INTRODUCTION

SYNCORIL SYRUP contains Ambroxol, Guaiphenesin, Terbutaline and Menthol which belong to the group of medicines called Mucolytics, Expectorants, Bronchodilators and Cooling agents respectively. It is used to treat productive cough associated with bronchospasm, bronchitis, bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis and chest congestion.

Before starting the treatment with SYNCORIL SYRUP your doctor might want you to take some diagnostic tests.

SYNCORIL SYRUP should be used with caution in patients having liver, kidney and heart diseases, high blood pressure, uncontrolled diabetes, hyperthyroidism, seizures (fits) and a history of stomach ulcers.

SYNCORIL SYRUP should be used with caution in pregnant and breastfeeding women. Consult your doctor for advice before taking.

The most common side effects of using SYNCORIL SYRUP are nausea, diarrhoea, vomiting and stomach discomfort. Consult with your doctor if any of these above side effects worsens or does not improve.

USES OF SYNCORIL SYRUP

It is used to treat:

• productive cough associated with bronchospasm
• bronchitis
• bronchial asthma
• chronic obstructive pulmonary disease
• bronchiectasis
• chest congestion

HOW SYNCORIL SYRUP WORKS

SYNCORIL SYRUP is a combination of Ambroxol, Guaiphenesin, Terbutaline and Menthol where Ambroxol is a mucolytic agent which thins and loosens the mucus (phlegm) and makes it easier to cough out. Guaiphenesin is an expectorant which decreases the stickiness of secretions present in the airways, thins the mucous and helps in their removal from the airways. Menthol is an organic compound (cooling agent) which produces a sensation of coolness by stimulating the cold receptors and relieves minor throat irritation. Terbutaline belongs to the bronchodilator which relaxes the muscles in the airways and results in the widening of the airways. Together, they make breathing easier and eliminates cough.

DIRECTIONS FOR USE

Take SYNCORIL SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, disease condition and body weight.

SIDE EFFECTS OF SYNCORIL SYRUP

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink a lot of fluids, such as water, squash or fruit juice to keep yourself hydrated. Do not consume any medicine by yourself without consulting your doctor. Ask for your doctor’s advice if diarrhea doesn’t improve.

Nausea And Vomiting

Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Drink clear or ice-cold drinks, eat light, bland foods and avoid fried, oily or sweet foods. Consult with your doctor if the symptom doesn’t improve.

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

There are no sufficient and well-controlled studies for SYNCORIL SYRUP in pregnant women. Consult your doctor before taking it.

BREASTFEEDING

Consult your doctor

There are no sufficient and well-controlled studies for SYNCORIL SYRUP in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Use with Caution

Caution should be exercised before driving or using any machinery after taking SYNCORIL SYRUP.

KIDNEY

Use with Caution

SYNCORIL SYRUP should be used with caution in patients with kidney disease. Consult your doctor before taking.

LIVER

Use with Caution

SYNCORIL SYRUP should be used with caution in patients with liver disease. Consult your doctor before taking.

ALLERGY

Contraindicated

Do not take SYNCORIL SYRUP if you are allergic to Ambroxol, Guaiphenesin, Terbutaline and Menthol or any other ingredients of this medicine.

HEART DISEASE

Use with Caution

SYNCORIL SYRUP should be used with caution in patients with heart disease and high blood pressure. Consult your doctor before taking.

INTERACTIONS

A. Drug – Drug Interactions:

Inform your physician if you are taking any of the following medicines before taking SYNCORIL SYRUP:

• other bronchodilators (Ex. aminophylline), beta 2 agonists (Ex. albuterol)
• corticosteroids such as prednisolone (used to treat inflammation)
• diuretics such as chlorthalidone (used to get rid of water and sodium from the body)
• monoamine oxidase inhibitors such as isocarboxazid, tricyclic antidepressants such as amitriptyline, nortriptyline (used to treat depression)

Overdosage:

If you or anyone else accidentally takes too much of SYNCORIL SYRUP, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep SYNCORIL SYRUP out of reach of children
• Store at room temperature

FAQs ABOUT SYNCORIL SYRUP

Q: What is SYNCORIL SYRUP used for?

A: SYNCORIL SYRUP contains Ambroxol, Guaiphenesin, Menthol and Terbutaline which belong to the group of medicines called Mucolytic agents, Expectorants, Bronchodilators and Cooling agents respectively. It is used to treat productive cough associated with bronchospasm, bronchitis, bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis and chest congestion.

Q: Can SYNCORIL SYRUP be used in patients having peptic (stomach) ulcers?

A: SYNCORIL SYRUP contains Ambroxol which is a mucolytic agent and acts by thinning the mucous. It can act on the mucous lining present in the stomach as well and can disrupt it. Therefore, SYNCORIL SYRUP should be used with caution in patients having history of peptic ulcers.

Q: Is SYNCORIL SYRUP safe to use in children?

A: SYNCORIL SYRUP is safe for use in children. Your doctor will decide the correct dose and duration of the treatment with SYNCORIL SYRUP depending on the age, disease condition and body weight of your child. Consult your doctor.

Q: Can SYNCORIL SYRUP be used during pregnancy and lactation?

A: There are no sufficient and well-controlled studies for SYNCORIL SYRUP in pregnant and breastfeeding women. Consult your doctor before taking it.

Q: Does SYNCORIL SYRUP cause headaches?

A: Yes. Headache is a common side effect of SYNCORIL SYRUP. Try to take a rest and don’t involve yourself in exertive activities. Apply a pain-relieving balm on your forehead. Consult with your doctor if the symptom does not improve.

REFERENCES

1. K.D. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 219 & 223.

2. Barbara G Wells, Joseph T DiPiro, Terry L Schwinghammer, Cecily V DiPiro. Infectious Diseases. Pharmacotherapy handbook. Ninth Edition. 2015. Page – 424.

3. Ahmad Kantar, Ludger Klimek, Dorotheea Cazan, Annette Sperl, Ulrike Sent, Margarida Mesquita. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. March 2020. [Accessed on 22nd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137760/

4. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Ambroxol. [Accessed on 22nd June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ambroxol#section=Mechanism-of-Action

5. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Terbutaline. [Accessed on 22nd June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Terbutaline#section=Mechanism-of-Action

6. Bionova Lifesciences. Pentakof – TM Syrup. [Accessed on 22nd June 2022] https://www.bionova.co.in/pentakof-tm-syrup.html

7. Centaur Pharmaceuticals. Kofarest - PD. [Revised in January 2022] [Accessed on 22nd June 2022] https://www.centaurpharma.com/downloads/2022/pediatrics/cough/Kofarest%20PD%20syrup.pdf

8. Neuracle Lifesciences. Tercip – A. [Accessed on 22nd June 2022] https://www.neuraclelife.com/product/ambroxol-terbutaline-menthol-guaiphenesin-syrup/

9. Drugbank.com. [Accessed on 22nd June 2022] https://go.drugbank.com/drugs/DB00874

10. Drugbank.com. [Accessed on 22nd June 2022] https://go.drugbank.com/drugs/DB00825

USEFUL DIAGNOSTIC TESTS

• Chest X-ray
• Complete Blood Count

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 06 Feb 2023 | 04:58 PM(IST)