SETRONEM 2MG contains Ondansetron which belongs to a group of medicines called anti-emetics, which help to stop feeling or being sick. It is indicated to prevent and treat nausea and vomiting induced by cytotoxic therapy and radiotherapy and post-operative nausea and vomiting. This medicine works by blocking the action of serotonin levels in the brain which causes nausea and vomiting during chemotherapy or any other surgery.
Cytotoxic chemotherapy triggers the release of serotonin from the enterochromaffin cells of the small intestine. The released serotonins stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Ondansetron is a selective 5-HT3 receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
Before receiving SETRONEM 2MG, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your doctor will administer the right dose depends on your child’s age and body weight. The common side effects are headache, constipation and dizziness.
SETRONEM 2MG is a selective 5-HT3-receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
SETRONEM 2MG should be only given by a doctor or nurse. Your healthcare provider will administer as intravenous injection (into a vein) or, after dilution, as intravenous infusion.
Headache:
Rest and drink plenty of fluids.
Constipation:
Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
SETRONEM 2MG is not recommended in the first trimester of pregnancy unless necessary. Consult your doctor for advice.
SETRONEM 2MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
This medicine has no or negligible effect on the ability to drive or use machines.
SETRONEM 2MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
Tell if you are allergic (hypersensitive) to Ondansetron.
SETRONEM 2MG should be used with caution in patients suffering from uneven heartbeat or any other active heart diseases. Consult your doctor for advice.
Inform your doctor if you have or had,
Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
Drug | : | Ondansetron |
Pharmacological Category | : | Selective 5-HT3 Receptor Antagonist |
Therapeutic Indication | : | Cancer chemotherapy-induced nausea and vomiting, Postoperative nausea and/or vomiting |
Dosage Forms | : | Tablet, Injection, Syrup |
Store below 20-25°C and keep out of reach of children.
Can SETRONEM 2MG be given in children?
Your doctor will administer the right dose depends on your child’s age and body weight.
Can use SETRONEM 2MG during pregnancy?
It is not recommended in the first trimester of pregnancy unless necessary. Consult your doctor for advice.
1. KD Tripathi MD. 5-HT, its antagonists and drug therapy of migraine. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 171.
2. Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1341-1342.
3. Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page – 285.
4. Parker, Samantha E. Van Bennekom, Carla, Anderka, Marlene, Mitchell, Allen A. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Aug 2018, vol-132; [Accessed Jan 5, 2021] https://journals.lww.com/greenjournal/Fulltext/2018/08000/Ondansetron_for_Treatment_of_Nausea_and_Vomiting.16.aspx
6. Siegfried Hameln GmbH (Germany); [Revised Sep, 2019] [Accessed Jan 6, 2021] https://mri.cts-mrp.eu/human/downloads/DE_H_0806_001_FinalPI_2of2.pdf
7. Mylan Pharmaceuticals ULC; [Revised March 19, 2015] [Accessed Jan 6, 2021] https://pdf.hres.ca/dpd_pm/00029957.PDF
8. GlaxoSmithKline. May, 2010. U.S. Food & Drug Administration [Accessed Jan 6, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020007s040,020403s018lbl.pdf
9. Fresenius Kabi Australia Pty Limited. Nov 28, 2012; [Revised May 28, 2010] [Accessed Jan 6, 2021] https://www.fresenius-kabi.com/au/documents/Ondansetron__PI.pdf
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