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Sodabicarb 8.4% Injection 25ml
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INTRODUCTION
SODABICARB 8.4% INJECTION contains Sodium Bicarbonate, which belongs to the group of medicines called alkalinizing agents. It is used to treat metabolic acidosis (the correction of the body's acid-alkaline balance), which can occur in conditions such as severe kidney disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal blood circulation, cardiac arrest, and drug overdoses such as barbiturates (where dissociation of the barbiturate-protein complex is desired), salicylate poisoning, methyl alcohol poisoning, and haemolytic reactions.
It is also used in severe diarrhea, which is often accompanied by a significant loss of bicarbonate. Additionally, it will be used to treat patients who have overused tricyclic antidepressants. It will be used only after the other resuscitation methods.
SODABICARB 8.4% INJECTION is not recommended in patients with kidney failure or kidney stones, high blood pressure, heart failure, shallow or slow breathing than usual (hypoventilation), any blood abnormalities such as high sodium levels, low levels of calcium, potassium, or chloride, or if your blood is less acidic than usual, fluid retention. SODABICARB 8.4% INJECTION should be used with caution in patients with liver diseases.
SODABICARB 8.4% INJECTION should be given to a pregnant woman only if clearly needed. Contact your doctor before receiving SODABICARB 8.4% INJECTION should be used with caution in neonates and children under 2 years of age. Serious side effects of receiving SODABICARB 8.4% INJECTION are pain, burning, or swelling at the site of the injection, extreme irritability, muscle spasms or cramps, breathing difficulties, low potassium levels, which can cause twitching and muscle weakness, etc. Consult your doctor if your symptoms get worse or persist.
USES OF SODABICARB 8.4% INJECTION
Treats:
- metabolic acidosis (correct the acid-alkaline balance in the body) which can develop in conditions like severe kidney disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal blood circulation, cardiac arrest and in drug overdoses like, salicylate poisoning, methyl alcohol poisoning, etc
- severe diarrhea which is often accompanied by a significant loss of bicarbonate
- patients who have taken too much tricyclic antidepressant medicine
HOW SODABICARB 8.4% INJECTION WORKS
SODABICARB 8.4% INJECTION is a systemic alkalizer, which increases plasma bicarbonate, buffers the excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical effects of acidosis.
DIRECTIONS FOR USE
SODABICARB 8.4% INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will fix the correct dose and duration for you depending on your age, body weight, and medical condition.
SIDE EFFECTS OF SODABICARB 8.4% INJECTION
RARE
Stop receiving SODABICARB 8.4% INJECTION and contact your doctor immediately if you experience any of the following side effects:
- pain, burning or swelling at the site of injection
- extreme irritability
- muscle spasms or cramps
- breathing difficulties
- low potassium levels can cause twitching, muscle weakness, "pins and needles" in the hands or feet, agitation, or an irregular heartbeat
- low blood sugar levels and a high sodium level in the blood can make you feel hunger, thirsty, anxious, confused, extremely irritated, shaky, or sweaty.
- excess acid in the blood, may cause rapid breathing (intracellular acidosis)
- a blood disease that causes an increase in volume of blood flow
- low calcium level may cause involuntary contraction of muscles
- inflammation due to accumulation of fluid under the skin
- bleeding inside the skull may occur in new-borns
- sodium bicarbonate leak out into the surrounding tissue may cause pain, redness, or skin irritation
- if the medication is not injected properly, skin around the injection site may die
WARNING & PRECAUTIONS
PREGNANCY
SODABICARB 8.4% INJECTION should be given to a pregnant woman only if clearly needed. Contact your doctor before receiving SODABICARB 8.4% INJECTION.
BREASTFEEDING
SODABICARB 8.4% INJECTION should be given to a breastfeeding woman only if clearly needed. Contact your doctor before receiving SODABICARB 8.4% INJECTION.
DRIVING AND USING MACHINES
SODABICARB 8.4% INJECTION is unlikely to affect your ability to drive or operate machines.
KIDNEY
SODABICARB 8.4% INJECTION is not recommended in patients with kidney failure or who have had kidney stones. Consult your doctor before receiving SODABICARB 8.4% INJECTION.
LIVER
SODABICARB 8.4% INJECTION should be used with caution in patients with liver diseases. Consult your doctor before receiving SODABICARB 8.4% INJECTION.
ALLERGY
Do not take SODABICARB 8.4% INJECTION if you are allergic to sodium bicarbonate or other ingredients of the medicine.
HEART DISEASE
SODABICARB 8.4% INJECTION is not recommended in patients with high blood pressure and heart failure. Consult your doctor before receiving SODABICARB 8.4% INJECTION.
OTHERS
SODABICARB 8.4% INJECTION is not recommended if you have:
- breathing is slower or more shallow than usual (hypoventilation)
- any blood abnormalities such as high sodium levels, low levels of calcium, potassium or chloride, or your blood is less acidic than usual
- suffer from fluid retention
Use in pediatrics:
SODABICARB 8.4% INJECTION should be used with caution neonates and children under 2 years of age, because it may cause hypernatremia, decrease in cerebrospinal fluid pressure and possible intracranial haemorrhage. Consult your doctor before receiving SODABICARB 8.4% INJECTION.
Use in geriatrics:
SODABICARB 8.4% INJECTION should be used with caution in elderly patients aged 65 years or above. Contact your doctor before receiving SODABICARB 8.4% INJECTION.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving SODABICARB 8.4% INJECTION, inform your doctor if you are taking any of the following medicine:
- corticosteroids such as prednisone or corticotropin (medicines used to reduce swelling or to treat hormone problems)
- antibiotics like tetracyclines such as doxycycline (used to treat bacterial infections)
- quinidine, flecainide (medicines used to treat heart problems)
- dobutamine (medicines used to treat cardiogenic shock and heart failure)
- amphetamines (medicines used to treat mental problems and drowsiness)
- ephedrine and pseudoephedrine (medicines used to treat colds and asthma)
- potassium supplements
- parenteral solutions containing calcium
- ethacrynic acid, bumetanide, thiazides, or frusemide (medicines used to treat water retention and problems such as passing urine)
- mecamylamine (medicine used to treat high blood pressure)
- memantine (medicine used for Alzheimer’s disease)
- chlorpropamide (medicine used to treat diabetes mellitus)
- lithium, norepinephrine (medicines used to treat mood disorders)
- aspirin (Acetylsalicylic acid) (medicine used to relieve pain, fever, and inflammation)
Overdosage:
If you or anyone else accidentally take too much of SODABICARB 8.4% INJECTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are spasms in the muscles, hands or feet, muscle cramps, extreme irritability, breathing difficulties, hyperventilation (over breathing), very sensitive to slight stimuli, twitching and high potassium levels in your blood may cause dizziness or tiredness.
SYNOPSIS
| Drug | : | Sodium Bicarbonate |
| Pharmacological Category | : | Alkalinising agents |
| Therapeutic Indication | : | Metabolic acidosis |
| Dosage Forms | : | Tablet, Injection, Suspension, Drops, Nasal wash, Sachet |
MORE INFORMATION
- Keep SODABICARB 8.4% INJECTION out of reach from children
- Store at room temperature
FAQs ABOUT SODABICARB 8.4% INJECTION
What is SODABICARB 8.4% INJECTION used for?
SODABICARB 8.4% INJECTION is used in the treatment of metabolic acidosis (correcting the acid-alkaline balance in the body), which can develop in conditions like severe kidney disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal blood circulation, cardiac arrest, and in drug overdoses like barbiturates (where dissociation of the barbiturate-protein complex is desired), salicylate poisoning, methyl alcohol poisoning, and in haemolytic reactions requiring alkalinization of the urine to reduce nephrotoxicity of blood pigments, which require alkalinization of the blood, a metabolitIt is also used in severe diarrhoea, which is often accompanied by a significant loss of bicarbonate. Additionally, it can be used to treat patients who have overused tricyclic antidepressants. It will be used only after the other resuscitation methods. Contact your doctor before taking SODABICARB 8.4% INJECTION. Contact your doctor before taking SODABICARB 8.4% INJECTION.
Can I use SODABICARB 8.4% INJECTION during pregnancy?
SODABICARB 8.4% INJECTION should be given to a pregnant woman only if clearly needed. Contact your doctor before receiving SODABICARB 8.4% INJECTION.
Can I use SODABICARB 8.4% INJECTION with children?
SODABICARB 8.4% INJECTION should be used with caution in neonates and children under 2 years of age, because it may cause hypernatremia, a decrease in cerebrospinal fluid pressure, and possible intracranial haemorrhage. Consult your doctor before receiving SODABICARB 8.4% INJECTION.
How does SODABICARB 8.4% INJECTION work?
SODABICARB 8.4% INJECTION is a systemic alkalizer that increases plasma bicarbonate, buffers the excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical effects of acidosis.
Can I use SODABICARB 8.4% INJECTION while breast-feeding?
SODABICARB 8.4% INJECTION should be given to a breastfeeding woman only if clearly needed. Contact your doctor before receiving SODABICARB 8.4% INJECTION.
REFERENCES
1. Senewiratne NL, Woodall A, Can AS. Sodium Bicarbonate. StatPearls [Internet]. NIH National Library of Medicine. National Center for Biotechnology Information. [Revised in September 2022] [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK559139
2. Martindale Pharma. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 4th November 2022] https://www.medicines.org.uk/emc/files/pil.3697.pdf
3. HOSPIRA, INC. Sodium Bicarbonate. [Accessed on 4th November 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f42c680d-1d80-4091-b794-17e07af10b2e&type=display
4. Phebra Pty Ltd. Sodium Bicarbonate. [Accessed on 4th November 2022] https://www.phebra.com/wp-content/uploads/2018/10/Sodium-Bicarbonate-8.4-CMI-V04.pdf
5. Pfizer. Sodium Bicarbonate. [Accessed on 4th November 2022] https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=9647
6. Pfizer. Sodium Bicarbonate. [Accessed on 4th November 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=7125
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 12 Nov 2022 | 01:01 PM(IST)
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