INTRODUCTION

ORIGUS 50MG contain diacerein which belongs to a group of medicine called anthraquinones. It is used for symptomatic treatment of osteoarthritis. Osteoarthritis is a disease characterized by degeneration of cartilage and its underlying bones within a joint as well as bony overgrowth. The breakdown of these tissue eventually leads to pain and joint stiffness. The joints most affected are the knees, hips, and those in the hands and spine.

It works by building cartilage (soft connective tissue around the joints) leading to joint repair. It also lowers pain and inflammation (swelling). The common side effects are diarrhoea, soft stools, abdominal pain, frequent bowel movements, flatulence, skin effects such as rash, itching, eczema.

Always take ORIGUS 50MG exactly as your doctor has told you. This medicine must be taken with food and try to take at the same time each day. It is not recommended for use in children and adolescents under 15 years. Consumption of alcohol is not recommended during treatment with this medicine. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.

USES OF ORIGUS 50MG

• Used for symptomatic treatment of osteoarthritis

HOW ORIGUS 50MG WORKS

ORIGUS 50MG works by building cartilage (soft connective tissue around the joints) leading to joint repair. It also lowers pain and inflammation (swelling).

DIRECTIONS FOR USE

Always take ORIGUS 50MG exactly as your doctor has told you. This medicine must be taken with food and try to take at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF ORIGUS 50MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.

Abdominal pain:

Try to rest and relax. Eat and drink slowly or have smaller and frequent meal. Applying heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• laxatives such as rhein
• antacids
• diuretics
• digoxin or other glycosides (used for heart treatment)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ORIGUS 50MG

Is ORIGUS 50MG a steroid or painkiller?

No, it is not a steroid or pain killer.

Is ORIGUS 50MG safe?

Yes, it is safe when taken for an indication and at a dose strictly instructed by your doctor.

Can I take ORIGUS 50MG during liver disease?

No, it is not recommended in patients with active liver diseases. Before taking this medicine consult your doctor.

REFERENCES

1. Karel Pavelka,1 Olivier Bruyère, corresponding author2 Cyrus Cooper,3 John A. Kanis,4 Burkhard F. Leeb,5 Emmanuel Maheu,6 Johanne Martel-Pelletier,7 Jordi Monfort,8 Jean-Pierre Pelletier,7 René Rizzoli,9 and Jean-Yves Reginster2. Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. US National Library of Medicines, National Institutes of Health. 5 Feb 2016. [Accessed 17 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756045/

2. T S A Fidelix 1, B G D O Soares, V F M Trevisani. Diacerein for osteoarthritis. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 25 Jan 2006. [Accessed 17 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/16437519/

3. Trima israel pharmaceutical products maabarot Ltd, Nov 2015; Electronic Medicines Compendium (EMC); [Accessed 17 Dec 2020] https://data.health.gov.il/drugs/alonim/Diatrim_eng_1462364199647.pdf

USEFUL DIAGNOSTIC TESTS

• Calcium
• Rheumatoid Factor IgG Antibody
• Rheumatoid Factor IgM Antibody