INTRODUCTION

SILOSTRIDE CAPSULE contains Silodosin which belongs to the group of medicines called Alpha-blockers. It is indicated for the treatment of signs and symptoms of Benign prostatic hyperplasia (BPH) in adults only.

Benign prostatic hyperplasia (BPH) also called prostate gland enlargement is a common condition. An enlarged prostate gland can cause uncomfortable urinary symptoms, such as blocking the flow of urine out of the bladder. It can also cause bladder, urinary tract or kidney problems.

Your doctor might want you to take some diagnostic tests before starting with the treatment. Before taking SILOSTRIDE CAPSULE inform your doctor if you have severe liver disease, kidney disease, undergoing cataract surgery, or have ever fainted or felt dizzy.

SILOSTRIDE CAPSULE is not recommended for use in women, children and adolescents under 18 years of age.

The most common side effects of using SILOSTRIDE CAPSULE are abnormal ejaculation, dizziness, blocked or runny nose, and diarrhoea. Consult with your doctor if any of these side effects worsen or does not improve.

USES OF SILOSTRIDE CAPSULE

• Used to treat signs and symptoms of Benign Prostatic Hyperplasia (BPH) in adults

HOW SILOSTRIDE CAPSULE WORKS

SILOSTRIDE CAPSULE treats the urinary symptoms associated with prostatic hyperplasia by acting on certain receptors present in prostate, bladder, and urethra. It blocks these receptors, causing the smooth muscles in these organs to relax.

DIRECTIONS FOR USE

Take SILOSTRIDE CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF SILOSTRIDE CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine yourself without consulting your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Inform your physician if you are taking any of the following medicine before taking SILOSTRIDE CAPSULE:

• medicines used to reduce the blood pressure (Ex. prazosin, doxazosin)
• antifungal medicines (Ex. ketoconazole, itraconazole)
• medicines used in the treatment of HIV-AIDS (Ex. ritonavir)
• medicines used after transplants to prevent organ rejection (Ex. ciclosporin)
• medicines used in treating problems in getting or keeping an erection (Ex. sildenafil, tadalafil)
• medicines used in the treatment of epilepsy (Ex. phenytoin)
• medicines used in the treatment of tuberculosis (Ex. rifampicin)

Overdosage:

If you or anyone else accidentally takes too much of SILOSTRIDE CAPSULE, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep SILOSTRIDE CAPSULE out of reach of children
• Store below 30°C

FAQs ABOUT SILOSTRIDE CAPSULE

What is SILOSTRIDE CAPSULE and why is it used?

SILOSTRIDE CAPSULE contains Silodosin which is an Alpha-adrenoreceptor blocker, and it is used to treat urinary symptoms associated with benign enlargement of prostate that are difficulty in starting to pass urine, feeling of not completely emptying the bladder, more frequent need to pass urine, even at night. Talk to your doctor for further queries.

Can I stop taking SILOSTRIDE CAPSULE on my own?

You should not stop taking SILOSTRIDE CAPSULE unless instructed by your doctor as it may cause your symptoms to re-appear. Talk to your doctor if you wish to discontinue SILOSTRIDE CAPSULE.

Is SILOSTRIDE CAPSULE intended for use by men of all ages?

SILOSTRIDE CAPSULE is intended for use in adult men. It should not be given to children below 18 years of age.

How to manage if I miss a dose of SILOSTRIDE CAPSULE?

You can take SILOSTRIDE CAPSULE later the same day if you have missed it earlier. Skip the dose you missed if it is almost time for the next dose. Do not take a double dose of SILOSTRIDE CAPSULE to make up for a missed dose.

Can SILOSTRIDE CAPSULE cause erectile dysfunction?

SILOSTRIDE CAPSULE usually does not affect erectile function. However, it may cause other sexual problems like ejaculatory dysfunction and failure to ejaculate. If you experience any side effects or uneasiness while taking this medication, contact your doctor immediately.

REFERENCES

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Schwinghammer, Cecily V. DiPrio. Benign Prostatic Hyperplasia. Pharmacotherapy Handbook. Ninth Edition. 2014. Page – 1455.

2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Silodosin. [Accessed on 1st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Silodosin#section=Mechanism-of-Action

3. P Capogrosso, A Serino, E Ventimiglia, L Boeri, F Dehò, R Damiano, A Briganti, F Montorsi, A Salonia. Effects of silodosin on sexual function - realistic picture from the everyday clinical practice. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. Nov 2015. [Accessed on 1st June 2022] https://pubmed.ncbi.nlm.nih.gov/26446512/

4. Accord Healthcare. Health Products Regulatory Authority (HPRA). [Revised in May 2020]. [Accessed on 1st June 2022] https://www.hpra.ie/img/uploaded/swedocuments/43c4ae37-d929-4bb5-b0eb-84a7405b8d2c.pdf

USEFUL DIAGNOSTIC TESTS

• Prostate Specific Antigen (PSA) Test
• Digital Rectal Exam
• Urine Analysis