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INTRODUCTION
T BET PF EYE DROPS is a combination of Timolol and Travoprost which belongs to the group of medicines called Beta-blockers and Prostaglandin analogs respectively. T BET PF EYE DROPS is indicated to decrease the elevated pressure in the eye among adult patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta blockers or prostaglandin analogues.
Ocular hypertension is an eye condition in which the pressure within the eye exceeds the normal range (above 16mmHg). Open-angle glaucoma is a chronic, progressive eye condition primarily caused due to elevated intraocular pressure (pressure in the eyes). It can lead to permanent loss of vision if not treated properly. Symptoms include intense eye pain or tenderness, blurred vision, eye redness or itching and headache.
Before using T BET PF EYE DROPS, inform your doctor if you have any respiratory or heart disease. If you wear soft contact lenses, apply T BET PF EYE DROPS at least 15 minutes before you wear your lens.
Do not use this medicine directly on your eyes while wearing your contact lenses in. If you are pregnant or trying to become pregnant, avoid direct exposure of T BET PF EYE DROPS. If any of the medicine encounters with your skin, immediately wash it off with soap and water.
T BET PF EYE DROPS is also not recommended for use in breastfeeding mothers, children and adolescents (aged below 18 years) due to lack of safety and effectiveness. T BET PF EYE DROPS is considered safe for use in elderly patients (aged 65 years or above).
The most common side effects of using T BET PF EYE DROPS are eye redness, pain, itching and eye dryness or discomfort.
It can also lead to a permanent change in the color of the iris or increase the length, thickness, color and/or number of your eyelashes. Contact your doctor if any of the side effects bothers you.
USES OF T BET PF EYE DROPS
- To decrease elevated pressure in the eye among adult patients with open-angle glaucoma or ocular hypertension (who are insufficiently responsive to topical beta blockers or prostaglandin analogues)
HOW T BET PF EYE DROPS WORKS
T BET PF EYE DROPS effectively reduces elevated pressure in the eye, where timolol acts by decreasing the production of fluid in the eye (aqueous humor) and travoprost acts by increasing the drainage of aqueous humor from the eye. Collectively they decrease the elevated pressure within the eye.
DIRECTIONS FOR USE
Use T BET PF EYE DROPS as advised by your physician. It is for ophthalmic use only. Instill the prescribed amount of the medicine into your eye(s). Follow the following steps while using T BET PF EYE DROPS:
- Wash your hands thoroughly before application
- Tilt your head slightly backwards and gently pull down your lower eyelid
- Gently squeeze the bottle and instill the medicine drop wise into your eye
- Close your eyes and gently press the corner of your eye with a finger for 2 minutes to avoid leakage of the medicine from your eye
- If necessary, repeat the same steps for the other eye
- Close the bottle and wash your hands
Do not touch the tip of the dropper with your fingertips, eyelids or other parts of the eye surface to avoid the risk of contamination. Do not use T BET PF EYE DROPS for more than 4 weeks after opening it to prevent infections. Your doctor will decide the correct dose for you depending upon your condition. Continue to use T BET PF EYE DROPS, if your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF T BET PF EYE DROPS
COMMON
- eye redness, pain or eye surface inflammation
- abnormal or blurred vision
- eye discomfort
- dry or itchy eyes
- signs of eye irritation (burning or stinging sensation in the eye)
UNCOMMON
- inflammation of the iris or eyelids
- eye swelling
- increased growth of eyelashes, excessive hair growth
- sensitivity to light, reduced vision
- tired eyes, eye allergy with increased tear production
- eyelid redness or changes in eyelid color
- skin darkening around the eye
- allergic reaction
- dizziness, headache
- changes in blood pressure
- shortness of breath
- dripping at the back of the throat
- skin itching and inflammation
- decreased heart rate
RARE
- thinning of the eye surface
- broken blood vessel in the eye
- eyelid crusting
- nervousness, hair loss, changes in voice tone
- cough, throat irritation, difficulty in breathing
- skin discoloration
- thirst
- tiredness
- nasal discomfort
- colored urine
- pain in hands and feet
HOW TO MANAGE SIDE EFFECTS
Eye redness, pain, discomfort, irritation or inflammation:
Close your eyes and relax. Place an ice pack on your eyes or eyelids to relieve your irritation. Avoid straining your eyes by looking at mobile phones, laptops, computers or other light sources. Consult your doctor if the symptom did not improve.
Dry or itchy eyes:
Close your eyes and relax. Place an ice pack on your eyes or eyelids. Avoid taking any medicine on your own for treating eye dryness. Ask your doctor to prescribe a suitable ophthalmic lubricant that does not affect the effects of this medicine.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Skin itching or inflammation:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
T BET PF EYE DROPS is not recommended for use in pregnant women or among women who are trying to become pregnant unless clearly necessary. Therefore, consult your doctor for advice before using this medicine. Women of child-bearing potential should use a suitable contraceptive method to avoid getting pregnant while using T BET PF EYE DROPS.
BREASTFEEDING
T BET PF EYE DROPS is not recommended for use in breastfeeding women as it could pass through the breast milk. Consult your doctor before using T BET PF EYE DROPS.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience blurred vision, dizziness, hallucination, nervousness or fatigue after using T BET PF EYE DROPS.
ALLERGY
Do not use T BET PF EYE DROPS if you are allergic to Timolol, Travoprost or other beta-blockers (Ex. betaxolol, levobunolol) or prostaglandin analogs (Ex. latanoprost, bimatoprost).
LUNGS
T BET PF EYE DROPS is not recommended for use in patients who have or had any respiratory problems (such as asthma, severe chronic obstructive bronchitis or other breathing problems) in the past. Consult your doctor before using T BET PF EYE DROPS.
HEART DISEASE
T BET PF EYE DROPS is not recommended for use in patients with heart disease (such as heart failure or irregular heartbeat). It should be used with caution among patients who have or had other heart problems such as coronary heart disease or low blood pressure in the past. Consult your doctor before using T BET PF EYE DROPS.
OTHERS
T BET PF EYE DROPS is not recommended for you, if you have:
- severe hay fever (an allergic reaction causing itchy eyes, runny nose, nasal congestion, sneezing and sinus pressure)
- cloudy eyes
Before using T BET PF EYE DROPS, inform your doctor if you have:
- blood circulation disorders (such as Raynaud’s disease or Raynaud’s syndrome)
- diabetes
- overactivity of the thyroid gland
- myasthenia gravis (long-term neuromuscular weakness)
- cataract surgery or any upcoming surgery
- an eye inflammation
Use in pediatrics:
T BET PF EYE DROPS is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness. Consult your doctor before using T BET PF EYE DROPS.
Use in geriatrics:
T BET PF EYE DROPS is considered safe for use in elderly patients (aged 65 years or above). However, consult your doctor before using T BET PF EYE DROPS.
INTERACTIONS
A. Drug-Drug interactions:
Before using T BET PF EYE DROPS inform to your doctor, if you are taking any of these medicines:
- medicines used to reduce elevated blood pressure (Ex. propranolol, atenolol, captopril, enalapril)
- medicines used to treat heart problems or some forms of malaria (Ex. quinidine, digoxin)
- medicines used to treat diabetes (Ex. metformin, insulin, glimepiride, glipizide)
- medicines used to treat depression (Ex. fluoxetine and paroxetine)
Overdosage:
If you or anyone else accidentally applied too much of T BET PF EYE DROPS, wash it all out with warm water. If required, contact your doctor or go to a hospital straight away.
SYNOPSIS
| Drug | : | Timolol, Travoprost |
| Pharmacological Category | : | Beta-blockers, Prostaglandin Analogs |
| Therapeutic Indication | : | Open-angle glaucoma, Ocular hypertension |
| Dosage Forms | : | Eye drops, Ophthalmic Solution |
MORE INFORMATION
- Keep T BET PF EYE DROPS out of reach of children
- Store T BET PF EYE DROPS at room temperature
FAQs ABOUT T BET PF EYE DROPS
Can T BET PF EYE DROPS be used to treat high blood pressure?
No, T BET PF EYE DROPS is only used to reduce increased pressure in the eye. Although timolol is a beta-blocker medicine, when given as an ophthalmic solution (eye drops), it helps in reducing only the elevated intraocular pressure in the eye. However, if you have an elevated blood pressure, contact your doctor for a suitable antihypertensive medicine. Avoid concomitant use of T BET PF EYE DROPS with other antihypertensive medicine or beta-blockers on your own without consulting your doctor.
Can T BET PF EYE DROPS cause bradycardia (slow heartbeat)?
Yes, T BET PF EYE DROPS can cause decrease in heartbeat in some individuals, although not everybody gets them. Contact your doctor if you are experiencing any unusual symptoms such as breathing difficulty or abnormal heart rhythm etc. Before using T BET PF EYE DROPS inform your doctor about previous medical history related to heart.
Can T BET PF EYE DROPS cause hair loss?
T BET PF EYE DROPS has increased ability to alter the pattern of a normal hair growth cycle. Although excessive hair growth and abnormal growth of eye lashes are more prevalent among patients, it can also cause hair loss (alopecia) in some individuals. Contact your doctor before using T BET PF EYE DROPS.
Can T BET PF EYE DROPS cause headache?
Yes, T BET PF EYE DROPS can cause headache in some individuals. Rest and relax. Try to drink lot of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Can I stop using T BET PF EYE DROPS once my symptoms subside?
No. do not stop using T BET PF EYE DROPS unless your doctor tells you to do so, because pre-mature discontinuation of T BET PF EYE DROPS can increase the risk of other eye problems (including reduced vision or complete blindness). Therefore, continue to use T BET PF EYE DROPS as long as your doctor prescribes you to achieve better control of elevated pressure within the eye.
REFERENCES
1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 151 & 155.
2. Thomas C. Westfall and David P. Westfall. Adrenergic agonist and antagonists. Jeffery D. Henderer and Christopher J. Rapuano. Ocular Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 326 & 1787.
3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3810 & 3890.
4. Tadashi Nakano, Shiro Mizoue, Nobuo Fuse, Aiko Iwase, Shun Matsumoto, and Keiji Yoshikawa. Fixed Combination of Travoprost and Timolol Maleate Reduces Intraocular Pressure in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Prospective Multicenter Open-Label Study. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2015. [Accessed on 28th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604505/
5. Vassilios Kozobolis, Aristeidis Konstantinidis, Haris Sideroudi, and Miguel Teus. Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation. NCBI; PMC US National Library of Medicine, National Institute of Health. November 2018. [Accessed on 28th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260185/
6. Balkanpharma-Razgrad Ad. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 28th October 2022] https://www.medicines.org.uk/emc/files/pil.10923.pdf
7. Novartis Pharma GmbH, S.A. Alcon-Couvreur N.V, Novartis Farmacéutica, S.A. and Siegfried El Masnou, S.A. European Medical Agency. [Revised in October 2010] [Accessed on 28th October 2022] https://www.ema.europa.eu/en/documents/product-information/duotrav-epar-product-information_en.pdf
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 29 Oct 2022 | 06:07 PM(IST)
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