INTRODUCTION

SPENZO 1MG contains Flupenthixol which belongs to a group of medicines known as antipsychotics (neuroleptics) which is used to treat schizophrenia. It is also used to treat depression in patients who may or may not, also be showing signs of anxiety. It act on nerve pathways in specific areas of the brain and helps to correct certain chemical imbalances that are causing the symptoms of illness.

Schizophrenia is a serious mental disorder in which people interpret reality abnormally. It results in some combination of hallucinations, delusions, and extremely disordered thinking and behavior that impairs daily functioning, and can be disabling. Flupenthixol is a thioxanthene derivative with antipsychotic properties. It is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Its antipsychotic activity is related to blocking of postsynaptic dopamine receptors in the CNS.

Always take SPENZO 1MG exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. It is not recommended for children. The common side effects are dizziness, dry mouth, constipation, headache and muscle spasms.

USES OF SPENZO 1MG

Treats

• Schizophrenia
• Depression

HOW SPENZO 1MG WORKS

SPENZO 1MG works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Dopamine is known as a neurotransmitter, it is involved in transmitting messages between brain cells. It is known to be involved in regulating mood and behaviour.

DIRECTIONS FOR USE

Always take SPENZO 1MG exactly as your doctor has told you. Swallow this medicine with a glass of water and do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF SPENZO 1MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.

Drowsiness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Dry mouth:

Chew sugar free candies to stimulate the flow of saliva and limit your caffeine intake. Drink small sips of water regularly.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• tricyclic antidepressant medicines
• guanethidine (used to lower the blood pressure)
• barbiturates
• levodopa (used to treat parkinson’s disease)
• metoclopramide (used to treat nausea and other stomach conditions)
• thioridazine (used to treat psychotic disorders)
• quinidine, amiodarone, sotalol, erythromycin, moxifloxacin, lithium (used to change the heartbeat)
• warfarin (used to prevent blood clots)
• piperazine (used to treat worm infections)
• sibutramine (used to reduce appetite)
• prednisolone
• medicines used to treat epilepsy
• medicines used to treat diabetes

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT SPENZO 1MG

Can SPENZO 1MG use during pregnancy?

It is not recommended during pregnancy and may be prescribed in pregnant women only if the benefits outweigh the risks involved with its use in pregnant women.

Is SPENZO 1MG safe?

Yes, it is safe if administered by your doctor. However, tell your doctor if you have any liver, kidney or heart diseases.

Does SPENZO 1MG make you tired?

It may cause drowsiness, tiredness or blurred vision. Do not drive or handle any machines if you experience these reactions.

REFERENCES

1. KD Tripathi MD. Antipsychotic and anti-manic drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 441.

2. Stahl SM. Flupenthixol. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. Page: 253-257.

3.  Jataveda Mahapatra, Seema N Quraishi, Anthony David, Stephanie Sampson and Clive E Adams. Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. June 10, 2014; [Accessed on Jan 25, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057031/ 

4. Lundbeck Canada Inc. [Revised on Dec 12, 2017] [Accessed on Jan 25, 2021] https://www.lundbeck.com/upload/ca/en/files/pdf/pm/Fluanxol%20PM%20EN%2012Dec%202017.pdf  

5. Lundbeck Limited. H. Lundbeck A/S. Electronic Medicines Compendium (EMC). [Revised on Sep, 2020] [Accessed Jan 25, 2021] https://www.medicines.org.uk/emc/files/pil.11768.pdf