INTRODUCTION

SCABEX LOTION contains Gamma benzene hexachloride which belongs to a group of medicines called Ectoparasiticides. SCABEX LOTION is used to treat scabies (itchy skin rash caused by burrowing mite) in patients who are intolerant/had a failed treatment with other approved therapies to treat the condition.

SCABEX LOTION is not recommended for use in patients allergic to Gamma benzene hexachloride. It is also not recommended for use in patient suffering from crusted scabies, second scabies attack, skin conditions (such as atopic dermatitis, psoriasis), and/or uncontrolled seizure disorders.

Before applying SCABEX LOTION, inform your doctor if you have/had head injury, brain/spinal cord tumour, HIV/AIDS, and/or liver problems (such as severe hepatic cirrhosis).

SCABEX LOTION should be used with caution in pregnant women only if it is clearly necessary. It is not recommended of use in breastfeeding women unless it is clearly necessary.

SCABEX LOTION is advised to be used with caution in children and adolescents (aged below 18 years) who weigh less than 50kgs (110 pounds) and is also advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.

The most common side effects of applying SCABEX LOTION are itching skin, burning skin, dry skin, and/or skin rash. Consult your doctor if any of these symptoms worsens.

USES OF SCABEX LOTION

• Treats scabies in patients who are intolerant/had a failed treatment with other approved therapies

HOW SCABEX LOTION WORKS

SCABEX LOTION works by blocking the action of GABA-gated chloride channel (neurotransmitter) in parasites which leads to low neuronal inhibition and paralysis in parasites thus resulting in its destruction and providing relief from skin disease caused by parasites (scabies) in affected individuals.

DIRECTIONS FOR USE

Always apply SCABEX LOTION as directed by your physician. It is for external use only. Shake well before use. Apply a thin layer of this medicine on the affected area. Treated areas should not be covered with a plaster/ bandage. Following application, wash the applied area after 8 to 12 hours. The medicine should be washed off completely. Avoid using the medicine again after first application and throw away the bottle after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF SCABEX LOTION

HOW TO MANAGE SIDE EFFECTS

Dry Skin:

Try moisturizing your skin with an ointment, cream/lotion 2 or 3 times a day, or as often as needed.  Moisturizers help to keep the area moisture, so they work best on damp skin. After you bathe, pat your skin dry and apply your moisturizer. Try to avoid using skin care products and soaps that contain alcohol, fragrances, dyes, and/or other chemicals.

Itchy Skin:

Try to pat/tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes, or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before applying SCABEX LOTION, inform your doctor if you are taking any of the following medicines:

• sedatives (used to treat anxiety, tension, seizures, pain & sleep disorders) Ex. barbiturates, benzodiazepines.
• antipsychotics (used to treat psychosis) Ex. amisulpride, asenapine
• antidepressants (used to treat depression) Ex.  fluoxetine, paroxetine
• theophylline (used to treat asthma, bronchitis)
• cyclosporin, mycophenolate mofetil (used to prevent organ rejection after transplant)
• tacrolimus (used to treat moderate to severe atopic dermatitis)
• penicillin, imipenem, quinolone (used to treat bacterial infections)
• chloroquine sulfate (used to treat and prevent malaria)
• isoniazid (used to treat tuberculosis)
• meperidine (used to relieve pain)
• methocarbamol (used to treat acute musculo skeletal pain)

Overdosage:

If you or anyone else applies too much of SCABEX LOTION or accidentally swallows it, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS

MORE INFORMATION

• Keep SCABEX LOTION out of reach of children
• Store [GBNKEYWORD at room temperature

FAQs ABOUT SCABEX LOTION

What is SCABEX LOTION used for?

SCABEX LOTION is used to treat scabies (itchy skin rash caused by burrowing mite) in patients who are intolerant/had a failed treatment with other approved therapies to treat the condition.

What are the common side effects of SCABEX LOTION?

The most common side effects of applying SCABEX LOTION are itching skin, burning skin, dry skin, and/or skin rash. Consult your doctor if any of these symptoms worsens.

How SCABEX LOTION works?

SCABEX LOTION works by blocking the action of GABA-gated chloride channel (neurotransmitter) in parasites which leads to low neuronal inhibition and paralysis in parasites thus resulting in its destruction and providing relief from skin disease caused by parasites (scabies) in affected individuals.

How to use SCABEX LOTION?

Always apply SCABEX LOTION as directed by your physician. It is for external use only. Shake well before use. Apply a thin layer of this medicine on the affected area. Treated areas should not be covered with a plaster/ bandage. Following application, wash the applied area after 8 to 12 hours. The medicine should be washed off completely. Avoid using the medicine again after first application and throw away the bottle after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Does SCABEX LOTION cause itching?

Yes, SCABEX LOTION causes itchy skin as it is the most common side effect associated with the use of SCABEX LOTION. If such side effect experienced, then try to pat/tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes, or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly to reduce itchiness of skin.

REFERENCES

1. KD Tripathi. Antiseptics, Disinfectants and Ectoparasiticides. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 903.

2. Jodi Raffi, Raagini Suresh, Daniel C. Butler. Review of Scabies in the Elderly. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. September 2019.  [Accessed on 4th December 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828878/

3. Lindane Lotion USP 1%. Food and Drug Administration (FDA). [Accessed on 4th December 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf

USEFUL DIAGNOSTIC TESTS

• Burrow ink test