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INTRODUCTION
PREGANERVE SR 75MG contains Pregabalin which belongs to the group of medicines called Anticonvulsants. It is used in adults to treat neuropathic pain. Neuropathic pain (also known as nerve pain) is a long-lasting pain caused due to damage of nerves fibers present in the body. It is characterized by hot, burning, sharp, shooting, throbbing, or stabbing pain sensations with tingling or numbness of body parts. It may also cause mood changes, sleep disturbances and tiredness if nerve fibers supplying the brain are damaged.
PREGANERVE SR 75MG can also be used to treat certain forms of epilepsy (fits or seizures) when used in combination with other anti-epileptic medicines. It may also be effective in treating generalized anxiety disorders (severe anxiety that affects daily activities) when other medicines are not effective.
Pregabalin controls seizure (fits) by reducing the abnormal activity of the nerve cells in the brain. It also reduces the pain by blocking the transmission of pain signals across the nervous system. It relieves anxiety by reducing the release of certain brain chemicals that causes abnormal mood stimulation and anxiety.
Before taking PREGANERVE SR 75MG inform your doctor if you have or had any lung, liver, kidney, or heart problems. You must also inform your doctor before taking PREGANERVE SR 75MG if you have diabetes, any other nerve or brain disorders or if you have a history of drug abuse.
Avoid consuming alcohol while taking PREGANERVE SR 75MG as it may make you feel dizzier which can eventually lead to increased risk of injuries, falls or accidents. Do not take PREGANERVE SR 75MG if you are pregnant or breastfeeding without consulting your doctor. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with PREGANERVE SR 75MG.
PREGANERVE SR 75MG should be used with extreme caution in elderly patients (aged above 65 years) particularly in those who have kidney problems. PREGANERVE SR 75MG may alter your blood sugar levels, therefore regularly check your blood sugar levels as a precaution. It may also cause weight gain in patients, particularly in those who are diabetic. If it bothers you, consult your doctor for advice.
Other most common side effects of taking PREGANERVE SR 75MG are dizziness, drowsiness, headache, dry mouth, blurred vision and swelling of body parts. Contact your doctor if any of these side effect worsens. Also, inform your doctor immediately if you experience extreme sadness with thought of harming or killing yourself (suicidal thoughts).
USES OF PREGANERVE SR 75MG
It is used in adults to treat:
- Peripheral and central neuropathic pain
- Epilepsy (fits or seizure) in combination with other medicines
- Generalized Anxiety Disorder
HOW PREGANERVE SR 75MG WORKS
PREGANERVE SR 75MG controls seizures by reducing the abnormal activity of the nerve cells in the brain. It acts as a specific analgesic for peripheral and central neuropathic pain by blocking the transmission of pain signals across the nervous system. It relieves anxiety by reducing the release of certain brain chemicals (GABA) that causes abnormal mood stimulation and anxiety.
DIRECTIONS FOR USE
Take PREGANERVE SR 75MG as advised by your physician. Swallow PREGANERVE SR 75MG with a glass of water. Do not crush or chew the medicine. PREGANERVE SR 75MG can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PREGANERVE SR 75MG without consulting your doctor.
SIDE EFFECTS OF PREGANERVE SR 75MG
COMMON
- dizziness, drowsiness, headache
- increased appetite
- increased mood, confusion, disorientation, irritability
- lack of attention, clumsiness, memory impairment
- tremor, difficulty in speaking
- tingling or numbness, sedation, lethargy
- difficulty in sleeping, tiredness
- blurred vision, double vision
- spinning sensation, problems with balance
- dry mouth, constipation, vomiting, flatulence, diarrhoea, nausea, swelling in abdomen
- swelling of the extremities (such as hands, legs, or fingers)
- feeling drunk, abnormal style of walking
- weight gain
- muscle cramps, joint or back pain, pain in limbs
- sore throat
- difficulties with erection, decreased sexual drive, delayed ejaculation
UNCOMMON
- loss of appetite, weight loss
- high or low blood sugar
- hallucinations, mood changes
- dry eyes, eye pain, watery eyes, eye swelling
- heart rate disturbances, high or low blood pressure
- flushing
- difficulty in breathing, dry nose, nasal congestion
- increased salivation, heartburn, numbness around mouth
- sweating, rash, chills, fever
- breast pain
- difficult or painful urination
- allergic reaction (swollen face, itchiness, hives, runny nose, nose bleeding)
- painful menstruation
- cold hands and feet
RARE
- abnormal sense of smell
- cold sweat, tightness of the throat, swelling of tongue
- inflammation of the pancreas
- difficulty with writing properly
- fluid in the lungs
- muscle damage
- discharge from breasts, abnormal growth of breast in men
- low urine output
- signs of Parkinsonism (muscle stiffness, shaking and decreased ability to move)
Stop taking PREGANERVE SR 75MG and consult your doctor immediately if you experience any of the following side effects:
- serious skin reaction involving reddish non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- yellow discoloration of the skin and whites of the eyes
- suicidal thoughts
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
Take PREGANERVE SR 75MG with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness or Drowsiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any heavy tools or machines completely while you are feeling dizzy or drowsy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
PREGANERVE SR 75MG is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method (non-hormonal methods) to avoid pregnancy while undergoing therapy with PREGANERVE SR 75MG.
BREASTFEEDING
PREGANERVE SR 75MG is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking PREGANERVE SR 75MG.
ALCOHOL
Avoid consumption of alcohol while taking PREGANERVE SR 75MG as it could increase your dizziness.
KIDNEY
PREGANERVE SR 75MG should be used with caution in patients with kidney diseases (such as decreased urination). Therefore, consult your doctor before taking it.
LIVER
PREGANERVE SR 75MG should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.
ALLERGY
Do not take PREGANERVE SR 75MG if you are allergic to the Pregabalin.
LUNGS
PREGANERVE SR 75MG should be used with caution in patients having respiratory problems. Therefore, consult your doctor before taking it.
HEART DISEASE
PREGANERVE SR 75MG should be used with caution in patients who have a history of heart disease (Ex. high or low blood pressure). Therefore, consult your doctor before taking it.
OTHERS
Before taking PREGANERVE SR 75MG, inform your doctor if you:
- have or had constipation
- have a history of drug abuse
Use in pediatrics:
PREGANERVE SR 75MG is generally not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Use in geriatrics:
PREGANERVE SR 75MG should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking PREGANERVE SR 75MG, inform your doctor if you are taking any of the following:
- oxycodone (used as a pain killer)
- lorazepam (used for reducing anxiety)
- oral contraceptives (birth control pills) Ex. ethinyl estradiol
Overdosage:
If you or anyone else accidentally took more PREGANERVE SR 75MG, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include feeling sleepy, confused, agitated, or restless and fits.
SYNOPSIS
| Drug | : | Pregabalin |
| Pharmacological Category | : | GABA analogs |
| Therapeutic Indication | : | Neuropathic pain, Epilepsy, Generalized Anxiety Disorders |
| Dosage Forms | : | Tablet, Capsule, Injection, Suspension |
MORE INFORMATION
- Keep PREGANERVE SR 75MG out of reach of children
- Store PREGANERVE SR 75MG at room temperature
FAQs ABOUT PREGANERVE SR 75MG
What is PREGANERVE SR 75MG used for?
PREGANERVE SR 75MG is an anticonvulsant drug with pain relieving properties. It is used in adults to treat neuropathic pain, certain forms of epilepsy (fits) and generalized anxiety disorders.
What if I forget to take a dose of PREGANERVE SR 75MG?
If your forgot to take a dose of PREGANERVE SR 75MG, take it as soon as you remember. However, if it is time to take the next dose of PREGANERVE SR 75MG, skip the missed one and take the next dose at regular times. Do not take a double dose of PREGANERVE SR 75MG to compensate the missed dose.
How long will it take for PREGANERVE SR 75MG to reduce nerve pain?
The time taken for PREGANERVE SR 75MG in treating your condition may vary from person-to-person depending upon the severity of the disease. But you may start noticing a difference from your condition after 2 weeks of using PREGANERVE SR 75MG. However, it may take several weeks for you to experience complete pain relief. Therefore, take PREGANERVE SR 75MG consistently as advised by your doctor. Do not skip doses or discontinue the therapy in the mid-way without consulting your doctor.
What happens if I stop taking PREGANERVE SR 75MG suddenly?
Do not stop taking PREGANERVE SR 75MG without consulting your doctor as it may precipitate unpleasant withdrawal symptoms (such as headache, difficulty in sleeping, nausea, anxiety, diarrhea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating, and dizziness). If you wish to stop PREGANERVE SR 75MG, talk to your doctor. Your doctor will gradually your daily dose of pregabalin and before complete cessation of therapy.
Will taking a higher dose of PREGANERVE SR 75MG be more effective?
No. Do not take a higher dose of PREGANERVE SR 75MG than the prescribed one without consulting your doctor. Taking a higher dose of PREGANERVE SR 75MG may not be beneficial. Instead, it may cause serious side effects. If the prescribed dose is not effective for you, consult your doctor. Your doctor would prescribe a suitable higher dose for you or suggest an alternative therapy after evaluating your disease condition.
Does PREGANERVE SR 75MG help with anxiety?
Yes. PREGANERVE SR 75MG is used to treat generalized anxiety disorders. It relieves anxiety by reducing the release of certain brain chemicals (GABA) that causes abnormal mood stimulation and anxiety.
What precautions should I need to follow while taking PREGANERVE SR 75MG?
Before taking PREGANERVE SR 75MG inform your doctor if you have or had any lung, liver, kidney, or heart problems. You must also inform your doctor before taking PREGANERVE SR 75MG if you have diabetes, any other nerve or brain disorders or if you have a history of drug abuse. Avoid consuming alcohol while taking PREGANERVE SR 75MG. Do not take PREGANERVE SR 75MG if you are pregnant or breastfeeding without consulting your doctor. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with PREGANERVE SR 75MG. Inform your doctor immediately if you experience extreme sadness with thought of harming or killing yourself (suicidal thoughts) after taking PREGANERVE SR 75MG.
Can PREGANERVE SR 75MG be used in children?
PREGANERVE SR 75MG is generally not recommended for use in children and adolescents (under 18 years of age) due to lack of clinical safety data. Therefore, consult your doctor for advice.
Can PREGANERVE SR 75MG cause headache after taking it?
Yes. Headache is a common side effect of taking PREGANERVE SR 75MG. In case if you are experiencing a headache after taking PREGANERVE SR 75MG, try to rest and relax. Keep drinking plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if needed. Do not consume too much of alcohol. Consult your doctor if headache persists for a long time.
REFERENCES
1. K.D. Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 420.
2. Charles P Taylor, Timothy Angelotti, Eric Fauman. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2007. [Accessed on 7th April 2022] https://pubmed.ncbi.nlm.nih.gov/17126531/
???????3. Vivek Verma, Nirmal Singh, Amteshwar Singh Jaggi. Pregabalin in Neuropathic Pain: Evidence and Possible Mechanisms. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 2014. [Accessed on 7th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915349/
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 7th April 2022] https://www.medicines.org.uk/emc/files/pil.7132.pdf
5. Parke Davis. U.S. Food & Drug Administration. [Revised in September 2017] [Accessed on 7th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209501s000lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Nerve conduction test
- Electroencephalogram (EEG)
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