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INTRODUCTION
THIOSPAS 4 CAPSULEcontains Thiocolchicoside, which belongs to the group of medicines called Muscle relaxants. It is used in adults and adolescents over 16 years of age to treat painful muscle contractions and for acute painful conditions related to the spine. Muscle spasms (muscle cramps) are painful contractions and tightening of your muscles. They’re common, involuntary, and unpredictable. The symptoms may include swelling, pain, stiffness, tenderness, and fatigue.
Your doctor may advise you to take relevant tests to understand your condition. Before taking THIOSPAS 4 CAPSULE, inform your doctor if you have flaccid paralysis (sagging of the face), muscular hypotonia (weak muscles), diarrhoea, lactose intolerance, seizure, or epilepsy.
THIOSPAS 4 CAPSULE is not recommended for use by pregnant or breastfeeding women. THIOSPAS 4 CAPSULE should not be used by children or adolescents under the age of 16. The most common side effects of taking THIOSPAS 4 CAPSULE are skin allergic reactions, drowsiness, diarrhea, and gastric symptoms. Consult your doctor if your symptoms get worse or persist.
USES OF THIOSPAS 4 CAPSULE
- painful muscle contractions
- acute painful conditions related to the spine
HOW THIOSPAS 4 CAPSULE WORKS
THIOSPAS 4 CAPSULE works through selective binding to the GABA-A receptor (neurotransmitter). It prevents muscle contractions by activating the GABA-inhibitory motor pathway and inhibiting the glycine receptors (neurotransmitters). Thus, relaxing the muscle pain and spasms.
DIRECTIONS FOR USE
Take THIOSPAS 4 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF THIOSPAS 4 CAPSULE
COMMON
- digestive disorders such as diarrhea and stomach pain
- gastralgia
- drowsiness
UNCOMMON
- itching, redness, bumps, vesicles or blisters on the skin
- allergic skin reaction
- nausea and vomiting
RARE
- allergic skin reactions like hives/urticaria
Stop taking THIOSPAS 4 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- seizures
- signs of a liver problem (loss of appetite, nausea or vomiting, abdominal discomfort, unexplained fatigue, dark-coloured urine, jaundice, fever, itching)
- angioedema (sudden swelling of the neck and face, possibly causing difficulty breathing)
- anaphylactic shock (drop in blood pressure, possibly preceded by an eruption of bumps, itching, redness of the skin, difficulty breathing, swelling of the face and/or neck)
HOW TO MANAGE SIDE EFFECTS
Nausea
Try to take THIOSPAS 4 CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your symptom gets worse.
Itchy skin:
Avoid taking hot showers as they can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when going outdoors or use unscented moisturizers to soothe and hydrate the skin. Consult your doctor if your symptom gets worse.
Diarrhoea:
Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any medicine on your own to treat diarrhoea. Consult your doctor if your symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
THIOSPAS 4 CAPSULE is not recommended for use in pregnant women, women planning to have a baby or women of childbearing potential who are not taking contraceptives. Consult your doctor before taking THIOSPAS 4 CAPSULE.
BREASTFEEDING
THIOSPAS 4 CAPSULE is not recommended for use by breastfeeding women. Consult your doctor before taking THIOSPAS 4 CAPSULE.
DRIVING AND USING MACHINES
Do not drive or use machines while taking THIOSPAS 4 CAPSULE as it can make you drowsy. Consult your doctor for advice.
ALLERGY
Do not take THIOSPAS 4 CAPSULE if you are allergic to Thiocolchicoside or any other ingredients of this medicine.
OTHERS
THIOSPAS 4 CAPSULE is not recommended for use if you:
- flaccid paralysis (sagging face)
- muscular hypotonia (muscle weakness)
Before taking THIOSPAS 4 CAPSULE, inform your doctor if you:
- have diarrhea
- have epilepsy or risk of seizure
- lactose intolerant
Use in pediatrics:
THIOSPAS 4 CAPSULE is not recommended for use in children below 16 years of age. Consult your doctor before taking THIOSPAS 4 CAPSULE.
INTERACTIONS
A. Drug-Drug interactions:
Before taking THIOSPAS 4 CAPSULE, inform your doctor if you are taking any of the following medicine:
- taking or have taken any other medicines, muscle relaxants or central nervous system sedatives
Overdosage:
If you or anyone else accidentally take too much of THIOSPAS 4 CAPSULE, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Thiocolchicoside |
| Pharmacological Category | : | Triaminopyridines |
| Therapeutic Indication | : | Painful muscle contractions, Acute painful conditions related to the spine |
| Dosage Forms | : | Gel, Tablet, Capsule, Injection |
MORE INFORMATION
- Keep THIOSPAS 4 CAPSULE out of reach from children
- Store at room temperature
FAQs ABOUT THIOSPAS 4 CAPSULE
What is THIOSPAS 4 CAPSULE used for?
THIOSPAS 4 CAPSULE is used as an add-on therapy in adults and adolescents 16 years of age and older for painful muscle contractions and acute painful spine conditions.
Can THIOSPAS 4 CAPSULE be used by children?
No, THIOSPAS 4 CAPSULE should not be used by children under the age of 16. Consult your doctor before taking THIOSPAS 4 CAPSULE.
How does THIOSPAS 4 CAPSULE work?
THIOSPAS 4 CAPSULE works through selective binding to the GABA-A receptor (a neurotransmitter). It prevents muscle contractions by activating the GABA-inhibitory motor pathway and inhibiting the glycine receptors (neurotransmitters). Thus, relaxing the muscle pain and spasms.
When is THIOSPAS 4 CAPSULE contraindicated?
THIOSPAS 4 CAPSULE is not recommended for use in patients with flaccid paralysis, muscular hypotonia, or hypersensitivity to this medicine. Consult your doctor before taking THIOSPAS 4 CAPSULE.
What if I skip a dose of THIOSPAS 4 CAPSULE?
If you miss a dose of THIOSPAS 4 CAPSULE, you should take it as soon as possible. If it’s time for the next dose, do not take the missed dose. Continue the treatment as scheduled by your doctor.
REFERENCES
1. KD Tripathi. Skeletal Muscle Relaxants. Essentials of medical pharmacology. Eighth Edition. 2019. Page –383-384.
2. Marco Gervasi, Davide Sisti, Piero Benelli, Eneko Fernández-Peña, Cinzia Calcabrini, Marco B.L. Rocchi, Luigi Lanata, Michela Bagnasco, Andrea Tonti, Stocchi Vilberto, and Piero Sestili. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness. [Accessed on 6th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627858/
3. A.R Umarkar, S.R Bavaskar & P.N.Yewale. Thiocolchicoside as Muscle Relaxant: A Review. [Revised in September 2011] [Accessed on 6th July 2022] http://www.ijpbsonline.com/uploads/1/2/1/8/12183777/364-371.pdf
4. Iasis Pharma Hellas s.a. Thiocolchicoside [Revised in October 2014] [Accessed on 6th July 2022] https://iasispharma.com/wp-content/uploads/pdf/RELIEF_PIL_ENG.pdf
5. European Medical Agency. Thiocolchicoside. [Revised on November 2013] [Accessed on] https://www.ema.europa.eu/en/documents/referral/thiocolchicoside-article-31-referral-annex-iii_en.pdf
6. Thiocolchicoside. Pubchem. [Revised in July 2022] [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Thiocolchicoside#section=Associated-Disorders-and-Diseases
7. Thiocolchicoside. Clevelandclinic. [Revised in March 2021] [Accessed on 6th July 2022] https://my.clevelandclinic.org/health/diseases/15466-muscle-spasms
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 12 Nov 2022 | 01:19 PM(IST)
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