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INTRODUCTION
TENEWIN M TABLET is a combination of Metformin and Teneligliptin which belongs to the group of medicines called Antidiabetic agents. It is used to treat Type II diabetes mellitus among patients when diet, exercise and treatment with other conventional medicines does not result in adequate control on blood glucose levels.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
Before taking TENEWIN M TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low potassium levels in blood or are severely dehydrated due to excessive vomiting or diarrhea recently.
During therapy with TENEWIN M TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. He/she might also ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption to achieve better results.
TENEWIN M TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism and in patients with severe systemic infections.
Consult your doctor before taking TENEWIN M TABLET if you are pregnant or breastfeeding. The most common side effects of taking TENEWIN M TABLET are low blood sugar levels, stomach upset, constipation, flatulence and altered taste sensations. Consult your doctor if they bother you.
USES OF TENEWIN M TABLET
- Treats Type II diabetes mellitus
HOW TENEWIN M TABLET WORKS
TENEWIN M TABLET is an antidiabetic medicine. It contains two medicines namely metformin and teneligliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absoprtion in the body.
Teneligliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, TENEWIN M TABLET controls blood sugar levels and improve glycemic control in patients with type II diabetes.
DIRECTIONS FOR USE
Take TENEWIN M TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking TENEWIN M TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF TENEWIN M TABLET
COMMON
- hypoglycemia (low blood sugar)
- nausea, vomiting
- flatulence, diarrhea, constipation, stomach pain, loss of appetite
- headache, dizziness
- changes in taste
RARE
Stop taking TENEWIN M TABLET and consult your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- severe skin rashes with redness and blistering of the skin
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- signs of liver damage (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
HOW TO MANAGE SIDE EFFECTS
Hypoglycemia (low blood sugar):
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or a drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking TENEWIN M TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
TENEWIN M TABLET should be used in pregnant women only if considered necessary by the physician. Your doctor will prescribe TENEWIN M TABLET only if the therapeutic benefits overweigh the risk to the fetus. Therefore, inform your doctor before taking it.
BREASTFEEDING
TENEWIN M TABLET is not recommended for use in breastfeeding women. However, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy after taking TENEWIN M TABLET.
ALCOHOL
Avoid consumption of alcohol while taking TENEWIN M TABLET as it may increase the risk of unwanted side effects.
KIDNEY
TENEWIN M TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.
LIVER
TENEWIN M TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones. Therefore, consult your doctor before taking it.
ALLERGY
Do not take TENEWIN M TABLET if you are allergic to Metformin or Teneligliptin.
LUNGS
TENEWIN M TABLET is not recommended for use in patients with severe infections of the lungs or respiratory tract. Therefore, consult your doctor before taking it.
HEART DISEASE
TENEWIN M TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure, recent heart attack, arrythmia, prolonged QT interval). Therefore, consult your doctor before taking it.
OTHERS
TENEWIN M TABLET is not recommended for use if you:
- have severe, uncontrollable diabetes
- have diabetic coma or precoma
- have nausea, vomiting, diarrhea or rapid weight loss
- have lactic acidosis or ketoacidosis (buildup of lactic acid or ketones in the body)
- are dehydrated (due to drinking less fluid or had severe vomiting or diarrhea during the recent days)
- have any severe systemic infection
- have shock or problems in blood circulation
- are an alcoholic
- are scheduled for any X-rays in the upcoming days
Before taking TENEWIN M TABLET, inform your doctor if you:
- have pituitary insufficiency or adrenal insufficiency
- are malnourished, starved, on an irregular diet or feeling weak
- perform extreme muscle exercises
- have a history of abdominal operation or intestinal obstruction
- have hypokalaemia (low blood potassium levels)
- have type I diabetes mellitus (insulin-dependent diabetes)
- have severe traumatic conditions
Use in Pediatrics:
The safety and effectiveness of TENEWIN M TABLET have not been established in infants, children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
The safety and effectiveness of TENEWIN M TABLET have not been established in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking TENEWIN M TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
- iodine contrast medium (used during X-rays)
- medicines used to treat asthma (Ex. salbutamol or terbutaline)
- corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
- diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
- medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
- medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- cimetidine (a medicine used to treat stomach ulcer)
- dolutegravir (a medicine used to treat HIV infection)
- verapamil (a medicine used to treat heart problems)
- rifampicin (a medicine used to treat tuberculosis)
- ranolazine (a medicine used to treat chest pain)
- trimethoprim (a medicine used to treat bacterial infection)
- medicines used to treat cancer (Ex. vandetanib, crizotinib and Olaparib)
- isavuconazole (a medicine used to treat fungal infections)
- salicylic acid (a medicine used to treat skin problems like acne)
- medicines used to treat depression (Ex. phenelzine, selegiline)
- adrenaline (a medicine used to treat shock caused by allergic reactions or collapse)
- thyroid hormones (used to treat thyroid deficiency) Ex. levothyroxine, liothyronine
- medicines used to treat irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol, etc.)
Overdosage:
If you or anyone else accidentally took more TENEWIN M TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps and fast breathing.
SYNOPSIS
| Drug | : | Metformin, Teneligliptin |
| Pharmacological Category | : | Biguanides, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep TENEWIN M TABLET out of the sight and reach of children
- Store TENEWIN M TABLET below 30°C
FAQs ABOUT TENEWIN M TABLET
What is TENEWIN M TABLET used for?
TENEWIN M TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with Type II diabetes mellitus.
How and when to take TENEWIN M TABLET?
Take TENEWIN M TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take TENEWIN M TABLET?
You need to take TENEWIN M TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What is the best time to take TENEWIN M TABLET?
TENEWIN M TABLET must be taken with meals to avoid gastrointestinal side effects.
What to do if I forgot to take a dose of TENEWIN M TABLET?
If you forgot to take a dose of TENEWIN M TABLET, take it as soon as you remember. However, if it is time for the next dose of TENEWIN M TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TENEWIN M TABLET to compensate the missed ones.
What are the most common side effects of taking TENEWIN M TABLET?
The most common side effects of taking TENEWIN M TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.
Can I stop taking TENEWIN M TABLET without consulting your doctor?
No. You should not stop taking TENEWIN M TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using TENEWIN M TABLET, consult your doctor for advice.
Will taking a higher dose of TENEWIN M TABLET be more effective?
No, taking a higher dose of TENEWIN M TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What precautions do I need to follow while taking TENEWIN M TABLET?
Before taking TENEWIN M TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking TENEWIN M TABLET if you are pregnant or breastfeeding.
Can I take medication for high blood pressure along with TENEWIN M TABLET?
It is not advisable to take medicines to control blood pressure while taking TENEWIN M TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with TENEWIN M TABLET as they have known interactions with TENEWIN M TABLET.
What should I do if I experience low blood sugar after taking TENEWIN M TABLET?
Low blood sugar is a common side effect of taking TENEWIN M TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.
Can TENEWIN M TABLET be taken with insulin?
Co-administration of TENEWIN M TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.
Can TENEWIN M TABLET be used in pregnant women?
TENEWIN M TABLET should be used in pregnant women only if considered necessary by the physician. Your doctor will prescribe TENEWIN M TABLET only if the therapeutic benefits overweigh the risk to the fetus. Therefore, inform your doctor before taking it.
How to take TENEWIN M TABLET?
You must take TENEWIN M TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.
How much TENEWIN M TABLET should I take?
TENEWIN M TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can TENEWIN M TABLET cause constipation?
Yes. Constipation is a common side effect of using TENEWIN M TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 & 275.
2. Linong Ji, Ling Li, Jianhua Ma, Xuefeng Li, Dongmei Li, Bangzhu Meng, Weiping Lu, Jiao Sun, Yanmei Liu, Gen Takayanagi and Yi Wang. Efficacy and safety of teneligliptin added to metformin in Chinese patients with type 2 diabetes mellitus inadequately controlled with metformin: A phase 3, randomized, double-blind, placebo-controlled study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. January 2021. [Accessed on 27th October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029565/
3. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 27th October 2022]. https://www.medicines.org.uk/emc/files/pil.11951.pdf
4. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 27th October April 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/2991.pdf
5. Centaur Pharmaceuticals Pvt Ltd. TEN20 – M. [Accessed on 27th October 2022]. https://www.centaurpharma.com/downloads/Ten20M2018.pdf
6. Johnlee Pharmaceuticals Pvt Ltd. TENALIP-M 1000. [Accessed on 27th October 2022]. http://johnleeindia.com/product/tenalip-m-1000/
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 29 Oct 2022 | 01:51 PM(IST)
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