INTRODUCTION

SEBUMCLEAR SOLUTION contains Clindamycin, which belongs to the group of medicines called Antibiotics. It is used in the treatment of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.

Before applying SEBUMCLEAR SOLUTION, inform your doctor if you have or ever had diarrhea, bloody diarrhea and pseudomembranous colitis. SEBUMCLEAR SOLUTION is not recommended for use if you have a history of regional enteritis (inflammation of the small intestine), ulcerative colitis (inflammation of the large intestine) or antibiotic-associated colitis.

SEBUMCLEAR SOLUTION should be used with caution during pregnancy or by breastfeeding women only if clearly needed. The safety and effectiveness of SEBUMCLEAR SOLUTION in children under the age of 12 has not been established. The most common side effects of applying SEBUMCLEAR SOLUTION are burning, itching, and redness of the skin. Consult your doctor if symptoms worsen.

USES OF SEBUMCLEAR SOLUTION

• Treats acne vulgaris

HOW SEBUMCLEAR SOLUTION WORKS

SEBUMCLEAR SOLUTION acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn prevents protein synthesis and kills the infection-causing bacteria.

DIRECTIONS FOR USE

Apply SEBUMCLEAR SOLUTION as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately and thoroughly with water. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF SEBUMCLEAR SOLUTION

WARNING & PRECAUTIONS

PREGNANCY

The safety and effectiveness of SEBUMCLEAR SOLUTION in pregnant women or women planning to have a baby have not been established yet. It will be given to you by the doctor only if clearly needed. Consult your doctor before applying SEBUMCLEAR SOLUTION.

BREASTFEEDING

SEBUMCLEAR SOLUTION should be used with caution in breastfeeding women as it is not known if the medicine is excreted in human milk. Your doctor will decide whether to discontinue nursing or the medicine, considering the benefits to the mother and baby. If it is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Consult your doctor before applying SEBUMCLEAR SOLUTION.

ALLERGY

Do not apply SEBUMCLEAR SOLUTION if you are allergic to Clindamycin or any other ingredients of this medicine.

INTERACTIONS

A. Drug-Drug interactions:

Before applying SEBUMCLEAR SOLUTION, inform your doctor if you are taking any of the following medicine:

• neuromuscular blocking agents (Ex. rocuronium, vecuronium)
• other anti-acne, topical agents

Overdosage:

If you or anyone else accidentally applied too much of SEBUMCLEAR SOLUTION, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep SEBUMCLEAR SOLUTION out of reach from children
• Store at room temperature

FAQs ABOUT SEBUMCLEAR SOLUTION

What is SEBUMCLEAR SOLUTION used for?

SEBUMCLEAR SOLUTION is used in the treatment of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.

How to use SEBUMCLEAR SOLUTION?

Apply SEBUMCLEAR SOLUTION as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately with plenty of water.

How does SEBUMCLEAR SOLUTION work?

SEBUMCLEAR SOLUTION acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn prevents protein synthesis and kills the infection-causing bacteria.

Can SEBUMCLEAR SOLUTION be used in pregnancy?

The safety and effectiveness of SEBUMCLEAR SOLUTION in pregnant women or women planning to have a baby have not been established yet. It will be given to you by the doctor only if clearly needed. Consult your doctor before applying SEBUMCLEAR SOLUTION.

Can SEBUMCLEAR SOLUTION be used in breastfeeding women?

SEBUMCLEAR SOLUTION should be used with caution in breastfeeding women as it is not known if the medicine is excreted in human milk. Your doctor will decide whether to discontinue nursing or the medicine, considering the benefits to the mother and baby. If it is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Consult your doctor before applying SEBUMCLEAR SOLUTION.

REFERENCES

1. KD Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Anti bacteria IN Antibiotics. Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –805-806.

2. Patrick B, Murphy, Karlyle G. Bistas, Jacqueline K.Le. Clindamycin. National Library of medicine, National center for biotechnology information. [Revised in July 2021] [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK519574/

3. Manuel Polanco Morales, Anna Paola Thome Carvallo, Karla Adriana Bautista Espinosa,and Edgar Enrique Meza Murillo. A young man with myelosuppression caused by clindamycin: a case report. National Library of medicine, National center for biotechnology information. Pubmed Central 2014. [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917410/

4. DPT Laboratories, Ltd.U.S. Food & Drug Administration. (Clindamycin topical gel). [Revised in November 2000] [Accessed on 11th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50782lbl.pdf

5. Perrigo Yeruham. Daily med. (Clindamycin phosphate lotion). [Revised in December 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a10dda0c-28fa-4678-8cea-a6ce2fce4b52

6. Pharmaceutical Society of Singapore. Clindamycin gel/solution/lotion 1%. [Revised in March 2016] [Accessed on 11th May 2022] https://www.pss.org.sg/sites/default/files/public-resource/clindamycin_pil_31-3-2016.pdf

7. Taro Pharmaceutical Industries Ltd. Dailymed. (Clindamycin topical solution). [Revised in April 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=5b8a6767-2d46-401c-9f85-d427dda9eff7

8. Torque Pharma. Ticin Gel. (Clindamycin gel 1%). [Accessed on 11th May 2022] https://www.torquepharma.com/ticin-gel/

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 26 Oct 2022 | 04:32 PM(IST)