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MRP ₹60.90
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INTRODUCTION

PENTASA contains mesalamine (mesalazine) which belongs to the group of medicines called salicylates. It is an anti-inflammatory drug used to treat and prevent mild-to-moderate Ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease in which the lining of the bowel, colon and rectum are inflamed and develops tiny breaks in its surface (ulcers) which may bleed.

PENTASA act locally in the colon and rectum and reduce inflammation. It can also prevent further episodes (flares) of ulcerative colitis. Along with this treatment, your doctor might recommend you, to avoid smoking and alcohol consumption, stick to simple meals and to drink plenty of water. Prior to the treatment, your doctor might take blood and urine test to access the function of your kidneys.

Open the foil sachet and empty the contents onto the tongue. Wash the granules down the throat immediately with some water or orange juice, ensuring that none remain in the mouth. Do not crush or chew the granules. Avoid concomitant use of PENTASA with other anti-inflammatory disease because it can increase the risk of side effects. On the course of treatment, regular monitoring of your liver, kidney and blood is required, to avoid any unwanted or toxic effects. If you are pregnant or think you may be pregnant, or breastfeeding inform your doctor before taking this medicine. The most common side effect of taking this medicine is abdominal pain, nausea, vomiting, bloating and headache.

USES OF PENTASA

  • Treats and prevents mild-to-moderate Ulcerative colitis

HOW PENTASA WORKS

PENTASA inhibits the production of prostaglandins (lipid compounds which produces tissue damage and inflammation) by blocking the activity of cyclooxygenase and lipoxygenase. Decreased production of prostaglandins reduces the inflammation in the colon and rectum, which in turn reduces the symptoms associated with ulcerative colitis.

DIRECTIONS FOR USE

Take PENTASA as directed by your physician. Your doctor will decide the correct dose and duration for you depending upon your condition. Open the foil sachet and empty the contents onto the tongue. Wash the granules down the throat immediately with some water or orange juice, ensuring that none remain in the mouth. Do not crush or chew the granules. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF PENTASA

SERIOUS

  • allergic reactions (such as skin rash, itching, shortness of breath, swelling of the face, lips or throat, increased heartbeat or chest pain)

COMMON

  • diarrhea
  • abdominal pain
  • nausea or vomiting
  • wind (bloating)
  • headache
  • rash

RARE

  • inflammation of pancreas (with back or stomach pain)
  • inflammation of heart (e.g. shortness of breath, chest pain and abnormal heartbeat)
  • dizziness
  • flatulence

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal and stick to simple meals. Do not eat rich or spicy food.

Diarrhea:

Drink lots of fluids to avoid dehydration. Avoid taking any medicines for diarrhoea without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Bloating or wind:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor straight away.

WARNING & PRECAUTIONS

PREGNANCY

PENTASA should not be used in pregnant women unless clearly necessary. Consult your doctor before taking this medicine.

BREASTFEEDING

PENTASA should not be used in breastfeeding mothers unless clearly necessary. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

Do not take PENTASA if you have a severe kidney impairment. Consult your doctor for advice.

LIVER

PENTASA should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to mesalazine (mesalamine), aspirin or other salicylates.

LUNGS

PENTASA should be taken with caution in patients with lung disease. Consult your doctor for advice.

OTHERS

Do not take this medicine, if you:

  • have stomach ulcers with or without bleeding in the gut

INTERACTIONS

Talk to your doctor, if you are taking,

  • non-steroidal anti-inflammatory drugs (such as ibuprofen, aspirin, celecoxib)
  • azathioprine (used to treat severe rheumatoid arthritis)
  • 6-mercaptopurine or thioguanine (used to treat cancer)
  • medicines that stops blood clotting (e.g. warfarin)

SYNOPSIS

Drug :  

Mesalazine (mesalamine/5-amino salicylic acid)

Pharmacological Category :   Salicylates, 5-Amino salicylic acid derivative
Therapeutic Indication :  

Ulcerative colitis

Dosage Forms :   Tablet, Powder, Enema, Pellet

MORE INFORMATION

Store at room temperature and keep out of reach of children.

FAQs ABOUT PENTASA

Can PENTASA be taken with juice?

Yes. This medicine can be taken with water or orange juice.

Can PENTASA cause flatulence?

This medicine may cause flatulence in some individuals, although not everybody gets them. Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor straight away.

REFERENCES

1. KD Tripathi. Drugs for Constipation and Diarrhoea. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 684.

2. Tilo Grosser, Emer Smyth and Garret A. Fitzgerald. Anti-inflammatory, Antipyretic, and analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 12 Edition. New York Mc Graw Hill Medical 2011. Page – 979.

3. Gerald G. Briggs, Roger K. Freeman. B. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 375-376.

4. Ferring Pharmaceuticals. Mesalamine 4 g Sachet for the Induction of Remission in Active, Mild to Moderate Ulcerative Colitis (UC). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2019] [Accessed 29th October 2020] https://clinicaltrials.gov/ct2/show/NCT02522767

5. Shire. Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects with Mild to Moderate Ulcerative Colitis (PACE). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2020] [Accessed 29th October 2020] https://clinicaltrials.gov/ct2/show/NCT02093663

6. Bei Ye and Daniel R van Langenberg. Mesalazine preparations for the treatment of ulcerative colitis: Are all created equal? NCBI; PMC National Library of Medicine, National Institute of Health. November 2015. [Accessed 29th October 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635154/

7. Ferring GmbH. Electronic Medicines Compendium (EMC); [Revised on June 2015] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/files/pil.6309.pdf

USEFUL DIAGNOSTIC TESTS

  • Anti Neutrophilic Cytoplasmic Antibody - P
  • Anti Saccharomyces Cerevisiae (ASCA), IgA
  • Anti Saccharomyces Cerevisiae (ASCA), IgG
  • C- Reactive Protein Quantitative
  • Erythrocyte Sedimentation Rate

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    10
    Ingredient
    MESALAZINE 1GM
    Hsn Code
    30049039
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Pentasa Powder 1gm

Pentasa Powder 1gm Mkt: Ferring Pharmaceuticals Pvt Ltd

M.R.P.: Rs.60.90
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