Availability & Expiry
INTRODUCTION
PHENPRES INJECTIONcontains Phenylephrine which belongs to the group of medicines called Anti-hypotensive agents. It is used in adults and children to relieve low blood pressure which may occur during an operation.
PHENPRES INJECTION is not recommended for use in patients with high blood pressure, overactive thyroid (hyperthyroidism), prostatic enlargement. Consult your doctor before receiving it.
PHENPRES INJECTION should be used with caution in patients with liver, kidney, heart disease, diabetes mellitus. Consult your doctor before receiving it.
PHENPRES INJECTION should be used during pregnancy only if it is considered clearly necessary. It should be used with caution in breastfeeding women. Consult your doctor before using it.
PHENPRES INJECTION should be used with caution in children and in elderly patients. Consult your doctor before receiving it. Inform your doctor if you experience any side effects after receiving PHENPRES INJECTION.
USES OF PHENPRES INJECTION
- To relieve low blood pressure
HOW PHENPRES INJECTION WORKS
PHENPRES INJECTION is an alpha-1 adrenergic agonist and after injection it produces peripheral vasoconstriction (narrowing of blood vessels), leading to increased blood pressure.
DIRECTIONS FOR USE
PHENPRES INJECTION will be given to you only by a doctor as an injection into the muscle (intramuscular injection) or just under the skin (subcutaneous injection) or into a vein (intravenous injection). Your doctor will decide the correct dosage and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF PHENPRES INJECTION
RARE
Stop receiving PHENPRES INJECTION and contact your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (itching/rash, swelling of your face, lips or throat or difficulty in breathing/ wheeziness)
- chest pain, irregular heartbeat, feeling the heart pumping in the chest
- bleeding in the brain (speech disorder, dizziness, paralysis of one side of the body)
- psychosis (losing contact with reality)
WARNING & PRECAUTIONS
PREGNANCY
PHENPRES INJECTION should be used during pregnancy only if it is considered clearly necessary. Consult your doctor before receiving it.
PHENPRES INJECTION should be used with caution in women with a history of pre-eclampsia (complicated pregnancy). Administration of PHENPRES INJECTION in late pregnancy or labour may cause fetal hypoxia (decreased oxygen supply to unborn baby) and bradycardia (slow heart rate). Consult your doctor before receiving it.
BREASTFEEDING
PHENPRES INJECTION should be used with caution in breastfeeding women as it is not known whether this medicine passes into breast milk. Consult your doctor before using it.
DRIVING AND USING MACHINES
PHENPRES INJECTION does not affect your ability to drive or use machines. However, if you feel unwell you must contact your doctor before driving or operating machinery.
KIDNEY
PHENPRES INJECTION should be used with caution in patients with kidney disease and may require dose adjustment. Consult your doctor before receiving it.
LIVER
PHENPRES INJECTION should be used with caution in patients with liver disease and may require dose adjustment. Consult your doctor before receiving it.
HEART DISEASE
PHENPRES INJECTION is not recommended for use in patients with high blood pressure. It should be used with caution in patients with heart conditions such as ischemic heart disease, arrhythmia (irregular heartbeats), angina pectoris (chest pain), partial heart block, occlusive vascular disease (poor blood circulation) or aneurysms (bulging of blood vessels) and serious heart failure. Consult your doctor before receiving it.
OTHERS
PHENPRES INJECTION is not recommended for use if:
- you have an overactive thyroid (hyperthyroidism)
- you have prostatic enlargement
- the anterior chamber of your eye is shallow
- you have a history of acute increase of eye pressure (acute narrow-angle glaucoma)
Before receiving PHENPRES INJECTION, inform your doctor if:
- you have diabetes mellitus
- you have diabetic autonomic neuropathy (a complication of diabetes mellitus)
- you have arteriosclerosis (hardening and thickening of the walls of the blood vessels)
- you have poor blood circulation in the brain
- you have closed-angle glaucoma (increased eye pressure)
Use in pediatrics:
PHENPRES INJECTION should be used with caution in children. Consult your doctor before receiving it.
Use in geriatrics:
PHENPRES INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.
INTERACTIONS
A. Drug - Drug interactions:
Before receiving PHENPRES INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used for depression (Ex. amitriptyline, iproniazid, nialamide, moclobemide, toloxatone, imipramine, milnacipran or venlafaxine)
- medicines used to treat high blood pressure, heart problems (Ex. atenolol, bisoprolol, lisinopril, furosemide, quinidine, losartan, spironolactone, nifedipine, reserpine, guanfacine, labetalol, guanethidine, digoxin)
- general anesthetics Ex. propofol, desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane (medicines used in anesthesia)
- medicines used to treat attention-deficit hyperactivity disorder (ADHD) Ex. atomoxetine
- antimuscarinics (Ex. atropine) to treat slow heart rate
- lithium (used to treat depression or aggression)
- steroids (used to treat inflammatory conditions) Ex. hydrocortisone
- ergot alkaloids such as methylergonovine maleate (used to treat or prevent bleeding from the uterus)
- oxytocin (used to induce labor)
- alpha adrenergic antagonist Ex. doxazosin (used to treat benign prostate hypertrophy)
- phosphodiesterase Type 5 inhibitors Ex. sildenafil (used to treat erectile dysfunction)
- benzodiazepines (used to treat anxiety and panic disorders) Ex. alprazolam
- medicine used to treat bacterial infections (Ex. linezolid)
- medicines used to treat migraine (Ex. dihydroergotamine, ergotamine, methylergometrine, methylsergide)
- medicines used to treat Parkinson disease (Ex. bromocriptine, lisuride, pergolide)
- medicine used to inhibit the production of a hormone responsible of lactation (Ex. cabergoline)
- medicine used as an appetite suppressant (Ex. sibutramine)
Overdosage:
PHENPRES INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like headache, nausea, vomiting, high blood pressure, a fast or irregular heartbeat, confusion, a sensation of fullness in the head, tingling of the hands and feet, hallucinations and fits.
SYNOPSIS
| Drug | : | Phenylephrine |
| Pharmacological Category | : | Alpha-1 adrenergic agonist |
| Therapeutic Indication | : | To relive low blood pressure |
| Dosage Forms | : | Tablet, Injection, Eye drops, Syrup |
MORE INFORMATION
- Keep PHENPRES INJECTION out of reach of children
- Store either in a refrigerator or at room temperature (2°C - 25°C)
FAQs ABOUT PHENPRES INJECTION
Q: Can PHENPRES INJECTION be used in pregnancy?
A: PHENPRES INJECTION should be used during pregnancy only if it is considered clearly necessary. PHENPRES INJECTION should be used with caution in women with a history of pre-eclampsia (complicated pregnancy). Administration of PHENPRES INJECTION in late pregnancy or labor may cause fetal hypoxia (decreased oxygen supply to unborn baby) and bradycardia (slow heart rate). Consult your doctor before receiving it.
Q: Who should not use PHENPRES INJECTION?
A: PHENPRES INJECTION is not recommended for use in patients with high blood pressure, overactive thyroid (hyperthyroidism), prostatic enlargement or of the anterior chamber of your eye is shallow, history of acute narrow angle glaucoma (acute increase of eye pressure) and allergic history to phenylephrine. Contact your doctor before receiving it.
Q: Is PHENPRES INJECTION safe for heart patients?
A: PHENPRES INJECTION should be used with caution in patients with heart conditions such as ischemic heart disease, arrhythmia (irregular heartbeats), angina pectoris (chest pain), partial heart block, occlusive vascular disease (poor blood circulation) or aneurysms (bulging of blood vessels) and serious heart failure. Consult your doctor before receiving it.
Q: How PHENPRES INJECTION is given?
PHENPRES INJECTION will be given to you only by a doctor as an injection into the muscle (intramuscular injection) or just under the skin (subcutaneous injection) or into a vein (intravenous injection). Your doctor will decide the correct dosage and duration for you depending on your age, body weight and disease condition.
Q: What are the side effects of PHENPRES INJECTION?
A: The most common reported side effects of receiving PHENPRES INJECTION during treatment are nausea, vomiting, headache, nervousness. Contact your doctor if any of the symptoms worsen.
REFERENCES
1. KD Tripathi. Adrenergic Transmission and Adrenergic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 148.
2. Young Hoon Park, Taeha Ryu, Seong Wook Hong, Kyung Hwa Kwak, Si Oh Kim. The effect of the intravenous phenylephrine on the level of spinal anesthesia. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. November 2011. [Accessed on 22nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229014/
3. Paul J Desjardins and Roger G Berlin. Efficacy of phenylephrine. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. July 2007. [Accessed on 22nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048561/
4. Amdipharm UK Limited. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 22nd August 2022] https://www.medicines.org.uk/emc/files/pil.5577.pdf https://www.medicines.org.uk/emc/product/5577/smpc
5. LABORATOIRE AGUETTANT. Electronic Medicines Compendium (EMC). [Revised in November 2015] [Accessed on 22nd August 2022] https://www.medicines.org.uk/emc/files/pil.1970.pdf, https://www.medicines.org.uk/emc/product/1970/smpc
6. Fresenius Kabi. Phenylephrine. [Revised in March 2018] [Accessed on 22nd August 2022] http://editor.fresenius-kabi.us/PIs/US-PH-Phenylephrine_FK-451580_Mar_2018-PI.pdf
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