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INTRODUCTION
RAZO 20MG INJECTION contains Rabeprazole which belongs to the group of medicines called Proton pump inhibitors. It is used to treat Gastro-oesophageal Reflux Disease (GERD) and peptic ulcer. It is used as an alternative to oral therapy when patients are not able to swallow rabeprazole orally.
GERD is a chronic digestive disease in which the stomach acid frequently flows into the oesophagus leading to the irritation of lining of the food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
Peptic ulcers are painful sores that develop on the linings of the stomach, oesophagus and/or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.
RAZO 20MG INJECTION will be administered to you only by a doctor or a nurse into the vein. Before starting the treatment with RAZO 20MG INJECTION inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumours in your stomach.
Inform your doctor before receiving RAZO 20MG INJECTION if you are pregnant or breastfeeding. The most common side effects of receiving RAZO 20MG INJECTION are sore throat, cough, flu-like symptoms, constipation, indigestion, stomach pain, headache and dizziness. Consult your doctor if any of the side effect troubles you.
You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after receiving RAZO 20MG INJECTION.
USES OF RAZO 20MG INJECTION
- Treats Gastro-Oesophageal Reflux Disease
- Treats and Prevents Peptic ulcers
HOW RAZO 20MG INJECTION WORKS
RAZO 20MG INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
DIRECTIONS FOR USE
RAZO 20MG INJECTION will be administered to you only by a doctor or a nurse into the vein (as intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RAZO 20MG INJECTION
COMMON
- cough, sore throat, runny nose
- difficulty in sleeping
- weakness
- headache, dizziness
- stomach pain, diarrhoea, flatulence, nausea, vomiting or constipation
- aches or back pain
- polyps in the stomach
UNCOMMON
- painful and blocked sinuses
- dry mouth, indigestion
- skin rash or redness
- muscle, leg or joint pain
- fractures involving wrist, hip and spine
- urinary tract infection
- changes in liver function
RARE
Inform your doctor immediately if you experience any of the following side effects after receiving RAZO 20MG INJECTION:
- allergic reactions (such as skin rash, itching, swelling of your face, difficulty in breathing and low blood pressure)
- skin rashes on sun exposed areas
- signs of frequent infections (such as chills, sore throat and fever)
- painful ulcers in the mouth or throat
- bruising or bleeding easily
- severe watery or bloody diarrhoea with fever, stomach pain or tenderness
- signs of vitamin B12 deficiency (such as pale skin, oral sores, disturbed vision, irritability, depression)
- signs of low magnesium levels (such as fits, tremor, muscle spasms, abnormal eye movements)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Diarrhea:
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
WARNING & PRECAUTIONS
PREGNANCY
RAZO 20MG INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
BREASTFEEDING
RAZO 20MG INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel sleepy after receiving RAZO 20MG INJECTION.
ALCOHOL
Avoid consumption of alcohol before receiving RAZO 20MG INJECTION.
LIVER
RAZO 20MG INJECTION should be used with caution in patients with liver disease. Therefore, consult your doctor before receiving it.
ALLERGY
Talk to your doctor before receiving RAZO 20MG INJECTION if you are allergic to Rabeprazole.
OTHERS
Before receiving RAZO 20MG INJECTION, inform your doctor if you:
- have a tumor in the stomach
- have risk factors for vitamin B12 deficiency
- had a skin reaction after treatment with a medicine similar to RAZO 20MG INJECTION
- have osteoporosis
- are going to have a specific blood test (Chromogranin A)
Use in pediatrics:
RAZO 20MG INJECTION is not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor for advice before receiving it.
Use in geriatrics:
RAZO 20MG INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
INTERACTIONS
A. Drug – Drug Interactions:
Before receiving RAZO 20MG INJECTION, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat fungal infections (Ex. ketoconazole or itraconazole)
- medicines used to treat HIV-infection (Ex. atazanavir)
- chemotherapy medicine used in high doses to treat cancer (Ex. methotrexate)
- corticosteroids (used to treat pain and inflammation) such as prednisolone
Overdosage:
RAZO 20MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Rabeprazole |
| Pharmacological Category | : | Proton Pump Inhibitors |
| Therapeutic Indication | : | GERD, Peptic ulcer, Zollinger-Ellison Syndrome |
| Dosage Forms | : | Tablet, Capsule, Powder, Injection, Infusion |
MORE INFORMATION
- Keep RAZO 20MG INJECTION out of reach of children
- Store RAZO 20MG INJECTION at room temperature
FAQs ABOUT RAZO 20MG INJECTION
What are the uses of RAZO 20MG INJECTION?
RAZO 20MG INJECTION is used to treat Gastro-esophageal Reflux Disease (GERD) and peptic ulcer in patients who are not able to swallow rabeprazole orally.
How RAZO 20MG INJECTION works?
RAZO 20MG INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
How long will it take for RAZO 20MG INJECTION to cure my disease?
The time taken for healing depends on the severity of the disease. You may notice improvement in your condition within 1-2 days of therapy with RAZO 20MG INJECTION. However, it may take several weeks for RAZO 20MG INJECTION to completely heal the ulcers.
When should I take RAZO 20MG INJECTION?
RAZO 20MG INJECTION is not meant for self-administration. It will be administered to you only by a doctor or a nurse into the vein (as intravenously).
What are the long-term side effects of RAZO 20MG INJECTION?
Taking RAZO 20MG INJECTION especially over the time of a year can slightly increase the risk of hip, wrist, or spine fracture. Inform your doctor if you suffer from osteoporosis or if you are taking corticosteroids which can increase the risk of osteoporosis. It may also cause vitamin B12 deficiency and low magnesium levels in the blood.
Can I stop therapy with RAZO 20MG INJECTION once my symptoms subside?
Do not stop therapy with RAZO 20MG INJECTION without consulting your doctor even if you feel better during the midway of the therapy. Make sure to receive all the doses of RAZO 20MG INJECTION for the stipulated duration recommended by your doctor to achieve complete healing of ulcers.
What precautions should be followed while taking RAZO 20MG INJECTION?
Before receiving RAZO 20MG INJECTION inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumors in your stomach. Inform your doctor before receiving RAZO 20MG INJECTION if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail. You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after receiving RAZO 20MG INJECTION.
Can I take RAZO 20MG INJECTION daily?
Your doctor will evaluate your health condition and suggest whether you need to take RAZO 20MG INJECTION every day or not.
Can the use of RAZO 20MG INJECTION affect the liver?
Yes. RAZO 20MG INJECTION may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before receiving it.
Can RAZO 20MG INJECTION be taken during pregnancy?
RAZO 20MG INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
How is RAZO 20MG INJECTION given?
RAZO 20MG INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Does RAZO 20MG INJECTION cause insomnia?
Yes, RAZO 20MG INJECTION may cause difficulty in falling asleep in some patients. If you are suffering from this, consult your doctor for advice. Do not take any medicine on your own without consulting your doctor.
Is RAZO 20MG INJECTION safe to use in children?
RAZO 20MG INJECTION is not recommended for use in children due to lack of data on safety and effectiveness. However, consult your doctor for advice.
REFERENCES
1. KD. Tripathi. Drugs for Peptic Ulcer and GERD. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653
2. Fabio Pace, Stefano Pallotta, Stefania Casalini, and Gabriele Bianchi Porro. A review of rabeprazole in the treatment of acid-related diseases. NIH National Library of Medicine, National Center for biotechnology information. June 2007. [Accessed on 3rd October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386363/
3. Seiichi Hayato, Setsuo Hasegawa, Seiichiro Hojo, Hiroki Okawa, Hiroaki Abe, Nobuyuki Sugisaki, Masahiro Munesue, Yukio Horai, Akihiro Ohnishi. Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes. NIH National Library of Medicine, National Center for biotechnology information. Pubmed.gov. May 2012. [Accessed on 3rd October 2022]. https://pubmed.ncbi.nlm.nih.gov/22108775/
4. Cipla Ltd. Ciplamed. [Revised in June 2020]. [Accessed on 3rd October 2022] https://www.ciplamed.com/content/rabicip-iv-injection
USEFUL DIAGNOSTIC TESTS
- Ultrasound
- Endoscopy
- Liver Function Test
- Complete Blood Count
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 03 Oct 2022 | 05:25 PM(IST)
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