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PRIXAIN D 75/20 Capsule 10's
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INTRODUCTION
PRIXAIN D 75/20 CAPSULE is a combination of Duloxetine and Pregabalin which belongs to the group of medicines called Antidepressants and Anticonvulsants respectively. It is used to treat severe nerve pain (such as diabetic neuropathy, postherpetic neuralgia) and fibromyalgia (severe muscle pain with tiredness, mood swings, sleepiness and memory loss).
Before taking this medicine inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have bleeding problems, mania, bipolar disorder, diabetes, glaucoma, constipation or a previous history of drug abuse as a precaution.
Avoid consuming alcohol while taking PRIXAIN D 75/20 CAPSULE as it may make you feel dizzier. Do not take PRIXAIN D 75/20 CAPSULE without consulting your doctor if you are pregnant or breastfeeding. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with PRIXAIN D 75/20 CAPSULE.
The most common side effects of taking PRIXAIN D 75/20 CAPSULE are sleepiness, dizziness, headache, mood changes, tremor, tingling or numbness, dry mouth, constipation, flatulence, feeling drunk, muscle cramps, sore throat, inability to reach orgasm, decreased sexual drive and weight loss. Consult your doctor if any of these side effect worsens.
You must also inform your doctor immediately if you experience worsening of depression along with suicidal thoughts or having severe muscle stiffness, shakiness, fever and/or chest pain as a precaution.
USES OF PRIXAIN D 75/20 CAPSULE
It is used to treat:
- nerve pain (such as diabetic neuropathy, postherpetic neuralgia)
- fibromyalgia (severe muscle pain with tiredness, mood swings, sleepiness and memory loss)
HOW PRIXAIN D 75/20 CAPSULE WORKS
PRIXAIN D 75/20 CAPSULE is a pain-relieving medication. It reduces pain sensation by altering the activity of certain brain chemicals (dopamine, serotonin and adrenaline) within the nervous system. As a result, it reduces the transmission of pain signals from the damaged nerves to the brain and vice versa.
DIRECTIONS FOR USE
Take PRIXAIN D 75/20 CAPSULE as advised by your physician. Swallow PRIXAIN D 75/20 CAPSULE with a glass of water. Do not crush or chew the medicine. PRIXAIN D 75/20 CAPSULE can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PRIXAIN D 75/20 CAPSULE without consulting your doctor.
SIDE EFFECTS OF PRIXAIN D 75/20 CAPSULE
COMMON
- dizziness, drowsiness, headache
- increased appetite
- increased mood, confusion, disorientation, irritability
- lack of attention, clumsiness, memory impairment
- tremor, difficulty in speaking
- tingling or numbness, sedation, lethargy
- difficulty in sleeping, tiredness
- blurred vision, double vision
- spinning sensation, problems with balance
- dry mouth, constipation, diarrhea, vomiting, flatulence, diarrhoea, nausea, swelling in abdomen
- swelling of the extremities (such as hands, legs, or fingers)
- feeling drunk, abnormal style of walking
- weight gain, increased sweating
- muscle cramps, joint or back pain, pain in limbs
- sore throat
- difficulties with erection, inability to reach orgasm, decreased sexual drive, delayed ejaculation
- flushing, fast heart rate, increased blood pressure
- painful urination, frequent urination
- weight loss (especially in children)
UNCOMMON
- high or low blood sugar
- hallucinations, mood changes
- dry eyes, eye pain, watery eyes, eye swelling
- heart rate disturbances, high or low blood pressure
- difficulty in breathing, dry nose, nasal congestion
- increased salivation, heartburn, numbness around mouth
- skin rash, chills, fever
- breast pain
- cold hands and feet
- teeth grinding
- muscle twitches
- changes in sense of taste
- ear pain
- liver problems
- bloody stools or vomits
- abnormal vaginal bleeding, heavy, painful menstrual periods
- increase in blood cholesterol levels
RARE
- abnormal sense of smell
- cold sweat, tightness of the throat, swelling of tongue
- inflammation of the pancreas
- difficulty in writing properly
- fluid in the lungs
- muscle damage
- discharge from breasts, abnormal growth of breast in men
- low urine output
- signs of Parkinsonism (muscle stiffness, shaking and decreased ability to move)
- low thyroid functions
- contraction of jaw muscles
Stop taking PRIXAIN D 75/20 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- suicidal thoughts and behaviour
- serious skin reaction involving reddish non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- feeling restless, urge to move, increased irritation
- signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- signs of allergic reactions (such as skin rash, itching, swellling of the face, lips, tongue and throat which causes difficulty in breathing or swallowing)
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Nausea And Vomiting
Take PRIXAIN D 75/20 CAPSULE with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredPRIXAIN D 75/20 CAPSULE is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method (non-hormonal methods) to avoid pregnancy while undergoing therapy with PRIXAIN D 75/20 CAPSULE.
BREASTFEEDING
ContraindicatedPRIXAIN D 75/20 CAPSULE is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking PRIXAIN D 75/20 CAPSULE.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking PRIXAIN D 75/20 CAPSULE as it could increase your dizziness.
KIDNEY
Consult your doctorPRIXAIN D 75/20 CAPSULE is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with other mild kidney problems (such as decreased urination). Therefore, consult your doctor before taking it.
LIVER
ContraindicatedPRIXAIN D 75/20 CAPSULE is not recommended for use in patients with severe liver diseases. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take PRIXAIN D 75/20 CAPSULE if you are allergic to the Pregabalin or Duloxetine.
LUNGS
Use with CautionPRIXAIN D 75/20 CAPSULE should be used with caution in patients having respiratory problems. Therefore, consult your doctor before taking it.
HEART DISEASE
Use with CautionPRIXAIN D 75/20 CAPSULE should be used with caution in patients who have a history of heart disease (Ex. high or low blood pressure). Therefore, consult your doctor before taking it.
OTHERS
Before taking PRIXAIN D 75/20 CAPSULE, inform your doctor if you:
- have or had constipation
- have a history of drug abuse
- have had seizures
- have mania (sudden extreme sense of excitement and hyperactivity)
- have or previously had bipolar disorder (alternative episodes of excitement and sadness)
- have glaucoma
- have or previously had any bleeding disorders
- are taking diuretic medications (water pills)
- have diabetes
Use in pediatrics:
PRIXAIN D 75/20 CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in geriatrics:
PRIXAIN D 75/20 CAPSULE should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug – Drug interactions:
Before taking PRIXAIN D 75/20 CAPSULE, inform your doctor if you are taking any of the following medicines such as:
- medicine used to treat depression like monoamine oxidase inhibitors (Ex. tranylcypromine, moclobemide iproniazid, nialamide, isocarboxazid, toloxatone), fluvoxamine, paroxetine, fluoxetine. clomipramine, amitriptyline, venlafaxine, lithium, selegiline, imipramine, bupropion, St. John’s wort
- medicines used to treat bacterial infection (such as ciprofloxacin, linezolid)
- medicines used to reduce anxiety and to induce sleep (such as alprazolam, midazolam, clonazepam, lorazepam, nitrazepam)
- medicines used for pain relief (such as oxycodone, tramadol, ibuprofen, diclofenac, pethidine)
- other medicines used to treat psychiatric disorders (such as pimozide, haloperidol, risperidone, thioridazine)
- medicines used to treat allergic reactions (such as azelastine, cyproheptadine, mequitazine)
- medicines used to treat migraine headache (such as sumatriptan)
- tryptophan (a medicine used to treat mental illness)
- buprenorphine (an opioid analgesic medication)
- medicines used for blood thinning (such as heparin, warfarin)
- oral contraceptives (birth control pills) Ex. ethinyl estradiol
Overdosage:
If you or anyone else accidentally took more PRIXAIN D 75/20 CAPSULE, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include feeling sleepy, confused, agitated, or restless, fits, vomiting, fast heart rate or signs of serotonin syndrome (such as excitement, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles).
SYNOPSIS
| Drug | : | Duloxetine, Pregabalin |
| Pharmacological Category | : | Serotonin and Noradrenaline reuptake inhibitors, GABA Analogs |
| Therapeutic Indication | : | Nerve pain, Fibromyalgia |
| Dosage Forms | : | Capsule |
MORE INFORMATION
- Keep out of reach of children
- store at room temperature
FAQs ABOUT PRIXAIN D 75/20 CAPSULE
Q: What is the use of PRIXAIN D 75/20 CAPSULE?
A: PRIXAIN D 75/20 CAPSULE is used to treat severe nerve pain (such as diabetic neuropathy, postherpetic neuralgia) and fibromyalgia (severe muscle pain with tiredness, mood swings, sleepiness and memory loss).
Q: How PRIXAIN D 75/20 CAPSULE works?
A: PRIXAIN D 75/20 CAPSULE is a pain-relieving medication. It reduces pain sensation by altering the activity of certain brain chemicals (dopamine, serotonin and adrenaline) within the nervous system. As a result, it reduces the transmission of pain signals from the damaged nerves to the brain and vice versa.
Q: What is the best time to take PRIXAIN D 75/20 CAPSULE?
A: Take PRIXAIN D 75/20 CAPSULE approximately at the same time each day. You can take PRIXAIN D 75/20 CAPSULE either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Q: Can PRIXAIN D 75/20 CAPSULE cause weight gain?
A: Yes. Weight gain is one of the common side effects of taking PRIXAIN D 75/20 CAPSULE. If this side effect bothers you, contact your doctor.
Q: Will PRIXAIN D 75/20 CAPSULE reduce my sex drive?
A: Yes. PRIXAIN D 75/20 CAPSULE may affect your sexual life. It may decrease sex drive or cause problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
Q: Will the use of PRIXAIN D 75/20 CAPSULE make you feel sleepy or tired?
A: Yes, PRIXAIN D 75/20 CAPSULE can make your feel sleepy, drowsy, or tired. Do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Q: Can PRIXAIN D 75/20 CAPSULE be used in children?
A: PRIXAIN D 75/20 CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Q: What to do if I forget to take a dose of PRIXAIN D 75/20 CAPSULE?
A: If you forget to take a dose of PRIXAIN D 75/20 CAPSULE, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of PRIXAIN D 75/20 CAPSULE to compensate a missed dose, as it could lead to toxicity.
Q: Will taking a higher dose of PRIXAIN D 75/20 CAPSULE than the prescribed one be beneficial?
A: No, taking a higher dose of PRIXAIN D 75/20 CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I stop taking PRIXAIN D 75/20 CAPSULE once my symptoms subside?
A: No. Do not stop taking PRIXAIN D 75/20 CAPSULE without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better after 2 weeks of therapy with PRIXAIN D 75/20 CAPSULE, but it might take several weeks for you to experience complete benefits. Also, sudden discontinuation of therapy may cause withdrawal symptoms such as nausea, vomiting, sweating, lack of sleep, anxiety and abnormal dreams.
Q: Can PRIXAIN D 75/20 CAPSULE be taken daily?
A: Yes. PRIXAIN D 75/20 CAPSULE can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Q: How long does it take for PRIXAIN D 75/20 CAPSULE to work?
A: It may take several weeks for PRIXAIN D 75/20 CAPSULE to heal your condition. Therefore, continue to take PRIXAIN D 75/20 CAPSULE for the stipulated duration recommended by your doctor without any interruption.
Q: How to take PRIXAIN D 75/20 CAPSULE?
A: Take PRIXAIN D 75/20 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. PRIXAIN D 75/20 CAPSULE can be taken with or without meals.
Q: Is PRIXAIN D 75/20 CAPSULE safe to use in pregnancy?
A: PRIXAIN D 75/20 CAPSULE is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method (non-hormonal methods) to avoid pregnancy while undergoing therapy with PRIXAIN D 75/20 CAPSULE.
Q: What are the common side effects of taking PRIXAIN D 75/20 CAPSULE?
A: The most common side effects of taking PRIXAIN D 75/20 CAPSULE are sleepiness, dizziness, headache, mood changes, tremor, tingling or numbness, dry mouth, constipation, flatulence, feeling drunk, muscle cramps, sore throat, inability to reach orgasm, decreased sexual drive and weight loss. Consult your doctor if any of these side effect worsens.
REFERENCES
1. KD. Tripathi. Antiepileptic Drugs. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. 7th Edition. Page – 420 & 462.
2. Robert J. Tanenberg, Gordon A. Irving, Richard C. Risser, Jonna Ahl, Michael J. Robinson, Vladimir Skljarevski and Sandra K. Malcolm. Duloxetine, Pregabalin, and Duloxetine Plus Gabapentin for Diabetic Peripheral Neuropathic Pain Management in Patients with Inadequate Pain Response to Gabapentin: An Open-Label, Randomized, Noninferiority Comparison. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2011. [Accessed on 3rd February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127557/
3. Pharmadox Healthcare Ltd. Duloxetine 30mg gastro-resistant capsules, hard Duloxetine 60mg gastro-resistant capsules, hard Duloxetine. Electronic Medicines Compendium. [Revised in May 2021]. [Accessed on 3rd February 2023] https://www.medicines.org.uk/emc/files/pil.10518.pdf
4. Milpharm Limited. Pregabalin. Electronic Medicines Compendium (EMC). [Revised in September 2022] [Accessed on 3rd February 2023] https://www.medicines.org.uk/emc/files/pil.7132.pdf
5. Cipla Ltd. Nova-D Capsules (Pregabalin + Duloxetine Delayed-Release Capsule). Ciplamed.com. [Revised in February 2022]. [Accessed on 3rd February 2023] https://ciplamed-library.com/content/nova-d-capsules
6. Torrent Pharmaceuticals Ltd. Pregab-D/Pregaba-D/Pregalin-D. [Revised in October 2021]. [Accessed on 3rd February 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3057.pdf
7. Pbren-D Pregabalin+Duloxetine. 50mg+20mg, 75mg+20mg, 75mg +30mg. December 2013. [Accessed on 3rd February 2023] https://www.larenon.com/wp-content/uploads/2022/11/PBREN-D-LBL.pdf
8. Leeford Healthcare Pvt Ltd. Pregabanyl-DX. [Accessed on 3rd February 2023] https://www.leeford.in/product/1446/pregabanyl-dx
USEFUL DIAGNOSTIC TESTS
- Nerve conduction test
- Electroencephalogram (EEG)
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