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PASILOW 50 Capsule 5's
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INTRODUCTION
PASILOW 50 CAPSULE contains Cyclosporine which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells.
It can also be used to treat various auto-immune disease conditions such as psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis (joint inflammation), nephrotic syndrome (a kidney disease) or eye inflammation (such as endogenous uveitis, including Behçet's uveitis). It is mostly used in combination with other immune suppressants (such as azathioprine) to achieve maximum benefits.
Take PASILOW 50 CAPSULE regularly as instructed by your doctor. While undergoing therapy with PASILOW 50 CAPSULE your doctor will periodically monitor your blood pressure, blood cholesterol levels, liver and kidney functions to avoid the risk of side effects.
Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During treatment with PASILOW 50 CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
Before taking PASILOW 50 CAPSULE inform your doctor if you have any liver problems or any signs of infections (such as fever or sore throat). You must also inform your doctor if you have hepatitis C infection, fits, low blood magnesium levels, gout, alcohol dependence or if you are about to receive any vaccinations as a precaution.
PASILOW 50 CAPSULE is not recommended for use in patients with severe uncontrollable infections, any types of cancer or severe high blood pressure. Do not take PASILOW 50 CAPSULE without consulting your doctor if you are pregnant or breastfeeding.
Avoid consuming grapefruit or drinking grapefruit juice while taking PASILOW 50 CAPSULE as it may increase the risk of side effects. The most common side effects of taking PASILOW 50 CAPSULE are increase in blood sugar levels, increase in blood cholesterol levels, increased blood potassium levels, high blood pressure, headache, loss of appetite, acne, hot flushes, tiredness, excessive facial hair and low blood magnesium levels in blood. Consult your doctor if any of these side effects worsen.
USES OF PASILOW 50 CAPSULE
- Prevents graft rejection following organ transplantation
- Treats auto-immune skin diseases such as psoriasis or atopic dermatitis
- Treats rheumatoid arthritis (joint inflammation)
- Treat nephrotic syndrome (a kidney disease)
- Treats eye inflammation (such as endogenous uveitis, including Behçet's uveitis)
HOW PASILOW 50 CAPSULE WORKS
PASILOW 50 CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells, interleukins and cytokines) that triggers the immune response. This action suppresses your body’s immune functions and enables your body to accept the newly transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
DIRECTIONS FOR USE
Take PASILOW 50 CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PASILOW 50 CAPSULE without consulting your doctor.
SIDE EFFECTS OF PASILOW 50 CAPSULE
COMMON
- high blood pressure
- headache, shakiness
- nausea, vomiting, loss of appetite, stomach pain, diarrhoea
- acne, hot flushes, fever, tiredness
- excessive facial hair
- high blood cholesterol levels
- high blood sugar levels
- tingling sensation in the body
- muscle spasm, swollen gums
- high blood levels of uric acid or potassium
- low levels of magnesium in blood
UNCOMMON
- lack of sleep
- oedema, weight gain
RARE
- inflammation of the pancreas, severe upper stomach pain
- menstrual irregularities, breast enlargement in men
Stop taking PASILOW 50 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- signs of infections (such as fever or sore throat)
- signs of brain infection called progressive multifocal leukoencephalopathy (such as vision changes, loss of coordination, being clumsy, memory loss, problems in speaking or understanding, muscle weakness)
- brain problems (causing seizures, confusion, disorientation, lack of response, behavioural changes, agitation, sleeplessness, vision changes, paralysis, stiff neck, loss of coordination with or without unusual speech or eye movements)
- swelling at the back of the eye with blurred vision
- signs of liver problems (such as yellow skin and eyes, nausea, loss of appetite and dark urine)
- low urine output, kidney problems
- low level of red blood cells or platelets (causing pale skin, tiredness, breathlessness, having dark urine, bruising or bleeding with no obvious reasons, confusion, disorientation, being less alert and having kidney problems)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try to take PASILOW 50 CAPSULE with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
PASILOW 50 CAPSULE is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
BREASTFEEDING
PASILOW 50 CAPSULE may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding woman. However, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if your ability is affected by PASILOW 50 CAPSULE.
ALCOHOL
Avoid consumption of alcohol while taking PASILOW 50 CAPSULE as it might worsen your condition.
KIDNEY
PASILOW 50 CAPSULE is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.
LIVER
PASILOW 50 CAPSULE should be used with caution in patients with liver problems (including Hepatitis C infection). Therefore, consult your doctor before taking it.
ALLERGY
Talk to your doctor before taking PASILOW 50 CAPSULE if you are allergic to cyclosporine.
OTHERS
PASILOW 50 CAPSULE is not recommended for use if you:
- have severe infections in the body which is unable to control
- have any type of cancer
- have uncontrollably high blood pressure
Before taking PASILOW 50 CAPSULE inform your doctor if you:
- have any signs of infection, such as fever or sore throat
- have low levels of magnesium in the body
- have high blood potassium levels
- have gout (joint pain caused due to fluid accumulation)
- are about to receive any vaccination
- have or ever had alcohol-related problems
- have epilepsy
Use in paediatrics:
PASILOW 50 CAPSULE should only be used to treat nephrotic syndrome in children. It is generally not recommended for preventing graft rejection or for treating other auto-immune disease condition apart from nephrotic syndrome in children. Therefore, consult your doctor before taking it.
Use in geriatrics:
PASILOW 50 CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug - Drug interactions:
Before taking PASILOW 50 CAPSULE, inform your doctor if you are taking any of the following medicines such as:
- St. John’s Wort (an herbal medicine used to treat depression)
- dabigatran etexilate (a medicine used to prevent blood clots after surgery)
- bosentan or aliskiren (medicines used to treat high blood pressure)
- vaccines
- medicines that can increase blood potassium levels in the body (such as potassium supplements or potassium-sparing diuretics (Ex. amiloride, triamterene or spironolactone))
- methotrexate (a medicine used to treat cancer and severe rheumatoid arthritis)
- medicines used to treat bacterial infections (Ex. erythromycin, azithromycin, gentamycin, tobramycin, ciprofloxacin)
- medicines used to treat fungal infections (Ex. voriconazole, itraconazole, terbinafine, amphotericin B)
- medicines used for heart problems or high blood pressure (Ex. diltiazem, nicardipine, verapamil, digoxin, amiodarone)
- metoclopramide (a medicine used to stop nausea and vomiting)
- danazol (a medicine used to treat overgrowth in the uterus)
- oral contraceptives (birth control pills) Ex. ethinylestradiol
- medicines used to treat gout (Ex. colchicine, allopurinol)
- medicines used to treat gallstones (Ex. ursodiol)
- medicines used to treat leukaemia and other cancers (Ex. imatinib, melphalan, etoposide, doxorubicin)
- barbiturates (used to reduce anxiety and to induce sleep) Ex. phenobarbital
- medicines used to treat epilepsy (Ex. carbamazepine, phenytoin, cannabidiol)
- octreotide (a medicine used to treat hormonal disorder, (acromegaly) and tumours)
- orlistat (a medicine that helps in weight loss)
- ticlopidine (a medicine used to prevent blood clots due to platelet aggregation)
- other medicines used to supress immune system (Ex. everolimus, sirolimus, tacrolimus)
- medicine used to reduce pain and inflammation Ex. diclofenac
- medicines used to lower cholesterol levels (Ex. fenofibrate, atorvastatin, Fluvastatin)
- medicines used to treat tuberculosis (Ex. isoniazid, rifampicin)
- medicines used to treat HIV infections (Ex. acyclovir, ritonavir, nelfinavir, saquinavir, efavirenz, etravirine, nevirapine)
- medicines used to treat hepatitis C infection (Ex. telaprevir, boceprevir, the combination ombitasvir/paritaprevir/ritonavir with or without dasabuvir, elbasvir/grazoprevir and glecaprevir/pibrentasvir)
- medicines used to treat gastric problems (Ex. omeprazole, cimetidine, magnesium hydroxide, aluminum hydroxide)
- trimethoprim or cotrimoxazole (used to treat bacterial infections)
- corticosteroids (used to treat allergic or autoimmune diseases) Ex. prednisolone, methylprednisolone
- medicines used to treat diabetes (Ex. repaglinide)
B. Drug – food interactions
Avoid consuming grapes or grapefruit juice while taking PASILOW 50 CAPSULE as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more PASILOW 50 CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include vomiting, drowsiness, headache, fast heartbeat and kidney damage.
SYNOPSIS
| Drug | : | Cyclosporine |
| Pharmacological Category | : | Calcineurin inhibitors |
| Therapeutic Indication | : | Graft rejection, Autoimmune diseases |
| Dosage Forms | : | Tablet, Capsule, Injection, Infusion, Oral Solution, Oral Suspension, Eye Drops, Ophthalmic Emulsion |
MORE INFORMATION
- Keep PASILOW 50 CAPSULE out of reach of children
- Store PASILOW 50 CAPSULE at room temperature
FAQs ABOUT PASILOW 50 CAPSULE
What is the use of PASILOW 50 CAPSULE?
PASILOW 50 CAPSULE is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells. It can also be used to treat various auto-immune disease conditions such as psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis, nephrotic syndrome or eye inflammation (such as endogenous uveitis, including Behçet's uveitis).
How PASILOW 50 CAPSULE works?
PASILOW 50 CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells, interleukins and cytokines) that triggers the immune response. This action suppresses your body’s immune functions and enables your body to accept the newly transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
How to take PASILOW 50 CAPSULE?
Take PASILOW 50 CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Is PASILOW 50 CAPSULE an antibiotic?
No. PASILOW 50 CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
What precautions must be followed while taking PASILOW 50 CAPSULE?
Before taking PASILOW 50 CAPSULE inform your doctor if you have any liver problems or any signs of infections (such as fever or sore throat). You must also inform your doctor if you have hepatitis C infection, fits, low blood magnesium levels, gout, alcohol dependence, severe uncontrollable infections, any types of cancer, severe high blood pressure or if you are about to receive any vaccinations as a precaution. Inform your doctor before taking PASILOW 50 CAPSULE if you are pregnant or breastfeeding.
How long should I take PASILOW 50 CAPSULE?
You need to take PASILOW 50 CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What to do if I forgot to take a dose of PASILOW 50 CAPSULE?
If you forgot to take a dose of PASILOW 50 CAPSULE, take it as soon as you remember. However, if it is time for the next dose of PASILOW 50 CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of PASILOW 50 CAPSULE to compensate the missed ones.
Is PASILOW 50 CAPSULE safe?
The most common side effects of taking PASILOW 50 CAPSULE are increase in blood sugar levels, increase in blood cholesterol levels, increased blood potassium levels, high blood pressure, headache, loss of appetite, acne, hot flushes, tiredness, excessive facial hair and low blood magnesium levels in blood. Consult your doctor if any of these side effects worsen.
Can I stop taking PASILOW 50 CAPSULE without consulting your doctor?
No. You should not stop taking PASILOW 50 CAPSULE without consulting your doctor because your body’s immune system may once again attempt to reject the newly transplanted organ. Therefore, take PASILOW 50 CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
What happens if I take too more of PASILOW 50 CAPSULE?
If you or anyone else accidentally took more PASILOW 50 CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include vomiting, drowsiness, headache, fast heartbeat and kidney damage.
Can I use PASILOW 50 CAPSULE if I suffer from kidney diseases?
PASILOW 50 CAPSULE is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.
Will taking a higher dose of PASILOW 50 CAPSULE be more effective?
No, taking a higher dose of PASILOW 50 CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I take medication for high blood pressure along with PASILOW 50 CAPSULE?
It is not advisable to take medicines to control blood pressure while taking PASILOW 50 CAPSULE without consulting your doctor as they have known interactions with PASILOW 50 CAPSULE.
Can PASILOW 50 CAPSULE be used in pregnant women?
PASILOW 50 CAPSULE is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
How much PASILOW 50 CAPSULE should I take?
PASILOW 50 CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Is PASILOW 50 CAPSULE a steroid?
No. PASILOW 50 CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
REFERENCES
1. KD. Tripathi. Immunosuppressant Drugs. Essentials of Medical pharmacology. 7th Edition. 2013. Page – 878.
2. Carolina Tapia, Trevor A. Nessel, Patrick M. Zito. Cyclosporine. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2022. [Accessed on 21st November 2022] https://www.ncbi.nlm.nih.gov/books/NBK482450/
3. James F. Burke, Jr., John D. Pirsch, Eleanor L. Ramos, Daniel R. Salomon, Donald M. Stablein, David H. Van Buren, and John C. West. Long-Term Efficacy and Safety of Cyclosporine in Renal-Transplant Recipients. The New England Journal of Medicine. August 1994. [Accessed on 21st November 2022]. https://www.nejm.org/doi/full/10.1056/NEJM199408113310604
4. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC) [Revised in May 2022] [ Accessed on 21st November 2022] https://www.medicines.org.uk/emc/files/pil.1034.pdf
5. Novartis Pharmaceuticals Canada Inc [Revised in August 2022] [ Accessed on 21st November 2022] https://www.ask.novartispharma.ca/download.htm?res=neoral_scrip_e.pdf&resTitleId=691
6. Biocon House, Semicon Park. [Revised in August 2019] [ Accessed on 21st November 2022] https://www.biocon.com/docs/domestic-market-pi/immuno/PSORID-CAPSULES%20PI.pdf
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