INTRODUCTION
SYNJECT 1% INJECTION contains Sodium Hyaluronate which belongs to the group of medicines called Musculo-skeletal agents. It is used to treat pain in osteoarthritis of the knee. Osteoarthritis is a type of arthritis that occurs when flexible tissue at the ends of bones wears down.
SYNJECT 1% INJECTION is not recommended for use in patients with infection of the knee joint, infection and diseases of the skin at the injection site and systemic bleeding disorders. Before receiving SYNJECT 1% INJECTION, inform your doctor if you have severe inflammation of the knee, lymphatic or venous stasis (in the leg to be injected) and chondrocalcinosis (mineralization of hyaline cartilage).
If you are pregnant, planning to get pregnant or breast-feeding women, consult your doctor for advice before receiving SYNJECT 1% INJECTION.
It should be used with caution in elderly patients. Consult your doctor before receiving SYNJECT 1% INJECTION.
The most common side effects of SYNJECT 1% INJECTION are joint pain or inflammation, injection site pain and joint effusion. Consult your doctor if any of the side effects worsen.
USES OF SYNJECT 1% INJECTION
- Treats pain in osteoarthritis of the knee
HOW SYNJECT 1% INJECTION WORKS
SYNJECT 1% INJECTION supports tendon and bone regeneration by improving oxygen and nutrient supply to the joints. In osteoarthritis, the joints lack nutrition and become inflamed. SYNJECT 1% INJECTION contains hyaluronic acid that acts as a nutritional supplement and helps to reduce inflammation and degradation of joints.
DIRECTIONS FOR USE
SYNJECT 1% INJECTION is administered by a doctor or a nurse directly into the knee joint. Your doctor will decide the correct dose, duration of SYNJECT 1% INJECTION for you depending upon your age and disease condition.
SIDE EFFECTS OF SYNJECT 1% INJECTION
COMMON
- joint pain
- join inflammation
- injection site pain
- joint effusion
- joints disease (arthropathy)
RARE
- rash, itching
- fever, chills
- headache, dizziness
- nausea
- muscle cramps
- general discomfort
- tingling or prickling sensation
- peripheral edema (leg swelling caused by the retention of fluid)
- respiratory difficulties
- flushing and facial swelling
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Inform your doctor if the symptom does not improve.
Skin rash:
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Inform your doctor if the symptoms worsen.
Dizziness:
Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if the symptoms worsen.
WARNING & PRECAUTIONS
PREGNANCY
Safety and effectiveness of SYNJECT 1% INJECTION has not been established in pregnant women. Consult your doctor before receiving SYNJECT 1% INJECTION.
BREASTFEEDING
Safety and effectiveness of SYNJECT 1% INJECTION has not been established in breast-feeding women. Consult your doctor before receiving SYNJECT 1% INJECTION.
DRIVING AND USING MACHINES
SYNJECT 1% INJECTION does not affect your ability to drive or use machinery.
ALLERGY
SYNJECT 1% INJECTION is not recommended for use if you are allergic to sodium hyaluronate preparations. It should be used with caution in patients with avian proteins, feathers or egg products.
OTHERS
SYNJECT 1% INJECTION is not recommended for use if you have:
- infection of the knee joint
- infection and diseases of the skin at the injection site
- systemic bleeding disorders
Before receiving SYNJECT 1% INJECTION, inform your doctor if you have:
- severe inflammation of the knee
- lymphatic or venous stasis (in the leg to be injected)
- chondrocalcinosis (mineralization of hyaline cartilage)
Use in Pediatrics:
Safety and effectiveness of SYNJECT 1% INJECTION has not been demonstrated in children (21 years of age or younger). Consult your child’s doctor for advice.
Use in Geriatrics:
SYNJECT 1% INJECTION should be used with caution in elderly patients. Consult your doctor before receiving SYNJECT 1% INJECTION.
INTERACTIONS
A. Drug-Drug Interactions:
Before receiving SYNJECT 1% INJECTION, inform your doctor if you are using any of the following medicines:
- skin disinfectants containing quaternary ammonium salts and compounds
- chlorhexidine (skin preparation agents)
Overdosage:
SYNJECT 1% INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving SYNJECT 1% INJECTION.
SYNOPSIS
| Drug | : | Sodium hyaluronate |
| Pharmacological Category | : | Glycosaminoglycan |
| Therapeutic Indication | : | Pain in osteoarthritis of the knee |
| Dosage Forms | : | Tablet, Capsule, Injection, Pre-filled syringe, Gel, Eye drops |
MORE INFORMATION
- Store at room temperature
FAQs ABOUT SYNJECT 1% INJECTION
What is SYNJECT 1% INJECTION used for?
SYNJECT 1% INJECTION contains Sodium Hyaluronate, which is used in the treatment of pain in osteoarthritis of the knee. Osteoarthritis is wearing down of the protective tissue at the ends of bones (cartilage), occurs gradually and worsens over time. Joint pain in the hands, neck, lower back, knees or hips is the most common symptom.
For how long should I receive SYNJECT 1% INJECTION?
Your doctor might advise you on how long you should continue to receive SYNJECT 1% INJECTION. You will need to consult your doctor from time to time to review your treatment and assess your symptoms.
How does SYNJECT 1% INJECTION work?
SYNJECT 1% INJECTION supports tendon and bone regeneration by improving oxygen and nutrient supply to the joints. In osteoarthritis, the joints lack nutrition and become inflamed. SYNJECT 1% INJECTION contains hyaluronic acid that acts as a nutritional supplement and helps to reduce inflammation and degradation of joints.
What are the common side effects of SYNJECT 1% INJECTION?
The most common side effects of receiving SYNJECT 1% INJECTION are joint pain or inflammation, injection site pain, joint effusion and joints disease (arthropathy). Consult your doctor if any of the side effects worsen.
How is SYNJECT 1% INJECTION administered?
SYNJECT 1% INJECTION is administered by a doctor or a nurse directly into the knee joint. Your doctor will decide the correct dose, duration of SYNJECT 1% INJECTION for you depending upon your age and disease condition.
REFERENCES
1. KD. Tripathi. Section 3, Antirheumatic and Antigout Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page –210 -218.
2. Huang TL, Chang CC, Lee CH, Chen SC, Lai CH, Tsai CL. Intra-articular injections of sodium hyaluronate (Hyalgan) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the Asian population. NIH. National Library of Medicine, National center for biotechnology information. October 2011. [Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203101/
3. Guarda-Nardini, L., Masiero, S. and Marioni, G., 2005. Conservative treatment of temporomandibular joint osteoarthrosis: intra-articular injection of sodium hyaluronate. Journal of Oral Rehabilitation. September 2005. [Accessed on 20th September 2022] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2842.2005.01505.x
4. Genzyme Biosurgery. Synvisc One. [Revised in September 2014] [Accessed on 20th September 2022] https://products.sanofi.us/synviscone/synviscone.pdf
5. Fidia Farmaceutici S.p.A. Hyalgan. Health Products Regulatory Authority (HPRA). [Revised in December 2009] [Accessed on 20th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0814-001-001_05042016103037.pdf
6. Hanmi Pharm Co. Ltd. Synojoynt. U.S. Food & Drug Administration. [Accessed on 20th September 2022] https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170016D.pdf
7. Anika Therapeutics, Inc. Monovisc. [Accessed on 20th September 2022] http://synthes.vo.llnwd.net/o16/LLNWMB8/IFUs/US/Monovisc-US-IFU_Word.pdf
PRODUCT DETAILS
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