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INTRODUCTION

PANCRAZIO DSR CAPSULE is a combination of Domperidone and Pantoprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. It is used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis.

Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus or intestines. It causes severe stomach pain with sensation of flatulence, indigestion, vomiting and fatigue.

GERD is a chronic digestive disease in which the acid from the stomach frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.

Reflux esophagitis can be defined as the inflammation of the food pipe accompanied with acid reflex.

PANCRAZIO DSR CAPSULE acts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn.

It should be taken at least 15-30 minutes before meals. During treatment with PANCRAZIO DSR CAPSULE your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects.

Before taking PANCRAZIO DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.

PANCRAZIO DSR CAPSULE is not recommended for use in patients having bleeding from the gut. Consult your doctor before taking PANCRAZIO DSR CAPSULE if you are pregnant or breastfeeding. The most common side effects of taking PANCRAZIO DSR CAPSULE are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.

You must also inform your doctor immediately if you experience any signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat).

USES OF PANCRAZIO DSR CAPSULE

It is used in adults to treat:

  • Peptic ulcer
  • Gastrointestinal Reflux disease (GERD)
  • Reflux esophagitis (inflammation of the esophagus)
  • Nausea and Vomiting
  • Acidity, Heartburn
  • Signs of indigestion (such as burping, bloating)

HOW PANCRAZIO DSR CAPSULE WORKS

PANCRAZIO DSR CAPSULE contains two medicines namely domperidone and pantoprazole. Domperidone is a prokinetic medicine with anti-emetic properties. It works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord.

This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and brain which reduces the onset of nausea and vomiting.

Pantoprazole is a proton pump inhibitor. It reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach.

By reducing stomach acid production, PANCRAZIO DSR CAPSULE it prevents the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).

DIRECTIONS FOR USE

Take PANCRAZIO DSR CAPSULE 15-30 minutes before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PANCRAZIO DSR CAPSULE unless your doctor advice you to stop.

SIDE EFFECTS OF PANCRAZIO DSR CAPSULE

COMMON

  • benign polyps in the stomach
  • dry mouth

UNCOMMON

  • low sex drive
  • headache, dizziness, drowsiness
  • anxiety, sleeplessness
  • breast enlargement in both men and in women
  • feeling weak
  • fragile bones (risk of bone fracture)
  • nausea or vomiting
  • diarrhea, constipation, stomach pain, flatulence

RARE

Stop taking PANCRAZIO DSR CAPSULE and inform your doctor immediately if you experience any of the following side effects such as:

  • severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
  • signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
  • severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
  • signs of kidney problem (such as lower back pain, painful urination)
  • signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
  • skin rashes on sun exposed areas
  • sudden weight loss, looking pale and weak (anemia)
  • signs of bleeding in the gut (such as bloody vomits/stools)
  • chest pain
  • severe, persistent diarrhea
  • fast or irregular heartbeat, difficulty in breathing, feeling faint
  • fits
  • uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try to take PANCRAZIO DSR CAPSULE with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Constipation:

Taking PANCRAZIO DSR CAPSULE with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

WARNING & PRECAUTIONS

PREGNANCY

PANCRAZIO DSR CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

BREASTFEEDING

PANCRAZIO DSR CAPSULE may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician. Consult your doctor for advice.

DRIVING AND USING MACHINES

PANCRAZIO DSR CAPSULE does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by PANCRAZIO DSR CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking PANCRAZIO DSR CAPSULE, as it could aggravate your existing condition.

KIDNEY

PANCRAZIO DSR CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

LIVER

PANCRAZIO DSR CAPSULE is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take PANCRAZIO DSR CAPSULE if you are allergic to Domperidone, Pantoprazole or to any other proton pump inhibitors (such as rabeprazole, omeprazole).

HEART DISEASE

PANCRAZIO DSR CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure. Therefore, consult your doctor before taking it.

OTHERS

PANCRAZIO DSR CAPSULE is not recommended for use if you:

  • have bloody stools or bleeding in the gut
  • have blockage or tear in the intestines
  • have severe fluid or electrolyte disturbances
  • have prolactinoma (a non-cancerous tumor of pituitary gland)
  • have low blood potassium or magnesium levels

Before taking PANCRAZIO DSR CAPSULE inform your doctor if you:

  • have osteoporosis
  • have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
  • are going to test Chromogranin A level

Use in pediatrics:

PANCRAZIO DSR CAPSULE is not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor before taking it.

Use in geriatrics:

PANCRAZIO DSR CAPSULE should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANCRAZIO DSR CAPSULE inform your doctor if you are taking any of the following medicines such as:

  • other medicines used to treat gastrointestinal problems (Ex. cisapride, dolasetron, prucalopride, diphemanil)
  • medicines used to treat heart problems or hypertension (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
  • medicines used to treat HIV infection (Ex. atazanavir, nelfinavir, saquinavir)
  • medicines used to treat fungal infections (such as ketoconazole, itraconazole, posaconazole)
  • medicines used for blood thinning (Ex. warfarin and phenprocoumon)
  • medicines used to treat hepatitis C (Ex. telaprevir)
  • antipsychotics (used to treat mental illness) Ex. haloperidol, pimozide, sertindole
  • antidepressants (used to treat depression) Ex. escitalopram or citalopram, fluvoxamine, St John’s wort
  • antibiotics (used to treat bacterial infections) Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin
  • medicines used to treat malaria (Ex. halofantrine, lumefantrine)
  • antihistamines (used to treat allergies) Ex. mizolastine, mequitazine
  • medicines used to treat cancer (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
  • methotrexate (used to treat cancer and auto-immune disease)
  • bepridil (used to treat hypertension)
  • methadone (used to relieve pain)
  • iron salts (used to treat iron deficiency anemia)
  • tacrolimus or mycophenolate mofetil (used to prevent graft rejection)
  • pentamidine (used to treat parasite infections)
  • rifampicin (a medicine used to treat tuberculosis)

Overdosage:

If you or anyone else accidentally took more PANCRAZIO DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.

SYNOPSIS

Drug :   Domperidone, Rabeprazole
Pharmacological Category :   Dopamine D2 antagonists, Proton-pump inhibitors
Therapeutic Indication :   Peptic ulcer, GERD, Reflux esophagitis   
Dosage Forms :   Tablet, Capsule

MORE INFORMATION

  • Keep PANCRAZIO DSR CAPSULE out of the sight and reach of children
  • Store PANCRAZIO DSR CAPSULE at room temperature

FAQs ABOUT PANCRAZIO DSR CAPSULE

What is PANCRAZIO DSR CAPSULE used for?

PANCRAZIO DSR CAPSULE is used to treat peptic ulcers, GERD and reflux esophagitis. It can also be used to treat nausea, vomiting, bloating, burping, acidity and heartburn.

How and when to take PANCRAZIO DSR CAPSULE?

Take PANCRAZIO DSR CAPSULE at least 15-30 minutes before meals. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

How long should I take PANCRAZIO DSR CAPSULE?

You need to take PANCRAZIO DSR CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

What is the best time to take PANCRAZIO DSR CAPSULE?

PANCRAZIO DSR CAPSULE must be taken before meals to avoid gastrointestinal side effects.

What to do if I forgot to take a dose of PANCRAZIO DSR CAPSULE?

If you forgot to take a dose of PANCRAZIO DSR CAPSULE, take it as soon as you remember. However, if it is time for the next dose of PANCRAZIO DSR CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of PANCRAZIO DSR CAPSULE to compensate the missed ones.

What are the most common side effects of taking PANCRAZIO DSR CAPSULE?

The most common side effects of taking PANCRAZIO DSR CAPSULE are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.

Can I stop taking PANCRAZIO DSR CAPSULE without consulting your doctor?

No. You should not stop taking PANCRAZIO DSR CAPSULE without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using PANCRAZIO DSR CAPSULE, consult your doctor for advice.

Will taking a higher dose of PANCRAZIO DSR CAPSULE be more effective?

No, taking a higher dose of PANCRAZIO DSR CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What precautions do I need to follow while taking PANCRAZIO DSR CAPSULE?

Make sure to take PANCRAZIO DSR CAPSULE 30 minutes before meals. Before taking PANCRAZIO DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones. Consult your doctor before taking PANCRAZIO DSR CAPSULE if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended by your doctor without fail.

Can I take medication for high blood pressure along with PANCRAZIO DSR CAPSULE?

It is not advisable to take medicines to control blood pressure while taking PANCRAZIO DSR CAPSULE without consulting your doctor as they have known interactions with PANCRAZIO DSR CAPSULE.

Can PANCRAZIO DSR CAPSULE be used in pregnant women?

PANCRAZIO DSR CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

How to take PANCRAZIO DSR CAPSULE?

You must take PANCRAZIO DSR CAPSULE as advised by your physician. Try to take PANCRAZIO DSR CAPSULE 30 minutes before and swallow it with a glass of water. Do not crush or chew the medicine.

How much PANCRAZIO DSR CAPSULE should I take?

PANCRAZIO DSR CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Can PANCRAZIO DSR CAPSULE cause constipation?

Yes. Constipation is a common side effect of using PANCRAZIO DSR CAPSULE. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.

Can PANCRAZIO DSR CAPSULE cause dry mouth?

Yes. Dry mouth is a common side effect of using PANCRAZIO DSR CAPSULE. Contact your doctor if this side effect bothers you.

REFERENCES

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 653.

2. Nur Fathurah Zamani, Afifah Sjamun Sjahid, Tuan Hairulnizam Tuan Kamauzaman, Yeong Yeh Lee and Md Asiful Islam. Efficacy and Safety of Domperidone in Combination with Proton Pump Inhibitors in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Journal of Clinical Medicine. August 2022. [Accessed on 21st October 2022]. https://www.mdpi.com/2077-0383/11/18/5268/htm

3. Cipla Ltd. NEW PANTOSEC D SR Capsules (Pantoprazole Gastro-resistant + Domperidone Prolonged Release Capsules IP). Ciplamed.com. [Revised in April 2020]. [Accessed on 21st October 2022]. https://www.ciplamed.com/content/new-pantosec-d-sr-capsules

4. Panacea Biotec Limited. OD-PEP-D CAPSULES. [Revised in July 2019]. [Accessed on 21st October 2022]. https://media.panaceabiotec.com/documents/2019/7/27/ProductMonograph-OP-PEP-D.pdf

5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021]. [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.556.pdf

6. Takeda GmbH. Electronic Medicines Compendium (EMC). [Revised in April 2022]. [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.483.pdf

7. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021]. [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.7090.pdf

8. Leeford Healthcare Ltd. Pantafol-D. [Accessed on 21st October 2022]. https://www.leeford.in/product/775/pantafol-d

9. Hetero Healthcare Ltd. Pantin RD Tablet. [Accessed on 21st October 2022]. https://www.heterohealthcare.com/pantin-rd-tablet

10. Central Drugs Standard Control Organization. Pantoprazole+Domperidone SR. [Revised in December 2004]. [Accessed on 21st October 2022]. https://cdscoonline.gov.in/CDSCO/Drugs

VIDEOS

Domperidone+Pantoprazole CAPSULE - Drug Information

Domperidone+Pantoprazole CAPSULE : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    DOMPERIDONE 30 mg+PANTOPRAZOLE 40 mg
    Hsn Code
    30049039
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PANCRAZIO DSR Capsule 10's

PANCRAZIO DSR Capsule 10's Mkt: Cadomed Pharmaceuticals India Pvt Ltd

M.R.P.: Rs.89.30
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