Simvas 5mg Tablet 10'S

High Cholesterol Rx required
NOT AVAILABLE

Best Price*  ₹ 35.20
MRP ₹44.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Micro Labs Ltd * Country of Origin: NA * Delivery charges if applicable will be applied at checkout



INTRODUCTION

SIMVAS 5MG contains Simvastatin which belongs to the group of medicines called HMG-CoA reductase inhibitors (statins). It is used to reduce elevated levels of cholesterol (LDL or bad cholesterol) and triglycerides in the blood. Cholesterol is type of a fatty substance found in the bloodstream. It mainly consists of low-density lipoprotein (LDL; bad cholesterol), high-density lipoprotein (HDL; good cholesterol) and triglycerides.

SIMVAS 5MG can be used in conditions such as primary hypercholesterolaemia (increased blood cholesterol levels), mixed hyperlipidaemia (increased fat levels in the blood), homozygous familial hypercholesterolaemia (a hereditary cholesterol disease), coronary heart disease or if at risk of any heart disease (such as diabetes, history of stroke, or other any cardiovascular disease) in addition with your cholesterol lowering diet.

Simvastatin works by reducing the elevated levels of LDL cholesterol and triglycerides in the blood. It also increases the HDL cholesterol (good cholesterol) and prolongs your life by reducing the risk of heart disease and stroke. Along with the treatment, your doctor might recommend you eat a low-fat diet with regular physical exercise. Before prescribing this medicine, your doctor may take several blood tests to analyze your condition and would regularly monitor your liver function to avoid unwanted side effects. Avoid smoking and consumption of alcohol while taking this medicine, as it may reduce its effectiveness.

While taking this medicine, inform your doctor immediately if you experience any unexplained muscle pain, tenderness, or weakness as it could be a serious side effect, including muscle breakdown and kidney damage. Your doctor might reduce your dose or suggest an alternative therapy. Avoid concomitant use of this medicine with oral fusidic acid and lomitapide as it may increase the risk of rhabdomyolysis (a serious muscle problems).

Avoid drinking grapefruit juice while taking this medicine, as it may alters the absorption of simvastatin in your body. Before taking this medicine, inform your doctor if you have lung, kidney or liver disease. SIMVAS 5MG is strictly not recommended for use in pregnant or breastfeeding women and in children aged below 10 years. Consult your doctor for advice before taking.

USES OF SIMVAS 5MG

  • Treats high cholesterol (LDL) and triglycerides levels in the blood
  • Reduces the risk of heart disease and stroke

HOW SIMVAS 5MG WORKS

SIMVAS 5MG works by blocking an enzyme called HMG-CoA reductase which is used to make cholesterol in the liver. When that enzyme is blocked less cholesterol is produced thus reducing the amount of cholesterol in the blood. It lowers the level of total cholesterol and low-density lipoprotein (LDL, or "bad" cholesterol), and raises high density lipoprotein (HDL, or "good" cholesterol) levels.

DIRECTIONS FOR USE

Take this medicine as directed by your physician. It can be taken with or without meals preferably in the evening. Swallow the medicine as a whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition.

If you are taking any bile acid sequestrants along with SIMVAS 5MG, take this medicine at least 2 hours before or 4 hours after taking the bile acid sequestrants. Avoid drinking grapefruit juice while taking this medicine. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF SIMVAS 5MG

SERIOUS

  • unexplained muscle pain, tenderness, or weakness
  • allergic reactions (such as skin rash, itching, swelling, sensitivity to sun, fever, flushing, weakness of limbs and neck muscles, pain or inflammation of the joints and unusual bleeding)
  • signs of liver inflammation (such as yellowing of skin and eyes, itching, dark-coloured urine or pale-coloured stool, feeling tired or weak, loss of appetite)
  • inflammation of pancreas often with severe abdominal pain

RARE

  • lichenoid drug eruptions (rash that may occur on skin or sores in mouth)
  • muscle rupture
  • breast enlargement in men
  • anemia
  • numbness or weakness of arms and legs
  • headache, dizziness
  • blurred vision
  • abdominal pain, constipation, flatulence, indigestion, diarrhea, nausea, vomiting
  • hair loss

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor immediately.

Constipation

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Headache:  

Rest and drink plenty of fluids. Do not drink too much alcohol. Ask your doctor to recommend a painkiller.

WARNING & PRECAUTIONS

PREGNANCY

SIMVAS 5MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

SIMVAS 5MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

SIMVAS 5MG should be taken with caution in patients with kidney problems. Consult your doctor for advice before taking.

LIVER

SIMVAS 5MG is not recommended for use in patients having liver problems. Consult your doctor for advice before taking.

ALLERGY

Do not take this medicine if you are allergic to simvastatin.

LUNGS

SIMVAS 5MG should be taken with caution in patients with severe lung disease. Consult your doctor for advice before taking.

HEART DISEASE

SIMVAS 5MG should be taken with caution in patients having high blood pressure. Consult your doctor for advice before taking.

OTHERS

Before taking SIMVAS 5MG, inform your doctor if you:

  • are alcoholic
  • are going to have an operation
  • are overweight
  • are elderly (aged 65 years or above)
  • are female
  • have diabetes or at risk of developing diabetes
  • have thyroid problems
  • had previously suffered any muscle problems after taking cholesterol-lowering medicines
  • have family history of a hereditary muscle disorder
  • have muscle weakness

INTERACTIONS

Talk to your doctor, if you are taking,

  • oral fusidic acid (used to treat bacterial infection)
  • ciclosporin (used to prevent graft rejection)
  • danazol (used to treat endometriosis)
  • medicines used to treat fungal infections (e.g. itraconazole, ketoconazole, fluconazole, posaconazole or voriconazole)
  • medicines used to treat bacterial infection (e.g. erythromycin, clarithromycin or telithromycin)
  • medicines used to treat HIV infection such as HIV protease inhibitors (e.g. indinavir, nelfinavir, ritonavir and saquinavir)
  • medicines used to treat hepatitis C virus infection (e.g. boceprevir, telaprevir, elbasvir or grazoprevir)
  • medicines used to treat heart problems such as high blood pressure, chest pain, irregular heartbeat (e.g. amiodarone, verapamil, diltiazem or amlodipine)
  • medicines used to prevent blood clots (e.g. warfarin, phenprocoumon or acenocoumarol)
  • other medicines used to reduce blood cholesterol levels (e.g. gemfibrozil, fenofibrate, niacin and bezafibrate)
  • nefazodone (used to treat depression and other mental illness)
  • cobicistat (used to increase the amount of atazanavir in the body)
  • lomitapide (used to treat a rare and serious genetic cholesterol condition)
  • daptomycin (used to treat blood infection and serious skin infection)
  • colchicine (used to treat gout)
  • ticagrelor (antiplatelet medicine that reduces the risk of heart attack or stroke)
  • rifampicin (used to treat tuberculosis)

SYNOPSIS

Drug :   Simvastatin
Pharmacological Category :   HMG-CoA reductase inhibitors (statins)
Therapeutic Indication :   High blood cholesterol and triglyceride levels
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT SIMVAS 5MG

Can I overdose SIMVAS 5MG?

No. Only take this medicine as directed by your physician. If you have accidentally took too many doses of this medicine, contact your doctor immediately to avoid the risk of side effects like muscle weakness and kidney damage.

Can you eat grapes while taking SIMVAS 5MG?

No. Avoid eating grapes or drinking grape juice while taking this medicine, as it may alters the absorption of simvastatin in your body.

Can I take SIMVAS 5MG on an empty stomach?

Yes. This medicine can be taken with or without meals preferably in the evening. Swallow the medicine as a whole with a sip of water. Do not crush or chew the medicine.

REFERENCES

1. KD. Tripathi. Hypolipidaemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page – 637-638.

2. Bersot TP. Drug Therapy for Hypercholesterolemia and Dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 898-894.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3538-3541.

4. Cardinal Tien Hospital. Evaluation of the Effects of Simvastatin 40mg. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2016] [Accessed 28th January 2021] https://www.clinicaltrials.gov/ct2/show/NCT00397826

5. Pfizer. Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD (IDEAL). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2015] [Accessed 28th January 2021] https://clinicaltrials.gov/ct2/show/NCT00159835

6. Alberto Serrano-Pozo, Gloria L. Vega, Dieter Lütjohann, Joseph J. Locascio, Marsha K. Tennis, Amy Deng, Alireza Atri, Bradley T. Hyman, Michael C. Irizarry and John H. Growdon. Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2013. [Accessed 28th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694274/

7. Merck Sharp & Dohme Limited. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 28th January 2021] https://www.medicines.org.uk/emc/files/pil.1010.pdf

8. Milpharm Limited or APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 28th January 2021] https://www.medicines.org.uk/emc/files/pil.542.pdf

9. Actavis UK Ltd. Electronic Medicines Compendium (EMC); [Revised on March 2018] [Accessed 28th January 2021] https://www.medicines.org.uk/emc/files/pil.4591.pdf

USEFUL DIAGNOSTIC TESTS

  • Cholesterol - HDL
  • Cholesterol - LDL
  • Cholesterol - Total

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    17.5
    Ingredient
    SIMVASTATIN 5MG
    Hsn Code
    30049099
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