections)

Overdosage:

If you or anyone else accidentally uses too much of TOBRAM EYE OINTMENT, consult your doctor immediately or visit the nearby hospital. Wash your eyes and rinse it all out with warm water.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at a temperature not exceeding 25°C

FAQs ABOUT TOBRAM EYE OINTMENT

What is TOBRAM EYE OINTMENT and why it is given?

TOBRAM EYE OINTMENT contains tobramycin which is used to treat bacterial infections of the external part of the eye, such as conjunctivitis which is the infection of the transparent membrane (conjunctiva) that lines the eyelid and covers the white part of your eyeball characterized by pain, discomfort, redness, itching, irritation and watering of the eyes.

How does TOBRAM EYE OINTMENT works?

TOBRAM EYE OINTMENT effectively works against the disease-causing bacteria by binding irreversibly to one of two amino glycoside binding sites on the 30 S ribosomal subunit of bacteria thereby terminating the bacterial growth.

How to use TOBRAM EYE OINTMENT?

Always use TOBRAM EYE OINTMENT exactly as directed by your physician. It is for ophthalmic use only. Apply the medicine into the affected eye 1 to 2 times a day or as directed by the physician. Your doctor will administer the right dose depends on your age, body weight and disease condition.

Does TOBRAM EYE OINTMENT cause eye irritation?

Yes, it may cause itching and burning sensation of eye in some patients. Close your eyes and relax for some time to reduce irritation. Place an ice pack over the eyes for few minutes. Avoid watching mobile phone, system, laptop or any other light sources which might irritate your eyes. If the symptom persists or worsens, contact your doctor.

Can TOBRAM EYE OINTMENT be used in children?

The safety and effectiveness of TOBRAM EYE OINTMENT in children under the age of 2 months has not been established. Consult your doctor for advice before using TOBRAM EYE OINTMENT.

REFERENCES

1. KD Tripathi MD. Aminoglycosides antibiotics. Essentials of Medical Pharmacology 8th edition. Page – 793.

2. Mark Abelson, Eugene Protzko, Aron Shapiro, Ana Garces-Soldana and Lyle Bowman azithromycin. A randomized trial assessing the clinical efficacy and microbial eradication of 1% azithromycin ophthalmic solution vs tobramycin in adult and pediatric subjects with bacterial conjunctivitis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. June 2007. [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704516/

3. Qin Xiang, MM, Dan Hu, MB and Xu Gao, Tobramycin/dexamethasone eye drops as a better choice for lacrimal duct probing in persistent congenital nasolacrimal duct obstruction. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. February 2019. [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380727/

4. Novartis New Zealand Limited. [Revised in November 2021] [Accessed 19th July 2022] https://www.medsafe.govt.nz/Consumers/cmi/t/tobrexdrops.pdf