INTRODUCTION

RITZA contains Rizatriptan which belongs to the group of medicines called Selective serotonin 5-hydroxytryptamine receptor agonist. RITZA is used in adults to treat headache phase of migraine attack.  

RITZA is not recommended for use in patients allergic to Rizatriptan. It is also not recommended for use in patients suffering from moderate/mild/severe high blood pressure (which is not controlled by medication), stroke, peripheral vascular disease (condition marked by blockage of blood vessels), heart problems (such as heart attack, angina), and/or severe kidney/liver problems.

Before taking RITZA, inform your doctor if you have diabetes, family history of heart disease, headache (associated with dizziness, difficulty in walking, lack of coordination), short lived symptoms (such as chest pain, tightness), and/or mild to moderate kidney/liver problems.

RITZA should be used with caution during pregnancy and in women planning for pregnancy only if it is clearly necessary as it is not known whether the medicine can cause harm to the unborn baby. It is also used with caution in breastfeeding women only if it is clearly necessary. Breastfeeding mothers should avoid nursing the child for next 24 hours after taking the medicine since it may cause unwanted effects in the nursing child.

RITZA is not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor. 

The most common side effects of taking RITZA are tingling sensation of hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsens.

USES OF RITZA

• Treats headache experienced during migraine attack in adult patients

HOW RITZA WORKS

RITZA works by constricting the blood vessels that surround the brain which results in reduced swelling in the blood vessels thus providing relief from headache that occurs in migraine attack in affected individuals.

DIRECTIONS FOR USE

Tablet

Take RITZA as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Oral Disintegrating Tablet / Mouth Dissolving Tablet:

Take RITZA as advised by your physician. Place RITZA inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF RITZA

HOW TO MANAGE SIDE EFFECTS

Headache:

If RITZA causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking RITZA. If it lasts more than a week or severe, inform your doctor.

Dry mouth and thirst:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions

Before taking RITZA, inform your doctor if you are taking any of the following medicine:

• other triptans (medicines used to treat migraine) Ex. ergotamine, dihydro-ergotamine, sumatriptan, naratriptan or zolmitriptan
• medicines used to treat depression such as selective serotonin reuptake inhibitors (SSRIs) (Ex.sertraline, escitalopram oxalate, uoxetine),  serotonin noradrenaline reuptake inhibitors (SNRIs) (Ex. venlafaxine, and duloxetine), monoamine oxidase (MAO) inhibitors (Ex. moclobemide, phenelzine, tranylcypromine, pargyline)
• medicines used to treat bacterial infections (Ex. linezolid)
• propranolol (used to treat heart problems, anxiety)
• methysergide (used to treat migraine)

Overdosage:

If you or anyone else accidentally takes too much of RITZA, visit the nearby hospital or consult your doctor immediately. Symptoms of overdose are dizziness, drowsiness, vomiting, fainting, and/or slow heart rate.

SYNOPSIS

MORE INFORMATION

• Keep RITZA out of sight and reach of children
• Do not store RITZA above 30°C

FAQs ABOUT RITZA

What is RITZA and why it is used?

RITZA contains Rizatriptan which belongs to the group of medicines called Selective serotonin 5-hydroxytryptamine receptor agonist. It is generally used to treat headache phase of migraine attack in adult patients.

What are the common side effects of RITZA?

The most common side effects of taking RITZA are tingling sensation of hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsens.

Can RITZA be used in pregnant and breastfeeding women?

Yes, RITZA can be used but with caution in pregnant and breastfeeding women only if necessary since it is not known whether the medicine can cause harm to the unborn baby/nursing child. Consult your doctor before taking the medicine.

How RITZA works?

RITZA works by constricting the blood vessels that surround the brain which results in reduced swelling in the blood vessels thus providing relief from headache that occurs in migraine attack in affected individuals.

What happens if RITZA is taken more than its required dosage?

If you or anyone else accidentally takes too much of RITZA, visit the nearby hospital or consult your doctor immediately. Symptoms of overdose are dizziness, drowsiness, vomiting, fainting, and/or slow heart rate.

REFERENCES

1. KD. Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine. Essentials of medical pharmacology. Seventh edition. Page- 179.
2. Offie P. Soldin, Julia Dahlin, Daniel M. O’Mara. Triptans in Pregnancy. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2013. [Accessed on 2nd December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644550/

3. MERCK SHARP & DOHME B.V. Electronic Medicines Compendium (EMC) [Revised in April 2022] [Accessed on 2nd December 2022] https://www.medicines.org.uk/emc/files/pil.7797.pdf

4. Intas Pharmaceuticals Ltd. Rizora- 5 & Rizora-10. [Accessed on 2nd December 2022] https://www.intaspharma.com/products/