INTRODUCTION
PIPZAM 4.5GM INJECTION is a combination of Piperacillin and Tazobactam which belongs to the group of medicines called Antibiotics. It is used to treat several bacterial infections such as lower respiratory tract infections such as pneumonia, acute bacterial exacerbation causing breathing difficulties, urinary tract infections, pyelonephritis, skin infections, abdominal, biliary tract infections and female pelvic infections such as postpartum endometritis or pelvic inflammatory disease, bacteraemia, and bacterial meningitis in infants and children.
It is also used along with other antibacterial agents in the management of neutropenic caused by bacterial infection.
Pneumonia is an infection which causes inflammation in the air sac producing cough with phlegm and shortness of breath. Pyelonephritis is a urinary tract infection affecting the urinary bladder later gets spreads to the kidneys. Bacteraemia is an infectious condition indicating presence of bacteria in the blood stream.
Bacterial meningitis is an infection caused by bacteria in the region surrounding the brain. Neutropenic is low levels of neutrophils (a type of white blood cells) in our body.
Kindly inform your doctor or your health-care professional before any laboratory tests as PIPZAM 4.5GM INJECTION will interact with medical investigations. Inform your doctor if you are allergic to any antibiotics or other medicines.
PIPZAM 4.5GM INJECTION should not be used in patients allergic to penicillin antibiotics, cephalosporin, and other beta-lactam antibiotics.
PIPZAM 4.5GM INJECTION should be used with caution in patients with pre-existing diarrhoea, low potassium levels, kidney, and liver diseases.
Avoid concomitant use of other aminoglycoside antibiotics and vancomycin along with this medicine.
PIPZAM 4.5GM INJECTION should be used with caution in pregnant and breast-feeding women. PIPZAM 4.5GM INJECTION should be used with caution in children above 2 months and in elderly people. Your doctor will administer the right dose depends on your child’s age, body weight and severity of the infection.
The common side effects of PIPZAM 4.5GM INJECTION are diarrhoea, yeast infection, headache, sleeplessness, stomach pain, vomiting, nausea, constipation, skin rash, itching, fever, and injection site reaction.
USES OF PIPZAM 4.5GM INJECTION
It is used to treat the following infections:
- intra-abdominal infection such as appendicitis and peritonitis
- skin and skin structure infection such as cutaneous abscesses, cellulitis, diabetic foot
- female pelvic infections such as postpartum endometritis or pelvic inflammatory disease
- lower respiratory tract infection such as community-acquired pneumonia, and ventilator-associated pneumonia
- bacterial septicaemia
- management of neutropenia associated with fever
HOW PIPZAM 4.5GM INJECTION WORKS
PIPZAM 4.5GM INJECTION works by destroying the bacterial growth responsible for causing infections. Piperacillin works by interrupting the cell wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall leading to cell death causing death of the organism. Tazobactam is responsible for the irreversible termination of enzymes (beta- lactamases) that protect the organism from antibiotics and produces less anti-bacterial actions when given alone so it’s always used in combination with other antibiotics. Thus, both the substances works by preventing cell growth and function inhibiting bacterial growth.
DIRECTIONS FOR USE
PIPZAM 4.5GM INJECTION will be administered into the vein (intravenously) by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF PIPZAM 4.5GM INJECTION
COMMON
- diarrhoea
- yeast infection
- headache
- sleeplessness
- stomach pain, vomiting, nausea, constipation
- skin rash, itching
- fever, injection site reaction
UNCOMMON
- low blood pressure
- inflammation of the veins
- skin redness, skin lesions
- joint and muscle pain
- chills
- hypokalaemia, breathing difficulty
- abnormal lab investigations
RARE
- lack of white blood cells (agranulocytosis), bleeding nose
- serious infection of colon
- inflammation of inner lining of mouth
- peeling of skin
Contact your immediately if you experience any of the following side effects after receiving PIPZAM 4.5GM INJECTION
- serious skin rashes appear as reddish target-like spots or circular patches often with blisters,) ulcers in mouth, throat, nose, extremities, genitals red and swollen eyes (Stevens-Johnson syndrome, dermatitis bullous, dermatitis exfoliative, toxic epidermal necrolysis)
- a potentially fatal allergic condition (drug reaction with eosinophilia and systemic symptoms) involving skin and other organs such as the kidney and liver
- skin condition (acute generalised exanthemata’s pustulosis) symptoms include numerous tiny fluids filled blisters with swollen and reddened skin
- swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing (angioedema)
- yellowing of the eyes or skin (jaundice)
- convulsions
- decrease in blood cells
- severe diarrhoea with fever
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drinking plenty of water and other electrolyte balanced fluids. Make sure to hydrate throughout the day. Do not consume any medicine on your own without consulting your doctor. If the symptom does not improve, contact your doctor.
Nausea And Vomiting
Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy, or sweet foods. Eat slowly and eat smaller, more frequent meals, drinking gradually larger amounts of clear liquids, avoid solid food until the vomiting episode has passed, take rest. If the symptom does not improve, contact your doctor.
Stomach Pain
Some diet and lifestyle changes can help with stomach pain. Eat smaller portions of meal. Chew your food well and eat slowly. Avoid foods that cause gas or indigestion. Avoid consumption of alcohol and caffeine.
Headache
Take some rest, in a quiet place avoid using user mobile phones and other electronic devices for a while. Drink enough amount of water, dehydration may lead you to develop a headache. If the symptom does not improve, contact your doctor.
Injection Site Reactions
Try using warm water compress to reduce swelling. Keeping the affected area elevated can help reduce the swelling. Not applying pressure to the affected area will help reducing pain and preventing further damage.
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in pregnant women. Consult your doctor before receiving the medicine.
BREASTFEEDING
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in breast-feeding women. Consult your doctor before receiving the medicine.
DRIVING AND USING MACHINES
Use with CautionDo not drive or handle heavy machines if you experience dizziness, drowsiness, tired, or if you have blurred vision while receiving PIPZAM 4.5GM INJECTION.
ALCOHOL
ContraindicatedConsumption of alcohol is not recommended during treatment with PIPZAM 4.5GM INJECTION.
KIDNEY
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in patients with kidney diseases and patients on haemodialysis. Consult your doctor before receiving the medicine.
LIVER
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in patients with liver diseases and patients with abnormal liver tests. Consult your doctor before receiving the medicine.
ALLERGY
ContraindicatedDo not receive PIPZAM 4.5GM INJECTION if you are allergic to Piperacillin or Tazobactam or to any other ingredients of this medicine.
LUNGS
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in patients with community-acquired pneumonia and ventilator-associated pneumonia. Consult your doctor before receiving the medicine.
USE IN PEDIATRICS
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in children above 2 months of age. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving the medicine.
USE IN GERIATRICS
Use with CautionPIPZAM 4.5GM INJECTION should be used with caution in elder patients (above 65 years of age). Consult your doctor before receiving the medicine.
OTHERS
Before receiving this medicine inform your doctor if you:
- are suffering from diarrhoea
- have low levels of potassium
INTERACTIONS
A. Drug-Drug interactions:
Before receiving PIPZAM 4.5GM INJECTION, inform your doctor if you are taking any of the following medicine:
- other antibiotics used to treat bacterial infections (Ex. gentamycin, streptomycin, neomycin, amikacin, vancomycin)
- medicine used to treat gout (Ex. Probenecid)
- medicine used as muscle relaxants during surgery (Ex. vecuronium)
- medicines used to treat blood clots (Ex. heparin, warfarin, aspirin)
- methotrexate (used to treat cancer, arthritis, or psoriasis)
- medicines reducing potassium levels (Ex. furosemide)
Overdosage:
It is unlikely to receive overdose since it will be administered by the doctor or nurse. If you experience any unusual side effects, consult your doctor immediately. Symptoms of overdose may occur such as nausea, vomiting, diarrhoea, neuromuscular disorders and convulsions.
SYNOPSIS
| Drug | : | Piperacillin, Tazobactam |
| Pharmacological Category | : | Beta-lactam antibiotics, Beta-lactamase inhibitors |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep PIPZAM 4.5GM INJECTION out of reach of children
- Store at room temperature
FAQs ABOUT PIPZAM 4.5GM INJECTION
Q: Will PIPZAM 4.5GM INJECTION treat different bacterial infections?
A: Yes, PIPZAM 4.5GM INJECTION is used in cases of serious infections of chest, urinary system and blood along with others.
Q: Can PIPZAM 4.5GM INJECTION be used in children?
A: Yes, it is safe to use PIPZAM 4.5GM INJECTION in children above 2 months of age, dose adjustments are necessary while used in children. Your doctor will administer the correct dose for your child depending on your child’s age, body weight and disease condition.
Q: How will PIPZAM 4.5GM INJECTION treat my infection?
A: PIPZAM 4.5GM INJECTION works by destroying the bacterial growth responsible for causing infections. Piperacillin works by interrupting the cell wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall leading to cell death causing death of the organism. Tazobactam is responsible for the irreversible termination of enzymes (beta- lactamases) that protect the organism from antibiotics and produces less anti-bacterial actions when given alone so it’s always used in combination with other antibiotics. Thus, both the substances works by preventing cell growth and function inhibiting bacterial growth.
Q: How long will PIPZAM 4.5GM INJECTION take to treat bacterial infections?
A: PIPZAM 4.5GM INJECTION will start working once it is injected in the blood stream. It will work faster compared with oral antibiotics as it is injected directly into the blood stream. However full course of antibiotic should be given to obtain its efficacy. Your doctor will decide the dose adjustments and termination of the medicine depending upon your health condition.
REFERENCES
1. K.D. Tripathi Beta-Lactam Antibiotics Page no -724, 725 Essentials of Pharmacology seventh edition Page no: 637.
2. Alfred Gin, Leanne Dilay, James A Karlowsky, Andrew Walkty, Ethan Rubinstein, George G Zhanel Piperacillin–tazobactam: a β-lactam/β-lactamase inhibitor combination Taylor Francis online, January 2014 [Accessed on 25th May 2022] https://www.tandfonline.com/doi/abs/10.1586/14787210.5.3.365?journalCode=ierz20
3. Pfizer, U.S. Food & Drug Administration [Revised on May 2017], [Accessed on 25th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050684s88s89s90_050750s37s38s39lbl.pdf
4. Wockhardt UK Ltd, Electronic Medicines Compendium (EMC) [Revised on May 2022] [Accessed on 25th May 2022] https://www.medicines.org.uk/emc/product/6526/smpc#ORIGINAL
5. Biocon Biologics India Limited, [Revised on September 2019] [Accessed on 25th May 2022] https://www.biocon.com/docs/domestic-market-pi/ccd/BIOPIPER%20TZ%20-PI.pdf
6. Cipla House, [Revised on May 2021] [Accessed on 25th May 2022] https://ciplamed.com/print-product-pdf/37119
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