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INTRODUCTION
POLYCLAV DS DRY SYRUP is combination of Amoxicillin and Clavulanic Acid which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as middle ear & sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin & soft tissue infections such as dental infections, bone & joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections. The symptoms of bacterial infection may include fever, difficulty in breathing, pus formation, and pain.
Do not take POLYCLAV DS DRY SYRUP if you are history of hypersensitivity to beta-lactams, including penicillin and cephalosporins, or any other ingredients of this medicine. POLYCLAV DS DRY SYRUP is not recommended for use if you have if you have history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction.
Before taking POLYCLAV DS DRY SYRUP, inform your doctor if you are suffering from hepatic or renal impairment. POLYCLAV DS DRY SYRUP should be used with caution in pregnant women only if it is considered clearly necessary. POLYCLAV DS DRY SYRUP should be used with caution in breastfeeding women. POLYCLAV DS DRY SYRUP should be used with caution in children (aged below 12 years) and elderly patients (above 50 years). Consult your doctor before taking POLYCLAV DS DRY SYRUP.
The common side effects associated with the use of POLYCLAV DS DRY SYRUP are diarrhoea, thrush (fungal infection in vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptom worsens.
USES OF POLYCLAV DS DRY SYRUP
It is used for treating the bacterial infections such as:
- middle ear & sinus infections
- respiratory tract infections
- genital tract infections
- urinary tract infections
- skin & soft tissue infections such as dental infections
- bone & joint infections
- septic abortion (any abortion complicated by uterine infection)
- abdominal infections
HOW POLYCLAV DS DRY SYRUP WORKS
POLYCLAV DS DRY SYRUP helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
DIRECTIONS FOR USE
Syrup/ Oral Suspension
Take POLYCLAV DS DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup, or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose to a child below 3 months accurately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Dry Syrup/Dry Suspension
Take POLYCLAV DS DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF POLYCLAV DS DRY SYRUP
COMMON
- diarrhoea
- thrush (fungal infection in vagina, skin folds, or mouth)
- nausea
- vomiting
UNCOMMON
- dizziness
- headache
- indigestion
- skin rash
- itching
- bumpy itchy rash (hives)
RARE
- erythema multiforme (a skin rash that looks like small targets)
- reversible leucopoenia including neutropenia (deficiency of white blood cells)
- reversible thrombocytopenia (deficiency of blood platelets)
Stop taking POLYCLAV DS DRY SYRUP and contact your doctor if you experience any of the following side effects:
- signs of allergic reactions on skin such as skin rash
- signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
- signs of allergic reactions such as fever, joint pain, swollen glands in the neck, armpit or groin
- signs of angioedema such as swelling on face or mouth resulting in difficulty in breathing, or collapse
- erythema multiforme (a skin rash that looks like small targets)
- Stevens-Johnson syndrome (widespread rash with blistering and skin peeling)
- exanthemous pustulosis (widespread red rash with blisters containing pus)
- bullous exfoliative dermatitis (itchy, red, scaly rash with bumps & blisters)
- signs of drug reaction with eosinophilia and systemic symptoms such as flu-like symptoms, rashes, fever, and swelling in glands
- inflammation of the liver (hepatitis)
- jaundice
- severe diarrhoea
HOW TO MANAGE SIDE EFFECTS
Diarrhoea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Nausea and vomiting
Try to take POLYCLAV DS DRY SYRUP with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
POLYCLAV DS DRY SYRUP should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking.
BREASTFEEDING
POLYCLAV DS DRY SYRUP should be used with caution in breastfeeding women. Consult your doctor before taking it.
KIDNEY
POLYCLAV DS DRY SYRUP should be used with caution in patients with renal impairment. Consult your doctor before taking it.
LIVER
POLYCLAV DS DRY SYRUP is not recommended for use if you have if you have history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking it.
ALLERGY
Do not take POLYCLAV DS DRY SYRUP if you are history of hypersensitivity to beta-lactams, including penicillin’s and cephalosporins, or any other ingredients of this medicine. Consult your doctor before taking it.
OTHERS
Use in Paediatrics
POLYCLAV DS DRY SYRUP should be used with caution in children (below 12 years). Consult your doctor before taking it.
Use in Geriatrics
POLYCLAV DS DRY SYRUP should be used with caution in elderly patients (above 50 years). Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions
Before taking POLYCLAV DS DRY SYRUP, inform your doctor, if you are taking any of the following medicine:
- medicine used to treat gout Ex. allopurinol, probenecid
- medicine used to delay blood clotting Ex. warfarin, acenocoumarol
- mycophenolate mofetil (a medicine used to prevent the organ rejection after organ transplant)
- contraceptives (medicines used to prevent conception) Ex. oestrogen
Overdosage:
If you or anyone else accidentally takes too much of POLYCLAV DS DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation), fluid & electrolyte disturbance, and amoxicillin crystalluria which may lead to renal failure in some cases.
SYNOPSIS
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Drops, Injections |
MORE INFORMATION
- Keep the medicine out of sight and reach from children
- Store POLYCLAV DS DRY SYRUP at a temperature not exceeding 25°C (77°F)
FAQs ABOUT POLYCLAV DS DRY SYRUP
What POLYCLAV DS DRY SYRUP is used for?
POLYCLAV DS DRY SYRUP is used for treating bacterial infections including middle ear & sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin & soft tissue infections such as dental infections, bone & joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections.
What happens if you take more POLYCLAV DS DRY SYRUP than your required dose?
If you or anyone else accidentally takes too much of POLYCLAV DS DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation), fluid & electrolyte disturbance, and amoxicillin crystalluria which may lead to renal failure in some cases.
What side effects are seen with POLYCLAV DS DRY SYRUP?
The common side effects associated with the use of POLYCLAV DS DRY SYRUP are diarrhoea, thrush (fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.
Who should avoid taking POLYCLAV DS DRY SYRUP?
Do not take POLYCLAV DS DRY SYRUP if you are a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins, or any other ingredients of this medicine. It is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction.
Is POLYCLAV DS DRY SYRUP safe to use in children?
POLYCLAV DS DRY SYRUP should be used with caution in children (below 12 years). For administering suspensions to children (below 3 months), a graduated syringe is used to dispense the accurate volume. For administering this medicine to children (aged 2 years or below), suspensions should be diluted to half-strength with water. Consult your doctor before taking it.
How does POLYCLAV DS DRY SYRUP work?
POLYCLAV DS DRY SYRUP helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
What is the method of taking POLYCLAV DS DRY SYRUP?
Syrup/ Oral Suspension
Take POLYCLAV DS DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup, or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose children below 3 months accurately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Dry Syrup/Dry Suspension
Take POLYCLAV DS DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
What if I forget to take POLYCLAV DS DRY SYRUP dose?
If you forgot to take POLYCLAV DS DRY SYRUP dose, take it as early as possible. Do not take a double dose to compensate for the missed dose. Consult your doctor before taking it if you are not sure what to do.
When to stop taking POLYCLAV DS DRY SYRUP?
Do not stop taking POLYCLAV DS DRY SYRUP without thoroughly discussing it with your doctor until the treatment course is completed, even if you start feeling better. This is because if some bacteria survive due to incomplete medication, they may relapse into the infection.
Is POLYCLAV DS DRY SYRUP safe to use in liver patients?
POLYCLAV DS DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking POLYCLAV DS DRY SYRUP.
REFERENCES
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 26th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/
3. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 27th October 2022] https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf
4. Micro Labs Ltd. Erox CV 228.5 Dry Syrup. [Assessed on 27th October 2022] http://www.microlabsltd.com/elibrary/node/2170
5 Micro Labs Ltd. Erox CV 457 Dry Syrup. [Assessed on 27th October 2022] http://www.microlabsltd.com/elibrary/node/2181
6. Geno Pharmaceuticals Pvt. Ltd. Genomox-CV. [Assessed on 27th October 2022] https://genopharma.com/pharma/
USEFUL DIAGNOSTIC TESTS
- blood tests
- urine tests
- liver function test
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