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(Inclusive of all taxes) *10 Capsule(s) in a Strip * Mkt: Hetero Healthcare Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

PANTIN L CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANTIN L CAPSULE is indicated for the short-term treatment of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone.

GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation and inflammation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.

PANTIN L CAPSULE can also be used to treat peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid).

Take PANTIN L CAPSULE preferably one hour before meals. Avoid consumption of alcohol while taking PANTIN L CAPSULE as it could potentiate the CNS depressive side effects.

Patients receiving long-term treatment with PANTIN L CAPSULE should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors like osteoporosis. 

Before taking PANTIN L CAPSULE inform your doctor if you have any liver, kidney or heart problems. PANTIN L CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children or adolescents (below 18 years of age).

PANTIN L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness).

The most common side effects of taking PANTIN L CAPSULE are nausea, vomiting, headache, dizziness, polyps in the stomach gut and flatulence. Consult your doctor if any of the side effects worsen during or after treatment with PANTIN L CAPSULE.

USES OF PANTIN L CAPSULE

  • To treat gastro-esophageal reflux disease (GERD) for short-term among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone
  • To treat peptic ulcer and Zollinger-Ellison syndrome

HOW PANTIN L CAPSULE WORKS

PANTIN L CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.

DIRECTIONS FOR USE

Take PANTIN L CAPSULE as advised by your physician. Swallow PANTIN L CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTIN L CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANTIN L CAPSULE without informing your doctor.

SIDE EFFECTS OF PANTIN L CAPSULE

COMMON

  • benign polyps in the stomach

UNCOMMON

  • headache, dizziness
  • nausea, vomiting
  • stomach pain, diarrhea, flatulence, constipation
  • dry mouth
  • skin rash with eruptions and itching
  • feeling weak, exhausted or generally unwell
  • sleep disturbances
  • fracture of the hip, wrist or spine

RARE

  • distortion or complete lack of taste sense
  • blurred vision
  • joint pain, muscle pain
  • changes in weight
  • high fever
  • peripheral edema (swelling of the ankles, legs, feet, arms, or hands)
  • allergic reactions
  • depression
  • breast enlargement in males

Stop taking PANTIN L CAPSULE and contact your doctor immediately if you experience any of the following side effects:

  • signs of decreased magnesium level in blood (such as fatigue, disorientation, involuntary muscle contractions, dizziness, convulsions and increased heart rate)
  • skin rash following sun exposure (Ex. subacute cutaneous lupus erythematosus)
  • sudden unintentional weight loss, recurrent vomiting, blood in vomit which might appear as dark coffee grounds, black, tarry or blood-stained stools, difficulty in swallowing, looking pale, feeling weak, chest pain, stomach pain and severe and/or persistent diarrhea
  • severe allergic reactions (such as skin rash, itching, swelling of the eyes, mouth, tongue and/or throat, difficulty in breathing or swallowing, severe dizziness with very fast heartbeat and heavy sweating)
  • serious skin reactions (such as Stevens-Johnson syndrome, Lyell syndrome or erythema multiforme causing skin rash with swelling, blistering or peeling, losing skin and bleeding around eyes, nose, mouth or genitals with rapid deterioration of general health, or photosensitivity)
  • signs of severe kidney problem (such as acute kidney injury or acute interstitial nephritis causing painful urination, fever, rash, enlarged kidneys and lower back pain)
  • jaundice (yellowing of the skin or whites of the eyes)
  • neuroleptic malignant syndrome (a life-threatening neurologic condition causing altered mental status, high fever, muscle rigidity, irregular pulse, accelerated heartbeat, increased rate of respiration, autonomic nervous system dysfunction resulting in high or low blood pressure, profuse perspiration and excessive sweating)
  • drug-induced movement disorders (tremor, akathisia (unable to stand still))

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Stick to simple meals while taking PANTIN L CAPSULE. Avoid eating oily, fried or spicy foods. Eat meals slowly and smaller and avoid doing activities immediately after eating. Consult your doctor if the symptom did not improve.  

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Constipation

Eat fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

PREGNANCY

PANTIN L CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking PANTIN L CAPSULE.

BREASTFEEDING

PANTIN L CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking PANTIN L CAPSULE.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANTIN L CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking PANTIN L CAPSULE, as it may cause additive sedative effects.

KIDNEY

PANTIN L CAPSULE is not recommended for use in patients with severe impaired kidney function consult your doctor before taking PANTIN L CAPSULE.

LIVER

PANTIN L CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANTIN L CAPSULE.

ALLERGY

Do not take PANTIN L CAPSULE if you are allergic to Levosulpiride or Pantoprazole. Consult your doctor before taking PANTIN L CAPSULE. 

HEART DISEASE

PANTIN L CAPSULE should be taken with caution in patients with cardiovascular disease or a family history of prolonged QT interval. Consult your doctor before taking PANTIN L CAPSULE.

OTHERS

PANTIN L CAPSULE is not recommended for use if you:

  • have phaeochromocytoma (tumors of adrenal gland)
  • have epilepsy
  • have mania or other mental disorders
  • have breast cancer or prolactinoma (a noncancerous tumor of pituitary gland)
  • have gastrointestinal bleeding or obstruction in the gut 

Before taking PANTIN L CAPSULE, inform your physician if you:

  • have gastric malignancy (cancers in the gut)
  • have or at risk of developing vitamin B12 deficiency
  • are going to test Chromogranin A level
  • have or at risk of having osteoporosis
  • have a history of cerebrovascular events (stroke, venous thromboembolism)
  • are alcoholic

Use in pediatrics:

PANTIN L CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and efficacy data. Consult your child’s doctor for advice.

Use in geriatrics:

PANTIN L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANTIN L CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function.

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANTIN L CAPSULE inform to your doctor, if you are taking any of these medicines:

  • medicines used to treat fungal infections (such as ketoconazole, itraconazole or posaconazole, amphotericin B)
  • erlotinib (used to treat certain types of cancer)
  • warfarin and phenprocoumon (used to treat or prevent thrombotic events and heart problems)
  • medicines used to treat HIV infection (such as atazanavir)
  • methotrexate (a medicine used to treat rheumatoid arthritis, psoriasis or cancer)
  • rifampicin (used to treat tuberculosis)
  • erythromycin and ampicillin esters (used to treat bacterial infections) Ex. hetacillin and pivampicillin
  • iron salts (used to treat anemia) Ex. ferrous sulphate, ferrous fumarate
  • medicine that can neutralize stomach acid such as antacids (Ex. aluminium- and magnesium-hydroxide) or sucralfate
  • anticholinergics (used to relax or reduce the movements of smooth muscles and suppresses body secretions (Ex. atropine, hyoscine)
  • analgesics (used to relieve pain) such as opioids (Ex. methadone) or non-opioids (Ex. naproxen, ibuprofen)
  • sedatives and hypnotics, tranquilizers (used to reduce anxiety and to induce sleep) Ex. alprazolam, chlordiazepoxide, diazepam
  • medicines used to treat depression (Ex. rasagiline, selegiline, phenelzine, haloperidol, imipramine, lithium, fluvoxamine and herbal medicine (St. John’s wort))
  • medicines used to treat abnormal heart rate (Ex. digitalis, quinine, quinidine, disopyramide, amiodarone, sotalol, flecainide, procainamide)
  • medicines used to treat high blood pressure or other heart problems such as beta-blockers (Ex. propranolol, atenolol) or calcium channel blockers (Ex. verapamil, diltiazem)
  • antipsychotics (used to treat mental illness) Ex. risperidone, paliperidone, amisulpiride, olanzapine, thioridazine
  • non-sedating antihistamines (used to treat allergic symptoms) Ex. fexofenadine, levocetirizine, loratadine
  • antimalarials (used to treat malaria) Ex. quinine, primaquine, halofantrine
  • cisapride (used to treat heartburn and acid reflux)
  • diuretics (used to reduce blood pressure by increasing urine output) Ex. spironolactone, chlorothiazide, acetazolamide
  • corticosteroids (used to treat allergy, pain or inflammation) Ex. dexamethasone, prednisolone
  • stimulant laxatives (used to treat constipation) Ex. bisacodyl
  • pimozide (used to reduce uncontrollable muscle movements)
  • pentamidine (used to treat lung infection)

Overdosage:

If you or anyone else accidentally take too much of PANTIN L CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PANTIN L CAPSULE might include extrapyramidal reactions (such as rigidity, tremor, drooling etc.) or sleep disturbances.

SYNOPSIS

Drug :   Levosulpiride, Pantoprazole
Pharmacological Category :   Dopamine D2 antagonists, Proton pump inhibitors
Therapeutic Indication :   GERD, Peptic ulcer, Zollinger-Ellison syndrome
Dosage Forms :   Tablet, Capsule

MORE INFORMATION

  • Keep PANTIN L CAPSULE out of reach of children
  • Store PANTIN L CAPSULE at room temperature

FAQs ABOUT PANTIN L CAPSULE

Can PANTIN L CAPSULE be used to treat depression?

No, PANTIN L CAPSULE is only used to treat gastrointestinal disorders such as GERD, peptic ulcer and Zollinger-Ellison syndrome. Although levosulpiride is an antipsychotic medicine, at this recommended dosage, it is only used to treat acid reflux and to improve gastric motility. For more queries, please consult your doctor before taking PANTIN L CAPSULE.  

Can PANTIN L CAPSULE cause constipation?

Yes, PANTIN L CAPSULE can cause constipation in some individuals which is nothing to worry about. Eat fiber rich diet with lots of fresh vegetables, fruits, cereals and drink plenty of water. Try to exercise more regularly (such as walking). Consult your doctor if the symptom did not improve on its own during treatment with PANTIN L CAPSULE.

Can PANTIN L CAPSULE be used in elderly patients?

PANTIN L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANTIN L CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function. 

Is PANTIN L CAPSULE safe to use in patients with liver problems?

PANTIN L CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANTIN L CAPSULE.

Can I drive or operate machines after taking PANTIN L CAPSULE?

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANTIN L CAPSULE. Consult your doctor for advice before taking PANTIN L CAPSULE.

REFERENCES

1. KD. Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 651-654.

2. Keith A. Sharkey and John L. Wallace. Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1311-1313.

3. Gerald G. Briggs and Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2960 & -2775.

4. Sony Mathews, Ashley Reid, Chenlu Tian, and Qiang Cai. An update on the use of pantoprazole as a treatment for gastroesophageal reflux disease. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2010. [Accessed on 1st November 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108659/

5. G.Bianchi Porro, .Lazzaroni1V.Imbesi, F.Montrone, T.Santagada.  Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study. Digestive and Liver disease. ScienceDirect. April 2000. [Accessed on 1st November 2021] https://www.sciencedirect.com/science/article/abs/pii/S159086580080821X

6. D. C. Metz, G. M. Comer, E. Soffer, C. E. Forsmark, B. Cryer, W. Chey and J. R. Pisegna. Three-year oral pantoprazole administration is effective for patients with Zollinger–Ellison syndrome and other hypersecretory conditions. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2019. [Accessed on 1st November 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736592/

7. Jordi Serra. [Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 2010. [Accessed on 1st November 2021] https://pubmed.ncbi.nlm.nih.gov/20850200/

8. Cipla Ltd. Pansec L Capsules (Hetero Labs) (Pantoprazole + Levosulpiride). Ciplamed.com. [Revised in July 2020]. [Accessed on 1st November 2021] https://www.ciplamed.com/content/pansec-l-capsules-hetero-labs

9. Takeda GmbH. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 1st November 2021] https://www.medicines.org.uk/emc/files/pil.484.pdf

10. Alkem Laboratories Ltd. (Pantoprazole sodium 40 mg And Levosulpiride (SR) 75 mg Capsules) Pan-L. [Revised in June 2016] [Accessed on 1st November 2021] https://www.alkemlabs.com/pdf/adverse/PAN%20L.pdf

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    LEVOSULPIRIDE 75MG+PANTOPRAZOLE 40MG
    Hsn Code
    30049039
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Pantin L Capsule 10'S

Pantin L Capsule 10'S Mkt: Hetero Healthcare Ltd

M.R.P.: Rs.131.00
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