SILVEZ Cream 20gm

Skin Infections Rx required

Best Price* ₹ 69.08 MRP ₹ 76.75
(Inclusive of all taxes) * Mkt: Laborate Pharmaceuticals India Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

SILVEZ CREAM contains Silver sulphadiazine which belongs to the group of medicines called Sulfonamides. SILVEZ CREAM is used in the prophylaxis and treatment of infection in burn wounds, leg ulcers and/or pressure sores caused by sensitive micro-organisms in affected individuals.

SILVEZ CREAM is also indicated for use in the conservative management of finger-tip injuries (which involves pulp, nail loss and/or partial loss of the distal phalanx (finger bones) in affected individuals.

SILVEZ CREAM is not recommended for use in patients allergic (hypersensitive) to silver sulphadiazine/sulphonamide, cetyl alcohol, and/or propylene glycol.

Before applying SILVEZ CREAM, inform your doctor if you suffer from glucose-6-phosphate dehydrogenase-deficiency (genetic disorder that affects red blood cells), and/or have lung problems (such as respiratory impairment), kidney problems (such as renal impairment), and liver problems (such as hepatic impairment).

SILVEZ CREAM is advised to be used with caution in pregnant and breast feeding women only if it is clearly necessary.

SILVEZ CREAM is not recommended for use in premature infants/new-born infants (aged below 3 months) and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.

The most common side effects of applying SILVEZ CREAM are leukopenia (low white blood cell count), application site reaction (such as burning, skin rash), and/or pruritis (itching). Consult your doctor if any of these symptoms worsens.

USES OF SILVEZ CREAM

  • Aids in the prophylaxis and treats infection associated with burn wounds, leg ulcers and/or pressure sores caused by sensitive micro-organisms
  • Aids in the conservative management of finger-tip injuries (that involves pulp, nail loss and/or partial loss of the distal phalanx (finger bones) in affected individuals

HOW SILVEZ CREAM WORKS

SILVEZ CREAM works by inhibiting bacterial enzyme dihydropteroate synthetase (enzyme responsible for folic acid synthesis in bacteria) which leads to blockade of DNA synthesis in bacteria resulting in prevention and synthesis of bacterial growth in burn wounds, leg ulcers and/or pressure sores in affected individuals.  

DIRECTIONS FOR USE

Apply SILVEZ CREAM as advised by your physician. It is for external use only. Wash your hands before and after use. The burn wounds should be cleansed and debrided. While applying SILVEZ CREAM to burn wounds wear sterile disposable gloves. Apply required quantity of cream over the wound area and cover the applied site with a sterile dressing or leave the area uncovered. The cream may also be applied with a conventional finger dressing when used on the finger-tip injuries. Your doctor will decide the exact dose and duration of treatment for the child depending on child’s age, body weight and disease condition.

SIDE EFFECTS OF SILVEZ CREAM

COMMON

  • signs of leukopenia (low white blood cell count) such as chills, sweating, sore throat, and/or shortness of breath
  • application site reaction such as burning, rash (including eczema, contact dermatitis)
  • pruritis (itching)

RARE

  • argyria (uncommon grey-blue pigmentation of skin and mucous membranes caused by prolonged silver exposure)

Stop applying SILVEZ CREAM and contact your physician immediately if you experience any of the following side effects:

  • skin reactions such as Stevens-Johnson Syndrome, toxic epidermal necrolysis associated with symptoms such as progressive skin rash, blisters, and/or mucosal lesions

HOW TO MANAGE SIDE EFFECTS

Itchy Skin:

Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes, or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly.

 

WARNING & PRECAUTIONS

PREGNANCY

SILVEZ CREAM should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before applying the medicine.

BREASTFEEDING

SILVEZ CREAM should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before applying the medicine.

DRIVING AND USING MACHINES

SILVEZ CREAM is unlikely to affect your ability to drive or operate machines. Consult your doctor before applying the medicine.

KIDNEY

SILVEZ CREAM should be used with caution in patients with kidney problems such as renal impairment.  Consult your doctor before applying SILVEZ CREAM.

LIVER

SILVEZ CREAM should be used with caution in patients with liver problems such as hepatic impairment.  Consult your doctor before applying SILVEZ CREAM.

ALLERGY

Do not apply SILVEZ CREAM if you are allergic (hypersensitive) to silver sulphadiazine/sulphonamides, cetyl alcohol, propylene glycol, and/or any other ingredients of this medicine.

LUNGS

SILVEZ CREAM should be used with caution in patients with lung problems such as respiratory impairment.  Consult your doctor before applying SILVEZ CREAM.

OTHERS

Before applying SILVEZ CREAM, inform your doctor if you:

  • have glucose-6-phosphate dehydrogenase-deficiency (genetic disorder that affects red blood cells)

Use in Paediatrics:

SILVEZ CREAM is not recommended for use in premature infants/new-born infants (aged below 3 months). Consult your doctor before applying the medicine.

Use in Geriatrics:

SILVEZ CREAM should be used with caution in elderly patients (aged 65 years/above). Consult your doctor before applying SILVEZ CREAM.

INTERACTIONS

A. Drug-Drug interactions:

  • enzymatic debriding agents (used to remove necrotic material from pressure ulcers, leg ulcers, wounds) Ex. trypsin, subtilisin
  • oral-hypoglycaemic agents (medicines used to treat diabetes) Ex. metformin, glimepiride
  • phenytoin (medicine used for fits)

Overdosage:

If you or anyone else accidentally apply too much of SILVEZ CREAM, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS

Drug :   Silver Sulphadiazine
Pharmacological Category :   Sulfonamide
Therapeutic Indication :   Burn wounds, leg ulcers, pressure sores (caused by sensitive micro-organisms), Conservative management of finger-tip injuries         
Dosage Forms :   Cream

MORE INFORMATION

  • Keep SILVEZ CREAM out of the sight and reach of children
  • Do not store SILVEZ CREAM above 25°C

FAQs ABOUT SILVEZ CREAM

What is SILVEZ CREAM used for?

SILVEZ CREAM is used in the prophylaxis and treatment of infection in burn wounds, leg ulcers and/or pressure sores caused by sensitive micro-organisms in affected individuals. It is also indicated for use in the conservative management of finger-tip injuries (which involves pulp, nail loss and/or partial loss of the distal phalanx (finger bones) in affected individuals.

What are the common side effects associated with the use of SILVEZ CREAM?

The most common side effects of applying SILVEZ CREAM are leukopenia (low white blood cell count), application site reaction (such as burning, skin rash), and/or pruritis (itching). Consult your doctor if any of these symptoms worsens.

How SILVEZ CREAM works?

SILVEZ CREAM works by inhibiting bacterial enzyme dihydropteroate synthetase (enzyme responsible for folic acid synthesis in bacteria) which leads to blockade of DNA synthesis in bacteria resulting in prevention and synthesis of bacterial growth in burn wounds, leg ulcers and/or pressure sores in affected individuals.

How SILVEZ CREAM should be applied?

Apply SILVEZ CREAM as advised by your physician. It is for external use only. Wash your hands before and after use. The burn wounds should be cleansed and debrided. While applying SILVEZ CREAM to burn wounds wear sterile disposable gloves. Apply required quantity of cream over the wound area and cover the applied site with a sterile dressing or leave the area uncovered. The cream may also be applied with a conventional finger dressing when used on the finger-tip injuries. Your doctor will decide the exact dose and duration of treatment for the child depending on child’s age, body weight and disease condition.

Can SILVEZ CREAM be applied in pregnant and breastfeeding women?

Yes, SILVEZ CREAM can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before applying the medicine.

REFERENCES

1. K.D. Tripathi. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page - 706.

2. Rosemary J. Oaks; Renford Cindass.Silver Sulfadiazine. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. May 2022. [Accessed on 1st September 2022] https://www.ncbi.nlm.nih.gov/books/NBK556054/

3. King Pharmaceuticals, Inc. U.S. Food and Drug Administration (USFDA). [Revised in September 2012] [Accessed on 1st September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017381s050lbl.pdf

4. Smith & Nephew GmbH. Health Products Regulatory Authority (HPRA). [Revised in July 2021] [Accessed on 1st September 2022] https://www.hpra.ie/img/uploaded/swedocuments/Licence_PA22696-002-001_19072021112637.pdf

USEFUL DIAGNOSTIC TESTS

  • Kidney function test
  • Complete blood count

PRODUCT DETAILS

    Country Of Origin
    India
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

SILVEZ Cream 20gm

SILVEZ Cream 20gm Mkt: Laborate Pharmaceuticals India Ltd

M.R.P.: Rs.76.75
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