INTRODUCTION

TEXIFEN contains Terbinafine which belongs to Antifungal agents, used to treat fungal infections of the skin and nails. It is indicated for athlete's foot, jock itch and ringworm, yeast infections. It acts by attacking and killing fungus which causes infection. A fungal infection known as mycosis, is a skin disease caused by a fungus. They live in the dirt, on plants, on household surfaces, and on your skin. This can lead to skin problems like rashes or bumps.

Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations it is fungicidal against dermatophytes, molds and certain dimorphic fungi. Terbinafine interferes with the production of ergosterol and causes a buildup of another substance called squalene in the fungal cell. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene, resulting in fungal cell death. Both actions cause the death of the fungus and elimination of the infection.

Before using this TEXIFEN, inform your doctor if you have any allergic reaction. Avoid contact of this medicine with eyes. Rinse thoroughly with running water in case of accidental contact. It is not recommended for children and adolescents below 12 years of age. The common side effects are flaking, peeling or irritation of skin.

USES OF TEXIFEN

• Treat fungal infections (nail, toes, fingers)

HOW TEXIFEN WORKS

TEXIFEN works by interfering in the production of a substance (ergosterol) that the fungus needs to grow and causes a buildup of another substance in the cells (squalene). Both actions cause the death of the fungus and elimination of the infection.

DIRECTIONS FOR USE

It is for external use only. Use as instructed by your doctor. Clean and dry the affected area and apply the medicine. Check the label for directions before use.

SIDE EFFECTS OF TEXIFEN

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT TEXIFEN

Is TEXIFEN safe in children?

It is recommended for children and adolescents above 12 years of age. 

How long does it take for TEXIFEN to work on the skin?

It is an anti fungal medicine acts on the skin and cures the fungal skin infections. The duration of the treatment varies from 1 to 2 weeks depending upon the type of fungal skin infection. Do not stop using it without completing the course.

How do we apply TEXIFEN on skin?

Clean and dry the affected skin properly. Then, apply a thin layer on and around the affected skin gently.

REFERENCES

1. KD Tripathi MD. Anti-fungal drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 795.

2. Bennett JE. Antifungal Agents. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1586, 1588.

3. Robertson DB, Maibach HI. Dermatologic Pharmacology. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 1051, 1053.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1329.

5. P Ravindra Babu, A J S Pravin, Gaurav Deshmukh, Dhiraj Dhoot, Aniket Samant and Bhavesh Kotak. Efficacy and Safety of Terbinafine 500 mg Once Daily in Patients with Dermatophytosis: Indian journal of dermatology. July-Aug 2017; [Accessed Dec 4, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527721/

6. SV Choudhary, S Bisati, AL Singh, and S Koley. Efficacy and Safety of Terbinafine Hydrochloride 1% Cream vs. Sertaconazole Nitrate 2% Cream in Tinea Corporis and Tinea Cruris: A Comparative Therapeutic Trial: Indian journal of Dermatology. 2013 Nov-Dec; [Accessed Dec 4, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827518/

7. Novartis Pharmaceuticals Canada Inc. [Revised May 17, 2016] [Accessed Dec 4, 2020] http://www.ask.novartispharma.ca/download.htm?res=lamisil_scrip_e.pdf&resTitleId=728