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INTRODUCTION
PANTOCEN 40 TABLET contains Pantoprazole which belongs to the group of medicines called Proton pump inhibitors. It is used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis and its associated symptoms such as acidity, heartburn, acid reflux and pain in swallowing.
Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus or intestines. It causes severe stomach pain with sensation of flatulence, indigestion, vomiting and fatigue.
GERD is a chronic digestive disease in which the acid from the stomach frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
Reflux esophagitis can be defined as the inflammation of the food pipe accompanied with acid reflex.
PANTOCEN 40 TABLET can also be used to prevent peptic ulcer caused due to long-term use of non-steroidal anti-inflammatory drugs (such as aspirin, ibuprofen). It is suitable for use both in adults and in children (aged 12 years or above weighing 35 kg or more).
Take PANTOCEN 40 TABLET at least 1 hour before meals to achieve maximum benefits. During treatment with PANTOCEN 40 TABLET your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects.
Before taking PANTOCEN 40 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have weak bones or any previous history of bleeding in the gut.
Consult your doctor before taking PANTOCEN 40 TABLET if you are pregnant or breastfeeding. The most common side effects of taking PANTOCEN 40 TABLET are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.
You must also inform your doctor immediately if you experience severe tiredness with abnormal muscle movements, dizziness, confusion, disorientation and irregular heartbeat, as it could be a sign of low magnesium levels in blood.
USES OF PANTOCEN 40 TABLET
It is used in adults and in children (aged 12 years or older weighing 35 kg or more) to treat:
- Peptic ulcer and prevents its recurrence
- Gastrointestinal Reflux disease (GERD)
- Reflux esophagitis (inflammation of the esophagus)
- Acidity, Heartburn, Pain in swallowing
HOW PANTOCEN 40 TABLET WORKS
PANTOCEN 40 TABLET is a proton pump inhibitor. It reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) across the stomach lining. As a result, it prevents the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, heartburn and acid reflux).
DIRECTIONS FOR USE
Take PANTOCEN 40 TABLET 30 minutes to 1 hour before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PANTOCEN 40 TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF PANTOCEN 40 TABLET
COMMON
- benign polyps in the stomach
UNCOMMON
- low sex drive
- headache, dizziness, drowsiness
- anxiety, sleeplessness
- breast enlargement in both men and in women
- feeling weak
- fragile bones (risk of bone fracture)
- nausea or vomiting
- diarrhea, constipation, stomach pain, flatulence
- dry mouth
RARE
- blurred vision
- joint pain, muscle pain
- raised body temperature
- swelling of the extremities (peripheral oedema)
- depression
- breast enlargement in males
- low WBC count in blood
- taste disorders
Stop taking PANTOCEN 40 TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
- signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
- severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
- signs of kidney problem (such as lower back pain, painful urination)
- signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
- skin rashes on sun exposed areas
- sudden weight loss, looking pale and weak (anemia)
- signs of bleeding in the gut (such as bloody vomits/stools)
- chest pain
- severe, persistent diarrhea
- fast or irregular heartbeat, difficulty in breathing, feeling faint
- fits
- uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try to take PANTOCEN 40 TABLET with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking PANTOCEN 40 TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
PANTOCEN 40 TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
BREASTFEEDING
PANTOCEN 40 TABLET may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician. Consult your doctor for advice.
DRIVING AND USING MACHINES
PANTOCEN 40 TABLET does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by PANTOCEN 40 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking PANTOCEN 40 TABLET, as it could aggravate your existing condition.
KIDNEY
PANTOCEN 40 TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
LIVER
PANTOCEN 40 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take PANTOCEN 40 TABLET if you are allergic to Pantoprazole.
OTHERS
Before taking PANTOCEN 40 TABLET, inform your doctor if you:
- have osteoporosis
- have a history of bleeding in the gut
- have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- are going to test Chromogranin A level
Use in pediatrics:
PANTOCEN 40 TABLET should be used in children and adolescents (aged 12 years or above, weighing 35kg or more). It is not recommended for use in children and adolescents (aged below 12 years). However, consult your doctor before taking it.
Use in geriatrics:
PANTOCEN 40 TABLET should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking PANTOCEN 40 TABLET inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat fungal infections (such as ketoconazole, itraconazole and Posaconazole)
- erlotinib (a medicine used to treat cancer)
- warfarin and phenprocoumon (medicines used for blood thinning)
- methotrexate (a medicine used to treat cancer and autoimmune diseases)
- atazanavir (a medicine used to treat HIV infection)
- fluvoxamine (a medicine used to treat depression)
- rifampicin (a medicine used to treat tuberculosis)
- St. John’s wort (an herbal medicine used to treat depression)
Overdosage:
If you or anyone else accidentally took more PANTOCEN 40 TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Pantoprazole |
| Pharmacological Category | : | Proton pump inhibitors |
| Therapeutic Indication | : | Peptic ulcer, GERD, Reflux esophagitis |
| Dosage Forms | : | Tablet, Capsule, Injection, Infusion, Prefilled Syringe, Kit |
MORE INFORMATION
- Keep PANTOCEN 40 TABLET out of the sight and reach of children
- Store PANTOCEN 40 TABLET at room temperature
FAQs ABOUT PANTOCEN 40 TABLET
What is PANTOCEN 40 TABLET used for?
PANTOCEN 40 TABLET is used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis and its associated symptoms such as acidity, heartburn, acid reflux and pain in swallowing.
How and when to take PANTOCEN 40 TABLET?
Take PANTOCEN 40 TABLET at least 1 hour before meals. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take PANTOCEN 40 TABLET?
You need to take PANTOCEN 40 TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What is the best time to take PANTOCEN 40 TABLET?
PANTOCEN 40 TABLET must be taken before meals to avoid gastrointestinal side effects.
What to do if I forgot to take a dose of PANTOCEN 40 TABLET?
If you forgot to take a dose of PANTOCEN 40 TABLET, take it as soon as you remember. However, if it is time for the next dose of PANTOCEN 40 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of PANTOCEN 40 TABLET to compensate the missed ones.
What are the most common side effects of taking PANTOCEN 40 TABLET?
The most common side effects of taking PANTOCEN 40 TABLET are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.
Can I stop taking PANTOCEN 40 TABLET without consulting your doctor?
No. You should not stop taking PANTOCEN 40 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using PANTOCEN 40 TABLET, consult your doctor for advice.
Will taking a higher dose of PANTOCEN 40 TABLET be more effective?
No, taking a higher dose of PANTOCEN 40 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What precautions do I need to follow while taking PANTOCEN 40 TABLET?
Make sure to take PANTOCEN 40 TABLET 30 minutes to 1 hour before meals. Before taking PANTOCEN 40 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have weak bones or a previous history of bleeding in the gut. Consult your doctor before taking PANTOCEN 40 TABLET if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended by your doctor without fail.
Can I take medication for high blood pressure along with PANTOCEN 40 TABLET?
It is not advisable to take medicines to control blood pressure while taking PANTOCEN 40 TABLET without consulting your doctor as they have known interactions with PANTOCEN 40 TABLET.
Can PANTOCEN 40 TABLET be used in pregnant women?
PANTOCEN 40 TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
How to take PANTOCEN 40 TABLET?
You must take PANTOCEN 40 TABLET as advised by your physician. Try to take PANTOCEN 40 TABLET 30 minutes before and swallow it with a glass of water. Do not crush or chew the medicine.
How much PANTOCEN 40 TABLET should I take?
PANTOCEN 40 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can PANTOCEN 40 TABLET cause constipation?
Yes. Constipation is a common side effect of using PANTOCEN 40 TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Can PANTOCEN 40 TABLET cause dry mouth?
Yes. Dry mouth is a common side effect of using PANTOCEN 40 TABLET. Contact your doctor if this side effect bothers you.
REFERENCES
1. KD Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Eighth Edition. 2019. Page –701.
2. Andrzej Dabrowski, Borut Štabuc and Leonid Lazebnik. Meta-analysis of the efficacy and safety of pantoprazole in the treatment and symptom relief of patients with gastroesophageal reflux disease. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2018. [Accessed on 22nd October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894447/
3. Balkanpharma – Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 22nd October 2022] https://www.medicines.org.uk/emc/files/pil.4713.pdf
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 22nd October 2022] https://www.medicines.org.uk/emc/files/pil.7090.pdf
5. Central Drugs Standard Control Organization. Pantoprazole Tablets. [Revised in December 1998]. [Accessed on 22nd October 2022] https://cdscoonline.gov.in/CDSCO/Drugs
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