Piril DX Syrup 100ml

INTRODUCTION

PIRIL DX SYRUP is a combination of Chlorpheniramine and Dextromethorphan which belongs to the group of medicines called Antihistamines and Antitussives respectively. It is used to relieve cough due to throat or bronchial irritation, sneezing and running nose caused by cold, dry cough, allergic cough, post-operative cough, smokers cough and night-time cough. It is also used to treat hay fever or upper respiratory allergies such as sneezing, runny nose, itchy, watery eyes, itching of the nose and throat.

Avoid consumption of alcohol while taking this medicine as this may lead to unwanted effects.  PIRIL DX SYRUP is not recommended for use in patients with or at risk of developing, respiratory failure (Ex.  chronic obstructive airways disease or pneumonia or an exacerbation of asthma).

PIRIL DX SYRUP should be used with caution in patients with lung disease, severe kidney or heart diseases.

PIRIL DX SYRUP is not recommended for use in pregnant or breastfeeding women. Contact your doctor before taking.

PIRIL DX SYRUP is not recommended for use in children under 2 years of age. Contact your doctor before taking.

PIRIL DX SYRUP should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.

The most common side effects of this medicine are sedation, somnolence, disturbance in attention, abnormal coordination, dizziness, drowsiness, headache, blurred vision, nausea, vomiting, dry mouth, abdominal discomfort, fatigue. Contact your physician if any of the symptoms worsen.

USES OF PIRIL DX SYRUP

• Used to treat cough (allergy, post-operative cough, smokers cough and night-time cough, throat irritation, sneezing and running nose)

HOW PIRIL DX SYRUP WORKS

PIRIL DX SYRUP helps to treat cough, where Chlorpheniramine is an antihistamine works by blocking the histamine H1 receptor and prevents the release of histamine (which normally produces symptoms of sneezing, itching, watery eyes and runny nose) and Dextromethorphan is a cough suppressant which relieves cough by acting on the cough centre in the brain. Together relives cough effectively.

DIRECTIONS FOR USE

Take PIRIL DX SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PIRIL DX SYRUP

HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea or vomiting bothers you.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if dizziness persists.

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if your headache did not improve.

Stomach pain:

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.

WARNING & PRECAUTIONS

PREGNANCY

PIRIL DX SYRUP is generally not recommended for use in pregnancy. Contact your doctor before taking.

BREASTFEEDING

PIRIL DX SYRUP is not recommended for use in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel drowsiness, dizziness, blurred vision and psychomotor impairment after taking PIRIL DX SYRUP.

ALCOHOL

Avoid consumption of alcohol while taking PIRIL DX SYRUP as it may lead to unwanted effects.

KIDNEY

PIRIL DX SYRUP should be used with caution in patients with severe kidney disease. Contact your doctor before taking.

LIVER

PIRIL DX SYRUP should be used with caution in patients with severe liver disease. Contact your doctor before taking.

ALLERGY

Do not take PIRIL DX SYRUP if you are allergic to Chlorpheniramine, Dextromethorphan or to other ingredients of this medicine.

LUNGS

PIRIL DX SYRUP is not recommended for use in patients with or at risk of developing, respiratory failure (Ex. chronic obstructive airways disease or pneumonia or an exacerbation of asthma) and should be used with caution in patients with asthma, bronchitis, bronchiectasis, emphysema. Contact your doctor before taking.

HEART DISEASE

PIRIL DX SYRUP should be used with caution in patients with severe heart diseases and severe hypertension. Contact your doctor before taking.

INTERACTIONS

A. Drug-Drug interactions:

Inform your physician, if you are taking:

• hypnotics or anxiolytics Ex. alprazolam, diazepam, lorazepam (medicines that induces sleep and to treat anxiety)
• sedatives Ex. phenobarbital, pentobarbital (medicines used to reduce excitement)
• opioid analgesics like tramadol, morphine, codeine, methadone (medicines used for severe pain)
• fluphenazine, thioridazine, haloperidol, perphenazine (medicines used to treat psychoses)
• antimuscarinic drugs Ex. dicyclomine (medicines used to relax stomach and intestine)
• fluoxetine, paroxetine, sertraline, amitriptyline, imipramine, selegiline, rasagiline, bupropion (medicines used for depression)
• cough and cold medicines
• phenytoin (medicines used to treat fits)
• quinidine, amiodarone, propafenone and flecainide (medicines used to treat heart rhythm disorders)
• cinacalcet (medicine used to treat hyperparathyroidism)
• terbinafine (medicines used to treat fungal infections)
• antihistamines (drugs used to treat the symptoms of allergic reactions) Ex. dimenhydrinate

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdosage are drowsiness, lethargy, nystagmus, ataxia, depression, nausea, vomiting and hyperactivity, excitation, mental confusion, tremors, psychosis, hallucinations, high fever and convulsions, restlessness, nervousness and irritability, stupor, dystonia and respiratory depression.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store PIRIL DX SYRUP below 30°C

FAQs ABOUT PIRIL DX SYRUP

For what conditions PIRIL DX SYRUP is used?

PIRIL DX SYRUP is used to relieve cough due to throat or bronchial irritation, sneezing and running nose caused by cold, dry cough, allergic cough, post-operative cough, smokers cough and night-time cough. It is also used to treat hay fever or upper respiratory allergies such as sneezing, runny nose, itchy, watery eyes, itching of the nose and throat. Contact  your doctor before taking.

How PIRIL DX SYRUP work?

PIRIL DX SYRUP helps to treat cough, where Chlorpheniramine is an antihistamine works by blocking the histamine H1 receptor and prevents the release of histamine (which normally produces symptoms of sneezing, itching, watery eyes and runny nose) and Dextromethorphan is a cough suppressant which relieves cough by acting on the cough centre in the brain. Together relives cough effectively.

What are the possible side effects of taking PIRIL DX SYRUP?

The most common side effects of this medicine are sedation, somnolence, disturbance in attention, abnormal coordination, dizziness, drowsiness, headache, blurred vision, nausea, vomiting, dry mouth, abdominal discomfort, fatigue. Contact your physician if any of the symptoms worsen.

How to take PIRIL DX SYRUP?

Take PIRIL DX SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Does PIRIL DX SYRUP cause sleepiness?

Yes. PIRIL DX SYRUP cause sleepiness. Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling sleepy. Do not consume alcohol, as it can aggravate your sleepiness. Contact your doctor if sleepiness did not improve.

REFERENCES

1. K.D. Tripathi. Drugs for cough and bronchial asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 220.

2. Bethesda (MD). Chlorpheniramine. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 21st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine

3. Bethesda (MD). Dextromethorphan. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 21st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5360696

4. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.3928.pdf

5. Delpharm Orleans. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.1523.pdf

6. GlaxoSmithKline Pharmaceuticals Limited. Chlorpheniramine and Dextromethorphan.  [Revised in November 2019] [Accessed on 21st June 2022] https://india-pharma.gsk.com/media/6399/piriton-cs.pdf

7. Accudial Pharmaceutical, Inc. Chlorpheniramine and Dextromethorphan. [Revised in November 2011] [Accessed on 21st June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=03401433-923e-4577-ba58-9087515c8053

8. Cheston CS Syrup (Chlorpheniramine and Dextromethorphan). Cipla Ltd. [Revised in November 2013] [Accessed on 21st June 2022] https://www.ciplamed.com/content/cheston-cs-syrup

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 23 Nov 2022 | 11:56 PM(IST)