INTRODUCTION

PRADIL 150MG TABLET contains Propafenone which belongs to the group of medicines called Anti-arrhythmic agents. It is used to slow down the heart rate and helps to regulate the heartbeat. It can be used to treat and prevent arrhythmias (abnormal heart rhythms).

PRADIL 150MG TABLET is not recommended for use in patients with chronic bronchitis or emphysema (known as COPD), Brugada syndrome (a heart rhythm disorder), heart failure, abnormally slow heartbeat, low blood pressure, a recent heart attack in the past 3 months. PRADIL 150MG TABLET should be used with caution in patients with asthma, liver and kidney disease. Consult your doctor before taking it.

PRADIL 150MG TABLET should be used in pregnancy only if considered necessary. It is not recommended for use in breastfeeding women. Consult your doctor before taking it.

PRADIL 150MG TABLET is not recommended for use in children. It should be used with caution in elderly patients. Consult your doctor before taking it.

The most common side effects of taking PRADIL 150MG TABLET are dizziness, irregular heartbeat, heart palpitations. Contact your doctor if any of the symptoms worsen.

USES OF PRADIL 150MG TABLET

• To slow down the heart rate
• To treat and prevent arrhythmias

HOW PRADIL 150MG TABLET WORKS

PRADIL 150MG TABLET works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to normal rhythm.

DIRECTIONS FOR USE

Take PRADIL 150MG TABLET as advised by your physician. It should be taken after food. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking PRADIL 150MG TABLET unless your doctor advises you to stop.

SIDE EFFECTS OF PRADIL 150MG TABLET

HOW TO MANAGE SIDE EFFECTS

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the dry mouth gets worse.

Headache:

Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Contact your doctor if your dizziness did not improve.

Nausea and vomiting:

Take PRADIL 150MG TABLET, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persist.

Stomach pain:

Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the stomach pain did not improve.

Skin rash:

Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the flatulence does not improve, contact your doctor.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Contact your doctor if your diarrhoea did not improve.

Loss of appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Contact your doctor if your appetite did not improve.

WARNING & PRECAUTIONS

PREGNANCY

PRADIL 150MG TABLET should be used in pregnancy only if considered necessary by your doctor. Consult your doctor before taking it.

BREASTFEEDING

PRADIL 150MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience blurred vision, dizziness, tiredness and low blood pressure after taking PRADIL 150MG TABLET.

KIDNEY

PRADIL 150MG TABLET should be taken with caution in patients with kidney disease and may require dose adjustment. Consult your doctor before taking it.

LIVER

PRADIL 150MG TABLET should be taken with caution in patients with liver disease and may require dose adjustment. Consult your doctor before taking it.

ALLERGY

Do not take PRADIL 150MG TABLET if you are allergic to Propafenone or any of the other ingredients of this medicine.

LUNGS

PRADIL 150MG TABLET is not recommended for use in patients with chronic bronchitis or emphysema (known as COPD) and should be used with caution in patients with asthma. Consult your doctor before taking it.

HEART DISEASE

PRADIL 150MG TABLET is not recommended for use in patients who have Brugada syndrome (a heart rhythm disorder), heart failure, abnormally slow heartbeat, low blood pressure, had a heart attack in the past 3 months or have any other heart problems except abnormal heart rhythm. PRADIL 150MG TABLET should be used with caution in patients with a pacemaker. Consult your doctor before taking it.

INTERACTIONS

A. Drug - Drug interactions:

Before taking PRADIL 150MG TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to treat heart conditions, angina, high blood pressure or medicines that may impact the heart rate Ex. propranolol, metoprolol, amiodarone, digoxin, quinidine
• amitriptyline, dothiepin, desipramine, venlafaxine, fluoxetine, paroxetine (used to treat depression)
• antibiotic such as erythromycin, rifampicin (used to treat bacterial infections)
• ketoconazole (used to treat fungal infections)
• cyclosporin (used to prevent organ transplant rejection or in the treatment of arthritis or psoriasis)
• lidocaine (used to treat dental surgery or other minor surgical procedures)
• anticoagulant medicines such as warfarin (used for thinning blood)
• cimetidine (used to treat stomach ulcers)
• theophylline (used to treat asthma)
• tropisetron or dolasetron (used to prevent and treat nausea and vomiting)
• mizolastine (used to treat to allergy)
• phenobarbital (used to treat epilepsy or seizures)
• antiviral medicine such as ritonavir (used to treat HIV)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking PRADIL 150MG TABLET.

Overdosage:

If you or anyone else accidentally take too much of PRADIL 150MG TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep PRADIL 150MG TABLET out of reach of children
• Store PRADIL 150MG TABLET below 25°C

FAQs ABOUT PRADIL 150MG TABLET

Q: Can PRADIL 150MG TABLET be taken with food?

A: Take PRADIL 150MG TABLET as directed by your physician. It should be taken after food with water. Your doctor will decide the correct dose and frequency for you based upon your age, body weight and disease condition.

Q: Can PRADIL 150MG TABLET use affect my pacemaker?

A: Yes. Before taking PRADIL 150MG TABLET, inform your doctor if you have a pacemaker as it may need to be re-programmed. Your doctor will check how your pacemaker is working during and after treatment with this medicine.

Q: How often can I use PRADIL 150MG TABLET?

A: Take PRADIL 150MG TABLET as advised by your physician. Generally, it is taken three times a day. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q: Can PRADIL 150MG TABLET be taken in pregnancy?

A: PRADIL 150MG TABLET should be used in pregnancy only if considered necessary by your doctor as safety of this medicine has not established. If you are pregnant or are planning to get pregnant, consult your doctor before taking this medicine.

Q: What if I forget to take a dose of PRADIL 150MG TABLET?

A: If you forget to take a dose of PRADIL 150MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.

Q: Can PRADIL 150MG TABLET be stopped?

A: Do not stop taking PRADIL 150MG TABLET until your doctor tells you to stop. Continue taking the medicine even if you feel better, as stopping it suddenly may worsen your condition. Consult your doctor if you any more doubts regarding the use of this medicine.

Q: What precautions do I need to follow while taking PRADIL 150MG TABLET?

A: If you are taking PRADIL 150MG TABLET, you must inform your doctor about your pre-existing disease conditions like kidney, liver, heart or breathing problems and muscle weakness, if you are taking a medicine for HIV infection (ritonavir) or if you are about to have any surgery. Patients should also inform if they are pregnant, breast-feeding or having any allergies. Contact your doctor if you have any unusual symptoms.

REFERENCES

1. KD. Tripathi. Antiarrhythmic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 532.

2. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Arrhythmias. Pharmacotherapy handbook. Ninth edition. 2015. Page- 48, 49.

3. Bryson, H.M., Palmer, K.J., Langtry, H.D. et al. Propafenone. Springer Link. October 2012. [Accessed on 4th July 2022] https://link.springer.com/article/10.2165/00003495-199345010-00008

4. Reimold SC, Maisel WH, Antman EM. Propafenone for the treatment of supraventricular tachycardia and atrial fibrillation: a meta-analysis. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed.gov. 1998. [Accessed on 4th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK67261/

5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 4th July 2022] https://www.medicines.org.uk/emc/files/pil.5404.pdf

6. Central Drugs Standard Control Organization (CDSCO). Propafenone. [Accessed on 4th July 2022] https://cdscoonline.gov.in/CDSCO/Drugs

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count (CBC)
• Electrocardiogram (ECG)
• Serum Electrolytes

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 13 Jan 2023 | 01:41 PM(IST)