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INTRODUCTION
TEXID TABLET contains Tranexamic Acid which belongs to the group of medicines called Antifibrinolytics. It is used in the prevention and treatment of bleeding in conditions such as heavy menstrual bleeding in women, bleeding inside the digestive system (Ex. inflammatory bowel disease), bleeding from the nose, blood in urine (not caused by the kidney (renal parenchyma)), control bleeding after dental extraction in patients with coagulopathies and after cervix surgery.
TEXID TABLET is not recommended for use in patients with blood clotting disorder or consumption coagulopathy, kidney disease, fits or seizure disorder, irregular menstrual cycle, acquired disturbances of color vision, venous or arterial thrombosis, active thromboembolic diseases such as deep vein thrombosis, pulmonary embolism and cerebral thrombosis, subarachnoid hemorrhage and blood in urine during periods.
Before taking TEXID TABLET, inform your doctor if you had or have changes in normal bleeding pattern, family history of endometrial cancer, abnormal bleeding between periods, bleeding during or after sexual intercourse, premenstrual pain, lower abdominal pain, bleeding after menopause, are at risk of having a blood clot, diabetic, overweight, polycystic ovary syndrome (PCOS).
TEXID TABLET should be used with caution in pregnant and breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking TEXID TABLET. Your doctor may recommend you to take relevant tests to understand your existing condition.
Safety and effectiveness of TEXID TABLET in children and adolescents below 18 years of age has not been established yet and it is not recommended for use in elderly women after menopause (stoppage of periods).
The most common side effects of taking TEXID TABLET are nausea, vomiting, diarrhea, headache, tiredness and stomach pain. Consult your doctor immediately if any of the side effect worsens.
USES OF TEXID TABLET
It is used to treat and prevent bleeding in conditions such as:
- heavy menstrual bleeding in women
- bleeding from the nose
- bleeding inside the digestive system (gastrointestinal system, Ex. inflammatory bowel disease))
- blood in urine (not caused by the kidney (renal parenchyma))
- bleeding after undergoing surgery (such as dental extraction in patients with coagulopathies, cervix surgery)
HOW TEXID TABLET WORKS
TEXID TABLET prevents bleeding by blocking the plasminogen from binding with fibrin which results in bleeding. As a result, it prevents and controls bleeding associated with various conditions.
DIRECTIONS FOR USE
Take TEXID TABLET as directed by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Do not take this medicine before your period has started as it will not work properly. Your doctor will decide the correct dose, duration and frequency of TEXID TABLET for you depending upon age, weight and disease conditions.
SIDE EFFECTS OF TEXID TABLET
COMMON
- nausea, vomiting
- diarrhea, stomach pain
- headache
- sinus and nasal symptoms
- back, muscle or joint pain
- muscle cramps
- migraine
- anemia
- tiredness
UNCOMMON
- allergic skin reactions
RARE
- thromboembolic events (blood clot in vein)
- vision disturbances
- giddiness
Stop taking TEXID TABLET and contact your doctor immediately if you experience any of the following side effects:
- impaired vision (especially color), blood clot in the eye
- itchy, red or swollen skin
- serious blood clots
- pain or feelings of heaviness in the chest
- pain or swelling in the arms or legs
- sudden shortness of breath, fainting
- coughing up blood
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
TEXID TABLET should be used with caution in pregnant women only if considered clearly necessary. Inform your doctor immediately if you become pregnant or think you may be pregnant before using TEXID TABLET.
BREASTFEEDING
TEXID TABLET should be used with caution in breastfeeding women only if advised by the doctor as it may pass through the breast milk. Consult your doctor before taking TEXID TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience dizziness after taking TEXID TABLET.
KIDNEY
TEXID TABLET is not recommended for use in patients with severe kidney impairment. TEXID TABLET should be used with caution in patients with mild to moderate kidney impairment and your doctor may adjust the dose depending upon kidney function. Consult your doctor for advice before taking TEXID TABLET.
LIVER
No dose adjustment is required in patients with hepatic impairment. Consult your doctor for advice.
ALLERGY
Do not take TEXID TABLET if you are allergic to Tranexamic Acid or any other ingredients of this medicine.
LUNGS
TEXID TABLET is not recommended for use in patients with pulmonary embolism (arteries of the lungs are blocked by clot). Consult your doctor before taking TEXID TABLET.
OTHERS
TEXID TABLET is not recommended for use if you:
- have a blood clotting disorder (consumption coagulopathy)
- have history of fits or seizure disorder
- have an irregular menstrual cycle
- have acquired disturbances of color vision
- have history of venous or arterial thrombosis (blood clot in artery/veins)
- have deep vein thrombosis, cerebral thrombosis (blood clot of cerebral vein in brain)
- have subarachnoid hemorrhage (bleeding in space between brain and tissue covering the brain)
- have blood in urine between periods
Before taking TEXID TABLET inform your physician if you:
- have changes in normal bleeding pattern
- have family history of endometrial cancer
- have abnormal bleeding between the periods
- have bleeding during or after sexual intercourse
- have premenstrual pain or lower abdominal pain
- have bleeding after menopause
- have obstruction of the urinary tract
- are at a risk for the formation of a blood clot
- are diabetic
- are overweight
- have polycystic ovary syndrome (PCOS)
Use in pediatrics:
Safety and effectiveness of TEXID TABLET in children and adolescents below 18 years of age has not been established yet. Consult your child’s doctor for advice.
Use in geriatrics:
TEXID TABLET is not recommended for use in elderly women after menopause (stoppage of periods). Consult your doctor before taking TEXID TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking TEXID TABLET inform your doctor if you are taking any of the following medicines:
- Ethinyl estradiol, levonorgestrel (oral contraceptives used to prevent pregnancy)
- estrogen (used to treat hormone disorder)
- streptokinase, reteplase, tenecteplase (used to a breakdown blood clots)
- tamoxifen (used to treat breast cancer)
- trans-retinoic acid (used to treat acne)
- factor IX complex concentrates (used to stop bleeding)
Overdosage:
If you or anyone else accidentally takes too much of TEXID TABLET, contact your doctor immediately or visit a nearby hospital immediately. Overdosage symptoms of TEXID TABLET are headache, nausea, vomiting, diarrhea, abnormal blood pressure, impaired vision, abnormal mental status, skin rashes, dizziness and fits or seizures.
SYNOPSIS
| Drug | : | Tranexamic Acid |
| Pharmacological Category | : | Antifibrinolytics |
| Therapeutic Indication | : | Prevent and treats bleeding in various conditions |
| Dosage Forms | : | Tablet, Gel, Injection |
MORE INFORMATION
- Keep out of reach from children
- Store at room temperature
FAQs ABOUT TEXID TABLET
Is TEXID TABLET safe for use in patients with impaired kidney function?
TEXID TABLET is not recommended for use in patients with severe kidney impairment. TEXID TABLET should be used with caution in patients with mild to moderate kidney impairment and your doctor may adjust the dose depending upon kidney function. Consult your doctor for advice before taking TEXID TABLET.
Does TEXID TABLET cause loose stools?
TEXID TABLET can cause side effects such as loose stools. To manage this effect, drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Is TEXID TABLET used for heavy menstrual bleeding?
TEXID TABLET is used only when your periods are regular to control heavy menstrual bleeding. It reduces the amount of blood lost during your period but may not help other symptoms such as period pain. Do not take this medicine if your periods are not heavy. Consult your doctor before taking TEXID TABLET.
What are the common side effects of TEXID TABLET?
The most common side effects of taking TEXID TABLET are nausea, vomiting, diarrhea, headache, tiredness, muscle cramps, migraine, anemia (lack of red blood cells), stomach pain, sinus and nasal symptoms. Consult your doctor immediately if any of the side effect worsens.
Can TEXID TABLET be used in pregnant women?
TEXID TABLET should be used with caution in pregnant women only if clearly advised by the doctor. Inform your doctor immediately if you become pregnant or think you may be pregnant before taking TEXID TABLET.
REFERENCES
1. KD. Tripathi. Drugs affecting blood and blood formation. Essentials of medical pharmacology. 8th Edition. 2019. Page – 676.
2. John M. Chauncey, Jerald S. Wieters. Tranexamic Acid. NIH National Library of Medicine, National center for biotechnology information. [Revised in January 2022] [Accessed on 14th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK532909/
3. Johnny Cai, Jessica Ribkoff, Sven Olson, Vikram Raghunathan, Hanny Al-Samkari, Thomas G. DeLoughery, and Joseph J. Shatzel. The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. 2019 [Accessed on 14th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023891/
4. Amring Pharmaceuticals, Inc. Tranexamic Acid. NIH National Library of Medicine, DailyMed. [Revised in December 2020] [Accessed on 14th July 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=031bf7c2-3b07-469d-bc5a-31fc6238e25f&type=display#section-9
5. Mercury pharma. Medsafe. Tranexamic acid film-coated tablets 500 mg. [Revised in September 2021] [Accessed on 14th July 2022] https://www.medsafe.govt.nz/profs/datasheet/t/tranexamicacidtab.pdf
6. Taj life sciences Pvt. Ltd. Tranexamic Acid Tablets BP. 250 mg. [Accessed on 14th July 2022] https://tajlifesciences.com/portfolio/tranexamic-acid-tablets-bp-250mg/
7. Taj life sciences Pvt. Ltd. Tranexamic Acid Tablets BP. 500 mg. [Accessed on 14th July 2022] https://tajlifesciesnces.com/portfolio/tranexamic-acid-tablets-bp-500mg/
8. Taj life sciences Pvt. Ltd. Tranexamic Acid Tablets BP. 750 mg. [Accessed on 14th July 2022] https://tajlifesciences.com/portfolio/tranexamic-acid-tablets-bp-750mg/
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- kidney function test
- Bleeding time/clotting time
- Urine analysis
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