REVOLADE 50MG TABLET contains Eltrombopag which belongs to the group of medicines called Thrombopoietin-receptor agonist. REVOLADE 50MG TABLET is used to treat immune thrombocytopenia (platelet disorder) in patients aged 1-year/above when other medicines (such as corticosteroids/immunoglobulins) become ineffective to treat the disease.
REVOLADE 50MG TABLET is also used to treat thrombocytopenia (low platelet count) in adults suffering from hepatitis C (viral) infection. The medicine is also indicated for use to treat low blood counts in adults suffering from severe aplastic anemia (rare blood disorder that occurs due to failure of bone marrow to produce new blood cells).
REVOLADE 50MG TABLET is not recommended for use in patients allergic to Eltrombopag.
Before taking REVOLADE 50MG TABLET, inform your doctor if you are at a risk of developing blood clot in veins/arteries, and/or have cancer, obesity, advanced chronic liver disease, and/or kidney problems (such as renal impairment).
REVOLADE 50MG TABLET is generally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with REVOLADE 50MG TABLET. It is also not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk.
REVOLADE 50MG TABLET is not recommended for use in children (aged below 1-year) suffering from immune thrombocytopenia. It is also not recommended for use in children (aged below 18 years) suffering from low platelet counts due to hepatitis C/severe aplastic anemia. The medicine is advised to be used with caution in elderly patients (aged 65 years/above) after taking the medicine.
The most common side effects of taking REVOLADE 50MG TABLET are common cold, cough, nausea, vomiting, diarrhea, constipation, and/or hair loss. Consult your doctor if any of these symptoms worsens.
REVOLADE 50MG TABLET works by binding and activating thrombopoietin receptor protein (molecules responsible for regulating platelet production) which helps in activating the pathways within the cells to increase production and development of bone marrow progenitor cells (membrane bound units responsible for producing all types of cell in bone marrow) which results in increased production of platelet cells in patients affected with immune thrombocytopenia bleeding disorder associated with/without hepatitis C or severe aplastic anemia.
Take REVOLADE 50MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Stop taking REVOLADE 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea and vomiting:
Take REVOLADE 50MG TABLET with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.
Diarrhoea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (such as going for a daily walk/ running) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Headache:
If REVOLADE 50MG TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking REVOLADE 50MG TABLET. If it lasts more than a week or becomes severe, then consult and inform your doctor.
Tiredness:
Make sure you take rest and drink plenty of fluids. Avoid/limit the consumption of alcohol. Try to take REVOLADE 50MG TABLET at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.
REVOLADE 50MG TABLET is generally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with REVOLADE 50MG TABLET. Consult your doctor before taking the medicine.
REVOLADE 50MG TABLET is not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk. Consult your doctor before taking the medicine.
Do not drive or operate any machines if you feel dizzy or less alert after taking REVOLADE 50MG TABLET.
REVOLADE 50MG TABLET should be taken with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking REVOLADE 50MG TABLET.
REVOLADE 50MG TABLET should be used with caution in patients suffering from advanced chronic liver disease only if necessary, since the medicine may increase the risk of occurrence of side effects/blood clot. Consult your doctor before taking REVOLADE 50MG TABLET.
Do not take REVOLADE 50MG TABLET if you are allergic to Eltrombopag, and/or any other ingredients of this medicine.
Before taking REVOLADE 50MG TABLET, inform your doctor if you:
Use in Pediatrics:
REVOLADE 50MG TABLET is not recommended for use in children (aged below 1-year) suffering from immune thrombocytopenia (platelet disorder). It is also not recommended for use in children (aged below 18 years) suffering from low platelet counts due to hepatitis C/severe aplastic anemia. Consult your doctor before taking REVOLADE 50MG TABLET.
Use in Geriatrics:
REVOLADE 50MG TABLET should be used with caution in elderly patients (aged 65-years/above). Consult your doctor before taking REVOLADE 50MG TABLET.
A. Drug-Drug interactions:
Before taking REVOLADE 50MG TABLET inform your doctor if you are taking any of the following medicine:
B. Drug-food interaction:
Avoid taking REVOLADE 50MG TABLET with dairy foods/drinks since calcium in dairy products may affect the absorption of the medicine and alter its effect.
Overdosage:
If you or anyone else accidentally take too much of REVOLADE 50MG TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Drug | : | Eltrombopag |
Pharmacological Category | : | Thrombopoietin-receptor agonist |
Therapeutic Indication | : | Immune thrombocytopenia, thrombocytopenia with hepatitis C virus infection/aplastic anemia |
Dosage Forms | : | Tablet |
What is REVOLADE 50MG TABLET used for?
REVOLADE 50MG TABLET is used to treat immune thrombocytopenia (platelet disorder) in patients aged 1-year/above when other medicines (such as corticosteroids/immunoglobulins) become ineffective to treat the disease. It is also used to treat thrombocytopenia (low platelet count) in adults suffering from hepatitis C (viral) infection and/or severe aplastic anemia (rare blood disorder) in affected individuals.
What are the common side effects of taking REVOLADE 50MG TABLET?
The most common side effects of taking REVOLADE 50MG TABLET are common cold, cough, nausea, vomiting, diarrhea, constipation, and/or hair loss. Consult your doctor if any of these symptoms worsens.
How REVOLADE 50MG TABLET works?
REVOLADE 50MG TABLET works by binding and activating thrombopoietin receptor protein (molecules responsible for regulating platelet production) which helps in activating the pathways within the cells to increase production and development of bone marrow progenitor cells (membrane bound units responsible for producing all types of cell in bone marrow) which results in increased production of platelet cells in patients affected with immune thrombocytopenia bleeding disorder associated with/without hepatitis C or severe aplastic anemia.
How REVOLADE 50MG TABLET should be taken?
Take REVOLADE 50MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can REVOLADE 50MG TABLET be used in pregnant women?
REVOLADE 50MG TABLET is generally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with REVOLADE 50MG TABLET. Consult your doctor before taking the medicine.
1. Kenneth Kaushansky and Thomas J. Kipps. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 751-767.
2. Thomas Kühne, Paul Imbach. Eltrombopag: an update on the novel, non-peptide thrombopoietin receptor agonist for the treatment of immune thrombocytopenia. Annals of Hematology. Springer Link. April 2010. [Accessed on 11th May 2022] https://link.springer.com/article/10.1007/s00277-010-0953-x
3. John W Bauman, Carolyn T Vincent, Bin Peng, Mary B Wire, Daphne D Williams, Jung Wook Park. Effect of hepatic or renal impairment on eltrombopag pharmacokinetics. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. May 2011. [Accessed on 11th May 2022] https://pubmed.ncbi.nlm.nih.gov/20663991/
4. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 11th May 2022] https://www.medicines.org.uk/emc/files/pil.7819.pdf
Written By Dr. K .AZEEM HUSSAIN, B.D.S
Last updated on 19 Dec 2022 | 05:48 PM(IST)
Eltrombopag TABLET : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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