INTRODUCTION
RABERA 20MG TABLET contains Rabeprazole which belongs to the group of medicines called Proton pump inhibitors. It is used to treat Gastro-esophageal Reflux Disease (GERD), peptic ulcer and Zollinger-Ellison syndrome (tumours in the pancreas causing the stomach to secrete more acid).
GERD is a chronic digestive disease in which the stomach acid frequently flows into the oesophagus leading to the irritation of lining of the food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
Peptic ulcers are painful sores that develop on the linings of the stomach, oesophagus and/or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.
Take RABERA 20MG TABLET preferably before meals or as directed by the physician. Before taking RABERA 20MG TABLET inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumors in your stomach.
Do not take RABERA 20MG TABLET if you are pregnant or breastfeeding without consulting your doctor. The most common side effects of taking RABERA 20MG TABLET are oral sores, constipation, indigestion, stomach pain, headache and dizziness. Consult your doctor if any of the side effect troubles you.
You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after taking RABERA 20MG TABLET.
USES OF RABERA 20MG TABLET
- Treats Gastro-Esophageal Reflux Disease
- Treats and Prevents Peptic ulcers
- Treats Zollinger-Ellison syndrome
HOW RABERA 20MG TABLET WORKS
RABERA 20MG TABLET is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
DIRECTIONS FOR USE
Take RABERA 20MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken in the mornings or at any time of the day before meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RABERA 20MG TABLET
COMMON
- mouth sores
- difficulty in sleeping
- headache, dizziness
- stomach pain, diarrhoea, flatulence, nausea, vomiting or constipation
- aches or back pain
- polyps in the stomach
UNCOMMON
- painful and blocked sinuses
- dry mouth, indigestion
- skin rash or redness
- muscle, leg or joint pain
- fractures involving wrist, hip and spine
- urinary tract infection
- changes in liver function
RARE
Stop taking RABERA 20MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (such as skin rash, itching, swelling of your face, difficulty in breathing and low blood pressure)
- skin rashes on sun exposed areas
- signs of frequent infections (such as chills, sore throat and fever)
- painful ulcers in the mouth or throat
- bruising or bleeding easily
- severe watery or bloody diarrhoea with fever, stomach pain or tenderness
- signs of vitamin B12 deficiency (such as pale skin, oral sores, disturbed vision, irritability, depression)
- signs of low magnesium levels (such as fits, tremor, muscle spasms, abnormal eye movements)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Take RABERA 20MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Diarrhea:
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
WARNING & PRECAUTIONS
PREGNANCY
RABERA 20MG TABLET is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
RABERA 20MG TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel sleepy after taking RABERA 20MG TABLET.
LIVER
RABERA 20MG TABLET should be used with caution in patients who have or ever had any liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take RABERA 20MG TABLET if you are allergic to Rabeprazole or to any other proton pump inhibitors (such as omeprazole, esomeprazole).
OTHERS
Before taking RABERA 20MG TABLET, inform your doctor if you:
- have a tumor in your stomach
- had a skin reaction after treatment with a medicine similar to RABERA 20MG TABLET
- have osteoporosis (weak bones)
- are going to have a specific blood test (Chromogranin A)
Use in pediatrics:
RABERA 20MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before administration.
Use in geriatrics:
RABERA 20MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug – Drug Interactions:
Before taking RABERA 20MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat fungal infections (Ex. ketoconazole or itraconazole)
- medicines used to treat HIV-infection (Ex. atazanavir)
- chemotherapy medicine used in high doses to treat cancer (Ex. methotrexate)
- corticosteroids (used to treat pain and inflammation) such as prednisolone
Overdosage:
If you or anyone else accidentally took more RABERA 20MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Rabeprazole |
| Pharmacological Category | : | Proton Pump Inhibitors |
| Therapeutic Indication | : | GERD, Peptic ulcer, Zollinger-Ellison Syndrome |
| Dosage Forms | : | Tablet, Capsule, Powder, Injection, Infusion |
MORE INFORMATION
- Keep RABERA 20MG TABLET out of reach of children
- Store RABERA 20MG TABLET at room temperature
FAQs ABOUT RABERA 20MG TABLET
What are the uses of RABERA 20MG TABLET?
RABERA 20MG TABLET is used to treat Gastro-esophageal Reflux Disease (GERD), peptic ulcer and Zollinger-Ellison syndrome (tumours in the pancreas causing the stomach to secrete more acid).
How RABERA 20MG TABLET works?
RABERA 20MG TABLET is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
How long will it take for RABERA 20MG TABLET to cure my disease?
The time taken for healing depends on the severity of the disease. You may notice improvement in your condition within 1-2 days of therapy with RABERA 20MG TABLET. However, it may take several weeks for RABERA 20MG TABLET to completely heal the ulcers.
When should I take RABERA 20MG TABLET?
RABERA 20MG TABLET should be taken on an empty stomach at mornings. It can also be taken before a meal. Swallow RABERA 20MG TABLET with a glass of water.
What are the long-term side effects of RABERA 20MG TABLET?
Taking RABERA 20MG TABLET especially over the time of a year can slightly increase the risk of hip, wrist, or spine fracture. Inform your doctor if you suffer from osteoporosis or if you are taking corticosteroids which can increase the risk of osteoporosis. It may also cause vitamin B12 deficiency and low magnesium levels in the blood.
Can I stop taking RABERA 20MG TABLET once my symptoms subside?
Do not stop taking RABERA 20MG TABLET without consulting your doctor even if you feel better during the midway of the therapy. Make sure to take RABERA 20MG TABLET for the stipulated duration recommended by your doctor to achieve complete healing of ulcers.
What is the best time to take RABERA 20MG TABLET?
RABERA 20MG TABLET should be taken while you are on empty stomach in the morning. It can also be taken before a meal.
What to do if I forgot to take a dose of RABERA 20MG TABLET?
If you have missed a dose of RABERA 20MG TABLET, take it as soon as you remember. However, if it is time for the next dose of RABERA 20MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of RABERA 20MG TABLET to compensate the missed ones.
What precautions should be followed while taking RABERA 20MG TABLET?
Before taking RABERA 20MG TABLET inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumors in your stomach. Do not take RABERA 20MG TABLET if you are pregnant or breastfeeding without consulting your doctor. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail. You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after taking RABERA 20MG TABLET.
Can I consume alcohol while taking RABERA 20MG TABLET?
Avoid consumption of alcohol while taking RABERA 20MG TABLET as it could aggravate your ulcers and delays the healing process.
Can I take RABERA 20MG TABLET daily?
Take RABERA 20MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggest whether can you take RABERA 20MG TABLET every day or not.
Can the use of RABERA 20MG TABLET affect the liver?
Yes. RABERA 20MG TABLET may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Can RABERA 20MG TABLET be taken during pregnancy?
RABERA 20MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
REFERENCES
1. KD. Tripathi. Drugs for Peptic Ulcer and GERD. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653
2. Seiichi Hayato, Setsuo Hasegawa, Seiichiro Hojo, Hiroki Okawa, Hiroaki Abe, Nobuyuki Sugisaki, Masahiro Munesue, Yukio Horai, Akihiro Ohnishi. Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes. NIH National Library of Medicine, National Center for biotechnology information. Pubmed.gov. May 2012. [Accessed on 1st October 2022]. https://pubmed.ncbi.nlm.nih.gov/22108775/
3. Eisai GmbH. Electronic Medicines Compendium (EMC). Revised in May2021. [Accessed on 10th May 2022]. https://www.medicines.org.uk/emc/files/pil.7867.pdf
4. Eisai R&D Management Co., Ltd. U.S. Food and Drug Administration. [Revised in December 2014]. [Accessed on 1st October 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020973s035204736s005lbl.pdf
5. Veloz 40. Rabeprazole Gastro-resistant Tablet. Torrent Pharmaceutical Ltd. [Revised in June 2022]. [Accessed on 1st October 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/3112.pdf
USEFUL DIAGNOSTIC TESTS
- Ultrasound
- Endoscopy
- Liver Function Test
- Complete Blood Count
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