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INTRODUCTION
OSTEOFOS 70MG contains Alendronic acid which belongs to the group of medicines called Bisphosphonates. It is used to treat and prevent osteoporosis (weak or brittle bones) in Postmenopausal Women.
It helps to improve bone mass density in patients with weak bones and can also be used to treat osteoporosis caused due to excessive use of corticosteroids (such as prednisone). It also helps in the treatment of Paget’s disease (abnormal bone growth due to disturbances in normal span of bone cells).
Alendronic acid prevents bone loss and helps in building bone mass and density. It works by attaching itself to the bone surface and then stops the action of certain bone cells that destroys the bone mass. It also stabilizes the replacement of new bone tissue growth and prevents abnormal bone growth.
Take OSTEOFOS 70MG on an empty stomach. Do not lie down immediately after taking OSTEOFOS 70MG. It is necessary to maintain a good oral hygiene while undergoing treatment with OSTEOFOS 70MG. Therefore, routinely have dental check-ups throught the treatment to avoid unwanted oral problems. You should also inform your doctor immediately if you experience any oral problems such as tooth pain or swelling or lossening after taking OSTEOFOS 70MG.
Before taking OSTEOFOS 70MG inform your doctor if you have any problems in the kidneys or in the stomach or are scheduled for any oral treatment or dental surgery. Do not take OSTEOFOS 70MG if you are pregnant or breastfeeding without consulting your doctor.
OSTEOFOS 70MG is not recommended for use in patients having problems in their food pipe. It is also not suitable for use in patients who are unable to sit or stand upright for at least 30 minutes at a time. The most common side effects of OSTEOFOS 70MG are headache, dizziness, stomach pain, bloating, indigestion, diarrhoea, constipation, or acid reflux. Consult your doctor if any of the side effect troubles you.
USES OF OSTEOFOS 70MG
- Treats osteoporosis (caused due to low bone mass, menopause or corticosteroid use)
- Treats Paget’s disease
HOW OSTEOFOS 70MG WORKS
OSTEOFOS 70MG prevents bone loss and helps in building bone mass and density, where alendronic acid works by attaching itself to the bone surface and then stops the action of certain bone cells that destroys the bone mass. It also stabilizes the replacement of new bone tissue growth and prevents abnormal bone growth. As a result, it improves bone mass, makes them stronger and prevents the risk of fracture.
DIRECTIONS FOR USE
Take OSTEOFOS 70MG as advised by your physician. Swallow the medicine with a glass full of plain water. Take OSTEOFOS 70MG on an empty stomach or at least 30 minutes before taking any food, drink or medicines.
Do not consume tea, coffee, mineral water, or juice along with OSTEOFOS 70MG. Do not lie down immediately after taking OSTEOFOS 70MG. Avoid taking OSTEOFOS 70MG at bedtime.
Stay upright (sitting, standing, or walking) for at least 30 minutes after taking OSTEOFOS 70MG and do not lie down until you have eaten the first meal of the day. This is followed to prevent the reflux of medicine back to the oesophagus.
Your doctor will decide the suitable dose and duration of therapy for you depending upon your age, body weight and health condition. You may also be prescribed with vitamin D or calcium supplements, along with OSTEOFOS 70MG to improve your disease condition. Do not stop taking OSTEOFOS 70MG without consulting your doctor as it can reduce the effectives of this medicine.
SIDE EFFECTS OF OSTEOFOS 70MG
COMMON
- gastric problems (ulceration of food pipe, difficulty and pain while swallowing, bloating, indigestion, diarrhoea, constipation, stomach pain and reflux of acid from stomach)
- headache, dizziness
- vertigo (spinning sensation)
- hair loss
- swelling in the joints
- lack of energy or weakness
- itching
- presence of excess of fluid especially in legs (peripheral oedema)
UNCOMMON
- black tarry stools
- nausea and vomiting
- skin redness
- temporary flu-like symptoms usually at the begining of the treatment (such as feeling ill, muscl pain and rarely fever)
- inflammation of the eye
- changes in sense of taste
RARE
- narrowing of the food pipe
- skin rashes due to light sensitivity
- muscle cramps or spasms and tingling sensation around the mouth or in finger because of low calcium levels
- pain and inflammation of jaw, mainly seen in people who had got tooth extraction done or had a mouth infection
Stop taking OSTEOFOS 70MG and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, lips, eyes, tongue or throat causing wheezing or difficulty in breathing)
- signs of severe skin reactions called as toxic epidermal necrolysis or Stevens Johnson syndrome (such as formation of blisters or rashes on the skin, or other effects seen on eyes, mouth or genitals, skin which leads to itching and increased body temperature)
- difficulty or pain while swallowing and pain behind breastbone
- new or worsened heartburn
- tooth problems (tooth pain, swelling or lossening)
- signs of fracture in thigh bone (such as pain, weakness or discomfort in the thigh, hip or groin)
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting
Take OSTEOFOS 70MG with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Constipation:
Eat lot of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness
Try to rest and relax. Get enough sleep. Lie down or sit immediately if you feel dizzy. Avoid driving or operating any heavy tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it could aggravate your dizziness. Consult your doctor if you continue to feel dizzy for a prolonged period.
WARNING & PRECAUTIONS
PREGNANCY
OSTEOFOS 70MG is not recommended for use in pregenant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
OSTEOFOS 70MG is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if your ability is affected by OSTEOFOS 70MG.
ALCOHOL
Do not take OSTEOFOS 70MG if you are allergic to Alendronic acid.
KIDNEY
OSTEOFOS 70MG should be used with caution in patients who have or ever had any kidney problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take OSTEOFOS 70MG if you are allergic to Alendronic acid.
OTHERS
OSTEOFOS 70MG is not recommended for use if you:
- have certain diseases of the food pipe such as difficulty in swallowing or narrowing of the food pipe
- have low blood calcium levels
- are not able to stand or sit straight for a minimum of 30 minutes
Before taking OSTEOFOS 70MG inform your doctor if you:
- Barrett’s oesophagus (a condition in which there are changes seen in the cells of lower food pipe)
- had surgery of stomach or food pipe (this does not include pyroplasty (a surgery of widening of stomach outlet))
- or had low Vitamin D levels in the body
- hypoparathyroidism (a condition in which the parathyroid gland does not work properly)
- had dental treatment or planning to undergo any dental surgery
- had pain, swelling and numbness of jaw or feel loosening of a tooth or heavy jaw feeling
- cancer or undergoing radiotherapy or chemotherapy, or taking steroids
- not been reciving regular dental care or smoke or have mouth infection
- inflammation of lining of stomach or the first section of small intestine
- stomach ulcer or other digestive problems such as bleeding in the stomach
Use in pediatrics:
OSTEOFOS 70MG is not recommended for use in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.
Use in geriatrics:
OSTEOFOS 70MG should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking OSTEOFOS 70MG, inform your doctor if you are taking any of the following medicines such as:
- non-steroidal anti-inflammatory drugs (used to relieve fever, pain and inflammation) Ex. aspirin and ibuprofen
B. Drug –Food Interactions
OSTEOFOS 70MG takes longer time to work if taken with heavy meal or after drinks. It is advised to take OSTEOFOS 70MG on an empty stomach or atleast 30 minutes before taking any food or drink.
Overdosage:
If you or anyone else accidentally took more OSTEOFOS 70MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are heartburn, stomach upset, inflammation of the stomach or food pipe, cramps in the stomach or in the muscle, fits and weakness.
SYNOPSIS
| Drug | : | Alendronic acid |
| Pharmacological Category | : | Bisphosphonates |
| Therapeutic Indication | : | Osteoporosis, Paget’s Disease |
| Dosage Forms | : | Tablet, Oral Jelly |
MORE INFORMATION
- Keep OSTEOFOS 70MG out of reach of children
- Store OSTEOFOS 70MG at room temperature
FAQs ABOUT OSTEOFOS 70MG
Who should not take OSTEOFOS 70MG?
OSTEOFOS 70MG should not be used in patients who are not able to swallow or having any problems in food pipe that hinders swallowing (such as narrowing of the gullet). It should also not be used in patients who can sit or stand constantly for 30 minutes. Women who are pregnant or planning to become pregnant must not take OSTEOFOS 70MG without consulting their doctor.
What is the use of OSTEOFOS 70MG?
OSTEOFOS 70MG is used to treat bone problems such as osteoporosis caused due to aging, menopause, or excessive corticosteroid use. It can also be used to treat Paget’s disease.
Why is OSTEOFOS 70MG taken once a week?
It is because, OSTEOFOS 70MG contains a medicine called alendronic acid which acts by blocking the actions of bone killing cells (osteoclasts). Since the process of replacing the older bone cells with newer ones takes around 2-3 weeks for completion, taking OSTEOFOS 70MG once a week would make it stay on the affected bones sites for a sustained period and effectively stop bone destruction.
What are the side effects of OSTEOFOS 70MG?
The most common side effects of OSTEOFOS 70MG are headache, dizziness, stomach pain, bloating, indigestion, diarrhoea, constipation, or acid reflux. Consult your doctor if any of the side effect troubles you. You should also inform your doctor immediately if you experience any oral problems such as tooth pain or swelling or lossening after taking OSTEOFOS 70MG.
Why am I instructed to stand upright for a few minutes after taking OSTEOFOS 70MG?
You need to stand upright for a few minutes after taking OSTEOFOS 70MG so that the medicine does not come back up again from your food pipe and does not harm you.
How to take OSTEOFOS 70MG?
Take OSTEOFOS 70MG as advised by your physician. Swallow the medicine with a glass full of plain water. Take OSTEOFOS 70MG on an empty stomach and at least 30 minutes before taking any food, drink, or medicines. Stay upright for at least 30 minutes after taking the medicine. Your doctor will decide the suitable dose and duration of therapy for you depending upon your age, body weight and health condition.
Can elderly patients take OSTEOFOS 70MG?
Yes, elderly patients can take OSTEOFOS 70MG after consulting their doctor.
Can OSTEOFOS 70MG cause hair loss?
Yes. OSTEOFOS 70MG may cause hair loss in some individuals, although not everybody gets them. Regularly wash your hair and moisturize it. Avoid using harsh chemicals on your hair as it can aggravate your hair fall. Consult your doctor if the symptom bothers you.
Can OSTEOFOS 70MG cure osteoporosis?
Yes. OSTEOFOS 70MG helps in preventing osteoporosis and helps in gaining back the lost bone mass. However, consult your doctor before taking.
Can OSTEOFOS 70MG be taken daily?
Take OSTEOFOS 70MG as advised by your physician. Your doctor will instruct you on how many days you may need to take this medicine. Strictly follow the instructions given by your doctor.
What precautions do I need to follow while taking OSTEOFOS 70MG?
Take OSTEOFOS 70MG on an empty stomach or at least have a time gap of 30 minutes between your first meal and the medicine. Do not take OSTEOFOS 70MG before going to bed or just after getting up in the morning. Sit or stand or walk straight for at least 30 minutes after taking OSTEOFOS 70MG. Do not lie down. Do not take OSTEOFOS 70MG if you are taking any painkiller such as aspirin or ibuprofen. Before taking OSTEOFOS 70MG inform your doctor if you have in trouble in swallowing.
Will taking a higher dose of OSTEOFOS 70MG be more effective?
No. Taking a higher dose of OSTEOFOS 70MG will not be effective. Stick to the dosage that your doctor has prescribed to you. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor will increase the dose or suggest an alternative therapy depending upon your health condition.
How OSTEOFOS 70MG works?
OSTEOFOS 70MG works by binding itself to the bone surface and by stopping the action of bone eating cells. This helps in preventing bone loss and risk of fracture. It also improves bone mass and makes your bones stronger.
Can OSTEOFOS 70MG cause dental problems?
Yes. OSTEOFOS 70MG may cause dental problems such as jaw inflammation or pain and loosening of tooth. Therefore, consult your doctor immediately if you experience any such symptoms.
Can I stop taking OSTEOFOS 70MG once my symptoms subside?
No. Do not stop taking OSTEOFOS 70MG without consulting your doctor once your symptoms subside, as it may reverse the healed condition. Continue to take OSTEOFOS 70MG as long as instructed by your doctor.
Can OSTEOFOS 70MG cause weight gain?
It is unlikely that OSTEOFOS 70MG would cause increase in weight in patients. However, it may cause peripheral edema (accumulation of fluid in the body) in some patients which may make them feel that they have gained a lot of weight.
REFERENCES
1. K.D. Tripathi. Drugs effecting Calcium balance. Essentials of medical pharmacology. Seventh edition. 2013. Page – 344-345.
2. M. Sharpe, S Noble and C M Spencer. Alendronate: an update of its use in osteoporosis. NIH National Library of Medicine, National center for biotechnology information. 2001. [Accessed on 12th May 2022] https://pubmed.ncbi.nlm.nih.gov/11434454/
3. Actavis Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2015]. [Accessed on 12th May 2022] https://www.medicines.org.uk/emc/files/pil.5697.pdf
4. Actavis Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2015]. [Accessed on 12th May 2022] https://www.medicines.org.uk/emc/files/pil.5431.pdf
5. Cipla Ltd. Osteofos Tablet (Alendronate). Ciplamed.com. [Revised in January 2021] [Accessed on 13th May 2022] https://www.ciplamed.com/content/osteofos-tablets
USEFUL DIAGNOSTIC TESTS
- Blood Calcium test
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