INTRODUCTION
OXITRUST 100MG INJECTION contains Oxaliplatin which belongs to the group of medicine called Anticancer drugs. It is used to treat cancers of the colon and/or rectum. It is highly used in combination with other anti-cancer medicines (such as 5-flurouracil and folinic acid) as an adjunct to treat stage III colon cancer after removing the primary tumour. It can also be used to treat metastatic colorectal cancer (cancer of colon and rectum that has been spread to other parts of the body).
Before receiving OXITRUST 100MG INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low white blood count in your blood or recently received or planning to receive any vaccination in the upcoming days.
OXITRUST 100MG INJECTION is not recommended for use in pregnant or breastfeeding women and in children aged below 18 years. Men and women receiving OXITRUST 100MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with OXITRUST 100MG INJECTION.
The most common side effects of receiving OXITRUST 100MG INJECTION are tingling and numbness of body parts, abnormal sensation in the throat, nausea, vomiting, stomach pain, headache, dizziness, tiredness, weight loss, changes in taste, skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your doctor if any of these side effect worsens.
USES OF OXITRUST 100MG INJECTION
It is used to treat:
- Colon cancer (stage III)
- Metastatic colorectal cancer
HOW OXITRUST 100MG INJECTION WORKS
OXITRUST 100MG INJECTION is an anticancer medication. It works by damaging the DNA (genetic material) of the cancer cells. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.
DIRECTIONS FOR USE
OXITRUST 100MG INJECTION will be given to you only by a doctor or a nurse into a vein (as an intravenous infusion).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF OXITRUST 100MG INJECTION
COMMON
- nerve pain, tingling and numbness of body parts
- abnormal sensation in the throat, problems in breathing
- diarrhea, nausea, vomiting, constipation, stomach pain
- indigestion, heartburn, hiccups
- low blood counts (causing bleeding, anemia and increased infections)
- injections site reactions (pain and discomfort)
- fever, shakiness, headache, dizziness, tiredness, body pains
- weight loss, lack of appetite
- changes in taste, nasal bleeds
- skin rash, itching, flaky skin, hair loss, flushing
- nail disorder, increased sweating
- joint pain
- passing little or no urine
- high blood pressure
- depression and lack of sleep
- low blood calcium levels
- neck stiffness
UNCOMMON
- nervousness
RARE
- loss of hearing
Contact your doctor immediately if you experience any of the following side effects after receiving OXITRUST 100MG INJECTION:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- mouth ulcers (oral sores)
- low platelet count in blood causing excessive unusual bruising
- dry cough, difficulty in breathing and crackling sounds
- sepsis (blood infections)
- low WBC count causing fever or flu-like symptoms
- signs of blood clots in lungs (chest pain, difficulty in breathing, coughing up blood)
- blockage or swelling in the intestines
- problems in hearing, ringing sound in the ears and spinning sensation
- severe persistent diarrhea and vomiting
- short-term vision loss
- signs of reversible posterior leukoencephalopathy syndrome (a nerve disorder causing headache, altered mental functioning, seizures and abnormal vision from blurriness to vision loss)
- signs of Haemolytic-uraemic syndrome (such as extreme tiredness, low RBC count, shortness of breath, low platelet count, abnormal bruising, passing little or no urine)
- inflammation of the lungs
- pain in upper abdomen and back with nausea and vomiting
- vascular disorders of the liver (symptoms include abdominal pain and swelling, weight gain and tissue swelling of the feet, ankles or other parts of the body)
- bleeding in the gut causing bloody stools or vomits
HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Nausea and Vomiting:
Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.
Mouth ulcers:
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Diarrhoea:
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.
WARNING & PRECAUTIONS
PREGNANCY
OXITRUST 100MG INJECTION is generally not recommended for use in pregnant women. However, consult your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with OXITRUST 100MG INJECTION and until 4 months after stopping the therapy. If you accidentally became pregnant while receiving OXITRUST 100MG INJECTION, inform your doctor immediately.
BREASTFEEDING
OXITRUST 100MG INJECTION is not recommended for use in women who are breastfeeding. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by OXITRUST 100MG INJECTION.
KIDNEY
OXITRUST 100MG INJECTION is not recommended to use in patients with severe kidney problems. It should be used with caution in patients with mild to moderate kidney problems. Therefore, consult your doctor before receiving it.
LIVER
OXITRUST 100MG INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
ALLERGY
Talk to your doctor before receiving OXITRUST 100MG INJECTION if you are allergic to Oxaliplatin or to any other platinum-based anticancer medicines (such as carboplatin, cisplatin).
HEART DISEASE
OXITRUST 100MG INJECTION should be used with caution in patients with heart problems (such as prolongation of the QT interval, an irregular heartbeat). It should also be used with caution in patients having a family history of heart problems. Therefore, consult your doctor before receiving it.
OTHERS
OXITRUST 100MG INJECTION is not recommended for use if you have:
- reduced number of blood cells
- tingling and numbness in the fingers and/or toes
- difficulty in performing delicate tasks (such as buttoning clothes)
Inform your doctor, before receiving OXITRUST 100MG INJECTION, if you:
- recently received any vaccine or plan to receive any vaccines
Use in pediatrics:
OXITRUST 100MG INJECTION is generally not recommended for use in children and adolescents (under 18 years of age). Therefore, consult your doctor before receiving it.
Use in geriatrics:
OXITRUST 100MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
INTERACTIONS
Drug-Drug interactions:
Inform your physician, before receiving OXITRUST 100MG INJECTION, if you are taking any of the following medicines such as:
- other medicines used to treat cancer (Ex. 5-fluorouracil, paclitaxel)
- medicines used as antibiotics (Ex. erythromycin)
- medicines used to relieve pain (Ex. salicylates)
- medicines used for vomiting (Ex. granisetron)
- medicines used to treat epilepsy (Ex. sodium valproate)
- live or attenuated vaccines (Ex. yellow fever vaccine)
Overdosage:
OXITRUST 100MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Oxaliplatin |
| Pharmacological Category | : | Platinum-based chemotherapy agent |
| Therapeutic Indication | : | Colorectal cancer |
| Dosage Forms | : | Injection, Infusion |
MORE INFORMATION
- Keep OXITRUST 100MG INJECTION out of reach of children
- Store OXITRUST 100MG INJECTION below 25°C
FAQs ABOUT OXITRUST 100MG INJECTION
What OXITRUST 100MG INJECTION is used for?
OXITRUST 100MG INJECTION is used to treat colorectal cancer. It can also be used to treat metastatic colorectal cancer and can be used an adjunct to treat stage III colon cancer after removing the primary tumour.
How OXITRUST 100MG INJECTION works on my body?
OXITRUST 100MG INJECTION is an anti-cancer medicine. It works by damaging the genetic material (DNA) of the cancer cells. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.
Can OXITRUST 100MG INJECTION cure cancer?
The cure rate of cancer depends upon the severity of the disease. However, OXITRUST 100MG INJECTION acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.
Can the use of OXITRUST 100MG INJECTION cause hair loss?
Hair loss is one of the common side effects of receiving OXITRUST 100MG INJECTION. If it bothers you, consult your doctor for advice.
Can the use of OXITRUST 100MG INJECTION cause mouth ulcers?
Mouth ulcers are one of the common side effects of receiving OXITRUST 100MG INJECTION. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Can OXITRUST 100MG INJECTION be used in children?
OXITRUST 100MG INJECTION should not be used in children aged below 18 years. Therefore, consult your doctor before receiving it.
Is OXITRUST 100MG INJECTION a chemo drug?
Yes. OXITRUST 100MG INJECTION contains a medicine called oxaliplatin which is a platinum-based chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.
What precautions must be followed while taking OXITRUST 100MG INJECTION?
Before taking OXITRUST 100MG INJECTION inform your doctor if you have any liver, kidney or heart problems. Inform your doctor before receiving OXITRUST 100MG INJECTION if you are a pregnant or a breastfeeding woman. Men and women receiving OXITRUST 100MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with OXITRUST 100MG INJECTION.
What happens if I stop receiving OXITRUST 100MG INJECTION?
No. Do not stop receiving OXITRUST 100MG INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take OXITRUST 100MG INJECTION as advised by your doctor for the stipulated duration.
Can OXITRUST 100MG INJECTION be used during pregnancy?
OXITRUST 100MG INJECTION is generally not recommended for use in pregnant women. If you accidentally became pregnant while receiving OXITRUST 100MG INJECTION, inform your doctor immediately.
Can the use of OXITRUST 100MG INJECTION make me feel tired?
Yes. OXITRUST 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving OXITRUST 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Can I drive a car after receiving OXITRUST 100MG INJECTION?
OXITRUST 100MG INJECTION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by OXITRUST 100MG INJECTION.
How OXITRUST 100MG INJECTION is administered?
OXITRUST 100MG INJECTION will be given to you only by a doctor or a nurse into a vein (as an intravenous infusion).
How to control nausea caused due to OXITRUST 100MG INJECTION?
Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with OXITRUST 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.
What are the side effects of receiving OXITRUST 100MG INJECTION?
The most common side effects of receiving OXITRUST 100MG INJECTION are tingling and numbness of body parts, abnormal sensation in the throat, nausea, vomiting, stomach pain, headache, dizziness, tiredness, weight loss, changes in taste, skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your doctor if any of these side effect worsens.
Who should avoid taking OXITRUST 100MG INJECTION?
OXITRUST 100MG INJECTION is not recommended for use if you are allergic to oxaliplatin. It is also not recommended for use in pregnant or breastfeeding women and in children (aged below 18 years).
Is OXITRUST 100MG INJECTION safe to use in kidney disease?
OXITRUST 100MG INJECTION should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.
Can the use of OXITRUST 100MG INJECTION affect the liver?
Yes. OXITRUST 100MG INJECTION may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
REFERENCES
1. KD. Tripathi. Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 862.
2. Zaoqin Yu, Rui Huang, Li Zhao, Ximin Wang, Xiaofang Shangguan, Wei Li, Min Li, Xianguo Yin, Chengliang Zhang and Dong Liu. Safety Profile of Oxaliplatin in 3,687 Patients With Cancer in China: A Post-Marketing Surveillance Study. Frontiers in Oncology. October 2021 [Accessed on 14th November 2022] https://www.frontiersin.org/articles/10.3389/fonc.2021.757196/full
3. T. Alcindor, MD and N. Beauger, PhD MBA. Oxaliplatin: a review in the era of molecularly targeted therapy. Journal of Current Oncology. February 2011 [Accessed on 14th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031353/
4. E.Raymond, S.G.Chaney, A.Taamma, E.Cvitkovic. Oxaliplatin: A review of preclinical and clinical studies. Journal of Annals of Oncology. October 1998 [Accessed on 9th November 2022] https://www.sciencedirect.com/science/article/pii/S0923753419482045
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 14th November 2022] https://www.medicines.org.uk/emc/files/pil.6088.pdf, https://www.medicines.org.uk/emc/product/6088/smpc
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.