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INTRODUCTION
PIOHOPE 15MG contains Pioglitazone which is an anti-diabetic medicine used to treat type 2 (non-insulin dependent) diabetes mellitus. It help to control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces. Diabetes mellitus is a metabolic disorder which causes high blood sugar. The hormone insulin helps in moving sugar from the blood into your cells which can be stored or used for energy production. In diabetes, your body does not produce required insulin or can't effectively use the insulin it does make.
Pioglitazone decreases insulin resistance, resulting in increased disposal of insulin-dependent glucose and decreased glucose production in the liver. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Do not take PIOHOPE 15MG if you have type 1 diabetes mellitus, diabetic ketoacidosis (high levels of acid in your blood), severe kidney or liver disease. Before taking this medicine, tell your doctor if you have or had heart, thyroid or some hormonal conditions, pregnant or breastfeeding. This medicine is not recommended for children and adolescents below 18 years of age. The common side effects are abnormal vision, respiratory infection and numbness.
USES OF PIOHOPE 15MG
- Treats type 2 diabetes mellitus
HOW PIOHOPE 15MG WORKS
PIOHOPE 15MG works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
DIRECTIONS FOR USE
Always take this medicine as directed by your doctor. Swallow as a whole, do not crush or chew it. It can be taken with or without food.
SIDE EFFECTS OF PIOHOPE 15MG
SERIOUS
- shortness of breath
- rapid increase in weight
- blood in your urine
- localised swelling
- broken bones
- blurred vision
- allergic reactions
COMMON
- abnormal vision
- respiratory infection
- weight gain
- numbness
WARNING & PRECAUTIONS
PREGNANCY
PIOHOPE 15MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
PIOHOPE 15MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
PIOHOPE 15MG will not normally affect your ability to drive or use machines but take care if you experience abnormal vision.
LIVER
PIOHOPE 15MG is not recommended in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Pioglitazone or any other ingredients in this medicine.
HEART DISEASE
PIOHOPE 15MG is not recommended in patients with severe heart disease. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- diabetic ketoacidosis
- bladder cancer
- blood in your urine
- macular oedema
- polycystic ovary syndrome
INTERACTIONS
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:
- gemfibrozil (used to lower cholesterol)
- rifampicin (used to treat tuberculosis and infections)
SYNOPSIS
| Drug | : | Pioglitazone |
| Pharmacological Category | : | Antidiabetic Agent |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT PIOHOPE 15MG
How long does PIOHOPE 15MG take to work?
It takes a few weeks to lower your blood sugar levels. It will help keep your blood sugar stable and reduce your chances of getting problems related to diabetes in the future.
Does PIOHOPE 15MG affect liver?
Yes, it may cause an increase in liver enzymes and treatment should be stopped if liver enzymes increase. Hence, it should be periodically checked and should not be prescribed to patients with liver disease.
Does it cause hypos (hypoglycaemia)?
It does not cause low blood sugar when taken on its own. If you are taking any other medicines for diabetes, your doctor may recommend reducing the dose.
REFERENCES
1. KD Tripathi MD. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 277.
2. Powers AC, D’Alessio D. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page- 1259 - 1261.
3. Nolte MS. Pancreatic hormones and antidiabetic drugs. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 742 - 743.
4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1124 - 1125.
5. Mylan Hungary Kft. Electronic Medicines Compendium (EMC); [Revised Aug 2016] [Accessed Oct 9, 2020] https://www.medicines.org.uk/emc/files/pil.8836.pdf
6. Takeda Pharmaceuticals America, Inc. 1999, U.S. Food & Drug Administration; [Revised July 2011] [Accessed Oct 9, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021073s043s044lbl.pdf
8. Rishi Shukla and Sanjay Kalra. Pioglitazone: Indian perspective: Indian journal of endocrinology and metabolism. 2011, [Accessed Oct 9, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193778/
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