Availability & Expiry
INTRODUCTION
QT 25 TABLET contains Quetiapine which belongs to the group of medicines called Antipsychotics. It is used to treat bipolar disorder, schizophrenia, and depression (major depressive disorder). Bipolar disorder (also known as manic depression) is a mental disorder characterized by alternative episodes of mania (sudden unusual extreme sense of happiness) and depression.
Schizophrenia is a mental disorder in which you hear or feel things that are not there, believe things that are not true or feel unusually suspicious, anxious, confused, guilty, tensed, or depressed. Major depressive disorder is a mental illness characterized by persistent sadness or depressed mood with a loss of interest in activities that can affect your daily life.
Quetiapine is an atypical antipsychotic. It acts by modulating the activities of certain brain chemicals (dopamine and serotonin) in the brain that causes mental disorders. As a result, it improves the positive and negative symptoms of schizophrenia and bipolar disorder.
Before taking QT 25 TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have diabetes, blood clots or a history of drug abuse in the past.
Avoid consumption of alcohol or grapefruit juice while undergoing treatment with QT 25 TABLET as it may increase the risk of side effects. Consult your doctor before taking QT 25 TABLET if you are pregnant or breastfeeding women. It should be used with caution in elderly patients with dementia.
QT 25 TABLET may increase your blood sugar or cholesterol levels. To avoid this, your doctor will regularly monitor your health condition through periodic blood tests.
Other common side effects of QT 25 TABLET are dry mouth, constipation, dizziness, sleepiness, headache, or weight gain. Contact your doctor if any of these side effects worsen. Also, inform your doctor immediately if your mood becomes excessively depressed along with thoughts of self-harming or killing after taking QT 25 TABLET.
USES OF QT 25 TABLET
It is used to treat:
- bipolar disorder
- schizophrenia
- depression (major depressive disorders)
HOW QT 25 TABLET WORKS
QT 25 TABLET effectively controls the symptoms of bipolar disorder and schizophrenia. It contains quetiapine which is an atypical antipsychotic. It acts by blocking certain receptors (dopamine (D2), serotonin 2A (5HT2A)) in the brain that causes abnormal mood changes and mental problems. As a result, it improves the positive and negative symptoms of schizophrenia and bipolar disorder.
DIRECTIONS FOR USE
Take QT 25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. QT 25 TABLET should be taken at least one hour before meals or prior to bedtime.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition. Do not stop taking QT 25 TABLET unless your doctor advises you to stop, as it may lead to certain withdrawal symptoms such as difficulty in sleeping, nausea, diarrhoea, vomiting, irritability, weight gain or increased hunger.
SIDE EFFECTS OF QT 25 TABLET
COMMON
- headache, dizziness, sleepiness
- dry mouth
- weight gain
- abnormal muscle movements (shaking, restlessness, muscle stiffness without pain)
- changes in blood fat levels
- constipation, stomach upset
- weakness
- swelling of arms or legs
- feeling dizzy or faint while standing up (orthostatic hypotension)
- increased blood sugar levels
- blurred vision
- unusual dreams or nightmares
- feeling irritated
- disturbance in speech and language
- raised levels of the hormone prolactin in the blood (signs include breast enlargement and milk production in both men and in women, irregular or lack of menstrual periods in women)
UNCOMMON
- allergic reactions (raised lumps, swelling of the skin and around the mouth)
- unpleasant sensations in the legs
- trouble swallowing
- sexual dysfunction
- slower than normal heart rate
- trouble passing urine
- stuffy nose
- changes in thyroid production
RARE
- jaundice (yellowish skin and eyes)
- walking, talking, eating or other activities in sleep
- low body temperature
- inflammation of the pancreas
- metabolic syndrome (an increase in fat around your abdomen, increased triglycerides levels, decreased good cholesterol in the blood, increased blood sugar and blood pressure)
Stop taking QT 25 TABLET and contact your doctor immediately if you experience any of the following side effects:
- blood clots in the veins especially in the legs (swelling, pain, and redness in the leg) which may travel through blood vessels to the lungs (causing chest pain and breathing problems)
- signs of a neuroleptic malignant syndrome (fever, sweating, stiff muscles, feeling very drowsy or faint)
- uncontrollable movements (especially face or tongue)
- dizziness or severe sleepiness
- priapism (long-lasting and painful erection)
- fast and irregular heartbeat, even when you are at rest, palpitations, or unexplained tiredness
- decreased WBC and platelet counts (signs include fever, flu-like symptoms, sore throat, or any other infection)
- bowel obstruction (signs include constipation, persistent abdominal pain)
- suicidal thoughts and worsening depression
- fits
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhoea becomes uncontrollable.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Nausea And Vomiting
Take QT 25 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorQT 25 TABLET is not recommended for use in pregnant women unless specifically directed by your doctor. If you are pregnant, think you may be pregnant or are planning to become pregnant, consult your doctor before taking it.
BREASTFEEDING
ContraindicatedQT 25 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy or sleepy after taking QT 25 TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking QT 25 TABLET as it might make you feel dizzy or sleepy.
KIDNEY
Consult your doctorQT 25 TABLET should be used with caution in patients having urinary retention (inability to completely empty your bladder). Therefore, consult your doctor before taking it.
LIVER
Use with CautionQT 25 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take QT 25 TABLET if you are allergic to Quetiapine.
HEART DISEASE
Consult your doctorQT 25 TABLET should be used with caution in patients with heart diseases (such as heart rhythm problems, weakening of the heart muscle, inflammation of the heart, or low blood pressure). Therefore, consult your doctor before taking it.
USE IN PEDIATRICS
ContraindicatedQT 25 TABLET is not recommended for use in children and adolescents (under 18 years of age). Therefore, consult your doctor before taking it.
USE IN GERIATRICS
Consult your doctorQT 25 TABLET should be used with caution in elderly patients who have stroke, dementia, or parkinsonism. Therefore, consult your doctor before taking it.
OTHERS
Before taking QT 25 TABLET, inform your doctor if you:
- had fits
- have sleep apnea (a condition where you stop breathing for short periods during sleep)
- have diabetes
- have a low number of white blood cells
- or any member of your family has a history of blood clots
- have an enlarged prostate (in men)
- have blockage in your intestine
- have increased pressure inside your eye
- have history of drug abuse
INTERACTIONS
A. Drug - Drug interactions:
Before taking QT 25 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat HIV infection (Ex. lopinavir, indinavir)
- medicines used to treat fungal infections (Ex. voriconazole, itraconazole)
- medicines used for bacterial infections (Ex. erythromycin or clarithromycin)
- nefazodone (a medicine used to treat depression)
- medicines used to treat fits (Ex. carbamazepine, phenytoin)
- medicines used to lower blood pressure (Ex. telmisartan, atenolol)
- medicines used to induce sleep (Ex. phenobarbital, pentobarbital)
- medicines used to treat edema (Ex. furosemide, chlorthalidone)
- medicines that cause constipation (Ex. ferrous sulphate, sertraline)
- medicines that affect heartbeat and muscle movements (Ex. atropine, dicyclomine)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking QT 25 TABLET as it may affect the way this medicine works.
Overdosage:
If you or anyone else accidentally took more QT 25 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are sleepiness, dizziness, and abnormal heartbeats.
SYNOPSIS
| Drug | : | Quetiapine |
| Pharmacological Category | : | Atypical antipsychotic |
| Therapeutic Indication | : | Bipolar disorder, Depression, Schizophrenia |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep QT 25 TABLET out of reach of children
- Store QT 25 TABLET at room temperature
FAQs ABOUT QT 25 TABLET
Q: Can QT 25 TABLET be taken by an elderly person with dementia?
A: QT 25 TABLET must be used with caution in elderly patients with dementia. Therefore, consult your doctor before taking it. Your doctor will access your health condition and would decide whether you should take QT 25 TABLET or not.
Q: What are the common side effects of QT 25 TABLET?
A: QT 25 TABLET may increase your blood sugar or cholesterol levels. It may also cause dry mouth, constipation, dizziness, sleepiness, headache, or weight gain. Contact your doctor if any of these side effects worsen. Also, inform your doctor immediately if your mood becomes excessively depressed along with thoughts of self-harming or killing after taking QT 25 TABLET.
Q: Can QT 25 TABLET cause weight gain?
A: Yes. You may gain weight after taking QT 25 TABLET. Please keep a check on it by monitoring your weight, having healthy balanced diet, and exercising regularly. Inform your doctor if you gain weight excessively after taking QT 25 TABLET.
Q: How to take QT 25 TABLET?
A: Take QT 25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. QT 25 TABLET should be taken at least one hour before meals or prior to bedtime.
Q: Is QT 25 TABLET safe to use in pregnancy?
A: QT 25 TABLET is generally not recommended for use in pregnant women. However, consult your doctor before taking. Studies have shown the onset of certain withdrawal symptoms (such as shaking, weakness, sleepiness, breathing problems and difficulty in feeding) in babies born to women taking QT 25 TABLET during their pregnancy.
Q: Can QT 25 TABLET be used in children?
A: No. QT 25 TABLET is not recommended for use in children and adolescents below 18 years of age due to increased side effects. Consult your doctor for advice before taking QT 25 TABLET.
Q: What should I do if I forget to take a dose of QT 25 TABLET?
A: If you forgot to take a dose of QT 25 TABLET, take it as soon as you remember. However, if it is time to take the next dose of QT 25 TABLET, skip the missed one and take the regular dose. Do not take a double dose of QT 25 TABLET to compensate the missed dose.
Q: Can I stop taking QT 25 TABLET on my own?
A: Do not alter or discontinue the daily dose of QT 25 TABLET after feeling better without consulting your doctor. Take QT 25 TABLET for the stipulated duration mentioned by your doctor. You may experience headache, diarrhoea, vomiting, dizziness, irritability, nauseous or may be unable to sleep on stopping QT 25 TABLET suddenly.
Q: Can I drive a car after using QT 25 TABLET?
A: Do not drive or travel after taking QT 25 TABLET as you may experience drowsiness or blurred vision after taking QT 25 TABLET which may hamper your responses and lead to accidents.
Q: Can I use QT 25 TABLET without consulting a doctor?
A: No. QT 25 TABLET should be used only under medical supervision and after a thorough mental assessment. Your doctor will decide the correct dose and duration of therapy with QT 25 TABLET for you depending upon your age, body condition and severity of the disease condition.
REFERENCES
1. KD. Tripathi. Antipsychotic and Antimanic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 442.
2. Muneer A. Pharmacotherapy of bipolar disorder with quetiapine: a recent literature review and an update. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. April 2015. [Accessed on 16th May 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423161/
3. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 16th May 2022] https://www.medicines.org.uk/emc/product/3079/pil
4. AstraZeneca UK Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 16th May 2022] https://www.medicines.org.uk/emc/product/6363/pil
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count (CBC)
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