INTRODUCTION

RAYMOXI contains Moxifloxacin which belongs to a group of antibiotics known as fluoroquinolones which works by killing bacteria that cause infections. It is indicated to treat bacterial conjunctivitis caused by susceptible microorganisms, corneal ulcers and blepharitis.

Moxifloxacin is a sterile ophthalmic, 8-methoxy fluoroquinolone anti-infective for topical ophthalmic use. The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. It provides prolonged contact with ocular surface that ensures longer duration of action.

Always use RAYMOXI exactly as directed by your doctor. Before using this medicine, inform your doctor if you have eye diseases or infection, are pregnant or breastfeeding. It is not recommended for use in infants below one year of age. The common side effects are eye pain or irritation and dry eyes. Do not wear contact lenses if you have signs and symptoms of bacterial conjunctivitis.

USES OF RAYMOXI

• Treats bacterial conjunctivitis caused by susceptible microorganisms, corneal ulcers and blepharitis

HOW RAYMOXI WORKS

RAYMOXI works by stopping the growth of bacteria. It binds and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, results in inhibition of DNA replication, repair and cell death.

DIRECTIONS FOR USE

Always use RAYMOXI exactly as your doctor has told you. It is for topical ophthalmic use only. Apply three times a day.

SIDE EFFECTS OF RAYMOXI

HOW TO MANAGE SIDE EFFECTS

Eye pain or irritation:

Place a cool compress over the eyes, by soaking clean cloth in warm or cold water and then squeezing it out.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• other quinolones medicines

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT RAYMOXI

Does RAYMOXI cause eye irritation?

Yes, it may cause slight eye irritations, if these reactions persist, consult your doctor for advice.

Can I stop using RAYMOXI when I feel better?

No, do not stop using without consulting your doctor even if you feel better. Your symptoms may improve before the infection is completely cured.

Can RAYMOXI be used during pregnant?

It is not recommended during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. Anti-microbial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 714.

2. William A. Petri Jr. Sulphonamides, Trimethoprim, Sulphamethaoxazole, Quinolones and Agents for urinary tract infections. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1470.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 940-941.

4. Darlene Miller. Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections. March, 2008; [Accessed on Jan 28, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698721/

5. Cipla Ltd.  Sep 19, 2014. [Revised on Oct, 2019] [Accessed Jan 28, 2021] https://www.ciplamed.com/printpdf/24090

6. Centaurpharma [Accessed Jan 28, 2021] https://www.centaurpharma.com/downloads/Centaflox%20eye%20ointment.pdf