INTRODUCTION

STALCHLOR 250MG CAPSULE contains Chloramphenicol which belongs to the group of medicine called Antibiotics. It is used to treat typhoid fever and other dangerous infections where other antibiotics are not effective.

Typhoid fever is a bacterial infection that can spread throughout the body, affecting many organs, without proper treatment, it can cause serious complications and can be fatal.

During the therapy your doctor might recommend you for routine blood tests to monitor in case of prolong use of this medicine, as chloramphenicol can damage blood cells.

Pregnant and breastfeeding women should consult their doctor before taking this medicine.

Before taking this medicine inform your doctor if you have blood, bone marrow disease, liver or kidney problems, high blood pressure. Consult your doctor for advice.

The common side effects are anaemia, dark coloured urine, sore throat and fever, unusual bleeding or bruising, difficulty in breathing, headache, nausea and vomiting, burning, numbness and tingling in the arms. Consult your doctor if any of the above side effects worsen or persists for a longer duration.

USES OF STALCHLOR 250MG CAPSULE

It is used to treat:

• typhoid fever
• other severe bacterial infections where other antibiotics are not effective

HOW STALCHLOR 250MG CAPSULE WORKS

Chloramphenicol is a semi-synthetic antibiotic. It diffuses through the bacterial cell wall and binds to the ribosome of the bacteria, thereby preventing the formation of bacterial protein consequently leading to inhibition of cell growth and cell lysis, resulting in suppressing the growth of bacteria.

DIRECTIONS FOR USE

Always take this medicine as directed by your physician. Swallow the medicine as a whole with a plenty of water and do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF STALCHLOR 250MG CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Try to take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Inform your physician if you are taking:

• Paracetamol (used to treat fever, pain)
• medicines that thin the blood such as warfarin
• antidiabetics such as gliclazide (used to treat diabetes)
• medicines that may suppress the bone marrow such as carbamazepine, penicillamine
• sulphonamide, phenylbutazone
• medicines to treat cancer
• clozapine, flupentixol, fluphenazine, procainamide (used to psychotic disorders)
• co-trimoxazole, penicillin or rifampicin, azithromycin, erythromycin (used to treat infection)
• phenytoin (used for epilepsy)
• barbiturates such as phenobarbitone
• immunosuppressants such as ciclosporin or tacrolimus
• vitamin B12 (hydroxocobalamin)
• oral contraceptives containing estrogen
• carbimazole, propylthiouracil (used to treat over-active thyroid disease)
• anti-retroviral medicines that treat HIV infection such as zidovudine
• pantoprazole, rabeprazole
• calcium channel blocker such as amlodipine, verapamil
• azole antifungals such as fluconazole, ketoconazole
• lidocaine, quinidine (used to treat heart problems)
• citalopram, sertraline
• sildenafil, vardenafil and avanafil
• atorvastatin (used to treat cholesterol levels)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at room temperature

FAQs ABOUT STALCHLOR 250MG CAPSULE

Does STALCHLOR 250MG CAPSULE used to relieve pain?

No, STALCHLOR 250MG CAPSULE not a pain killer. It only treats bacterial infections and provides relief from symptoms of infection.

Is it safe to use STALCHLOR 250MG CAPSULE for longer duration of time?

Use STALCHLOR 250MG CAPSULE only as prescribed by the doctor. Do not use for longer durations. Consult your doctor if your condition does not improve despite using this medicine for a week or if it worsens.

Can I stop taking STALCHLOR 250MG CAPSULE when I feel better?

No, do not stop taking STALCHLOR 250MG CAPSULE and complete the entire course of treatment even if you start feeling better or else you may experience treatment failure and the increased risk of recurrence of the infection.

Can the use of STALCHLOR 250MG CAPSULE cause diarrhoea?

Yes, the use of STALCHLOR 250MG CAPSULE may cause diarrhoea along with the desired effect, but not everyone gets them. It is an antibiotic that kills both good and bad bacteria, when good bacteria present in the intestine gets destroyed and it may cause diarrhoea. If you are experiencing severe diarrhoea, talk to the doctor about it.

What if my condition does not improve after taking STALCHLOR 250MG CAPSULE?

Talk to the doctor if your condition does not improve, even after taking STALCHLOR 250MG CAPSULE. If needed your doctor will provide an alternate medicine.

REFERENCES

1. KD. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723 & 724.

2. M. Abdollahi, S.Mostafalou. Chloramphenicol. Encyclopaedia of Toxicology. Third edition. 2014. Page-837 & 840.

3. Ginny C.Oong, Prasanna Tadi. Chloramphenicol. Continuing Education Activity. https://www.ncbi.nlm.nih.gov/books/NBK555966/

4. Chemidex Pharma Limited, Electronic Medicines Compendium (EMC); [Revised on May 2020] [Accessed on Feb 25, 2022] https://www.medicines.org.uk/emc/files/pil.12893.pdf

5. Mint Life Pharma Limited., Electronic Medicines Compendium (EMC); [Revised on August 2021] [Accessed on March 14 2022] https://www.fdaghana.gov.gh/img/pils/Chloramphenicol%20250mg%20Capsule%20(Chloramphenicol).pdf

6. Pub chem. Chloramphenicol: [Revised on Feb 14, 2022] [Accessed on Feb 25, 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chloramphenicol

7. Mims.com. Chloramphenicol [Accessed on Feb 25, 2022] https://www.mims.com/malaysia/drug/info/chloramphenicol/patientmedicine/chloramphenicol%2B-%2Bora

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Peripheral Smear Examination