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INTRODUCTION

SIGNOCOLD AF SYRUP is a combination of Phenylephrine and Chlorpheniramine which belongs to the group of medicines called Nasal decongestants and Antihistamines respectively. It is used to relieve nasal and sinus congestion, allergic symptoms of the nose or throat due to upper respiratory tract allergies, sinus pain and headache.

Also, it is used adjunctly with antibacterials to treat sinusitis (inflammation of the tissue lining the sinuses), tonsillitis (inflammation of the tonsils) and otitis media (middle ear infection).

Before giving SIGNOCOLD AF SYRUP to your child, inform child’s doctor if your child has kidney, liver or heart problems, diabetes, fits or severely raised blood pressure.

SIGNOCOLD AF SYRUP is not recommended for use in pregnant or breast-feeding women and elderly patients as it is used only in children.

The most common side effects of SIGNOCOLD AF SYRUP are nausea, vomiting, dry mouth, dizziness and tiredness. Consult your child’s doctor if any of the side effects worsen.

USES OF SIGNOCOLD AF SYRUP

  • Relieves nasal and sinus congestion
  • Relieves allergic symptoms of the nose or throat due to upper respiratory tract allergies
  • Relieves sinus pain and headache
  • Used adjunctly with antibacterials to treat sinusitis, tonsillitis and otitis media

HOW SIGNOCOLD AF SYRUP WORKS

SIGNOCOLD AF SYRUP relieves cold symptoms where phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the sinus cavities and chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine.

DIRECTIONS FOR USE

Give SIGNOCOLD AF SYRUP to your child as advised by the physician. Shake well before use. Use a measuring cup to properly measure the dose. Your child’s doctor will decide the correct dose and duration of SIGNOCOLD AF SYRUP for your child depending upon child’s age, body weight and disease condition.

SIDE EFFECTS OF SIGNOCOLD AF SYRUP

COMMON

  • drowsiness and sedation
  • disturbance in concentrating, un-coordination, dizziness, headache
  • blurred vision
  • nausea or vomiting
  • dry mouth
  • tiredness

RARE

  • increased heart rate, palpitation
  • fear, anxiety, restlessness
  • tremor, weakness
  • painful urination
  • insomnia
  • hallucinations, convulsions

Stop giving SIGNOCOLD AF SYRUP to your child and contact doctor immediately if your child experiences any of the following side effects:

  • develop rash, hives, itching, red or swollen or blistered or peeling skin; wheezing, tightness in the chest or throat, trouble breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face lips, tongue or throat

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.

Nausea and vomiting:

Follow simple meal plan for your child while administering SIGNOCOLD AF SYRUP. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.

Dry mouth:

Tell your child to sip water regularly and other sugar free liquids. Tell your child not to use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Consult child’s doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

SIGNOCOLD AF SYRUP is not recommended for use in pregnant women as it is used only in children. Consult your doctor for advice.

BREASTFEEDING

SIGNOCOLD AF SYRUP is not recommended for use in breast-feeding women as it is used only in children. Consult your doctor for advice.

DRIVING AND USING MACHINES

Do not let your child ride bicycles or drive other vehicles or operate any tools if your child experiences dizziness, drowsiness and sedation after taking SIGNOCOLD AF SYRUP.

ALCOHOL

Avoid medicines containing alcohol during administration of SIGNOCOLD AF SYRUP.

KIDNEY

SIGNOCOLD AF SYRUP should be used with caution in children with kidney failure. Consult your child’s doctor for advice before administration of SIGNOCOLD AF SYRUP to your child.

LIVER

SIGNOCOLD AF SYRUP should be used with caution in children with liver impairment. Consult your child’s doctor for advice before administration of SIGNOCOLD AF SYRUP to your child.

ALLERGY

Talk to your child’s doctor if your child is allergic to Phenylephrine, Chlorpheniramine or any other ingredients of this medicine.

HEART DISEASE

SIGNOCOLD AF SYRUP is not recommended for use in children with severely high blood pressure. SIGNOCOLD AF SYRUP should be used with caution in patients with any other cardiovascular problems. Consult your child’s doctor for advice before administration of SIGNOCOLD AF SYRUP to your child.

OTHERS

SIGNOCOLD AF SYRUP is not recommended for use if your child:

  • has phaeochromocytoma (rare tumours that start in the inner part of the adrenal gland)
  • peripheral or mesenteric vascular thrombosis (blood clots usually in legs or major veins (one or more) that drain blood from the intestine

Before giving SIGNOCOLD AF SYRUP to your child, inform your physician if your child:

  • has diabetes
  • has overactive thyroid
  • has closed angle glaucoma
  • has history of fits

Use in pediatrics:

SIGNOCOLD AF SYRUP should be used with caution in children from 1 month to 12 years of age. Consult your child’s doctor for advice before administration of SIGNOCOLD AF SYRUP.

Use in geriatrics:

SIGNOCOLD AF SYRUP is not recommended for use in elderly patients as it is used only in children. Consult your doctor for advice.

INTERACTIONS

A. Drug - Drug interactions:

Before giving SIGNOCOLD AF SYRUP to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines: 

  • medicines used to treat depression (Ex. selegiline, phenelzine, amitriptyline)
  • ephedrine (used to treat low blood pressure)
  • phenytoin (used to treat epilepsy)
  • digoxin (used to treat irregular heartbeat)
  • medicines used to treat anxiety and induce sleep (Ex. alprazolam, chlordiazepoxide, clonazepam)

Overdosage:

If you or anyone else accidentally take too much of SIGNOCOLD AF SYRUP, contact your doctor immediately or visit a nearby hospital. Overdosage symptoms of SIGNOCOLD AF SYRUP includes extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations and possibly seizures.

SYNOPSIS

Drug :   Phenylephrine, Chlorpheniramine
Pharmacological Category :   Nasal decongestant, Antihistamine
Therapeutic Indication :   Relieves nasal and sinus congestion, allergic symptoms, sinus pain, sinusitis, tonsillitis and otitis media (in addition with antibiotics)
Dosage Forms :   Capsule, Tablet, Syrup, Oral drops

MORE INFORMATION

  • Keep SIGNOCOLD AF SYRUP out of reach of children
  • Store at room temperature

FAQs ABOUT SIGNOCOLD AF SYRUP

What if I forget to give a dose of SIGNOCOLD AF SYRUP to my child?

If you forget to give a dose of SIGNOCOLD AF SYRUP to your child, give it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not give the medicine two times to make up for the forgotten dose.

Can I stop giving SIGNOCOLD AF SYRUP to my child if the symptoms subside?

Continue giving SIGNOCOLD AF SYRUP to your child until your child’s doctor tells you to stop, unless your experience child’s any unwanted effects, worsening of the condition or any new symptoms. In such cases, contact your child’s doctor right away.

What precautions do I need to follow while giving SIGNOCOLD AF SYRUP to my child?

Before giving SIGNOCOLD AF SYRUP to your child, you must inform child’s doctor about their pre-existing conditions like any kidney, liver, heart or thyroid problems, diabetes, fits or severely raised blood pressure and any other allergies. Consult your child’s doctor if your child experiences anything different.

Can I give other medicines to my child along with SIGNOCOLD AF SYRUP?

Before giving SIGNOCOLD AF SYRUP to your child, inform your child’s doctor if your child is taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicines, as these might interact with each other and cause serious side effects.

Can SIGNOCOLD AF SYRUP be used in children with liver problems?

SIGNOCOLD AF SYRUP should be used with caution in children with liver impairment. Child’s doctor may monitor your child’s liver function before and during treatment with this medicine to prevent the risk of any unusual effects. Consult your child’s doctor for advice before administration of SIGNOCOLD AF SYRUP to your child.

REFERENCES

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page- 813.

2. KD. Tripathi. Adrenergic System and Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 135.

3. Mayuresh Kiran and Lalit Pawaskar. Study of Safety and Efficacy for the Combination of Chlorpheniramine maleate and Phenylephrine in Infants suffering from Allergic Rhinitis and Associated Symptoms. International Research of Contemporary Medical Research. March 2019. [Accessed on 20th July 2022] https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_2406_v1.pdf

4. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 20th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action

5. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops (Phenylephrine + Chlorpheniramine). [Revised in January 2022] [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/2022/pediatrics/cold/Sinarest%20AF%20oral%20drops.pdf

6. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops/Syrups [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/Sinarest-AF-Syr-Drops2018.pdf

7. Zuventus Healthcare Limited. Maxtra Syrup (Phenylephrine + Chlorpheniramine maleate). [Accessed on 20th July 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=149

8. GlaxoSmithKline Consumer Healthcare. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 20th July 2022] https://www.medicines.org.uk/emc/files/pil.3928.pdf

USEFUL DIAGNOSTIC TESTS

  • Nasal cytology

PRODUCT DETAILS

    Country Of Origin
    India
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

SIGNOCOLD AF Syrup 60ml

SIGNOCOLD AF Syrup 60ml Mkt: Care On Pharmaceuticals

M.R.P.: Rs.58.00
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