Deliver to
Offers

Pantop LS Capsule 10'S

Choose Generic substitutes to Save up to 50% off
Ulcerative Colitis/Bowel Inflammatory Disease Rx required
Levosulpiride 75 mg+Pantoprazole 40 mg
OUT OF STOCK
MRP ₹236.45
Inclusive of all taxes
Get this at ₹193.89
Cart Total
₹0
*10 Capsule(s) in a Strip * Mkt: Aristo Pharmaceuticals Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

INTRODUCTION

PANTOP LS CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANTOP LS CAPSULE is indicated for the short-term treatment of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone.

GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation and inflammation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.

PANTOP LS CAPSULE can also be used to treat peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid).

Take PANTOP LS CAPSULE preferably one hour before meals. Avoid consumption of alcohol while taking PANTOP LS CAPSULE as it could potentiate the CNS depressive side effects.

Patients receiving long-term treatment with PANTOP LS CAPSULE should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors like osteoporosis. 

Before taking PANTOP LS CAPSULE inform your doctor if you have any liver, kidney or heart problems. PANTOP LS CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children or adolescents (below 18 years of age).

PANTOP LS CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness).

The most common side effects of taking PANTOP LS CAPSULE are nausea, vomiting, headache, dizziness, polyps in the stomach gut and flatulence. Consult your doctor if any of the side effects worsen during or after treatment with PANTOP LS CAPSULE.

USES OF PANTOP LS CAPSULE

  • To treat gastro-esophageal reflux disease (GERD) for short-term among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone
  • To treat peptic ulcer and Zollinger-Ellison syndrome

HOW PANTOP LS CAPSULE WORKS

PANTOP LS CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.

DIRECTIONS FOR USE

Take PANTOP LS CAPSULE as advised by your physician. Swallow PANTOP LS CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTOP LS CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANTOP LS CAPSULE without informing your doctor.

SIDE EFFECTS OF PANTOP LS CAPSULE

COMMON

  • benign polyps in the stomach

UNCOMMON

  • headache, dizziness
  • nausea, vomiting
  • stomach pain, diarrhea, flatulence, constipation
  • dry mouth
  • skin rash with eruptions and itching
  • feeling weak, exhausted or generally unwell
  • sleep disturbances
  • fracture of the hip, wrist or spine

RARE

  • distortion or complete lack of taste sense
  • blurred vision
  • joint pain, muscle pain
  • changes in weight
  • high fever
  • peripheral edema (swelling of the ankles, legs, feet, arms, or hands)
  • allergic reactions
  • depression
  • breast enlargement in males

Stop taking PANTOP LS CAPSULE and contact your doctor immediately if you experience any of the following side effects:

  • signs of decreased magnesium level in blood (such as fatigue, disorientation, involuntary muscle contractions, dizziness, convulsions and increased heart rate)
  • skin rash following sun exposure (Ex. subacute cutaneous lupus erythematosus)
  • sudden unintentional weight loss, recurrent vomiting, blood in vomit which might appear as dark coffee grounds, black, tarry or blood-stained stools, difficulty in swallowing, looking pale, feeling weak, chest pain, stomach pain and severe and/or persistent diarrhea
  • severe allergic reactions (such as skin rash, itching, swelling of the eyes, mouth, tongue and/or throat, difficulty in breathing or swallowing, severe dizziness with very fast heartbeat and heavy sweating)
  • serious skin reactions (such as Stevens-Johnson syndrome, Lyell syndrome or erythema multiforme causing skin rash with swelling, blistering or peeling, losing skin and bleeding around eyes, nose, mouth or genitals with rapid deterioration of general health, or photosensitivity)
  • signs of severe kidney problem (such as acute kidney injury or acute interstitial nephritis causing painful urination, fever, rash, enlarged kidneys and lower back pain)
  • jaundice (yellowing of the skin or whites of the eyes)
  • neuroleptic malignant syndrome (a life-threatening neurologic condition causing altered mental status, high fever, muscle rigidity, irregular pulse, accelerated heartbeat, increased rate of respiration, autonomic nervous system dysfunction resulting in high or low blood pressure, profuse perspiration and excessive sweating)
  • drug-induced movement disorders (tremor, akathisia (unable to stand still))

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Stick to simple meals while taking PANTOP LS CAPSULE. Avoid eating oily, fried or spicy foods. Eat meals slowly and smaller and avoid doing activities immediately after eating. Consult your doctor if the symptom did not improve.  

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Constipation: 

Eat fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

PREGNANCY

PANTOP LS CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking PANTOP LS CAPSULE.

BREASTFEEDING

PANTOP LS CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking PANTOP LS CAPSULE.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANTOP LS CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking PANTOP LS CAPSULE, as it may cause additive sedative effects.

KIDNEY

PANTOP LS CAPSULE is not recommended for use in patients with severe impaired kidney function consult your doctor before taking PANTOP LS CAPSULE.

LIVER

PANTOP LS CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANTOP LS CAPSULE.

ALLERGY

Do not take PANTOP LS CAPSULE if you are allergic to Levosulpiride or Pantoprazole. Consult your doctor before taking PANTOP LS CAPSULE. 

HEART DISEASE

PANTOP LS CAPSULE should be taken with caution in patients with cardiovascular disease or a family history of prolonged QT interval. Consult your doctor before taking PANTOP LS CAPSULE.

OTHERS

PANTOP LS CAPSULE is not recommended for use if you:

  • have phaeochromocytoma (tumors of adrenal gland)
  • have epilepsy
  • have mania or other mental disorders
  • have breast cancer or prolactinoma (a noncancerous tumor of pituitary gland)
  • have gastrointestinal bleeding or obstruction in the gut 

Before taking PANTOP LS CAPSULE, inform your physician if you:

  • have gastric malignancy (cancers in the gut)
  • have or at risk of developing vitamin B12 deficiency
  • are going to test Chromogranin A level
  • have or at risk of having osteoporosis
  • have a history of cerebrovascular events (stroke, venous thromboembolism)
  • are alcoholic

Use in pediatrics:

PANTOP LS CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and efficacy data. Consult your child’s doctor for advice.

Use in geriatrics:

PANTOP LS CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANTOP LS CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function.

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANTOP LS CAPSULE inform to your doctor, if you are taking any of these medicines:

  • medicines used to treat fungal infections (such as ketoconazole, itraconazole or posaconazole, amphotericin B)
  • erlotinib (used to treat certain types of cancer)
  • warfarin and phenprocoumon (used to treat or prevent thrombotic events and heart problems)
  • medicines used to treat HIV infection (such as atazanavir)
  • methotrexate (a medicine used to treat rheumatoid arthritis, psoriasis or cancer)
  • rifampicin (used to treat tuberculosis)
  • erythromycin and ampicillin esters (used to treat bacterial infections) Ex. hetacillin and pivampicillin
  • iron salts (used to treat anemia) Ex. ferrous sulphate, ferrous fumarate
  • medicine that can neutralize stomach acid such as antacids (Ex. aluminium- and magnesium-hydroxide) or sucralfate
  • anticholinergics (used to relax or reduce the movements of smooth muscles and suppresses body secretions (Ex. atropine, hyoscine)
  • analgesics (used to relieve pain) such as opioids (Ex. methadone) or non-opioids (Ex. naproxen, ibuprofen)
  • sedatives and hypnotics, tranquilizers (used to reduce anxiety and to induce sleep) Ex. alprazolam, chlordiazepoxide, diazepam
  • medicines used to treat depression (Ex. rasagiline, selegiline, phenelzine, haloperidol, imipramine, lithium, fluvoxamine and herbal medicine (St. John’s wort))
  • medicines used to treat abnormal heart rate (Ex. digitalis, quinine, quinidine, disopyramide, amiodarone, sotalol, flecainide, procainamide)
  • medicines used to treat high blood pressure or other heart problems such as beta-blockers (Ex. propranolol, atenolol) or calcium channel blockers (Ex. verapamil, diltiazem)
  • antipsychotics (used to treat mental illness) Ex. risperidone, paliperidone, amisulpiride, olanzapine, thioridazine
  • non-sedating antihistamines (used to treat allergic symptoms) Ex. fexofenadine, levocetirizine, loratadine
  • antimalarials (used to treat malaria) Ex. quinine, primaquine, halofantrine
  • cisapride (used to treat heartburn and acid reflux)
  • diuretics (used to reduce blood pressure by increasing urine output) Ex. spironolactone, chlorothiazide, acetazolamide
  • corticosteroids (used to treat allergy, pain or inflammation) Ex. dexamethasone, prednisolone
  • stimulant laxatives (used to treat constipation) Ex. bisacodyl
  • pimozide (used to reduce uncontrollable muscle movements)
  • pentamidine (used to treat lung infection)

Overdosage:

If you or anyone else accidentally take too much of PANTOP LS CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PANTOP LS CAPSULE might include extrapyramidal reactions (such as rigidity, tremor, drooling etc.) or sleep disturbances.

SYNOPSIS

Drug :   Levosulpiride, Pantoprazole
Pharmacological Category :   Dopamine D2 antagonists, Proton pump inhibitors
Therapeutic Indication :   GERD, Peptic ulcer, Zollinger-Ellison syndrome
Dosage Forms :   Tablet, Capsule

MORE INFORMATION

  • Keep PANTOP LS CAPSULE out of reach of children
  • Store PANTOP LS CAPSULE at room temperature

FAQs ABOUT PANTOP LS CAPSULE

Can PANTOP LS CAPSULE be used to treat depression?

No, PANTOP LS CAPSULE is only used to treat gastrointestinal disorders such as GERD, peptic ulcer and Zollinger-Ellison syndrome. Although levosulpiride is an antipsychotic medicine, at this recommended dosage, it is only used to treat acid reflux and to improve gastric motility. For more queries, please consult your doctor before taking PANTOP LS CAPSULE.  

Can PANTOP LS CAPSULE cause constipation?

Yes, PANTOP LS CAPSULE can cause constipation in some individuals which is nothing to worry about. Eat fiber rich diet with lots of fresh vegetables, fruits, cereals and drink plenty of water. Try to exercise more regularly (such as walking). Consult your doctor if the symptom did not improve on its own during treatment with PANTOP LS CAPSULE.

Can PANTOP LS CAPSULE be used in elderly patients?

PANTOP LS CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANTOP LS CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function. 

Is PANTOP LS CAPSULE safe to use in patients with liver problems?

PANTOP LS CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANTOP LS CAPSULE.

Can I drive or operate machines after taking PANTOP LS CAPSULE?

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANTOP LS CAPSULE. Consult your doctor for advice before taking PANTOP LS CAPSULE.

REFERENCES

1. KD. Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 651-654.

2. Keith A. Sharkey and John L. Wallace. Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1311-1313.

3. Gerald G. Briggs and Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2960 & -2775.

4. Sony Mathews, Ashley Reid, Chenlu Tian, and Qiang Cai. An update on the use of pantoprazole as a treatment for gastroesophageal reflux disease. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2010. [Accessed on 1st November 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108659/

5. G.Bianchi Porro, .Lazzaroni1V.Imbesi, F.Montrone, T.Santagada.  Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study. Digestive and Liver disease. ScienceDirect. April 2000. [Accessed on 1st November 2021] https://www.sciencedirect.com/science/article/abs/pii/S159086580080821X

6. D. C. Metz, G. M. Comer, E. Soffer, C. E. Forsmark, B. Cryer, W. Chey and J. R. Pisegna. Three-year oral pantoprazole administration is effective for patients with Zollinger–Ellison syndrome and other hypersecretory conditions. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2019. [Accessed on 1st November 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736592/

7. Jordi Serra. [Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 2010. [Accessed on 1st November 2021] https://pubmed.ncbi.nlm.nih.gov/20850200/

8. Cipla Ltd. Pansec L Capsules (Hetero Labs) (Pantoprazole + Levosulpiride). Ciplamed.com. [Revised in July 2020]. [Accessed on 1st November 2021] https://www.ciplamed.com/content/pansec-l-capsules-hetero-labs

9. Takeda GmbH. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 1st November 2021] https://www.medicines.org.uk/emc/files/pil.484.pdf

10. Alkem Laboratories Ltd. (Pantoprazole sodium 40 mg And Levosulpiride (SR) 75 mg Capsules) Pan-L. [Revised in June 2016] [Accessed on 1st November 2021] https://www.alkemlabs.com/pdf/adverse/PAN%20L.pdf

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 02 Dec 2022 | 11:19 AM(IST)

PRODUCT DETAILS
    Net Qty
    1 N
    Shelf Life
    24
    Item Weight
    17.5 g
    Ingredient
    Levosulpiride 75 mg+Pantoprazole 40 mg
    Hsn Code
    30049039
ALTERNATE BRANDS View All
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.