INTRODUCTION

PIGOLYN CREAM contains Trioxsalen which belongs to the group of medicines called Photosensitizers. It is used in the treatment of vitiligo (a pigmentation disorder of the skin that causes loss of skin color in patches) along with ultraviolet (UV) light and to increase the tolerance of the skin from the sunlight.

Trioxsalen works by photosensitization of the skin when exposed to UV or sunlight which is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue (reduces the abnormal cells and re-pigments the discolored skin).

After photoactivation it creates cross-links in DNA, which can cause programmed cell death. Your doctor may recommend you take relevant tests to understand your existing condition.

Before using PIGOLYN CREAM inform your doctor if you have had an allergy or disease condition. Consult your doctor for advice.

Safety and effectiveness of PIGOLYN CREAM in pregnant, breastfeeding women and children has not been established yet. Consult your doctor before using.

The most common side effects are erythema (skin redness), blisters on skin, edema (swelling), itching. Consult your doctor or visit a nearby hospital if you experience any unusual symptoms.  

USES OF PIGOLYN CREAM

• Used to treat vitiligo

HOW PIGOLYN CREAM WORKS

PIGOLYN CREAM works by photosensitization of the skin when exposed to UV or sunlight which reduces the abnormal cells and re-pigments the discolored skin. As a result, it treats depigmented skin.

DIRECTIONS FOR USE

Always use PIGOLYN CREAM as directed by your physician. It is for external use only. Apply a thin layer of this medicine to the affected area. Your doctor will decide the right dose and duration for you depending on your age and disease condition.

SIDE EFFECTS OF PIGOLYN CREAM

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before using PIGOLYN CREAM, inform your doctor if you are taking or using any medicines, with prescription, non-prescription or herbal medicines.

Overdosage:

If you or anyone else accidentally applied more of PIGOLYN CREAM, contact your doctor immediately or visit a nearby hospital immediately if the symptoms worsen.

SYNOPSIS

MORE INFORMATION

• Keep out of reach from children
• Store at room temperature

FAQs ABOUT PIGOLYN CREAM

What is PIGOLYN CREAM used for?

It is used in the treatment of vitiligo (a pigmentation disorder of the skin that causes loss of skin color in patches) along with ultraviolet (UV) light and to increase the tolerance of the skin from the sunlight.

How does [GBNKWYORD] works?

PIGOLYN CREAM works by photosensitization of the skin when exposed to UV or sunlight which reduces the abnormal cells and re-pigments the discolored skin. As a result, it treats depigmented skin.

How to use PIGOLYN CREAM?

Always use PIGOLYN CREAM as directed by your physician. It is for external use only. Apply a thin layer of this medicine to the affected area. Consult your doctor for more information.

Can PIGOLYN CREAM cause side effects?

Yes. PIGOLYN CREAM can cause include itching, irritation and nausea, blistering, redness, rash and swelling, dizziness, if any of the above side effects worsen consult your doctor immediately.

Is PIGOLYN CREAM used along with UV light?

Yes. PIGOLYN CREAM is used along with UV light to treat vitiligo (a pigmentation disorder of the skin that causes loss of skin color in patches). With the help of UV light PIGOLYN CREAM activates itself and enhances cell death.

REFERENCES

1. KD. Tripathi. Miscellaneous drugs. Essentials of medical pharmacology. 8th Edition. 2019. Page – 950.

2. O P Salo, A Lassus, J Taskinen. NIH National Library of Medicine, National center for biotechnology information. Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results. Pubmed.gov 1981. [Accessed on 23rd July 2022] https://pubmed.ncbi.nlm.nih.gov/6177169/

3. M Hannuksela, J Karvonen. NIH National Library of Medicine, National center for biotechnology information. Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. Pubmed.gov December 1978. [Accessed on 23rd July 2022] https://pubmed.ncbi.nlm.nih.gov/737133/

4. DrugBank. Trioxsalen. [Revised on September 2007] [Accessed on 23rd July 2022] https://go.drugbank.com/drugs/DB04571

5. Canbro healthcare. Tribel. (Trioxsalen 0.2%). [Accessed on 23rd July 2022] https://www.canbro.in/product/trioxsalen-0-2

6. Albatross pharma. Trioxen lotion. (Trioxsalen 0.2%). [Accessed on 23rd July 2022] http://www.albatrosspharma.com/PDFs/Trioxen.pdf