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RIFAFRND 550 Tablet 10's
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INTRODUCTION
RIFAFRND 550 TABLET contains Rifaximin which belongs to the group of medicines called Antibiotics. It is used in adults with liver diseases to reduce the recurrence of episodes of overt hepatic encephalopathy. Overt hepatic encephalopathy is a neurological disorder caused due to accumulation of toxins in the blood because of liver damage (such as liver cirrhosis). It is characterized by recurrent episodes of hepatic encephalopathy (such as confusion, muscle problems, shaking and difficulty in speech) within the last 6 months.
RIFAFRND 550 TABLET is also used in adults to treat irritable bowel syndrome with diarrhoea. Irritable bowel syndrome (IBS) is a common gastrointestinal disease that affects the large intestine. It is characterized by altered bowel habits with persistent stomach pain or discomfort, diarrhea and bloating.
Rifaximin is a broad-spectrum antibiotic used for gastrointestinal and liver diseases. It treats hepatic encephalopathy by preventing the growth of toxin-producing bacteria in the digestive tract. This reduces toxin accumulation in the blood and prevents the onset or recurrence of disorders caused due to toxin accumulation (such as hepatic encephalopathy). It also treats diarrhea associated with irritable bowel syndrome by killing the susceptible bacteria in the gut that causes infections.
Before taking RIFAFRND 550 TABLET inform your doctor if you have any liver problems. You must also inform your doctor if you are pregnant or breastfeeding before taking RIFAFRND 550 TABLET.
RIFAFRND 550 TABLET may cause pink or reddish discoloration of urine. This is usually harmless and disappears after discontinuation of the therapy. However, consult your doctor if it bothers you.
Other most common side effects of taking RIFAFRND 550 TABLET are dizziness, nausea, vomiting, headache, shortness of breath, stomach pain, accumulation of fluid in the abdominal cavity (ascites), diarrhoea, and depressed mood. Contact your doctor if any of these side effect worsens. Also inform your doctor if you experience severe diarrhea even after stopping treatment with RIFAFRND 550 TABLET before several months.
USES OF RIFAFRND 550 TABLET
It is used in adults to:
- Reduce the recurrence of overt hepatic encephalopathy episodes
- Treat irritable bowel syndrome with diarrhoea
HOW RIFAFRND 550 TABLET WORKS
RIFAFRND 550 TABLET is a broad-spectrum antibiotic used for gastrointestinal and liver diseases. It treats hepatic encephalopathy by preventing the growth of ammonia (toxin)-producing bacteria in the digestive tract. This reduces toxin accumulation in the blood and prevents the onset or recurrence of disorders caused due to toxin accumulation (such as hepatic encephalopathy). It also treats diarrhea associated with irritable bowel syndrome by killing the susceptible bacteria in the gut that causes infections.
DIRECTIONS FOR USE
Take RIFAFRND 550 TABLET as advised by your physician. Swallow RIFAFRND 550 TABLET with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose of RIFAFRND 550 TABLET and duration of therapy for you depending upon your age, body weight and severity of the infection. Do not stop taking RIFAFRND 550 TABLET without consulting your doctor even if you feel better during the midway of the therapy.
SIDE EFFECTS OF RIFAFRND 550 TABLET
COMMON
- dizziness, headache
- shortness of breath
- nausea or vomiting
- stomach pain or bloating/swelling
- diarrhoea, constipation
- depressed mood
- skin rash or itching
- muscle cramps and joint pain
- swelling of ankles, feet, or fingers
UNCOMMON
- yeast infections (such as thrush)
- urinary infection (such as cystitis)
- anaemia
- loss of appetite
- hyperkalaemia (increased blood potassium levels)
- feeling confused or anxious
- feeling sleepy
- unsteady posture
- loss of memory and concentration
- reduced sense to touch
- convulsions
- hot flushes
- fluid around the lungs (pleural effusion)
- dry mouth
- needing to pass urine more often than usual
- difficulty or pain while passing urine
- fever
RARE
- chest infections including pneumonia
- cellulitis (inflammation of tissue under skin), bruising
- upper respiratory tract infections (nose, mouth, throat)
- dehydration (body water loss)
- changes in blood pressure
- constant breathing problems (such as chronic bronchitis)
- feeling weak
Stop taking RIFAFRND 550 TABLET and contact your doctor immediately if you experience any of the following side effects:
- oesophageal varices (bleeding from swollen blood vessels in your throat)
- severe diarrhoea
- severe allergic reaction (such as skin rash, itching, swelling of the face, tongue and throat, difficulty in breathing or swallowing)
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat more fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of water. Exercise more regularly. Consult your doctor if this side effect bothers you.
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable or if you see blood in your stools.
Nausea And Vomiting
Take RIFAFRND 550 TABLET along with, or just after meals. Avoid eating oil rich or spicy foods. Stick on to simple healthy foods. Consult your doctor if your nausea worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorIt is not known whether the use of RIFAFRND 550 TABLET can affect the growth of an unborn baby. Therefore, RIFAFRND 550 TABLET should not be used in pregnant women unless considered necessary by the physician.
BREASTFEEDING
Consult your doctorIt is not known whether RIFAFRND 550 TABLET can pass through breast milk or not. Therefore, RIFAFRND 550 TABLET should not be used in breastfeeding women unless considered necessary by the physician.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy after taking RIFAFRND 550 TABLET.
LIVER
Use with CautionRIFAFRND 550 TABLET should be used with caution in patients with severe liver problems. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take RIFAFRND 550 TABLET if you are allergic to rifaximin or to similar types of antibiotics (such as rifampicin or rifabutin).
USE IN PEDIATRICS
ContraindicatedRIFAFRND 550 TABLET is generally not recommended for use in children and adolescents (under 18 years of age) due to lack of safety data. However, consult your doctor before taking it.
USE IN GERIATRICS
Use with CautionRIFAFRND 550 TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
OTHERS
RIFAFRND 550 TABLET is not recommended for use if you:
- have blockage in the intestines
INTERACTIONS
A. Drug-Drug interactions:
Before taking RIFAFRND 550 TABLET, inform your doctor if you are taking any of the following medicines such as:
- antibiotics (used to treat infections)
- cyclosporin (a medicine to suppress the body’s immune system)
- warfarin (a medicine used to prevent blood clotting)
- oral contraceptives (used to prevent pregnancy) Ex. drospirenone, ethinyl Estradiol
- midazolam (a medicine used to reduce anxiety and to induce sleep)
- antiepileptics (used to treat epilepsy) Ex. carbamazepine, phenytoin
- antiarrhythmics (used to treat abnormal heartbeat) Ex. digitalis, amiodarone, flecainide
Overdosage:
If you or anyone else accidentally took more RIFAFRND 550 TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Rifaximin |
| Pharmacological Category | : | Rifamycin Antibiotics |
| Therapeutic Indication | : | Hepatic encephalopathy, Irritable Bowel Syndrome |
| Dosage Forms | : | Tablet, Syrup, Suspension |
MORE INFORMATION
- Keep RIFAFRND 550 TABLET out of reach of children
- Store RIFAFRND 550 TABLET at room temperature
FAQs ABOUT RIFAFRND 550 TABLET
Q: Can RIFAFRND 550 TABLET be used in children?
A: RIFAFRND 550 TABLET is generally not recommended for use in children and in adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Q: Can I stop taking RIFAFRND 550 TABLET suddenly?
A: No. Do not stop taking RIFAFRND 550 TABLET even if you feel better during the midway of the therapy. Take RIFAFRND 550 TABLET for the stipulated duration instructed by your doctor. Also, inform your doctor if you cannot see any improvement in your condition even after using RIFAFRND 550 TABLET for the stipulated duration. If you have any further questions regarding the use of RIFAFRND 550 TABLET, consult your doctor.
Q: Can RIFAFRND 550 TABLET cause weight gain?
A: RIFAFRND 550 TABLET does not cause weight gain. In case you feel there is an increase in weight, consult your doctor for advice.
Q: Can RIFAFRND 550 TABLET cause constipation?
A: Yes. RIFAFRND 550 TABLET may cause constipation in some individuals. If you feel constipated, eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of water. Exercise more regularly. Consult your doctor if this side effect troubles you.
Q: Can I take RIFAFRND 550 TABLET during pregnancy?
A: It is not known whether the use of RIFAFRND 550 TABLET can affect the growth of an unborn baby. Therefore, RIFAFRND 550 TABLET should not be used in pregnant women unless considered necessary by the physician.
Q: Is RIFAFRND 550 TABLET a strong antibiotic?
A: Yes. RIFAFRND 550 TABLET is a potent antibiotic with bactericidal and bacteriostatic effects. It can effectively kill the bacteria and prevents its multiplication within our body.
Q: What is RIFAFRND 550 TABLET used for?
A: RIFAFRND 550 TABLET is a broad-spectrum antibiotic used to reduce the recurrence of overt hepatic encephalopathy. It can also be used to treat diarrhea associated with irritable bowel syndrome.
Q: Can the use of RIFAFRND 550 TABLET cause red urine?
A: Yes. RIFAFRND 550 TABLET may cause pink or reddish discoloration of urine. This is usually harmless and disappears after stopping the therapy. However, consult your doctor if it bothers you.
Q: How to take RIFAFRND 550 TABLET?
A: Take RIFAFRND 550 TABLET as advised by your physician. Swallow RIFAFRND 550 TABLET with a glass of water. Do not crush or chew the medicine. RIFAFRND 550 TABLET can be taken with or without food. Continue to take RIFAFRND 550 TABLET for the stipulated duration instructed by your doctor even if you feel better during the midway of the therapy.
Q: What RIFAFRND 550 TABLET does to my body?
A: RIFAFRND 550 TABLET is a broad-spectrum antibiotic used for gastrointestinal and liver diseases. It treats hepatic encephalopathy by preventing the growth of ammonia (toxin)-producing bacteria in the digestive tract. This reduces toxin accumulation in the blood and prevents the onset or recurrence of disorders caused due to toxin accumulation (such as hepatic encephalopathy). It also treats diarrhea associated with irritable.
REFERENCES
1. KD. Tripathi. Drugs for constipation and diarrhoea. Essentials of Pharmacology. Seventh edition. 2013. Page – 681.
2. Steven L. Flamm. Rifaximin treatment for reduction of risk of overt hepatic encephalopathy recurrence. NIH. National Library of Medicine, National Center for Biotechnology Information. PMC, PubMed central, May 2011 [Accessed on 2nd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105611/
3. Kamesh Gupta, Harparam Singh Ghuman and Shivani Vijay Handa. Review of Rifaximin: Latest Treatment Frontier for Irritable Bowel Syndrome Mechanism of Action and Clinical Profile. NIH. National Library of Medicine, National Center for Biotechnology Information. PMC, PubMed central. August 2017 [Accessed on 2nd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582649/
4. Alfasigma S.p.A. Electronic Medicines Compendium (EMC). [Revised on March 2021] [Accessed on 2nd June 2022] https://www.medicines.org.uk/emc/files/pil.2976.pdf
5. Valeant Pharmaceuticals North America LLC. U.S. Food & Drug Administration; [Revised in December 2017] [Accessed on 2nd June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021361s023lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Ammonia
- Liver Function Test
- Potassium
- Sodium
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