REVOLADE 50mg Tablet is used to treat low blood platelet counts in adults with chronic (long-term) idiopathic thrombocytopenic purpura (ITP), also called immune thrombocytopenic purpura. ITP is a blood disorder that may cause bleeding due to an abnormally low number of platelets in the blood.

REVOLADE 50mg Tablet is prescribed in ITP patients only when other treatments, including medications or surgery to remove the spleen, have not been successful enough in increasing the platelet levels. REVOLADE 50mg Tablet is used to increase the platelet levels enough to decrease the risk of bleeding, but it is not used to normalize platelet counts. REVOLADE 50mg Tablet belongs to a group of medications called thrombopoietin receptor agonists.

ITP, idiopathic (of unknown cause) thrombocytopenic purpura, is caused when the immune system attacks and destroys platelets in the blood. Platelets are blood cells that are necessary for normal blood clotting, which helps the body to form blood clots during injury. REVOLADE 50mg Tablet works by increasing the number of platelets, thus lowering the risk of bleeding in people with ITP.

REVOLADE 50mg Tablet may also be used to treat low blood platelet counts in adults with chronic hepatitis C virus (HCV) infection to allow the initiation and maintenance of interferon-based therapy. This medicine may also be used to treat other conditions as determined by your doctor.

The dosage of REVOLADE 50mg Tablet prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Take REVOLADE 50mg Tablet on an empty stomach, at least 1 hour before a meal or 2 hours after a meal. Also, take REVOLADE 50mg Tablet at least 4 hours before or 4 hours after taking certain products such as dairy products (calcium-rich foods), antacids and mineral supplements containing calcium, iron, zinc, selenium, aluminum and magnesium.

If your physician has instructed or directed you to take REVOLADE 50mg Tablet medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose. Do not take more than 1 dose of REVOLADE 50mg Tablet in 24 hours.

Any medication taken in excess can have serious consequences. If you suspect an overdose of REVOLADE 50mg Tablet, seek medical attention immediately.

Overdose symptoms of REVOLADE 50mg Tablet may include skin rash, slow heart rate, sudden cough, loss of balance or sudden headache.

• Acetaminophen
• Acyclovir
• Atazanavir
• Atorvastatin
• Ciprofloxacin
• Diclofenac
• Fentanyl
• Fluvastatin
• Fluvoxamine
• Gemfibrozil
• Ibuprofen
• Levofloxacin
• Methotrexate
• Naproxen
• Nateglinide
• Penicillin G
• Pioglitazone
• Pravastatin
• Repaglinide
• Rifampin
• Rosuvastatin
• Ticlopidine
• Trimethoprim
• Verapamil

It may be noted that drugs other than those listed above may also interact with REVOLADE 50mg Tablet.

REVOLADE 50mg Tablet can interact with the following types of medicines: calcium supplements, anticoagulants, nonsteroidal anti-inflammatory medications, antibiotics, diabetes medications, heart rhythm medications, birth control pills, stomach acid reducers, cholesterol-lowering medicines, antacids containing magnesium, calcium or aluminum, and vitamin/mineral supplements containing iron, magnesium, selenium or zinc.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of REVOLADE 50mg Tablet, so that the doctor can warn you of any possible drug interactions.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

Like other medicines, REVOLADE 50mg Tablet can cause some side effects. If they do occur, the side effects of REVOLADE 50mg Tablet are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of REVOLADE 50mg Tablet cannot be anticipated. If any side effects of REVOLADE 50mg Tablet develop or change in intensity, the doctor should be informed as soon as possible.

REVOLADE 50mg Tablet can cause side effects such as:

• Nausea
• Vomiting
• Diarrhea
• Upper abdominal pain
• Back pain
• Muscle pain
• Common cold
• Tingling sensation in feet or hands
• Abnormal liver function tests
• Cataracts and rash

This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking REVOLADE 50mg Tablet.

Before you take REVOLADE 50mg Tablet, tell your doctor if you have had splenectomy (surgery to remove your spleen) and also if you have liver or kidney disease, blood clotting disorder, bone marrow disorder, blood cancer and cataract. Also tell your doctor if you are of East Asian descent. Tell your doctor if you are pregnant or plan to become pregnant, or are breast-feeding.

Store REVOLADE 50mg Tablet at room temperature away from heat and moisture.

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Before you take REVOLADE 50mg Tablet, tell your doctor if you have had splenectomy (surgery to remove your spleen) and also if you have liver or kidney disease, blood clotting disorder, bone marrow disorder, blood cancer and cataract. Also tell your doctor if you are of East Asian descent. Tell your doctor if you are pregnant or plan to become pregnant, or are breast-feeding.

Store REVOLADE 50mg Tablet at room temperature away from heat and moisture.