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INTRODUCTION
PARI CR 12.5MG contains an antidepressant medicine called paroxetine which belongs to a group of medicines called selective serotonin re-uptake inhibitors. It used in adults to treat depressive and anxiety disorders like major depression, obsessive compulsive disorder, panic disorder, social anxiety disorders, anxiety after traumatic experience or generalized anxiety disorder.
Endogenous serotonin is responsible for stabilization of mood, feelings of well-being and happiness. It also helps with proper sleeping, eating and digestion. Lower levels of serotonin leads to depression or anxiety . Paroxetine inhibits presynaptic reuptake of serotonin and this inhibition raises the level of serotonin in the synaptic cleft, relieving various depressive and anxiety symptoms.
Take PARI CR 12.5MG in the morning with food or as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. The most common side effect of taking this medicine is worsening of depression and suicidal thoughts. If this happens, contact your doctor immediately. Do not drive or use any tools or machines if your ability is affected by this medicine.
USES OF PARI CR 12.5MG
- Treats depressive and anxiety disorders
HOW PARI CR 12.5MG WORKS
Paroxetine enhances the activity of serotonin by inhibiting serotonin re-uptake at pre-synapse by the serotonin (SERT) receptor. This inhibition raises the level of serotonin in the synaptic cleft, relieving various depressive and anxiety symptoms.
DIRECTIONS FOR USE
Always take this medicine as directed by your physician. Your doctor will decide the dose and duration depending upon your health condition. Take the medicine in the morning with food or as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine.
SIDE EFFECTS OF PARI CR 12.5MG
SERIOUS
- worsening of mood
- thoughts of harming themselves
- unusual bruising or bleeding
- difficulty in urination
- seizures (fits)
- akathisia (a feel of restlessness)
- feeling tired, weak or confused
- muscle pain
- serotonin syndrome (an allergic reactions accompanied by a red and lumpy skin rash, swelling of the eyelids, face, lips, mouth or tongue, difficulty breathing or swallowing)
- acute glaucoma (an eye disease)
- skin rash
COMMON
- nausea or vomiting
- loss of appetite
- dry mouth
- diarrhea or constipation
- weight gain
- headache
- change in sex drive or sexual function.
- insomnia (lack of sleep) or feeling sleepy
- abnormal dreams (including nightmares)
- feeling agitated
- tachycardia (faster heartbeat)
- hallucinations (strange visions or sounds)
- abnormal movements in the mouth and tongue
RARE
- a slow heartbeat
- panic attacks
- mania (overactive behavior or thoughts)
- pain in the joints or muscles
- problems in menstruation (heavy or irregular periods, bleeding between periods and absence or delay of periods)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try taking this medicine with, or just after, a meal and stick to simple meals. Do not eat rich or spicy food.
Constipation:
Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise regularly.
Diarrhoea:
Drink lots of fluids to avoid dehydration. Avoid taking any other medicines for diarrhoea without speaking to a doctor.
WARNING & PRECAUTIONS
PREGNANCY
PARI CR 12.5MG should be used with caution in pregnant women. Consult your doctor for advice.
BREASTFEEDING
PARI CR 12.5MG should be used with caution in breastfeeding women. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or use any tools or machines if your ability is affected by this medicine.
ALCOHOL
Do not drink alcohol while you are taking paroxetine, as it may make your symptoms worse.
KIDNEY
PARI CR 12.5MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
PARI CR 12.5MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take this medicine if you are allergic to paroxetine.
OTHERS
Talk to your doctor before taking this medicine, if you:
- have epilepsy, have ever had episodes of mania, a history of bleeding disorders, glaucoma or diabetes
INTERACTIONS
Talk to your doctor, if you are taking,
- other medicines used to treat depression (e.g. moclobemide, clomipramine, nortriptyline and desipramine)
- medicines used to treat psychosis (e.g. thioridazine, lithium, risperidone, perphenazine, clozapine or pimozide)
- medicines used to thin blood (warfarin)
- medicine used to relieve pain (e.g. aspirin, ibuprofen, fentanyl, celecoxib, etodolac, diclofenac, meloxicam tramadol and pethidine)
- medicines used to treat migraine (sumatriptan)
- medicines used to treat epilepsy (phenytoin or carbamazepine)
- medicines used to treat an irregular heartbeat (propafenone, flecainide)
- combination of fosamprenavir and ritonavir (used to treat HIV infection)
- St. John’s Wort (a herbal remedy for depression)
- atomoxetine (used to treat attention deficit hyperactivity disorder)
- procyclidine (used to relieve tremor)
SYNOPSIS
| Drug | : | Paroxetine |
| Pharmacological Category | : | Anticonvulsant |
| Therapeutic Indication | : | Selective serotonin re-uptake inhibitors |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT PARI CR 12.5MG
Is PARI CR 12.5MG habit forming?
Yes. This medicine is habit forming and produces withdrawal symptoms like headache, dizziness and insomnia. Do not stop taking this medicine unless your doctor tells you to do so.
Can PARI CR 12.5MG be used in children?
No. This medicine is not recommended for use in children under 18 years of age.
REFERENCES
1. KD. Tripathi. Drugs Used in Mental illness: Antidepressants and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 461.
2. James M. O’Donnell and Richard C. Shelton. Drug therapy of Depression and Anxiety disorders. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 405-407.
3. Gerald G. Briggs and Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2975-2996.
4. National Institute of Mental Health (NIMH). Evaluation of Clonazepam and Paroxetine for Panic Disorder with Depression. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on March 2008] [Accessed 23rd November 2020] https://www.clinicaltrials.gov/ct2/show/NCT00031317
5. David J. Portman, Andrew M. Kaunitz, Kazem Kazempour, Hana Mekonnen, Sailaja Bhaskar, and Joel Lippman. Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause.
6. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2014. [Accessed 19th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175016/
7. Farmaceutisch Analytisch Laboratorium Duiven B.V (FAL Duiven B.V) and Medochemie Ltd. Electronic Medicines Compendium (EMC); [Revised on December 2018] [Accessed 23rd November 2020] https://www.medicines.org.uk/emc/files/pil.9582.pdf
8. Balkanpharma and Wasdell Packaging Ltd. Electronic Medicines Compendium (EMC); [Revised on June 2020] [Accessed 23rd November 2020] https://www.medicines.org.uk/emc/files/pil.5833.pdf
9. Balkanpharma and Wasdell Packaging Ltd. Electronic Medicines Compendium (EMC); [Revised on June 2020] [Accessed 23rd November 2020] https://www.medicines.org.uk/emc/files/pil.4286.pdf
10. Generics [UK] Limited, Gerard Laboratories and Mylan Hungary Kft. Electronic Medicines Compendium (EMC); [Revised on November 2015] [Accessed 23rd November 2020] https://www.medicines.org.uk/emc/files/pil.8487.pdf
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