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INTRODUCTION
PAZINIB 200 contains pazopanib which belongs to the group of medicines called tyrosine kinase inhibitors. It is used to treat advanced kidney cancer or certain forms of soft-tissue sarcoma (a type of cancer that affects the supportive tissues of the body) in adults. It prevents the activity of proteins which are involved in the growth and spread of cancer cells. It can raise your blood pressure. So, inform your doctor if you are previously suffering from high blood pressure. Try taking this medicine at the same time each day. Take it at least 1 hour before or 2 hours after a meal. Avoid drinking grapefruit juice while taking this medicine.
Take PAZINIB 200 as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal. Before taking this medicine, inform your doctor if you are undergoing any operation. This medicine may affect fertility in both men and women and should not be used in pregnant or breastfeeding women and in children below 18 years of age. Do not drive or operate any machines if you feel dizzy, tired or weak, or if your energy levels are low. The common side effects such as diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite, weight loss, taste disturbance, sore mouth and headache.
USES OF PAZINIB 200
- Treats advanced kidney cancer or advanced soft-tissue sarcoma in adults
HOW PAZINIB 200 WORKS
PAZINIB 200 is a tyrosine kinase inhibitor which inhibits the activity of various growth factor receptors associated with angiogenesis and tumor cell proliferation. Following oral administration, it inhibits the activity of vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-alpha and -beta and c-kit and prevents the growth and spread of cancer cells.
DIRECTIONS FOR USE
Take PAZINIB 200 as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal. Try taking this medicine at the same time each day. Avoid drinking grapefruit juice while taking this medicine, which may increase the chance of side effects. Your doctor will decide the correct dose for you depending upon your condition. Do not stop taking this medicine, unless your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF PAZINIB 200
SERIOUS
- reversible posterior leukoencephalopathy syndrome (such as swelling of the brain with loss of speech, change of vision, seizure, confusion and high blood pressure)
- cardiovascular dysfunction (such as irregular heartbeat, fainting, chest pain, pain in arms, back, neck or jaw, shortness of breath, leg swelling and stroke)
- passing blood in stools or urine
- yellowing of skin or whites of eyes
- dark urine
- Tumor lysis syndrome
- infections (such as fever, flu-like symptoms)
COMMON
- high blood pressure
- diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite
- weight loss
- taste disturbance
- sore mouth
- headache
- tumor pain
- feeling weak or tired
- unusual hair loss or thinning
- loss of skin pigment, skin rash, redness and swelling of palms or soles
- slow heartbeat
- swelling of face, hands, ankles, feet or eyelids
- tingling, weakness or numbness of hands, arms, legs or feet
- unusual bleeding
- sensation of coldness and shivering
- excessive sweating
- dehydration
- muscle, joint or tendon pain
- coughing up blood
RARE
- pneumonitis (inflammation of lung)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try taking this medicine with or just after meal. Stick to simple meals. Do not eat rich or spicy food.
Bloating:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor immediately.
Diarrhea:
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
WARNING & PRECAUTIONS
PREGNANCY
PAZINIB 200 is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
PAZINIB 200 is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy, tired or weak, or if your energy levels are low.
ALCOHOL
Avoid consumption of alcohol while taking this medicine.
KIDNEY
PAZINIB 200 should be taken with caution in patients with kidney disease. Consult your doctor for advice.
LIVER
PAZINIB 200 should be taken with caution in patients with liver disease. Consult your doctor for advice.
ALLERGY
Do not take this medicine if you are allergic (hypersensitive) to pazopanib or any other ingredients in this medicine.
LUNGS
PAZINIB 200 should be taken with caution in patients who had prior collapse of a lung. Consult your doctor for advice.
HEART DISEASE
PAZINIB 200 should be taken with caution in patients with heart disease or have had heart failure or a heart attack previously. Consult your doctor for advice.
OTHERS
Before taking this medicine, inform your doctor if you haveor had:
- problems with bleeding, blood clots or narrowing of the arteries
- perforation or fistula in the bowel
- thyroid problems
INTERACTIONS
Talk to your doctor, if you are taking,
- medicines used to treat bacterial infection (e.g. clarithromycin, ketoconazole, itraconazole, rifampicin, telithromycin, voriconazole)
- medicines used to treat HIV infections (e.g. atazanavir, indinavir, nelfinavir, ritonavir, saquinavir)
- medicines used to reduce stomach acid (e.g. omeprazole, cimetidine, ranitidine, aluminium hydroxide)
- nefazodone (used to treat depression)
- statins (used to treat high cholesterol levels) e.g. simvastatin, atorvastatin, rosuvastatin
SYNOPSIS
| Drug | : | Pazopanib |
| Pharmacological Category | : | Anti-neoplastic agent, Tyrosine kinase inhibitor vascular endothelial growth factor receptor inhibitor |
| Therapeutic Indication | : | Advanced kidney cancer, Advanced soft-tissue sarcoma |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT PAZINIB 200
Can PAZINIB 200 cure cancer?
Yes. This medicine is used to cure advanced kidney cancer or soft-tissue sarcoma in adults.
Can PAZINIB 200 be taken with simvastatin?
No. Avoid concomitant use of simvastatin with this medicine, because it may increase the risk of side effects.
Can PAZINIB 200 be used in children?
No. This medicine is strictly not recommended for use in children below 18 years of age.
REFERENCES
1. Bruce A. Chabner, Jeffery Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades and Paul Richardson. Targeted therapies: Tyrosine kinase inhibitors, Monoclonal antibodies and Cytokines. Goodman & Gilman’s: The Pharmacological basics of therapeutics. 12th Edition. New York Mc Graw Hill Medical 2011. Page – 1739.
2. Gerald G. Briggs, Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation, Tenth Edition. Page – 3005-3006.
3. Novartis. Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to evaluate the efficacy and safety of VOTRIENT® (pazopanib) tablets in first-line or cytokine-pretreated patients (N=435) with advanced RCC of clear cell or predominantly clear cell histology. Clinical Trials Votrient. [Revised on August 2020] [Accessed 27th October 2020] https://www.novartis.us/sites/www.novartis.us/files/votrient.pdf
4. Novartis Pharmaceuticals. A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) (PROTECT). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2020] [Accessed 27th October 2020] https://clinicaltrials.gov/ct2/show/NCT01235962
5. David Cella and Jennifer L. Beaumont. Pazopanib in the treatment of advanced renal cell carcinoma. NCBI; PMC U.S. National Library of Medicine, National Institute of Health. February 2016 [Accessed 27th October 2019] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707425/#:~:text=In%20clinical%20trials%2C%20pazopanib%20has,sunitinib%20in%20this%20patient%20cohort.
6. Novartis Pharmaceuticals UK Ltd. [Revised on October 2020] 2016 [Accessed 27th October 2019] https://www.medicines.org.uk/emc/files/pil.572.pdf
7. GlaxoSmithKline. [Revised on October 2009] 2016 [Accessed 27th October 2019] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022465lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Biopsy
- Computerized tomography (CT) scan
- Magnetic resonance imaging (MRI)
- Positron emission tomography (PET) scan
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