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INTRODUCTION

TELROSE is a combination of Rosuvastatin and Telmisartan which belongs to the group of medicines called HMG-CoA reductase inhibitors and Angiotensin-II receptor blockers respectively. It is used to treat hypertension (high blood pressure) and high blood cholesterol levels. It can also be used to reduce the risk of cardiovascular events such as heart attack or stroke in patients who are at risk of heart diseases.

Telmisartan is an angiotensin II receptor blocker. It reduces blood pressure by relaxing the blood vessels supplying the heart and other vital organs. Rosuvastatin is an HMG-CoA reductase inhibitor. It reduces the bad cholesterol levels in the body by the blocking the actions of certain enzymes that are involved in the cholesterol production. Collectively they decrease blood pressure and blood lipid levels.

Before taking TELROSE inform your doctor if you have diabetes, thyroid problems, any family history of muscle disorders or problems in your heart. You must also inform your doctor if you are severely dehydrated or on a low-salt diet or taking antibiotics (such as fusidic acid) to treat any existing infections.

TELROSE is strictly not recommended for use in patients with severe liver problems, kidney problems, or an abnormally low blood pressure. It is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby. Stop taking TELROSE and inform your doctor immediately if you become pregnant while undergoing therapy with TELROSE.

TELROSE may make you feel dizzy while standing up suddenly or changing positions. Therefore, do not drive or operate any heavy tools or machines as a precaution. Also, avoid drinking alcohol as it might make you feel dizzier and drowsier.

TELROSE may alter your blood sugar levels and electrolyte levels. Therefore, your doctor will constantly monitor your blood sugar levels and kidney functions during therapy with TELROSE to avoid the risk of unwanted side effects.

The most common side effects of taking TELROSE are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens. You must also inform your doctor if you experience severe muscle pain or cramps with fever and malaise after taking TELROSE.

USES OF TELROSE

It is used to:

  • Treat high blood pressure
  • Treat high cholesterol levels
  • Prevent the risk of heart attack or stroke

HOW TELROSE WORKS

TELROSE effectively reduces high blood pressure and high blood cholesterol levels. It contains two medicines namely, telmisartan and rosuvastatin. Telmisartan reduces blood pressure by blocking the actions of certain hormones (angiotensin-II) in the body that causes narrowing of blood vessels and increase in blood pressure.

Rosuvastatin reduces the levels of bad cholesterol (LDL) and triglycerides in the body by the blocking the actions of certain enzymes (HMG-CoA reductase) that is involved in the cholesterol production. Collectively they decrease blood pressure, blood lipid levels, and reduces the risk of heart attack or stroke.

DIRECTIONS FOR USE

Take TELROSE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. TELROSE can be taken with or without meals. Try to take TELROSE at the same time each day.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take TELROSE for the stipulated duration instructed by your doctor without interruption to achieve better results.

SIDE EFFECTS OF TELROSE

COMMON

  • low blood pressure
  • nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
  • headache, dizziness
  • joint pain, muscle pain or back pain
  • high blood sugar levels (causing frequent urination, excessive thirst, or hunger)
  • high blood potassium levels (causing muscle weakness, irregular heartbeat, chest pain)

UNCOMMON

  • loss of appetite
  • weight gain
  • difficulty in sleeping
  • tingling or numbness in fingers or toes, loss of pain or touch sensation
  • altered taste sensation, loss of memory
  • blurred vision
  • hair loss
  • neck pain, muscle tiredness
  • swollen ankles (edema)
  • signs of upper respiratory tract infections (sore throat, inflamed sinuses, common cold)
  • depression, fainting
  • vertigo (spinning sensation)
  • orthostatic hypotension (dizziness while standing up from sitting or lying position)
  • increased sweating

RARE

  • unexpected bleeding or bruising
  • tendon injury (bone injury)
  • eczema (skin disease)
  • signs of increased white blood cells (weight loss, fever, cough, rash, weakness)
  • excessive sleepiness
  • dry mouth

Stop taking TELROSE and contact your doctor immediately if you experience any of the following side effects:

  • severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
  • severe skin reactions (such as peeling and swelling of the skin, blistering of skin around mouth, eyes, genitals, and fever, skin rash with red raised lump on palms of hands or sole of the feet)
  • muscle weakness, tenderness or pain with fever, tiredness, red-brown discoloration of urine (signs of rhabdomyolysis)
  • lupus-like disease syndrome (such as joint disorders, rash and altered count of blood cells)
  • sepsis (infection of blood)

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take TELROSE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS

PREGNANCY

TELROSE is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking TELROSE if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with TELROSE, stop taking it and consult your doctor immediately.

BREASTFEEDING

TELROSE is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking TELROSE.

ALCOHOL

Avoid consumption of alcohol while taking TELROSE as it might make you feel dizzier and drowsier.

KIDNEY

TELROSE is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with kidney transplant, renal artery stenosis (narrowing of blood vessels leading to kidneys) or dialysis. Therefore, consult your doctor before taking it.

LIVER

TELROSE is not recommended for use in patients with severe liver problems (such as cholestasis or biliary obstruction). It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take TELROSE if you are allergic to Rosuvastatin and Telmisartan.

LUNGS

TELROSE should be used with caution in patients with severe respiratory failure (breathing problem). Therefore, consult your doctor before taking.

HEART DISEASE

TELROSE should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.

OTHERS

TELROSE is not recommended for you, if you:

  • have diabetes related kidney problems
  • have hypothyroidism (thyroid deficiency)
  • have unexplained muscle pain
  • are alcoholic

Before taking TELROSE, inform your doctor if you:

  • have low blood pressure or are severely dehydrated (due to diarrhea, vomiting or excess sweating)
  • are on a low-salt diet
  • have primary hyperaldosteronism (problems in adrenal gland)
  • have diabetes
  • have hyperkalemia (high blood potassium levels)
  • have a history of hereditary muscular disorders
  • previously had any muscle problems after taking statins (such as rosuvastatin)
  • are overweight
  • are undergoing any major surgery

Use in pediatrics:

TELROSE is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use in geriatrics:

TELROSE should be used with caution in elderly patients (aged 70 years or older) especially who have muscle related problems. Therefore, consult your doctor before taking.

INTERACTIONS

A. Drug-Drug Interaction:

Before taking TELROSE inform your doctor, if you are taking any of the following:

  • other medicines used to treat elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, losartan, valsartan)
  • other medicines used to reduce blood cholesterol levels (Ex. gemfibrozil, ezetimibe, fenofibrate)
  • medicines used to treat angina or other heart problems (Ex. amlodipine, diltiazem, verapamil, amiodarone, and digoxin)
  • lithium, St. John’s wort (medicines used to treat depression)
  • potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
  • non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
  • medicines to prevent graft rejection (Ex. cyclosporin, tacrolimus, sirolimus)
  • diuretics (used to treat edema and hypertension) such as furosemide
  • corticosteroids (used to treat pain and inflammation) Ex. prednisolone
  • narcotics (used for pain relief) Ex. morphine, pethidine, fentanyl
  • barbiturates (used to induce sleep) Ex. pentobarbital, phenobarbital
  • antidepressants (used to treat depression) such as sertraline, fluoxetine, escitalopram, amitriptyline, nortriptyline, imipramine
  • baclofen (a medicine used for relaxing muscles)
  • amifostine (a kidney protectant used along with chemotherapeutic agents)
  • medicines used to treat Hepatitis C infection (Ex. telaprevir, boceprevir and combination of elbasvir/grazoprevir, or sofosbuvir/velpatasvir/voxilaprevir)
  • medicines used to treat fungal infection (Ex. ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
  • medicines used to treat bacterial infections (Ex. fusidic acid, erythromycin, trimethoprim)
  • medicines used to treat HIV infection (Ex. ritonavir, lopinavir, atazanavir, indinavir, darunavir)
  • warfarin, ticagrelor or clopidogrel (used to prevent or treat blood clots)
  • letermovir (a medicine used to treat cytomegalovirus)
  • oral contraceptives (birth control pill) Ex. levonorgestrel, ethinylestradiol
  • cimetidine (a medicine used to treat heartburn and stomach ulcers)
  • antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, milk of magnesia
  • darolutamide (a medicine used to treat cancer)
  • hormone replacement therapy (used to treat hormonal imbalance) Ex. dydrogesterone, estradiol

Overdosage:

If you or anyone else accidentally take too much of this medicine, consult your doctor immediately. Overdosage may cause side effects such as low blood pressure, increased or decreased heartbeat, low blood pressure and dizziness.

SYNOPSIS

Drug :  

Rosuvastatin, Telmisartan

Pharmacological Category :   HMG-CoA reductase inhibitors, Angiotensin-II receptor blockers
Therapeutic Indication :  

High blood pressure, High blood cholesterol levels, Prevention of heart attack or stroke

Dosage Forms :  

Tablet

MORE INFORMATION

  • Keep TELROSE out of reach of children
  • Store TELROSE at room temperature

FAQs ABOUT TELROSE

Is TELROSE safe to use in diabetic patients?

TELROSE may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking TELROSE as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects. Also, inform your doctor if you experience any unusual tiredness, hunger or thirst while undergoing therapy with TELROSE.

What precautions should be followed while taking TELROSE?

Before taking TELROSE inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have diabetes, family history of muscle problems or are severely dehydrated. Regularly visit your doctor and take all the necessary tests which your doctor recommends to you without fail. Consult your doctor before taking TELROSE if you have any severe liver or heart diseases (such as low blood pressure). If you are pregnant or become pregnant while taking TELROSE stop taking it immediately and consult your doctor.

Can TELROSE causes electrolyte imbalance?

Yes. TELROSE may the levels of certain electrolytes (sodium or potassium) in the body. To avoid this, your doctor will closely monitor the electrolytes levels in the blood periodically. However, if you experience any unusual symptoms such as chest pain, muscle weakness, irregular heartbeat, confusion, drowsiness, nausea, or vomiting, consult your doctor for advice.

Can I consume alcohol while taking TELROSE?

Avoid consumption of alcohol while taking TELROSE as it might make you feel dizzier and drowsier.

What happens if I accidentally take more TELROSE?

If you or anyone else accidentally took more TELROSE, consult your doctor immediately. Overdosage may cause low blood pressure and abnormal heartbeat.

Can I take TELROSE daily?

Take TELROSE as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take TELROSE every day or not.

Can I stop taking TELROSE if my blood pressure reduces?

Do not stop taking TELROSE without consulting your doctor as your blood pressure may raise once again. Make sure to take TELROSE for the stipulated duration recommended by your doctor to achieve maximum results.

What is TELROSE used for?

TELROSE is used to treat hypertension (high blood pressure) and high blood cholesterol levels. It can also be used to reduce the risk of cardiovascular events such as heart attack or stroke in patients who are at risk of heart diseases.

What are the side effects of TELROSE?

The most common side effects of taking TELROSE are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens. You must also inform your doctor if you experience severe muscle pain or cramps with fever and malaise after taking TELROSE.

Can I stop taking TELROSE once my symptoms subside?

No. Do not stop taking TELROSE without consulting your doctor. As high blood pressure and high blood cholesterol levels are chronic conditions, long term treatment is necessary to control its symptoms. Therefore, take TELROSE as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may cause the symptoms to reappear.

What should I do if I forget to take a dose of TELROSE?

If you forget to take a dose of TELROSE, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose of TELROSE and take the next one at the regular time. Do not take a double dose of TELROSE to compensate the missed dose.

Can the use of TELROSE affect the liver?

Yes. TELROSE may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Therefore, consult your doctor before taking it.

Which medicines should I avoid while taking TELROSE?

While undergoing therapy with TELROSE, avoid concomitant use of antibiotics (erythromycin), antifungals (ketoconazole) and antiviral medicines (ritonavir) without consulting your doctor.

Can TELROSE cause muscle pain?

Yes. TELROSE may lead to abnormal muscle breakdown known as rhabdomyolysis which can be identified by symptoms such as muscle pain, tenderness or weakness, red-brown discoloration of urine and high fever. Consult your doctor immediately, if you experience any such symptoms.

What foods should I avoid while taking TELROSE?

While taking TELROSE avoid eating foods high in fat or cholesterols such as fried or processed foods, grapefruit juice, dairy products, and red meat which can lead to poor therapeutic outcome in treating the disease.

For how long should I take TELROSE?

You should continue taking TELROSE unless your doctor tells you to stop the medicine. TELROSE will be usually taken for lifetime to prevent complications due to high blood pressure and high cholesterol levels. Therefore, consult your doctor for advice regarding the duration of therapy.

Can TELROSE be taken during pregnancy?

No. TELROSE is not recommended for use in pregnancy as it may cause serious   harm to the baby. Women of childbearing age should follow effective method of birth control to prevent pregnancy while taking TELROSE. In case of accidental pregnancy immediately, stop taking TELROSE and contact your doctor.

Is TELROSE safe to use in kidney disease?

TELROSE should be used with caution in patients with kidney diseases (such as those having renal artery stenosis, kidney transplant or in those undergoing haemodialysis). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking TELROSE as a precaution.

REFERENCES

1. KD. Tripathi. Drugs affecting renin angiotensin system and plasma kinins & Hypolipidaemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page –507 & 636-637.

2. Zhendong Liu, Yingxin Zhao, Fang Wei, Lin Ye, Fanghong Lu, Hua Zhang, Yutao Diao, Hongbin Song, Zayden Qi. Treatment with telmisartan/rosuvastatin combination has a beneficial synergistic effect on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2014. [Accessed on 13th July 2022] https://pubmed.ncbi.nlm.nih.gov/24495792/

3. Actavis Ltd. Health Products Regulatory Authority (HPRA). [Revised in July 2021]. [Accessed on 13th July 2022] http://www.hpra.ie/img/uploaded/swedocuments/8c0fc811-cf88-4bd5-818e-609e07fe1190.pdf

4. AstraZeneca Pharmaceuticals LP. U.S. Food & Drug Administration. [Revised in May 2010] [Accessed on 13th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021366s016lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Kidney Function Test
  • Lipid profile

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    ROSUVASTATIN 10 mg+TELMISARTAN 40 mg
    Hsn Code
    30049079
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Telrose Tablet 10'S

Telrose Tablet 10'S Mkt: Micro Labs Ltd

M.R.P.: Rs.212.00
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