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MRP ₹32.02
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INTRODUCTION

PERINORM contains Metoclopramide which belongs to a group of medicines called anti-emetics. It is used to prevent delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy) and also treats nausea and vomiting which occurs with a migraine. This medicine works on a part of your brain that prevents you from nausea and vomiting.   

Metoclopramide acts by opposing the effect of dopamine in the central nervous system and other organ systems. This action helps to reduce feelings of sickness (nausea) and helps to stop vomiting.

PERINORM will be administered by your doctor or nurse. Before receiving this medicine, tell your doctor if you have or had any kidney, liver or heart impairment, epilepsy or bleeding disorders. Pregnant and breastfeeding mothers consult your doctor before using the medicine. It is not advisable for use in children below 1 year of age because it may increase the uncontrollable movements. The common side effects are drowsiness, uncontrollable movements, restlessness and weakness. Do not drive or handle any machines that require mental attention.

USES OF PERINORM

  • Prevents delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy)
  • Treats nausea and vomiting which occurs with a migraine

HOW PERINORM WORKS

PERINORM works by blocking a natural substance (dopamine) in the brain that controls vomiting and helps to speed the movement of food through the stomach and intestines, by stimulating the muscles of the gastrointestinal tract.

DIRECTIONS FOR USE

PERINORM will be administered as a slow injection into a vein (over at least 3 minutes) or by injection into a muscle by your doctor or nurse.

SIDE EFFECTS OF PERINORM

SERIOUS

  • uncontrollable movements (involves head or neck)
  • high fever, increase in blood pressure, convulsions, sweating, production of saliva
  • itching, skin rashes, swelling of the face, lips or throat, breathing difficulty

COMMON

  • drowsiness
  • depression
  • rigidity, tremors
  • uncontrollable movements 
  • restlessness
  • diarrhoea
  • weakness

RARE

  • confusional state
  • convulsion (especially in patients with epilepsy)

HOW TO MANAGE SIDE EFFECTS

Drowsiness:

Get up and move around to feel awake, take naps and give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS also can be used to prevent dehydration.

WARNING & PRECAUTIONS

PREGNANCY

If necessary, PERINORM will be given during pregnancy. Your doctor will weigh the benefits and any potential risks before giving it to you. Consult your doctor for advice.

BREASTFEEDING

PERINORM is not recommended if you are breast-feeding because it may pass into breast milk and affect your baby. Consult your doctor for advice.

DRIVING AND USING MACHINES

Do not drive or handle any machines if you experience drowsiness, dizziness or having uncontrollable twitching, jerking or writhing movements and unusual muscle tone causing distortion of the body or vision problems.

ALCOHOL

Alcohol should not be consumed during treatment with PERINORM because it may increase the sedative effects.

KIDNEY

PERINORM should be used with caution in patients suffering from kidney diseases, if needed dose will be adjusted accordingly. Consult your doctor for advice.

LIVER

PERINORM should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Tell your doctor if you are allergic (hypersensitive) to Metoclopramide.

HEART DISEASE

PERINORM should be used with caution in patients with abnormal heart beats. Consult your doctor for advice.

OTHERS

Tell your physician before taking this medicine, if you have or had,

  • bleeding, obstruction, tear in your stomach 
  • tumour of the adrenal gland 
  • involuntary muscle spasms 
  • epilepsy
  • parkinson’s disease
  • abnormal blood pigment levels or NADH cytochrome-b5 deficiency
  • increase in salt level in blood
  • neurological problems
  • porphyria (inherited blood disease)

INTERACTIONS

Tell your doctor if you are taking,

  • levodopa (treats Parkinson’s disease)
  • anticholinergics (relieves stomach cramps and spasms)
  • morphine derivatives (treats severe pain)
  • sedative medicines
  • medicines used for mental health problems
  • digoxin (treats heart failure)
  • cyclosporine (treats problems with the immune system)
  • mivacurium, suxamethonium (used to relax muscles)
  • fluoxetine and paroxetine (treats depression)
  • atovaquone (treats pneumonia)
  • neuroleptic medicines (used for mental illness, nausea and vomiting)
  • aspirin, paracetamol or opioids (treats pain)

SYNOPSIS

Drug :   Metoclopramide
Pharmacological Category :   Anti-emetics
Therapeutic Indication :   Treats nausea and vomiting
Dosage Forms :   Tablet, Capsule, Injection, Syrup

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT PERINORM

What is PERINORM used for?

It is used to prevent delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy) and also treats nausea and vomiting which occurs with a migraine.

How long does PERINORM last?

The onset of pharmacological action of this medicine is 1 to 3 minutes following an intravenous dose, 10 to 15 minutes following intramuscular administration.

Can PERINORM cause sleepiness?

It may cause drowsiness in some individuals, consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. 5-HT, its antagonists and drug therapy of migraine. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013.Page –177.

2. Sasank Isola, Azhar Hussain, Anterpreet Dua, Karampal Singh and Ninos Adams. Metoclopramide. April 19, 2021. [Accessed on Sep 21, 2021] https://www.ncbi.nlm.nih.gov/books/NBK519517/

3. Ismet Parlak, Bulent Erdur, Mine Parlak, Ahmet Ergin, Ibrahim Turkcuer, Onder Tomruk, Cuneyt Ayrik, and Nesrin Ergin. Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects? [Published on Oct, 2007] [Accessed on Sep 21, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600133/

4. Hameln pharma Ltd. Siegfried Hameln GmbH. Electronic Medicines Compendium (EMC); [Revised on July, 2020] [Accessed on Sep 21, 2021] https://www.medicines.org.uk/emc/files/pil.6283.pdf

5. Sandoz Canada Inc. [Revised on Nov 18, 2014] [Accessed on Sep 21, 2021] https://www.sandoz.ca/sites/www.sandoz.ca/files/Metoclopramide%20HCl%20PMe%2020141118.pdf

6. Drugs.com. Metoclopramide. [Accessed on Sep 21, 2021] https://www.drugs.com/ppa/metoclopramide.html

PRODUCT DETAILS

    Net Qty
    1
    Shelf Life
    24 months
    Item Weight
    30
    Ingredient
    Metoclopramide Hydrochloride 5 MG
    Hsn Code
    30049035
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Perinorm Injection 20ml

Perinorm Injection 20ml Mkt: Ipca Laboratories Ltd

M.R.P.: Rs.32.02
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