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INTRODUCTION
THEGEST N TABLET contains Norethisterone, which belongs to a group of medicines called Progestogens. It is used to treat and manage heavy menstrual bleeding or abnormal uterine bleeding (that occurs due to hormonal imbalance), painful periods, irregular periods or periods that are more frequent than normal (polymenorrhoea), premenstrual tension, endometriosis (abnormal growth of endometrial tissue of the uterus that causes pain and menstrual irregularities), metriopatheias haemorrhagia (intermenstrual bleeding) and breast cancer. It is also used to delay the menstrual cycle.
THEGEST N TABLET is not recommended for use in patients with pulmonary embolism (blood clots in the lung), liver disease, heart attack (myocardial infarction) or angina and deep vein thrombosis. THEGEST N TABLET should be used with caution in patients with asthma, kidney disease, fits, and migraine headaches.
THEGEST N TABLET is not recommended for use during pregnancy as it may affect the developing baby. Inform your doctor if you have had repeated miscarriages. THEGEST N TABLET should be used with caution in breastfeeding women as it may pass through the breast milk. If you experience mood changes and depressive symptoms, contact your doctor as soon as possible.
The most common side effects of taking THEGEST N TABLET are irregular bleeding, heavy menstruation, spotting between menstrual cycles, delayed or not having a menstrual cycle, stomach discomfort, nausea, vomiting, breast tenderness, headache, and dizziness. Contact your physician if the symptoms worsen
USES OF THEGEST N TABLET
THEGEST N TABLET manages and treats:
- heavy periods
- painful periods
- irregular periods
- increased frequency of periods
- premenstrual tension
- endometriosis (a disease where the tissue lining the uterus, grows outside the uterus)
- breast cancer
- metropathia
- haemorrhagia (intermenstrual bleeding)
- abnormal uterine bleeding
- breast cancer
- to delay the next periods
HOW THEGEST N TABLET WORKS
THEGEST N TABLET inhibits the release of pituitary hormones that are responsible for the release of female hormones (such as oestrogen and progesterone) and thereby suppressing ovulation. This action modifies the lining of the endometrium and thus ceases bleeding in menstrual abnormalities in cancer THEGEST N TABLET may act by pituitary inhibition or by direct action on tumour deposits.
DIRECTIONS FOR USE
Follow the instructions given by your doctor. Take THEGEST N TABLET as advised according to your symptoms and disease severity. Swallow the whole tablet with a glass of water.
SIDE EFFECTS OF THEGEST N TABLET
COMMON
- irregular bleeding, heavy menstruation
- spotting between menstrual cycles
- delayed or not having a menstrual cycle
- stomach discomfort, nausea, vomiting
- breast tenderness
- headache and dizziness
RARE
Stop taking THEGEST N TABLET and contact your doctor immediately if you experience any of the following side effects:
- yellowing of the skin or white area of the eyes (jaundice)
- migraine headache for the very first time (a headache that usually restricts itself to one side of your head)
- high blood pressure
- symptoms of severe allergic reaction such as itchy skin rash, swelling of the face or tongue, hands or feet causing wheezing, difficulty breathing or feeling faint
- symptoms of a blood clot in the lungs include a sudden, severe, sharp pain in the chest, coughing up blood, shortness of breath, rapid heartbeats
- symptoms of a blood clot in the brain (stroke) include unusually severe or long headache, change in sight, difficulty speaking, collapsing, or fainting, and weakness or paralysis of any part of your body
- symptoms of a deep-vein thrombosis such as severe pain, tenderness or swelling in your calf, ankle or foot, purplish discolouration of the skin of the leg and red or warmth skin
HOW TO MANAGE SIDE EFFECTS
Nausea, vomiting:
Take the medicine with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea and vomiting get worse.
Headache:
Rest and relax. Apply a pain-relieving balm to your forehead if needed. Do not consume alcohol. Contact your doctor if your headache does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if you feel dizzy. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if the dizziness worsens.
Stomach pain:
Try to rest and relax. Eat small meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if the stomach pain does not improve.
WARNING & PRECAUTIONS
PREGNANCY
THEGEST N TABLET is not recommended for use during pregnancy and if you have a history of Idiopathic jaundice during pregnancy or an itchy rash or blisters on the abdomen known as pemphigoid gestationis (rare autoimmune skin disorder in pregnancy) and THEGEST N TABLET should be used with caution in patients with a history of repeated miscarriages. Contact your doctor before taking THEGEST N TABLET.
BREASTFEEDING
THEGEST N TABLET should be used with caution in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking THEGEST N TABLET.
DRIVING AND USING MACHINES
THEGEST N TABLET does not affect the ability to drive or operate machinery.
KIDNEY
THEGEST N TABLET should be used with caution in patients with kidney disease. Contact your doctor before taking THEGEST N TABLET.
LIVER
THEGEST N TABLET should be used with caution in patients with liver disease. Contact your doctor before taking THEGEST N TABLET.
ALLERGY
Do not use THEGEST N TABLET if you are allergic to norethisterone, similar other hormone medicines, or any other ingredients in the medicine.
LUNGS
THEGEST N TABLET is not recommended for use in patients who have or had a pulmonary embolism (blood clots in the lung) and should be used with caution in patients with asthma. Contact your doctor before taking THEGEST N TABLET.
HEART DISEASE
THEGEST N TABLET is not recommended for use in patients with active or recent angina (chest pain) or heart attack. Contact your doctor before taking THEGEST N TABLET.
OTHERS
THEGEST N TABLET is not recommended for use if you have:
- blood disorders like porphyria
- clotting disorders like deep vein thrombosis or a family history of the same
- pruritis (a condition with severe generalised itching of the body)
- undiagnosed vaginal bleeding (not a period)
Before taking THEGEST N TABLET tell your doctor if you have:
- epilepsy
- migraine headache
- are very overweight
- systemic lupus erythematosus.
- a blood clot in the veins
- are unable to move for long periods (Ex. after an operation)
- serious injury
- have major surgery or are going to have an operation (particularly abdominal or orthopaedic surgery to the lower limbs)
- blood tests (for liver function, thyroid function, and coagulation).
- vision impairment, bulging eyes, double vision
- depression
INTERACTIONS
A. Drug-Drug Interactions:
- antiepileptic medicines (used to treat fits) (phenytoin, carbamazepine, phenobarbitone)
- antibiotics ex. tetracyclines, co-trimoxazole, ampicillin, oxacillin (medicines used for bacterial infections)
- medicines used for tuberculosis (rifampicin, rifabutin)
- antiviral medicines for treatment of HIV (ritonavir, nelfinavir, efavirenz)
- anticancer medicines
- aminoglutethimide (used in Cushing’s syndrome)
- ciclosporin (immunosuppressants or medicines used to prevent rejection of a transplanted organ)
- nonsteroidal anti-inflammatory drugs NSAID’s (medicines used for pain)
- medicines for treating high blood pressure (amlodipine, captopril, atenolol, telmisartan)
- st. john’s wort (medicines used to treat depression)
Overdosage:
If you or anyone else accidentally took more of THEGEST N TABLET, contact your doctor immediately or visit a nearby hospital immediately if the symptoms worsen. The symptoms may include nausea, vomiting, breast enlargement and vaginal bleeding.
SYNOPSIS
| Drug | : | Norethisterone |
| Pharmacological Category | : | Progestogens |
| Therapeutic Indication | : | Menstrual disorders and breast cancer |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep THEGEST N TABLET below 25°C
- Keep THEGEST N TABLET out of sight and reach from children
FAQs ABOUT THEGEST N TABLET
Can THEGEST N TABLET affect the regular menstrual cycle?
THEGEST N TABLET is a synthetic form of the hormone progesterone. Rather than allowing for the natural fall in progesterone during your period, THEGEST N TABLET keeps your progesterone levels high. This delays the shedding of your womb lining and the period.
When will my menstrual cycle start after taking THEGEST N TABLET?
Your doctor will advise you when to take THEGEST N TABLET and for how long. You'll usually be prescribed 3 THEGEST N TABLET tablets a day, starting 3 to 4 days before you expect your period to begin. Your period should arrive 2 to 3 days after you stop taking the THEGEST N TABLET.
How long will THEGEST N TABLET take to stop bleeding?
If a period is very heavy or prolonged, your doctor may advise you to take THEGEST N TABLET 5mg three times daily for 10 days. Bleeding will usually stop within 24-48 hours of starting treatment.
What happens if I take THEGEST N TABLET too late?
It is important to take THEGEST N TABLET three days before your menstrual cycle. If you take THEGEST N TABLET too late, it may delay your menstrual cycle.
Can THEGEST N TABLET cause mood depression?
Yes, THEGEST N TABLET may cause depressed mood, acne, breast tenderness, fluid retention and loss of libido. Contact your doctor if you get any of the side effects.
REFERENCES
1. K D Tripathi. Hormones and Related Drugs. Essentials of Medical Pharmacology. 7th Edition. Page 309-310.
2. Wockhardt UK Ltd. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 19th July 2022] https://www.medicines.org.uk/emc/product/1494/pil
3. Norethisterone. Torrent Pharmaceuticals Ltd. [Revised in May 2020] [Accessed on 19th Jul 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2955.pdf
4. Norethisterone. Torrent Pharmaceuticals Ltd. [Revised in July 2020] [Accessed on 19th Jul 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2950.pdf
5. Norethisterone. Leeford Health Care Ltd. Accessed on 19th Jul 2022] https://www.leeford.in/product/1516/rethrowel-10-cr
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Thyroid functions
- HCG
- Pap smear
PRODUCT DETAILS
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.