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INTRODUCTION

SONAXA NT is a combination of Nortriptyline and Pregabalin which belongs to the group of medicines called Tricyclic antidepressants and Anticonvulsants respectively. SONAXA NT is indicated for the treatment of neuropathic pain. Neuropathic pain is a chronic painful nerve condition caused by damage or disease affecting the somatosensory (sense of touch) nervous system. It can be caused by injury or disease of spinal cord and/or brain, prolonged diabetes mellitus (Ex. diabetic neuropathy), infectious diseases (such as HIV infection or leprosy), chemotherapy, auto-immune disease (Ex. Guillain-Barre syndrome), post-herpetic neuralgia (a long-lasting painful condition that affects the areas around the skin and nerve fibers where shingles were present), fibromyalgia (generalized musculoskeletal pain with fatigue, and altered sleep, memory, and mood) or by other metabolic dysfunctions. Symptoms include shooting, burning, or stabbing pain for normal daily activities that are typically not painful, tingling and numbness or spontaneous pain (pain without stimulus).

Nortriptyline is a tricyclic antidepressant that acts by inhibiting the movement of pain signals from the brain and pregabalin is an anticonvulsant that acts by blocking the influx of calcium and various pain-causing chemicals through the damaged nerves and the brain, thus causing pain relief.

Continue to take SONAXA NT as long as your doctor tells you to do so, because premature discontinuation can cause withdrawal symptoms like insomnia, headache, nausea, anxiety, diarrhea, depression, convulsion, and excessive perspiration. SONAXA NT can increase the risk of suicidal thoughts and behavior in some individuals and therefore, patients (or caregivers) should seek immediate medical advice if any such signs emerge.

SONAXA NT is not recommended for use in patients having severe heart or kidney disease. Consult your doctor before taking SONAXA NT. This medicine is not recommended for use in pregnant or breastfeeding women and in children (aged below 6 years). The most common side effects of SONAXA NT are nausea, vomiting, constipation, dizziness, headache, or somnolence. Consult your doctor if any of the symptoms worsen.

USES OF SONAXA NT

  • treats neuropathic pain

HOW SONAXA NT WORKS

SONAXA NT effectively relieves nerve pain, where nortriptyline acts by inhibiting the movement of pain signals from the brain by blocking the reuptake of certain chemical messengers (norepinephrine and serotonin) at the pre-synapse, and pregabalin acts by interfering with influx of calcium and various pain signals travelling through the damaged nerves and the brain, thus leading to a significant pain relief in various neuropathic pain states.

DIRECTIONS FOR USE

Take SONAXA NT as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Do not stop taking SONAXA NT without informing your doctor.   

SIDE EFFECTS OF SONAXA NT

SERIOUS

 

 

COMMON

  • dizziness, drowsiness, headache
  • nausea or vomiting
  • dry mouth
  • diarrhea, constipation, swollen abdomen, flatulence
  • increased appetite, weight gain
  • blurred vision
  • vertigo (spinning sensation)
  • mania, confusion, irritability, disorientation
  • insomnia (lack of sleep) or sleepiness
  • decreased sex drive, erectile dysfunction
  • lack of control over body movements, tremor (shaking)
  • memory impairment, attention disturbance
  • dysarthria (unable to speak properly)
  • numbness or pain in the body
  • generalized edema (swelling of the body including extremities)
  • muscle cramps
  • pain in the joints, back or limbs
  • sore throat

UNCOMMON

  • loss of appetite and weight loss
  • decreased blood glucose level
  • low self-esteem, depression, agitation, hallucinations, nightmares, panic attack, apathy
  • mental impairment or difficulty with thinking
  • increase in sexual interest
  • eye problems (problems in vision, dry eyes, eye irritation, swelling or pain)
  • skin sensitivity, loss of taste
  • weakness or fainting
  • increased sensitivity to noise
  • heart problems (such as changes in heart rate, changes in blood pressure or heart failure)
  • hot flushes
  • difficulty in breathing, dry nose, nasal congestion
  • increased saliva secretion, heartburn, numbness around the mouth
  • skin rash, sweating, chills with fever
  • muscle stiffness or twitching, joint swelling, neck pain
  • pain in breasts
  • difficulty or painful urination, increased urge to urinate
  • excessive thirst, chest tightness
  • severe allergic reactions (such as swollen face, itching, nasal congestion, nasal bleeds, cough, and snoring)
  • painful menstrual periods
  • chillness of hands and feet

RARE

  • ascites (fluid buildup in abdomen)
  • fluid buildup in the lungs
  • discharge from the breast or abnormal breast growth
  • gynecomastia (breast enlargement in males)
  • signs of decreased WBC count (mouth sores, fever, repeated infections)
  • cold sweat, swollen throat, tightness of throat
  • difficulty in swallowing
  • abnormal smell sense
  • altered vision, vision loss, dilated pupils, cross eyes
  • inflammation of the pancreas
  • slow or reduced movement of the body
  • difficulty in writing
  • convulsions
  • irregular menstrual cycle
  • rhabdomyolysis (muscle damage)
  • kidney failure, decreased urine output, difficulty in urination
  • allergic reactions (such as difficulty in breathing, inflammation of the eyes and a serious skin reaction characterized by rash, blisters, pain, and skin peeling)
  • liver problems (such as jaundice (yellowing of the skin and eyes), liver failure or hepatitis (inflammation of the liver))

Stop taking SONAXA NT and consult your doctor immediately if you experience the following side effects:

  • swollen face or tongue
  • skin redness with blisters or peeling

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take SONAXA NT with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your doctor if the symptom did not improve.

Constipation

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

PREGNANCY

SONAXA NT is not recommended for use in pregnant women. Consult your doctor before taking SONAXA NT.

BREASTFEEDING

SONAXA NT is not recommended for use in breastfeeding women. Consult your doctor before taking SONAXA NT.

DRIVING AND USING MACHINES

Do not drive or operate any tools or machines if you experience dizziness or sleepiness after taking SONAXA NT. 

ALCOHOL

Avoid consumption of alcohol while taking SONAXA NT as it could make you feel dizzier or sleepier.

KIDNEY

SONAXA NT should be taken with caution in patients with kidney disease. Consult your doctor before taking.

LIVER

SONAXA NT is not recommended for use in patients having severe liver disease and should be used with caution in patients with liver disease. Consult your doctor before taking SONAXA NT.

ALLERGY

Do not take SONAXA NT if you are allergic to Pregabalin or Nortriptyline or any other tricyclic antidepressants such as amitriptyline, imipramine.

HEART DISEASE

SONAXA NT is not recommended for use in patients having heart disease (such as recent heart attack, heart block, or cardiac arrhythmias). Consult your doctor before taking SONAXA NT.

OTHERS

SONAXA NT is not recommended for use if you:

  • have mania (abnormally excited mood)

Before taking SONAXA NT, inform your physician if you:

  • have anxiety, hyperactivity, or schizophrenia (disorder of thinking)
  • have or had a history of alcoholism or substance abuse
  • have suicidal ideation or aggressive behavior
  • have or had a history of epilepsy
  • have thyroid disorder
  • are going to have an electroconvulsive therapy
  • have diabetes
  • have an enlarged prostate
  • are going to receive an anesthetic
  • have narrow angle glaucoma (an eye condition)

Use in pediatrics:

SONAXA NT is strictly not recommended for use in children aged below 6 years. Consult your doctor before taking SONAXA NT.

Use in geriatrics:

SONAXA NT should be taken with caution in elderly patients (aged 65 years or above). Proper dose titration (preferably lower doses) and careful monitoring are required to rule out any unwanted side effects. Consult your doctor for advice before taking SONAXA NT.

INTERACTIONS

A. Drug-Drug interactions:

Before taking SONAXA NT inform to your doctor, if you are taking any of these medicines:

  • other antidepressants (used to treat depression) Ex. fluoxetine, sertraline, amitriptyline, imipramine
  • antipsychotics (used to treat mental illness) Ex. chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine 
  • sympathomimetic agents (used to treat respiratory or circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine
  • medicines used to treat high blood pressure (Ex. guanethidine, betanidine, debrisoquine, clonidine, reserpine)
  • medicines used to treat irregular heartbeat (Ex. quinidine, propafenone, flecainide and encainide)
  • carbamazepine (a medicine used to treat epilepsy)
  • valproic acid (used to treat epilepsy or bipolar disorder)  
  • medicines used to reduce anxiety such as barbiturates (Ex. phenobarbital, pentobarbital) or lorazepam      
  • cimetidine (used to treat stomach ulcers)
  • oxycodone (used to treat pain)

Overdosage:

If you or anyone else take too much of SONAXA NT, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of SONAXA NT include somnolence, restlessness, confusion, dizziness, change in body temperature, vomiting, blurred vision, abnormal heart rate, seizures, dry mouth, or breathing difficulties.

SYNOPSIS

Drug :  

Nortriptyline, Pregabalin

Pharmacological Category :  

Tricyclic antidepressants, Anticonvulsants

Therapeutic Indication :  

Neuropathic pain

Dosage Forms :  

Tablet

MORE INFORMATION

  • Keep SONAXA NT out of reach of children
  • Store SONAXA NT at room temperature

FAQs ABOUT SONAXA NT

Can I stop taking SONAXA NT once my pain is relieved?

No. Do not stop taking SONAXA NT abruptly on your own without consulting your doctor, because premature discontinuation of this medicine can cause withdrawal symptoms like insomnia, headache, nausea, anxiety, diarrhea, depression, convulsion, and excessive perspiration in some individuals. If there is a need for stopping SONAXA NT, your doctor will closely monitor your health condition and gradually reduce the dose over time. For more information, consult your doctor.

Can I consume alcohol while taking SONAXA NT?

No. Avoid consumption of alcohol while taking SONAXA NT as it could make your feel dizzier or drowsier. SONAXA NT can also increase the risk of depressive side effects like thoughts of self-harming or killing, extreme sadness, agitation, or irritability especially in patients with history of emotional disturbances or suicidal ideation.

Can SONAXA NT affect sex drive?

SONAXA NT can affect the sexual life of both men and women. It may cause decreased sex libido, erectile dysfunction, or discomfort during intercourse in some individuals. If you experience any of these symptoms while taking SONAXA NT, contact your doctor immediately.

Will SONAXA NT be more effective at doses higher than the recommended dose?

No. Always take SONAXA NT as advised by your physician to avoid unwanted side effects. Your doctor will select the correct dose of SONAXA NT and duration of therapy depending upon your age, body weight and health condition. Consuming a higher dose than the recommended dose may lead to toxicity or increased risk of harmful side effects. Consult your doctor if the recommended dosage of SONAXA NT does not completely relieve your pain.

What to do If I forget to take SONAXA NT?

You should take SONAXA NT immediately when you remember. If it is time for your next dose of SONAXA NT skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose. 

Can SONAXA NT get you high?

Yes. SONAXA NT can cause mania (abnormal excitement) in some individuals, although everybody does not get them. If mania worsens or if you experience any other unusual mental illness, please contact your doctor immediately.  

Can SONAXA NT causes weight gain?

Yes. SONAXA NT can cause weight gain in some individuals mainly due to its effects on appetite and taste alternation. To manage weight, try to exercise regularly and cut down extra calorie intake. If you are still bothered about weight gain, please consult your doctor.

REFERENCES

1. KD. Tripathi. Antiepileptic Drugs and Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 419-420 & 455-460.

2. Gerald G. Briggs and Roger K. Freeman. P. and N. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3223-3225 & 2822-2824.

3. Shazli Azmi, Kariem T. ElHadd, Andrew Nelson, Adam Chapman, Frank L. Bowling, Anughara Perumbalath, Jonathan Lim, Andrew Marshall, Rayaz A. Malik, and Uazman Alam. Pregabalin in the Management of Painful Diabetic Neuropathy: A Narrative Review. NCBI; PMC US National Library of Medicine, National Institute of Health. [Revised in February 2019]. [Accessed on 27th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349275/

4. Kanika khajuria, Seema gupta, Dev raj dogra, Dinesh kumar and Vijay Khajuria. COMPARISON OF PREGABALIN AND NORTRIPTYLINE ON EFFICACY AND SAFETY IN POSTHERPETIC NEURALGIA. Asian Journal of Pharmaceutical and Clinical research. July 2021. [Accessed on 27th October 2021] https://innovareacademics.in/journals/index.php/ajpcr/article/view/41872

5. Santosh Bhusal, Sherilyn Diomampo, and Marina N Magrey. Clinical utility, safety, and efficacy of pregabalin in the treatment of fibromyalgia. NCBI; PMC US National Library of Medicine, National Institute of Health. February 2016. [Accessed on 27th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762578/

6. Cory Toth. Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. NCBI; PMC US National Library of Medicine, National Institute of Health. February 2014. [Accessed on 27th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110876/

7. Dalim Kumar Baidya, Anil Agarwal, Puneet Khanna, and Mahesh Kumar Arora. Pregabalin in acute and chronic pain. NCBI; PMC US National Library of Medicine, National Institute of Health. July-September 2011. [Accessed on 27th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161452/

8. Sheena Derry, Philip J Wiffen, Dominic Aldington, R Andrew Moore, and Cochrane Pain. Nortriptyline for neuropathic pain in adults. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2015. [Accessed on 27th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485407/

9. Akums Drugs & Pharmaceuticals Ltd. PREGALIN NT. Torrentian.com. [Revised in November 2019] [Accessed on 27th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2774.pdf

10. John lee Pharmaceuticals Pvt. Ltd. PREBEL-N. [Accessed on 27th October 2021] https://johnleeindia.com/product/prebel-n/

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    25 g
    Ingredient
    Pregabalin Sr 75 MG+NORTRIPTYLINE 10MG
    Hsn Code
    30049082
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Sonaxa NT 10mg Tablet 15'S

Sonaxa NT 10mg Tablet 15'S Mkt: Eris Lifesciences Ltd

M.R.P.: Rs.297.00
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