PIOGLIZONE M 15 Tablet 10's

Diabetes Rx required

Best Price* ₹ 76.00 MRP ₹ 95.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: PREVEGO HEALTHCARE & RESEARCH PRIVATE LIMITED * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

PIOGLIZONE M 15 is a combination of Metformin and Pioglitazone which belongs to the group of medicine called Antidiabetic agents. PIOGLIZONE M 15 is indicated as a second line therapy for the treatment of Type II diabetes mellitus in adult patients when diet, exercise and therapy with other single agents does not result in adequate glycemic control. Type II diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue, and blurred vision.   

Metformin is a biguanide which effectively reduces the amount of sugar released into the blood by the liver and pioglitazone is a thiazolidinedione which regulates the level of glucose in the body by improving insulin sensitivity, thus leading to enhanced cellular uptake of glucose and better glycemic control. Along treatment with PIOGLIZONE M 15, follow regular exercise and diet plan as advised by your doctor to achieve better results. Before and during therapy with PIOGLIZONE M 15, your doctor might recommend you have several blood tests to check your liver functions and would monitor your body weight to rule out unwanted side effects.  

Stop taking PIOGLIZONE M 15 and inform your doctor if you did not notice any improvements even after using this medicine for 3-6 months. PIOGLIZONE M 15 is strictly not recommended for use in pregnant or breastfeeding women, and in patients with active bladder cancer or hematuria (blood in urine). Consult your doctor before taking PIOGLIZONE M 15. It should be used with extreme caution in elderly patients due to risk of bladder cancer, heart failure or bone fracture. The most common side effects of taking PIOGLIZONE M 15 are upper respiratory tract infections, headache, weight gain, changes in taste, nausea, vomiting, diarrhea, or stomach pain. Contact your doctor if any of the symptoms worsen.

USES OF PIOGLIZONE M 15

  • Treats type II diabetes mellitus (as second line of therapy)

HOW PIOGLIZONE M 15 WORKS

PIOGLIZONE M 15 helps to control blood sugar levels, where metformin works by reducing the amount of glucose released into the blood by the liver and pioglitazone acts by improving insulin sensitivity, thus leading to enhanced utilization of glucose in the peripheral organs and better glycemic control.

DIRECTIONS FOR USE

Always take PIOGLIZONE M 15 as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Do not stop taking PIOGLIZONE M 15 without informing your doctor.

SIDE EFFECTS OF PIOGLIZONE M 15

COMMON

  • signs of upper respiratory tract infection (cough, sore throat, chest tightness, or wheezing)
  • anemia
  • hypo-aesthesia (diminished sense of touch)
  • headache
  • visual disturbance
  • arthralgia (joint pain), back pain
  • erectile dysfunction
  • blood in urine (hematuria)
  • weight gain
  • nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
  • taste disturbance
  • numbness

UNCOMMON

  • difficulty sleeping
  • inflammation of sinus (sinusitis)
  • flatulence

RARE

Stop taking PIOGLIZONE M 15 and contact your doctor immediately if you experience any of the following side effects:

  • serious allergic reaction (such as skin rash, itching, swelling of the face, lips, mouth, tongue or throat, difficulty in swelling or breathing)
  • symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty in breathing, muscle cramps, general weakness with severe tiredness or reduced body temperature)
  • signs of liver inflammation (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
  • signs of heart failure (such as unusual shortness of breath, rapid increase in body weight or localized swelling)
  • signs of kidney problems (such as hematuria or bladder cancer)
  • hypoglycemia (decreased blood glucose level)
  • bone fracture
  • blurred vision due to swelling at the back of the eye

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

Loss of appetite:

Eat when you are hungry. Try to eat smaller meals more often than usual. Snack only when you're hungry. Try to eat a nutritious snack that is high in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

PREGNANCY

PIOGLIZONE M 15 is not recommended for use in pregnant women. Consult your doctor before taking PIOGLIZONE M 15.

BREASTFEEDING

PIOGLIZONE M 15 is not recommended for use during breastfeeding as it is not known whether it may be present in the breast milk. Consult your doctor before taking PIOGLIZONE M 15.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected after taking PIOGLIZONE M 15 and should be alerted about the risk of low blood sugar levels before performing activities which requires mental attention.

ALCOHOL

Avoid consumption of alcohol while taking PIOGLIZONE M 15 due to increased risk of lactic acidosis.

KIDNEY

PIOGLIZONE M 15 is strictly not recommended for use in patients with kidney diseases (such as kidney failure, kidney dysfunction, hematuria (blood in urine), bladder cancer or a history of bladder cancer). Consult your doctor before taking PIOGLIZONE M 15.

LIVER

PIOGLIZONE M 15 is not recommended for use in patients with active liver disease. Consult your doctor before taking PIOGLIZONE M 15.

ALLERGY

Do not take PIOGLIZONE M 15 if you are allergic to Metformin or Pioglitazone.

LUNGS

PIOGLIZONE M 15 is not recommended for use in patients with infection affecting the lungs. Consult your doctor before taking PIOGLIZONE M 15.

HEART DISEASE

PIOGLIZONE M 15 is not recommended for use in patients with severe heart disease (such as grade III-IV heart failure, recent myocardial infarction, stroke, edema, or circulatory failure. Consult your doctor before taking PIOGLIZONE M 15.

OTHERS

PIOGLIZONE M 15 is not recommended for use if you:

  • have acute alcohol intoxication (abnormal behavior during or after alcohol consumption) or alcoholism
  • have diabetic pre-coma
  • have diabetic ketoacidosis (a diabetic complication causing nausea, vomiting, stomach pain and rapid weight loss)
  • have severe dehydration (either due to vomiting, diarrhea, or shock)
  • have severe infection
  • are scheduled for X-ray or scan using iodination contrast agents
  • have an upcoming major surgery

Before taking PIOGLIZONE M 15 inform you doctor if you:

  • have or had a previous history of smoking
  • had previous irradiation of the pelvic region
  • are receiving chemotherapy or radiotherapy
  • have macular oedema (swelling of the back of the eye with worsening of the vision)
  • have polycystic ovary syndrome (presence of cysts on your ovaries)
  • are fasting or malnourished

Use in pediatrics:

PIOGLIZONE M 15 is generally not recommended for use in children and adolescents (under 18 years) due to lack of safety data and increased risk of serious side effects. Consult your doctor before taking PIOGLIZONE M 15

Use in geriatrics:

PIOGLIZONE M 15 should be used with extreme caution in elderly patients (65 years or above) due to risk of bladder cancer, heart failure, and bone fracture. Proper dose adjustments and careful monitoring are required in such patients. Consult your doctor before taking PIOGLIZONE M 15.

INTERACTIONS

A. Drug-Drug interactions:

Before taking PIOGLIZONE M 15 inform to your doctor, if you are taking any of these medicines:

  • other medicines used to treat diabetes (Ex. insulin, glipizide, glyburideglimepiride)
  • cyclophosphamide (a medicine used to treat certain types of cancer)
  • non-steroidal anti-inflammatory drugs and COX-2-inhibitors (used to treat pain) Ex. celecoxib, etoricoxib or ibuprofen
  • gemfibrozil (a medicine used to lower blood cholesterol level)
  • rifampicin (a medicine used to treat tuberculosis)
  • corticosteroids (used to treat inflammation) Ex. dexamethasone, prednisolone
  • sympathomimetic agents (used to treat circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine
  • diuretics (medicines used to increase urine output) Ex. furosemide, chlorothiazide, hydrochlorothiazide
  • ACE inhibitors such as captopril, perindopril, and angiotensin II receptor antagonists such as azilsartan, losartan (used to treat low blood pressure)
  • beta-2 agonists such as salbutamol or terbutaline (used to treat asthma)
  • cimetidine (used to treat stomach ulcers)
  • dolutegravir (used to treat HIV infection)
  • ranolazine (used to treat chest pain)
  • trimethoprim (used to treat bacterial infections)
  • isavuconazole (used to treat fungal infections)
  • crizotinib (used to treat non-small cell lung cancer)
  • olaparib (used to treat ovarian cancer)

Overdosage:

If you or anyone else take too much of PIOGLIZONE M 15, contact your doctor immediately or go to a nearest hospital straight away as it could lead to severe hypoglycemia or lactic acidosis. Symptoms of lactic acidosis might include nausea, vomiting, stomach pain with muscle cramps, decreased heartbeat, general weakness with severe tiredness, difficulty in breathing or reduced body temperature.

SYNOPSIS

Drug :   Metformin, Pioglitazone
Pharmacological Category :   Antidiabetic agents
Therapeutic Indication :   Type II diabetes mellitus
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep PIOGLIZONE M 15 out of reach of children
  • Store at room temperature

FAQs ABOUT PIOGLIZONE M 15

Can I consume alcohol while taking PIOGLIZONE M 15?

No. Avoid consumption of alcohol while taking PIOGLIZONE M 15 since it may increase the risk of lactic acidosis. Also, prior to the treatment with PIOGLIZONE M 15, please inform your doctor if have a history of alcoholism or acute alcohol intoxication as a precaution.

Can you crush PIOGLIZONE M 15?

Take PIOGLIZONE M 15 with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Do not stop taking PIOGLIZONE M 15 without informing your doctor.    

Is PIOGLIZONE M 15 safe to use in elderly patients?

Yes. PIOGLIZONE M 15 should be used with extreme caution in elderly patients (65 years or above) due to risk of bladder cancer, heart failure, and bone fracture. Proper dose adjustments and careful monitoring are required in such patients. Consult your doctor before taking PIOGLIZONE M 15.   

Can PIOGLIZONE M 15 be taken during pregnancy?

PIOGLIZONE M 15 is not recommended for use in pregnant women. If you are pregnant or planning to get pregnant, consult your doctor for advice before taking PIOGLIZONE M 15.

Can PIOGLIZONE M 15 cause weight gain?

Yes. PIOGLIZONE M 15 may cause weight gain in some individuals, although not everybody gets them. To manage your weight, avoid eating fatty foods and stick on to the regular diabetic diet as advised by your physician. Try to exercise more regularly, for example, by going for a daily walk or run. While taking PIOGLIZONE M 15, if you experience any other symptom like abnormal heartbeat, shortness of breath, or edema along with a sudden rapid weight gain, contact your doctor immediately as it could be a sign of heart failure.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275-277.

2. Gerald G. Briggs and Roger K. Freeman. P and M. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3514-3515 & 2451-2456.

3. Takeda. Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in July 2011] [Accessed on16th October 2021] https://clinicaltrials.gov/ct2/show/study/NCT00727857

4. Antonio Ceriello, Don Johns, Mario Widel, David J Eckland, Kathryn J Gilmore, Meng H Tan. Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2005. [Accessed on 16th October 2021] https://pubmed.ncbi.nlm.nih.gov/15677777/

5. Kohei Kaku. Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2009. [Accessed on 16th October 2021] https://pubmed.ncbi.nlm.nih.gov/19309251/

6. TORRENT PHARMACEUTICALS LTD. PIOPOD MF Pioglitazone and Metformin Hydrochloride (Extended Release) Tablets. [Revised in January 2016] [Accessed on 16th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1851.pdf

7. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2016] [Accessed on 16th October 2021] https://www.medicines.org.uk/emc/files/pil.8836.pdf

8. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 16th October 2021] https://www.medicines.org.uk/emc/files/pil.11950.pdf

USEFUL DIAGNOSTIC TESTS

  • Glucose - Fasting Blood
  • Glucose - Postprandial Blood
  • Glycosylated Hemoglobin

PRODUCT DETAILS

    Country Of Origin
    India
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PIOGLIZONE M 15 Tablet 10's

PIOGLIZONE M 15 Tablet 10's Mkt: PREVEGO HEALTHCARE & RESEARCH PRIVATE LIMITED

M.R.P.: Rs.95.00
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